NO912411L - Fremgangsmaate for fremstilling av bicykliske heterocykliske forbindelser. - Google Patents

Fremgangsmaate for fremstilling av bicykliske heterocykliske forbindelser.

Info

Publication number
NO912411L
NO912411L NO91912411A NO912411A NO912411L NO 912411 L NO912411 L NO 912411L NO 91912411 A NO91912411 A NO 91912411A NO 912411 A NO912411 A NO 912411A NO 912411 L NO912411 L NO 912411L
Authority
NO
Norway
Prior art keywords
preparation
bicycleic
procedure
sulfinyl
thio
Prior art date
Application number
NO91912411A
Other languages
English (en)
Other versions
NO912411D0 (no
Inventor
Pierre Andre Raymond Bruneau
Graham Charles Crawley
Original Assignee
Ici Pharma
Ici Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ici Pharma, Ici Plc filed Critical Ici Pharma
Publication of NO912411D0 publication Critical patent/NO912411D0/no
Publication of NO912411L publication Critical patent/NO912411L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
    • C07D273/04—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Oppfinnelsen angår en fremgangsmåte for fremstilling av en bicyklisk heterocyklisk forbindelse med formel I. hvor Q er en eventuelt substituert 10-leddet bicyklisk heterocyklisk del som inneholder ett eller to nitrogenatomer og et ytterligere oksygen- eller svovel-heteroatom;. Ai er en direkte binding til Xeller utgjør (l-3C)alkylen;. Xer oksy, tio, sulfinyl, sulfonyl eller imino;. Ar er eventuelt substituert fenylen eller pyridylen;. Rer (l-4C)alkyl, (3-4C)alkenyl eller (3-4C)alkynyl; og. R2 og3 sammen danner en gruppe med formel -AX2-A, som sammen med karbonatomet som A2 og Aer tilknyttet, utgjør en ring med 5 til 7 ringatomer, hvor2 oghver er (l-3C)alkylen, og Xer oksy, tio, sulfinyl eller sulfonyl;. eller et farmasøytisk akseptabelt salt derav.Forbindelsene fremstillet i henhold til oppfinnelsen er hemmere av enzymet 5-lipoksygenase.
NO91912411A 1990-06-21 1991-06-20 Fremgangsmaate for fremstilling av bicykliske heterocykliske forbindelser. NO912411L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP90401757 1990-06-21
EP91400076 1991-01-15

Publications (2)

Publication Number Publication Date
NO912411D0 NO912411D0 (no) 1991-06-20
NO912411L true NO912411L (no) 1991-12-23

Family

ID=26127306

Family Applications (1)

Application Number Title Priority Date Filing Date
NO91912411A NO912411L (no) 1990-06-21 1991-06-20 Fremgangsmaate for fremstilling av bicykliske heterocykliske forbindelser.

Country Status (26)

