ES2132245T3 - Derivados de 1-azaadamantano como agonistas o antagonistas de 5-ht. - Google Patents

Derivados de 1-azaadamantano como agonistas o antagonistas de 5-ht.

Info

Publication number
ES2132245T3
ES2132245T3 ES93916671T ES93916671T ES2132245T3 ES 2132245 T3 ES2132245 T3 ES 2132245T3 ES 93916671 T ES93916671 T ES 93916671T ES 93916671 T ES93916671 T ES 93916671T ES 2132245 T3 ES2132245 T3 ES 2132245T3
Authority
ES
Spain
Prior art keywords
azaadamanthane
agonists
antagonists
derivatives
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93916671T
Other languages
English (en)
Inventor
Daniel Lee Flynn
Robert L Shone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of ES2132245T3 publication Critical patent/ES2132245T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

ESTA INVENCION SE REFIERE A COMPUESTOS DE LA FORMULA (I) O A UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LOS MISMOS, EN DONDE Z SE SELECCIONA DEL GRUPO QUE CONSISTE EN (A) Y (B), R1 ES ALCOXI DE UNO A SEIS ATOMOS DE CARBONO; R2, R3, R4 Y R5 SON IGUALES O DIFERENTES Y SE SELECCIONAN DEL GRUPO QUE CONSISTE EN HIDROGENO, HALOGENO, CF3, HIDROXI, ALCOXI DE UNO A SEIS ATOMOS DE CARBONO, ACILO DE DOS A SIETE ATOMOS DE CARBONO, AMINO, AMINO SUSTITUIDO POR UNO O DOS GRUPOS ALQUILO DE UNO A SEIS ATOMOS DE CARBONO, ACILAMINO C2-C7, AMINOCARBONILO, AMINOSULFONA OPCIONALMENTE SUSTITUIDA POR UNO O DOS GRUPOS ALQUILO DE UNO A SEIS ATOMOS DE CARBONO, ALQUILSULFONA C1-C6 Y NITRO; M ES 1 O 2; X ES 0 O NR7; Y R7 ES HIDROGENO O ALQUILO DE 1 A 6 ATOMOS DE CARBONO.
ES93916671T 1992-07-27 1993-06-25 Derivados de 1-azaadamantano como agonistas o antagonistas de 5-ht. Expired - Lifetime ES2132245T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/919,679 US5840903A (en) 1992-07-27 1992-07-27 4-aminomethyl-1-azaadamantane derived benzamides

Publications (1)

Publication Number Publication Date
ES2132245T3 true ES2132245T3 (es) 1999-08-16

Family

ID=25442463

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93916671T Expired - Lifetime ES2132245T3 (es) 1992-07-27 1993-06-25 Derivados de 1-azaadamantano como agonistas o antagonistas de 5-ht.

Country Status (11)

