DE3481191D1 - Antineoplastisches mittel. - Google Patents

Antineoplastisches mittel.

Info

Publication number
DE3481191D1
DE3481191D1 DE8484902821T DE3481191T DE3481191D1 DE 3481191 D1 DE3481191 D1 DE 3481191D1 DE 8484902821 T DE8484902821 T DE 8484902821T DE 3481191 T DE3481191 T DE 3481191T DE 3481191 D1 DE3481191 D1 DE 3481191D1
Authority
DE
Germany
Prior art keywords
antineoplastic agent
antineoplastic
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8484902821T
Other languages
English (en)
Inventor
Takeo Kawaguchi
Tokorozawa-Corp Saito
Yoshiki Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP58130756A external-priority patent/JPS6023398A/ja
Priority claimed from JP848084A external-priority patent/JPS60152419A/ja
Application filed by Teijin Ltd filed Critical Teijin Ltd
Application granted granted Critical
Publication of DE3481191D1 publication Critical patent/DE3481191D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE8484902821T 1983-07-20 1984-07-19 Antineoplastisches mittel. Expired - Lifetime DE3481191D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP58130756A JPS6023398A (ja) 1983-07-20 1983-07-20 ５−フルオロ−２′−デオキシウリジン誘導体その製造法およびそれを有効成分とする抗腫瘍剤
JP848084A JPS60152419A (ja) 1984-01-23 1984-01-23 抗腫瘍剤
PCT/JP1984/000368 WO1985000608A1 (en) 1983-07-20 1984-07-19 Antineoplastic agent

Publications (1)

Publication Number Publication Date
DE3481191D1 true DE3481191D1 (de) 1990-03-08

Family

ID=26342994

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484902821T Expired - Lifetime DE3481191D1 (de) 1983-07-20 1984-07-19 Antineoplastisches mittel.

Country Status (4)