Country Link
US (3) US5217969A (no)
EP (1) EP0462813B1 (no)
JP (1) JP3112981B2 (no)
KR (1) KR920000738A (no)
AR (1) AR247886A1 (no)
AT (1) ATE129497T1 (no)
AU (1) AU637500B2 (no)
CA (1) CA2044219A1 (no)
CS (1) CS187491A3 (no)
DE (1) DE69114052T2 (no)
DK (1) DK0462813T3 (no)
ES (1) ES2079576T3 (no)
FI (1) FI913048A (no)
GB (1) GB9113132D0 (no)
GR (1) GR3017888T3 (no)
HU (2) HU210919B (no)
IE (1) IE911919A1 (no)
IL (1) IL98396A (no)
MY (1) MY106366A (no)
NO (1) NO912411L (no)
NZ (1) NZ238470A (no)
PL (1) PL168310B1 (no)
PT (1) PT98041A (no)
RU (1) RU2059627C1 (no)
TW (1) TW217412B (no)
ZW (1) ZW7091A1 (no)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5254581A (en) * 1990-06-21 1993-10-19 Imperial Chemical Industries Plc Pyran derivatives and their use as inhibitors of 5-lipoxygenase
IE911853A1 (en) * 1990-06-21 1992-01-01 Ici Plc Heterocyclene derivatives
IE913655A1 (en) * 1990-11-06 1992-05-22 Zeneca Ltd Synergistic agents
IE914005A1 (en) * 1990-12-14 1992-06-17 Zeneca Ltd Novel intermediates
DE69206725T2 (de) * 1991-09-10 1996-05-02 Zeneca Ltd Benzolsulfonamidderivate als 5-Lipoxygenasehemmer
CA2094465A1 (en) * 1992-04-23 1993-10-24 Pierre Andre Raymond Bruneau Cycloalkane derivatives
CA2095006A1 (en) * 1992-05-12 1993-11-13 Philip Neil Edwards Oxime derivatives
CA2095005A1 (en) * 1992-05-12 1993-11-13 Philip Neil Edwards Hydroxylamine derivatives
AU4444393A (en) * 1992-09-01 1994-03-10 Zeneca Limited Pyrrolidine derivatives
US5354865A (en) * 1992-09-10 1994-10-11 Abbott Laboratories Phenylmethyl derivatives having lipoxygenase inhibitory activity
IL109254A (en) * 1993-04-29 1999-03-12 Zeneca Ltd History of the tetrahydropyran and tetrahydropuran site preparation and pharmaceutical preparations containing them
US5424320A (en) * 1993-06-23 1995-06-13 Merck Frosst Canada, Inc. Heteroaryl coumarins as inhibitors of leukotriene biosynthesis
US5360815A (en) * 1993-06-23 1994-11-01 Merck Frosst Canada, Inc. Heteroaryl cinnamic acids as inhibitors of leukotriene biosynthesis
US5459271A (en) * 1993-07-20 1995-10-17 Merck Frosst Canada, Inc. Arylbicyclooctanes as inhibitors of leukotriene biosynthesis
EP0636624A1 (en) * 1993-07-27 1995-02-01 Zeneca Limited Thiazole derivatives as lipoxygenase inhibitors
IL110280A0 (en) * 1993-07-27 1994-10-21 Zeneca Ltd Thiazole derivatives
ZA945250B (en) * 1993-07-27 1995-01-27 Zeneca Ltd Thiazole derivatives
US5350760A (en) * 1993-08-04 1994-09-27 Merck Frosst Canada, Inc. Aza-5,5-fused hetrocyclic acids as leukotriene antagonists
EP0752990B1 (en) * 1994-03-28 1998-08-05 Pfizer Inc. Benzisothiazoles derivatives as inhibitors of 5-lipoxygenase biosynthesis
WO1995030668A1 (en) * 1994-05-06 1995-11-16 Zeneca Limited Cyclic ether derivatives and pharmaceutical composition containing them
US5643933A (en) * 1995-06-02 1997-07-01 G. D. Searle & Co. Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
US5891460A (en) * 1995-06-07 1999-04-06 University Of Southern California University Park Campus Method for reducing or preventing post-surgical adhesion formation using ketotifen and analogs thereof
US6677364B2 (en) * 1998-04-20 2004-01-13 G.D. Searle & Co. Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
EP1385835A1 (en) 2001-04-23 2004-02-04 Astrazeneca AB Benzoxazinone derivatives for use in the treatment of angiogenesis
US7378415B2 (en) 2004-09-30 2008-05-27 Roche Palo Alto Llc Benzoxazine and quinoxaline derivatives and uses thereof
WO2007087250A2 (en) * 2006-01-23 2007-08-02 Amira Pharmaceuticals, Inc. Tricyclic inhibitors of 5-lipoxygenase
WO2007130014A1 (en) * 2006-04-28 2007-11-15 E. I. Du Pont De Nemours And Company Organosilicon polymers
PL2170826T3 (pl) * 2007-06-04 2022-09-05 Techfields Inc Proleki nsaia o bardzo wysokim współczynniku przenikania przez skórę i błony oraz ich nowe zastosowania lecznicze
US11033523B2 (en) 2009-04-29 2021-06-15 Amarin Pharmaceuticals Ireland Limited Pharmaceutical compositions comprising EPA and a cardiovascular agent and methods of using the same