Country Link
US (2) US5840903A (es)
EP (1) EP0652879B1 (es)
JP (1) JP3383668B2 (es)
AT (1) ATE178900T1 (es)
AU (1) AU4644893A (es)
CA (1) CA2136837A1 (es)
DE (1) DE69324492T2 (es)
DK (1) DK0652879T3 (es)
ES (1) ES2132245T3 (es)
GR (1) GR3030506T3 (es)
WO (1) WO1994002482A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030119916A1 (en) 2000-03-01 2003-06-26 David Fowler Treatment of functional gastrointestinal disorders
US7897766B2 (en) * 2005-09-23 2011-03-01 Abbott Laboratories Amino-aza-adamantane derivatives and methods of use
US8314119B2 (en) * 2006-11-06 2012-11-20 Abbvie Inc. Azaadamantane derivatives and methods of use
CA2680275C (en) 2007-03-09 2016-08-23 Renovis, Inc. Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
CA2679876A1 (en) * 2007-03-23 2008-10-02 Abbott Laboratories 4-substituted azaadamantane derivatives and methods of use thereof
CN101641356B (zh) * 2007-03-23 2012-09-05 雅培制药有限公司 氮杂金刚烷的乙酰胺和甲酰胺衍生物及其使用方法
MX2009010173A (es) 2007-03-23 2009-10-12 Abbott Lab Derivados de aminometil aza-adamantano y uso de los mismos como moduladores selectivos del receptor de acetilcolina nicotinico alfa-7 neuronal (nnrs).
ES2363998T3 (es) * 2007-03-23 2011-08-22 Abbott Laboratories Derivados ester y carbamato de azaadamantano y métodos de uso de los mismos.
CN103180321A (zh) 2010-09-23 2013-06-26 Abbvie公司 氮杂金刚烷衍生物的一水合物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2514006A1 (fr) * 1981-10-05 1983-04-08 Nativelle Sa Ets Acylamino-4 aza-1 adamantanes, procede pour leur preparation, et application en therapeutique
FR2557110B1 (fr) * 1983-12-23 1989-11-24 Sandoz Sa Nouveaux derives d'amines cycliques, leur preparation et leur utilisation comme medicaments
DE3587151T2 (de) * 1984-12-20 1993-07-15 Sandoz Ag Behandlung von gastrointestinalkrankheiten durch anwendung von 5-ht3-antagonisten.
GB8523211D0 (en) * 1985-09-19 1985-10-23 Beecham Group Plc Compounds
GB8525844D0 (en) * 1985-10-19 1985-11-20 Beecham Group Plc Compounds
US4910193A (en) * 1985-12-16 1990-03-20 Sandoz Ltd. Treatment of gastrointestinal disorders
NL8701682A (nl) * 1986-07-30 1988-02-16 Sandoz Ag Werkwijze voor het therapeutisch toepassen van serotonine antagonisten, aktieve verbindingen en farmaceutische preparaten die deze verbindingen bevatten.
US4950759A (en) * 1988-07-07 1990-08-21 Duphar International Research B.V. Substituted 1,7-annelated 1H-indazoles
US4992461A (en) * 1989-09-11 1991-02-12 G. D. Searle & Co. N-azabicyclo(3.3.0)octane amides of aromatic acids, compositions, and methods of use thereof
US5140023A (en) * 1990-04-27 1992-08-18 G. D. Searle & Co. Azatetracycle compounds

Also Published As

Publication number Publication date
JP3383668B2 (ja) 2003-03-04
DK0652879T3 (da) 1999-10-25
EP0652879A1 (en) 1995-05-17
CA2136837A1 (en) 1994-02-03
EP0652879B1 (en) 1999-04-14
AU4644893A (en) 1994-02-14
WO1994002482A1 (en) 1994-02-03
GR3030506T3 (en) 1999-10-29
DE69324492D1 (de) 1999-05-20
US5840903A (en) 1998-11-24
JPH07509242A (ja) 1995-10-12
US5643917A (en) 1997-07-01
DE69324492T2 (de) 1999-09-02
ATE178900T1 (de) 1999-04-15

Similar Documents

Publication Publication Date Title
PT894084E (pt) Derivados de acido cinamico e sua utilizacao como antagonistas de integrina
DE69705300D1 (de) Cyclopropylalkansäurederivate
ATE203515T1 (de) Meta-substituierte phenylsulphonamidderivate
ES2162676T3 (es) Derivados de fenileno sustituidos en meta y su uso como antagonistas o inhibidores de integrina alfav,beta3.
FI980341A0 (fi) 2-oksi-indolijohdannaisia
IL124537A0 (en) Naphthyl-substituted benzimidazole derivatives and pharmaceutical compositions containing the same
ES2070660A1 (es) Un procedimiento para la preparacion de 2,5-damino-3-hidroxihexanos sustituidos, utiles como inhibidores de proteasas retrovirales.
ES2190428T3 (es) Antagonistas biciclicos de fibrinogeno.
MA23355A1 (fr) COMPOSES SULFONAMIDES TRICYCLIQUES UTILES POUR l'INHIBITION DE LA FONCTION PROTEINE G
ES8801245A1 (es) Un procedimiento para preparar derivados de piperidina
CA2103590A1 (en) Benzamide derivative
ES2132245T3 (es) Derivados de 1-azaadamantano como agonistas o antagonistas de 5-ht.
ATE20732T1 (de) Halogenierte proteaseinhibitoren.
DE69330601D1 (de) Serotoninergische ergolin derivate
YU5893A (sh) Sulfonilkarbamid i postupak za njegovo dobijanje
NO914375D0 (no) Fremgangsmaate for fremstilling av 7-acyl-3-(substituerte carbamoyloxy)cefem-forbindelser
ES8307258A1 (es) "procedimiento para la preparacion de nuevas cefalosporinas".
YU200791A (sh) Trifluorometil 1-karba (1-detia) cefemi
AU551901B2 (en) Substituted thienobenzodiazepinones

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 652879

Country of ref document: ES