ES2053742T3 - Derivados de 2'-deoxi-5-fluorouridina. - Google Patents

Derivados de 2'-deoxi-5-fluorouridina.

Info

Publication number
ES2053742T3
ES2053742T3 ES88306984T ES88306984T ES2053742T3 ES 2053742 T3 ES2053742 T3 ES 2053742T3 ES 88306984 T ES88306984 T ES 88306984T ES 88306984 T ES88306984 T ES 88306984T ES 2053742 T3 ES2053742 T3 ES 2053742T3
Authority
ES
Spain
Prior art keywords
group
deoxi
alkyl group
fluorouridine derivatives
fluorouridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88306984T
Other languages
English (en)
Inventor
Yukio Tada
Atsuhiko Uemura
Mitsugi Yasumoto
Setsuo Takeda
Hitoshi Saito
Norio Unemi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2053742T3 publication Critical patent/ES2053742T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A UN DERIVADO DE 2''- DESOXI - 5 FLUORURIDINA DE FORMULA(I), O UNA SAL SUYA, EN LA QUE R1 YR2 SON UNO UN GRUPO BENCILO QUE PUEDE ESTAR SUSTITUIDO CON UN SUSTITUYENTE SELECCIONADO DE ENTRE UN GRUPO ALQUILO O ALCOXI DE 1 A 6C, ALQUILO DE 1 A 3C HALOGENADO, UN ATOMO DE HALOGENO, UN GRUPO HIDROXILO O UN GRUPO NITRO SOBRE EL ANILLO FENILO, Y EL OTRO ES UN RESIDUO AMINOACIDO. LOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO DEL CANCER.
ES88306984T 1987-07-31 1988-07-28 Derivados de 2'-deoxi-5-fluorouridina. Expired - Lifetime ES2053742T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP19319287 1987-07-31

Publications (1)

Publication Number Publication Date
ES2053742T3 true ES2053742T3 (es) 1994-08-01

Family

ID=16303837

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88306984T Expired - Lifetime ES2053742T3 (es) 1987-07-31 1988-07-28 Derivados de 2'-deoxi-5-fluorouridina.

Country Status (12)

Country Link
US (1) US4946951A (es)
EP (1) EP0301873B1 (es)
KR (1) KR890002223A (es)
CN (1) CN1022249C (es)
AT (1) ATE106891T1 (es)
AU (1) AU610913B2 (es)
CA (1) CA1313866C (es)
DE (1) DE3889993T2 (es)
DK (1) DK171236B1 (es)
ES (1) ES2053742T3 (es)
FI (1) FI89497C (es)
NO (1) NO883387L (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0247381B1 (en) * 1986-04-30 1993-08-04 Otsuka Pharmaceutical Co., Ltd. 5-flurorouracil derivatives
EP0346108A3 (en) * 1988-06-09 1991-04-24 The Wellcome Foundation Limited Anti-infective nucleosides
JP3074341B2 (ja) * 1993-12-24 2000-08-07 大鵬薬品工業株式会社 ２’−デオキシ−５−フルオロウリジン誘導体
KR100394429B1 (ko) * 2000-03-15 2003-08-09 영진화학공업 주식회사 알릴아민계 항균첨가제 및 직물항균가공제와 그 제조방법및 직물항균가공방법
CN1315863C (zh) * 2003-12-12 2007-05-16 河南省科学院质量检验与分析测试研究中心 β－L－2'－脱氧－核苷衍生物、其合成方法及其药物用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2658672A1 (de) * 1976-12-23 1978-06-29 Robugen Gmbh Neue nucleosid-verbindungen und verfahren zu ihrer herstellung
JPS5535057A (en) * 1978-09-05 1980-03-11 Funai Corp 2'-deoxy-5-fluorouridine derivative, its preparation, and antitumor agent comprising it
US4340728A (en) * 1979-11-28 1982-07-20 Fuji Kagaku Kogyo Kabushiki Kaisha Nucleoside derivatives and process for preparing same
DE3002197A1 (de) * 1980-01-22 1981-07-23 Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen 5-alkylsubstituierte pyrimidin-nukleoside, verfahren zu deren herstellung und daraus hergestellte virostatische und cytostatische mittel
JPS5791994A (en) * 1980-11-26 1982-06-08 Fuji Kagaku Kogyo Kk 5'-o-(n-alkylcarbamoylalanyl)-5-fluorouridine and its preparation
DE3263939D1 (en) * 1981-12-09 1985-07-04 Teijin Ltd 5-fluoro-2'-deoxyuridine derivatives and a process for the preparation thereof
JPS5929699A (ja) * 1982-08-11 1984-02-16 Funai Corp ２′−デオキシ−５−フルオロウリジンのエ−テル誘導体およびその製造方法並びにこれを含有する抗腫瘍剤
DE3469533D1 (en) * 1983-05-23 1988-04-07 Taiho Pharmaceutical Co Ltd Novel 2'-deoxy-5-substituted uridine derivatives, processes for preparing the same and antitumor agent containing the same
DE3481191D1 (de) * 1983-07-20 1990-03-08 Teijin Ltd Antineoplastisches mittel.
DK174238B1 (da) * 1984-10-30 2002-10-07 Otsuka Pharma Co Ltd 5-Fluoruracilderivater, deres fremstilling og lægemidler indeholdende sådanne forbindelser
JPS61189292A (ja) * 1985-02-15 1986-08-22 Funai Corp ５−フルオロデオキシウリジン誘導体の新規な固溶体及びこれを活性成分として含有する制癌剤
JPS62187484A (ja) * 1986-02-12 1987-08-15 Taiho Yakuhin Kogyo Kk ３′−０−ベンジル−２′−デオキシ−β−ウリジン類の製造方法
EP0247381B1 (en) * 1986-04-30 1993-08-04 Otsuka Pharmaceutical Co., Ltd. 5-flurorouracil derivatives

Also Published As

Publication number Publication date
DK423988D0 (da) 1988-07-29
NO883387L (no) 1989-02-01
DK171236B1 (da) 1996-08-05
NO883387D0 (no) 1988-07-29
EP0301873A3 (en) 1990-11-28
FI89497C (fi) 1993-10-11
US4946951A (en) 1990-08-07
CN1022249C (zh) 1993-09-29
DK423988A (da) 1989-02-01
DE3889993T2 (de) 1994-09-22
ATE106891T1 (de) 1994-06-15
CN1032169A (zh) 1989-04-05
AU610913B2 (en) 1991-05-30
KR890002223A (ko) 1989-04-10
DE3889993D1 (de) 1994-07-14
CA1313866C (en) 1993-02-23
AU2002288A (en) 1989-02-02
FI883584A0 (fi) 1988-07-29
FI883584A (fi) 1989-02-01
EP0301873A2 (en) 1989-02-01
EP0301873B1 (en) 1994-06-08
FI89497B (fi) 1993-06-30

Similar Documents

Publication Publication Date Title
NO992549D0 (no) Sukkerforbindelse, geleringsmiddel og fremgangsmÕte for fremstilling derav
MX9202142A (es) Nuevos derivados de urea, proceso para su preparacion, y composicion farmaceutica que los comprende.
DE69428476T2 (de) Heterocyclische Verbindungen als Bradykinin Antagonisten
KR890000489A (ko) 6 환 화합물
MY106366A (en) Bicyclic heterocyclic pryan derivatives and their use as inhibitors of 5-lipoxygenase
NO20004485D0 (no) Sykloalkenderivater, deres fremstilling og anvendelse
PT918776E (pt) Sintese total de acilfulvenos antitumorais
NO301543B1 (no) 2-£4-(kinazolinylmetylamino)benzamido|-4-(tetrazolyl)smörsyrederivater med anti-tumor-aktivitet
DK0390654T3 (da) Aminobenzensulfonsyrederivater
ES2075850T3 (es) Derivados de beta-lactama.
DK0565377T3 (da) Terapeutiske midler til behandling af Parkinsons sygdom
DK0490566T3 (da) Fremstilling og anvendelse af N-iodpropargyloxycarbonylaminosyreestere og derivater som antimikrobielle midler
PT98362A (pt) Processo para a preparacao de derivados de tioalquiltio-cefalosporina e de composicoes farmaceuticas que os contem
ES2055867T3 (es) Derivados de dibenzotiazepina utiles como agentes antiespasmodicos.
DK291488A (da) Alkansulfonanilidderivater
ES497064A0 (es) Un procedimiento para la preparacion de indolo benzoxazinas.
ES2053742T3 (es) Derivados de 2'-deoxi-5-fluorouridina.
EP0496347A3 (en) Methods of preparing fluorobenzene derivatives and related compounds
NO900922D0 (no) Fremgangsmaate for fremstilling av laktam-derivater.
ATE148462T1 (de) Isoxazole derivate als lichtschutzmittel
CA2359031A1 (en) Thiazolidinone or oxazolidinone derivatives for treatment of ulcerative disease

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 301873

Country of ref document: ES