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3661917A (en) * 1970-05-21 1972-05-09 Smith Kline French Lab 3-sulfonamido-4-hydroxyphenyl-2-piperidylcarbinols
US3743737A (en) * 1970-05-21 1973-07-03 Smith Kline French Lab 3-sulfonamido-4-hydroxyphenyl-2-piperindinylcarbinol compositions
US4794188A (en) * 1982-12-01 1988-12-27 Usv Pharmaceutical Corporation Certain unsymmetrical quinolinyl ethers having anti-inflammatory and anti-allergic activity
IE56702B1 (en) * 1982-12-01 1991-11-06 Usv Pharma Corp Antiinflammatory antiallergic compounds
US4567184A (en) * 1982-12-01 1986-01-28 Usv Pharmaceutical Corporation Certain aryl or hetero-aryl derivatives of 1-hydroxy-pentane or 1-hydroxy-hexane which are useful for treating inflammation and allergies
NO174506B (no) * 1984-10-30 1994-02-07 Usv Pharma Corp Analogifremgangsmaate ved fremstilling av terapeutisk aktive forbindelser
US4625034A (en) * 1985-02-04 1986-11-25 Usv Pharmaceutical Corp. 1,2-Dihydro; 1,2,3,4-tetrahydro; 5,8 dihydro; and 5,6,7,8-tetrahydroquinoline derivatives
US4728668A (en) * 1985-04-16 1988-03-01 Usv Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4839369A (en) * 1985-04-16 1989-06-13 Rorer Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4631287A (en) * 1985-04-16 1986-12-23 Usv Pharmaceutical Corp. Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4725619A (en) * 1985-04-16 1988-02-16 Usv Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4876346A (en) * 1985-05-02 1989-10-24 American Home Products Corporation Quinoline compounds
EP0271287A3 (en) * 1986-12-11 1990-06-13 Merck Frosst Canada Inc. Quinoline dioic acids and amides
US4920130A (en) * 1987-11-02 1990-04-24 Rorer Pharamceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4920133A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4920132A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4920131A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4918081A (en) * 1988-06-20 1990-04-17 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene d4
EP0349062A1 (en) * 1988-06-27 1990-01-03 Merck Frosst Canada Inc. Quinoline ether alkanoic acid
GB8926981D0 (en) * 1988-12-23 1990-01-17 Ici Plc Heterocyclic derivatives
US5003087A (en) * 1989-02-03 1991-03-26 Tanabe Seiyaku Co., Ltd. Process for preparing a naphthalene derivative and a synthetic intermediate thereof
IE70521B1 (en) * 1989-02-28 1996-12-11 Zeneca Pharma Sa Heterocycles with inhibitory activity of 5-lipoxygenase
IL93343A0 (en) * 1989-02-28 1990-11-29 Ici Plc Heterocyclic cycloalkanes
IL93344A0 (en) * 1989-02-28 1990-11-29 Ici Plc Heterocyclic cyclic ethers
JP2996475B2 (ja) * 1989-12-22 1999-12-27 サントリー株式会社 ベンズオキサジノン誘導体及びそれを有効成分として含有する除草剤

Also Published As

Publication number Publication date
AU7816191A (en) 1992-01-02
EP0462813B1 (en) 1995-10-25
HU211133A9 (en) 1995-10-30
CA2044219A1 (en) 1991-12-22
ATE129497T1 (de) 1995-11-15
PL168310B1 (pl) 1996-02-29
US5217969A (en) 1993-06-08
FI913048A (fi) 1991-12-22
GR3017888T3 (en) 1996-01-31
EP0462813A2 (en) 1991-12-27
DK0462813T3 (da) 1996-02-05
KR920000738A (ko) 1992-01-29
IL98396A0 (en) 1992-07-15
JPH04230283A (ja) 1992-08-19
US5321025A (en) 1994-06-14
DE69114052T2 (de) 1996-10-17
PL290757A1 (en) 1992-08-24
IE911919A1 (en) 1992-01-01
GB9113132D0 (en) 1991-08-07
HU210919B (en) 1995-09-28
ZW7091A1 (en) 1992-03-25
NZ238470A (en) 1993-07-27
DE69114052D1 (de) 1995-11-30
AU637500B2 (en) 1993-05-27
TW217412B (no) 1993-12-11
JP3112981B2 (ja) 2000-11-27
ES2079576T3 (es) 1996-01-16
FI913048A0 (fi) 1991-06-20
RU2059627C1 (ru) 1996-05-10
US5373007A (en) 1994-12-13
AR247886A1 (es) 1995-04-28
CS187491A3 (en) 1992-02-19
MY106366A (en) 1995-05-30
NO912411D0 (no) 1991-06-20
HU912003D0 (en) 1991-12-30
PT98041A (pt) 1992-04-30
IL98396A (en) 1995-11-27
HUT61298A (en) 1992-12-28
EP0462813A3 (en) 1992-01-22

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