Country Link
US (1) US4757139A (de)
EP (1) EP0151189B1 (de)
DE (1) DE3481191D1 (de)
WO (1) WO1985000608A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61189215A (ja) * 1985-02-18 1986-08-22 Teijin Ltd ５−フルオロ−２′−デオキシウリジンエステル類の油状医薬組成物
EP0247381B1 (de) * 1986-04-30 1993-08-04 Otsuka Pharmaceutical Co., Ltd. 5-Fluoro-Uracil-Derivate
JPS6339893A (ja) * 1986-08-05 1988-02-20 Daikin Ind Ltd ５−フルオロウリジン類およびその製法
AU610913B2 (en) * 1987-07-31 1991-05-30 Taiho Pharmaceutical Co., Ltd. 2'-deoxy-5-fluorouridine derivatives
US4992534A (en) * 1987-08-12 1991-02-12 Otsuka Pharmaceutical Co., Ltd. 3'-O-,5'-O-derivatives of 2'-deoxy-5-fluorouridine
US6743782B1 (en) 1987-10-28 2004-06-01 Wellstat Therapeutics Corporation Acyl deoxyribonucleoside derivatives and uses thereof
US6329350B1 (en) 1987-10-28 2001-12-11 Pro-Neuron, Inc. Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis
US5691320A (en) * 1987-10-28 1997-11-25 Pro-Neuron, Inc. Acylated pyrimidine nucleosides for treatment of systemic inflammation and inflammatory hepatitis
ZA888083B (en) * 1987-10-28 1990-06-27 Pro Neuron Inc Acyl deoxyribonucleoside derivatives and uses thereof
US6348451B1 (en) 1987-10-28 2002-02-19 Pro-Neuron, Inc. Acyl deoxyribonucleoside derivatives and uses thereof
US5470838A (en) 1987-10-28 1995-11-28 Pro-Neuron, Inc. Method of delivering exogenous uridine or cytidine using acylated uridine or cytidine
US5736531A (en) 1987-10-28 1998-04-07 Pro-Neuron, Inc. Compositions of chemotherapeutic agent or antiviral agent with acylated pyrimidine nucleosides
US6020322A (en) * 1993-11-09 2000-02-01 Pro-Neuron, Inc. Acyl deoxyribonucleoside derivatives and uses thereof
US7776838B1 (en) 1987-10-28 2010-08-17 Wellstat Therapeutics Corporation Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
US6919320B1 (en) 1987-10-28 2005-07-19 Wellstat Therapeutics Corporation Pharmaceutical compositions containing deoxyribonucleosides for wound healing
US5246708A (en) * 1987-10-28 1993-09-21 Pro-Neuron, Inc. Methods for promoting wound healing with deoxyribonucleosides
US5968914A (en) 1987-10-28 1999-10-19 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
ZA892928B (en) * 1988-04-25 1991-01-30 Pro Neuron Inc Pharmaceutical compositions containing deoxyribonucleosides for wound healing
US4920126A (en) * 1988-05-10 1990-04-24 Uniroyal Chemical Ltd/Uniroyal Chemical Ltee Barbituric acid derivative and treatment of leukemia and tumors therewith
US7169765B1 (en) 1988-10-27 2007-01-30 Wellstat Therapeutics Corporation Acyl deoxyribonucleoside derivatives and uses thereof
US5049551A (en) * 1989-05-30 1991-09-17 Ube Industries, Ltd. 5-fluorouracil, 2'-deoxy-5-fluorouridine and 1-carbomoyl-5-fluorouracil compounds
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
JPH05505815A (ja) * 1990-04-04 1993-08-26 ニユコメド・イメージング・アクシエセルカペト ヌクレオシド誘導体
ATE205850T1 (de) * 1991-07-05 2001-10-15 Pro Neuron Inc Behandlung der toxischen wirkung von chemotherapeutischen und antiviralen wirkstoffen mit acylierten pyrimidinnukleosiden
IL102407A (en) * 1991-07-05 1997-01-10 Pro Neuron Inc Use of acylates of non-methylated pyrimidine nucleosides in medicaments for preventing or treating undesirable side-effects in anticancer or antiviral chemotherapy and pharmaceutical compositions containing the acylates
FI105556B (fi) * 1991-09-30 2000-09-15 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten pyrimidiiniukleosidijohdannaisten valmistamiseksi, joilla on kasvaimen vastaista vaikutusta
ATE282627T1 (de) * 1992-12-08 2004-12-15 Wellstat Therapeutics Corp Pyrimidinnukleotid-vorläufer zur behandlung entzündlicher hepatitis
WO1994026761A1 (en) * 1993-05-14 1994-11-24 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
JP2526414B2 (ja) * 1994-05-20 1996-08-21 工業技術院長 制ガン剤エステル化合物及びその製造方法
MX9700109A (es) * 1994-07-01 1997-04-30 Pro Neuron Inc Precursores nucleotidos de pirimidina para el tratamiento de inflamaciones sistemicas y hepatitis inflamatoria.
US7160537B2 (en) * 2003-12-15 2007-01-09 Siemens Medical Solutions Usa, Inc. Method for preparing radiolabeled thymidine having low chromophoric byproducts
US20050131224A1 (en) * 2003-12-15 2005-06-16 Cti Pet Systems, Inc. Method for preparing radiolabeled thymidine
EP2136626A4 (de) * 2007-03-19 2011-02-23 Oregon State Wirkstoffe mit n-oxiden aus mannich-basen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5159880A (en) * 1974-11-22 1976-05-25 Asahi Chemical Ind N44 ashirunukureoshidojikarubonsanesuteruno seiho
US4118484A (en) * 1976-03-29 1978-10-03 The Upjohn Company Method of treating rheumatoid arthritis
JPS56115799A (en) * 1980-02-15 1981-09-11 Funai Corp 2'-deoxy-3',5'-di-o-alkylcarbonyl-5-fluorouridine derivative, its preparation, and antitumor agnet containing the same
JPS5849315A (ja) * 1981-09-18 1983-03-23 Mitsui Pharmaceut Inc 抗腫瘍剤
DE3141199A1 (de) * 1981-10-16 1983-04-28 Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen "desoxyuridinderivate, verfahren zu ihrer herstellung und daraus bereitete arzneimittel"

Also Published As

Publication number Publication date
EP0151189B1 (de) 1990-01-31
WO1985000608A1 (en) 1985-02-14
EP0151189A4 (de) 1987-04-14
EP0151189A1 (de) 1985-08-14
US4757139A (en) 1988-07-12

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee