DE69117355T2 - Bizyklische Pyran-Derivate und ihre Verwendung als 5-Lipoxygenasehemmer - Google Patents
Bizyklische Pyran-Derivate und ihre Verwendung als 5-LipoxygenasehemmerInfo
- Publication number
- DE69117355T2 DE69117355T2 DE69117355T DE69117355T DE69117355T2 DE 69117355 T2 DE69117355 T2 DE 69117355T2 DE 69117355 T DE69117355 T DE 69117355T DE 69117355 T DE69117355 T DE 69117355T DE 69117355 T2 DE69117355 T2 DE 69117355T2
- Authority
- DE
- Germany
- Prior art keywords
- bicyclic
- lipoxygenase inhibitors
- sulphinyl
- sulphonyl
- thio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- Rheumatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP90401759 | 1990-06-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69117355D1 DE69117355D1 (de) | 1996-04-04 |
DE69117355T2 true DE69117355T2 (de) | 1996-08-08 |
Family
ID=8205729
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69117355T Expired - Fee Related DE69117355T2 (de) | 1990-06-21 | 1991-06-19 | Bizyklische Pyran-Derivate und ihre Verwendung als 5-Lipoxygenasehemmer |
Country Status (6)
Country | Link |
---|---|
US (4) | US5179115A (de) |
JP (1) | JPH04243865A (de) |
AT (1) | ATE134630T1 (de) |
DE (1) | DE69117355T2 (de) |
ES (1) | ES2083526T3 (de) |
GR (1) | GR3019161T3 (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5254581A (en) * | 1990-06-21 | 1993-10-19 | Imperial Chemical Industries Plc | Pyran derivatives and their use as inhibitors of 5-lipoxygenase |
IE914005A1 (en) * | 1990-12-14 | 1992-06-17 | Zeneca Ltd | Novel intermediates |
EP0555067A1 (de) * | 1992-02-07 | 1993-08-11 | Zeneca Limited | Hydroxylaminderivate als 5-Lipoxygenasehemmer |
GB9300894D0 (en) * | 1992-02-07 | 1993-03-10 | Zeneca Ltd | Oxime derivatives |
CA2094465A1 (en) * | 1992-04-23 | 1993-10-24 | Pierre Andre Raymond Bruneau | Cycloalkane derivatives |
CA2095005A1 (en) * | 1992-05-12 | 1993-11-13 | Philip Neil Edwards | Hydroxylamine derivatives |
CA2095006A1 (en) * | 1992-05-12 | 1993-11-13 | Philip Neil Edwards | Oxime derivatives |
US5290801A (en) * | 1992-05-29 | 1994-03-01 | The Du Pont Merck Pharmaceutical Company | Benzimidazoles for the treatment of atherosclerosis |
AU4444393A (en) * | 1992-09-01 | 1994-03-10 | Zeneca Limited | Pyrrolidine derivatives |
US5354865A (en) * | 1992-09-10 | 1994-10-11 | Abbott Laboratories | Phenylmethyl derivatives having lipoxygenase inhibitory activity |
US6512121B2 (en) | 1998-09-14 | 2003-01-28 | G.D. Searle & Co. | Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
US6515014B2 (en) | 1995-06-02 | 2003-02-04 | G. D. Searle & Co. | Thiophene substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
US5643933A (en) * | 1995-06-02 | 1997-07-01 | G. D. Searle & Co. | Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
AU5886296A (en) | 1995-06-02 | 1996-12-18 | G.D. Searle & Co. | Heterocyclo substituted hydroxamic acid derivatives as cyclo oxygenase-2 and 5-lipoxygenase inhibitors |
US5891460A (en) * | 1995-06-07 | 1999-04-06 | University Of Southern California University Park Campus | Method for reducing or preventing post-surgical adhesion formation using ketotifen and analogs thereof |
US6677364B2 (en) * | 1998-04-20 | 2004-01-13 | G.D. Searle & Co. | Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
EP3539560A1 (de) | 2007-02-22 | 2019-09-18 | Children's Hospital & Research Center at Oakland | Fettsäureformulierungen und verwendungsverfahren dafür |
JP2017500541A (ja) * | 2013-10-31 | 2017-01-05 | 3スキャン インコーポレイテッド | 走査型顕微鏡撮像のための運動方略 |
EP4276089A3 (de) | 2016-03-03 | 2023-12-20 | Universite De Moncton | Modulatoren der lypoxygenase- und cyclooxygenaseenzymaktivität |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3661917A (en) * | 1970-05-21 | 1972-05-09 | Smith Kline French Lab | 3-sulfonamido-4-hydroxyphenyl-2-piperidylcarbinols |
US3743737A (en) * | 1970-05-21 | 1973-07-03 | Smith Kline French Lab | 3-sulfonamido-4-hydroxyphenyl-2-piperindinylcarbinol compositions |
US4205077A (en) * | 1977-04-12 | 1980-05-27 | Ciba-Geigy Corporation | Benzimidazole sulphides as anthelmintic agents |
US4205775A (en) * | 1978-11-16 | 1980-06-03 | Swan Walter B | Polygonal container |
IE56702B1 (en) * | 1982-12-01 | 1991-11-06 | Usv Pharma Corp | Antiinflammatory antiallergic compounds |
US4794188A (en) * | 1982-12-01 | 1988-12-27 | Usv Pharmaceutical Corporation | Certain unsymmetrical quinolinyl ethers having anti-inflammatory and anti-allergic activity |
US4567184A (en) * | 1982-12-01 | 1986-01-28 | Usv Pharmaceutical Corporation | Certain aryl or hetero-aryl derivatives of 1-hydroxy-pentane or 1-hydroxy-hexane which are useful for treating inflammation and allergies |
NZ213986A (en) * | 1984-10-30 | 1989-07-27 | Usv Pharma Corp | Heterocyclic or aromatic compounds, and pharmaceutical compositions containing such |
US4625034A (en) * | 1985-02-04 | 1986-11-25 | Usv Pharmaceutical Corp. | 1,2-Dihydro; 1,2,3,4-tetrahydro; 5,8 dihydro; and 5,6,7,8-tetrahydroquinoline derivatives |
US4902131A (en) * | 1985-03-28 | 1990-02-20 | Kabushiki Kaisha Toshiba | Surface inspection method and apparatus therefor |
US4725619A (en) * | 1985-04-16 | 1988-02-16 | Usv Pharmaceutical Corporation | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
US4631287A (en) * | 1985-04-16 | 1986-12-23 | Usv Pharmaceutical Corp. | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
US4728668A (en) * | 1985-04-16 | 1988-03-01 | Usv Pharmaceutical Corporation | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
US4839369A (en) * | 1985-04-16 | 1989-06-13 | Rorer Pharmaceutical Corporation | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
US4876346A (en) * | 1985-05-02 | 1989-10-24 | American Home Products Corporation | Quinoline compounds |
US4835166A (en) * | 1986-06-09 | 1989-05-30 | Pfizer Inc. | Antiallergy and antiinflammatory agents |
EP0271287A3 (de) * | 1986-12-11 | 1990-06-13 | Merck Frosst Canada Inc. | Chinolindicarbonsäuren und ihre Amide |
US4920133A (en) * | 1987-11-03 | 1990-04-24 | Rorer Pharmaceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
US4920132A (en) * | 1987-11-03 | 1990-04-24 | Rorer Pharmaceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
US4920130A (en) * | 1987-11-02 | 1990-04-24 | Rorer Pharamceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
US4920131A (en) * | 1987-11-03 | 1990-04-24 | Rorer Pharmaceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
US4918081A (en) * | 1988-06-20 | 1990-04-17 | Rorer Pharmaceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene d4 |
EP0349062A1 (de) * | 1988-06-27 | 1990-01-03 | Merck Frosst Canada Inc. | Chinolinetheralkansäuren |
-
1991
- 1991-06-19 AT AT91305576T patent/ATE134630T1/de not_active IP Right Cessation
- 1991-06-19 US US07/717,501 patent/US5179115A/en not_active Expired - Fee Related
- 1991-06-19 DE DE69117355T patent/DE69117355T2/de not_active Expired - Fee Related
- 1991-06-19 ES ES91305576T patent/ES2083526T3/es not_active Expired - Lifetime
- 1991-06-20 JP JP3148335A patent/JPH04243865A/ja active Pending
-
1992
- 1992-09-24 US US07/950,164 patent/US5278177A/en not_active Expired - Fee Related
-
1993
- 1993-10-08 US US08/133,335 patent/US5364877A/en not_active Expired - Fee Related
-
1994
- 1994-07-15 US US08/275,380 patent/US5462953A/en not_active Expired - Fee Related
-
1996
- 1996-02-29 GR GR960400468T patent/GR3019161T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
US5179115A (en) | 1993-01-12 |
DE69117355D1 (de) | 1996-04-04 |
JPH04243865A (ja) | 1992-08-31 |
US5462953A (en) | 1995-10-31 |
ES2083526T3 (es) | 1996-04-16 |
GR3019161T3 (en) | 1996-05-31 |
US5278177A (en) | 1994-01-11 |
US5364877A (en) | 1994-11-15 |
ATE134630T1 (de) | 1996-03-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |