KR890000489A - 6 환 화합물 - Google Patents

6 환 화합물 Download PDF

Info

Publication number
KR890000489A
KR890000489A KR1019880007643A KR880007643A KR890000489A KR 890000489 A KR890000489 A KR 890000489A KR 1019880007643 A KR1019880007643 A KR 1019880007643A KR 880007643 A KR880007643 A KR 880007643A KR 890000489 A KR890000489 A KR 890000489A
Authority
KR
South Korea
Prior art keywords
group
carbon atoms
amino
alkyl
alkyl group
Prior art date
Application number
KR1019880007643A
Other languages
English (en)
Other versions
KR960002853B1 (ko
Inventor
히로아끼 다가와
마사미찌 스기모리
히로후미 데라사와
아끼오 에지마
사또루 오스끼
Original Assignee
스즈기 다다시
다이이찌 세이야꾸 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 스즈기 다다시, 다이이찌 세이야꾸 가부시끼가이샤 filed Critical 스즈기 다다시
Publication of KR890000489A publication Critical patent/KR890000489A/ko
Application granted granted Critical
Publication of KR960002853B1 publication Critical patent/KR960002853B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Luminescent Compositions (AREA)
  • Lubricants (AREA)
  • Fats And Perfumes (AREA)
  • Liquid Crystal Substances (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

내용 없음

Description

6환 화합물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 하기일반식(Ⅰ)의 화합물 :
    상기식에서, R1및 R2는 각각 수소원자 ; 히드록시기, 탄소수 1-6개의 알킬기, 탄소수 1-6개의 알케닐기 ; 탄소수 1-6개의 알키닐기; 탄소수 1-6개의 알콕시기 ; 탄소수 1-6개의 아미노알콕시기 ; 할로겐 원자 ; 니트로기 ; 시아노기 ; 메르캅토기 ; 탄소수 1-6개의 알킬티오기 ; 탄소수 1-6개의 히드록시 알킬기 ; 탄소수 1-6개의 할로케노 알킬기 ; 탄소수 1-6개의 시아노 알킬기 ; 탄소수 1-6개의 니트로 알킬기 ; 보호기 또는 탄소수 1-6개의 알킬기를 함유하여도 좋은 탄소수 1-6개의 아미노 알킬기 ; 보호기 또는 아미노 위치에 탄소수 1-6개의 알킬기를 갖어도 좋은 탄소수 1-6개의 아미노알킬 아미노기 ; 탄소수 1-6개의 알킬기 ; 탄소수 1-6개의 알콕시기, 아미노기, 할로게노기, 니트로기 또는 시아노기를 갖는 탄소수 1-6개의 복소환 알킬기 ; 탄소수 1-6개의 알킬기 ; 탄소수 1-6개의 알콕시기 ; 아미노기(보호기를 함유하여도 좋음), 할로게노기, 니트로기, 시아노기 또는 보호기를 함유하여도 좋은 탄소수 1-6개의 복소환 알킬 아미노기 ; 보호된 또는 복소환 부위 또는 아미노 위치의 질소 원자에 탄소수 1-6개의 알킬기를 갖어도 좋은 아미노-복소환기 ; 보호기 또는 복소환 부위 또는 아미노 위치의 질소 원자에 탄소수 1-6개의 알킬기를 갖어도 좋은 복소환 아미노기 ; 보호기 또는 탄소수 1-6개의 알킬기를 갖어도 좋은 카바모일기 ; 탄소수 1-6개의 알킬기 ; 탄소수 1-6개의 알콕시기, 아미노기, 히드록시기, 할로게노기, 니트로기 및 시아노기를 갖어도 좋은 복소환 카르보닐기를 나타태며, R3는 탄소수 1-6개의 알킬기를 나타내고, Z는 산소, 황, 일반식 CH-R4(식중, R4는 수소원자 또는 탄소수 1-6개의 알킬기이다)또는 일반식 N-R5(식중, R5는 수소원자, 탄소수 1-6개의 알킬기 또는 아미노기의 보호기이다)를 나타내며, m 및 n은 각각 0,1 또는 2를 나타낸다.
  2. 제 1 항에 있어서, 상기 화합물에 상기 일반식(Ⅰ)을 F-링에서 치환체에 대해 S-타입 배열을 갖는 화합물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880007643A 1987-06-24 1988-06-24 6환 화합물 KR960002853B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP156990/1987 1987-06-24
JP15699087 1987-06-24
JP005503/1988 1988-01-13
JP550388 1988-01-13
JP63-5503 1988-01-13
JP62-156990 1988-01-13

Publications (2)

Publication Number Publication Date
KR890000489A true KR890000489A (ko) 1989-03-15
KR960002853B1 KR960002853B1 (ko) 1996-02-27

Family

ID=26339454

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880007643A KR960002853B1 (ko) 1987-06-24 1988-06-24 6환 화합물

Country Status (13)

Country Link
US (2) US4939255A (ko)
EP (1) EP0296597B1 (ko)
KR (1) KR960002853B1 (ko)
AT (1) ATE111913T1 (ko)
AU (1) AU610189B2 (ko)
CA (1) CA1304370C (ko)
DE (1) DE3851577T2 (ko)
DK (1) DK344488A (ko)
ES (1) ES2064329T3 (ko)
FI (1) FI91872C (ko)
IE (1) IE61281B1 (ko)
NO (1) NO167738C (ko)
PH (1) PH27557A (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19980076076A (ko) * 1997-04-04 1998-11-16 유현식 전선용 발포성 수지조성물

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4939255A (en) * 1987-06-24 1990-07-03 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic camptothecin derivatives
US5552154A (en) * 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US6407115B1 (en) * 1991-01-16 2002-06-18 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic compound
US5658920A (en) * 1991-01-16 1997-08-19 Daiichi Pharmaceutical Co., Ltd. Substituted 1H,12H-benz-[DE]pyrano[3',4':6,7] indolizino[1,2-B]quinoline-10,13(9H,15H)-dione compound
JP3008226B2 (ja) * 1991-01-16 2000-02-14 第一製薬株式会社 六環性化合物
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
US5391745A (en) * 1992-07-23 1995-02-21 Sloan-Kettering Institute For Cancer Research Methods of preparation of camptothecin analogs
US5446047A (en) * 1992-07-23 1995-08-29 Sloan-Kettering Institute For Cancer Research Camptothecin analogues
US6504029B1 (en) * 1995-04-10 2003-01-07 Daiichi Pharmaceutical Co., Ltd. Condensed-hexacyclic compounds and a process therefor
US5663177A (en) * 1995-05-31 1997-09-02 Smithkline Beecham Corporation Water soluble camptothecin analogs
US5670500A (en) * 1995-05-31 1997-09-23 Smithkline Beecham Corporation Water soluble camptothecin analogs
CA2223484A1 (en) * 1995-06-07 1996-12-19 Thomas Jefferson University Anti-fungal agents and methods of identifying and using the same
SG50747A1 (en) * 1995-08-02 1998-07-20 Tanabe Seiyaku Co Comptothecin derivatives
SG104284A1 (en) * 1996-10-30 2004-06-21 Tanabe Seiyaku Co S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof
US6046209A (en) * 1997-05-27 2000-04-04 Smithkline Beecham Corporation Water soluble camptothecin analogs
IN189180B (ko) 1997-07-09 2003-01-04 Chong Kun Dang Corp
JP4094710B2 (ja) 1997-11-06 2008-06-04 株式会社ヤクルト本社 新規なカンプトテシン誘導体
EP2266607A3 (en) 1999-10-01 2011-04-20 Immunogen, Inc. Immunoconjugates for treating cancer
FR2801309B1 (fr) * 1999-11-18 2002-01-04 Adir Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
BR0214615A (pt) * 2001-11-30 2004-09-14 Chugai Pharmaceutical Co Ltd Composto hexacìclico
US8034831B2 (en) 2002-11-06 2011-10-11 Celgene Corporation Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies
US7563810B2 (en) 2002-11-06 2009-07-21 Celgene Corporation Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
EP1599484A2 (en) 2003-02-21 2005-11-30 Chugai Seiyaku Kabushiki Kaisha Process for the preparation of hexacyclic camptothecin derivatives
JP4823894B2 (ja) 2004-04-09 2011-11-24 中外製薬株式会社 新規水溶性プロドラッグ
TW200744603A (en) 2005-08-22 2007-12-16 Chugai Pharmaceutical Co Ltd Novel anticancer concomitant drug
CN102060713A (zh) * 2010-12-09 2011-05-18 中华人民共和国嘉兴出入境检验检疫局 用于检测偶氮类染料的芳香胺半抗原及其制备方法
HRP20221280T1 (hr) 2019-03-29 2022-12-23 Medimmune Limited Spojevi i njihovi konjugati
JP2023511184A (ja) 2020-01-22 2023-03-16 メドイミューン・リミテッド 化合物及びその複合体
TW202140076A (zh) 2020-01-22 2021-11-01 英商梅迪繆思有限公司 化合物及其軛合物
US11806405B1 (en) 2021-07-19 2023-11-07 Zeno Management, Inc. Immunoconjugates and methods
WO2023180484A1 (en) 2022-03-23 2023-09-28 Synaffix B.V. Antibody-conjugates for targeting of tumours expressing ptk7
WO2023180490A1 (en) 2022-03-23 2023-09-28 Synaffix B.V. Antibody-conjugates for targeting of tumours expressing nectin-4
AU2023241225A1 (en) 2022-03-23 2024-08-29 Synaffix B.V. Antibody-conjugates for targeting of tumours expressing trop-2
WO2023180489A1 (en) 2022-03-23 2023-09-28 Synaffix B.V. Antibody-conjugates for targeting of tumours expressing carcinoembyronic antigen
WO2024140933A1 (zh) * 2022-12-30 2024-07-04 长春金赛药业有限责任公司 喜树碱衍生物、药物组合物及其制备方法和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US32518A (en) * 1861-06-11 Improvement in city railroads
JPS51288A (ja) * 1974-06-18 1976-01-05 Tamura Seisakusho Kk Hanshakyoshinhoshasochi
US4399282A (en) * 1979-07-10 1983-08-16 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives
US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
US4473692A (en) * 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPS5839685A (ja) * 1981-09-04 1983-03-08 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体及びその製造法
JPS58154582A (ja) * 1982-03-10 1983-09-14 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体およびその製造法
JPS6019790A (ja) * 1983-07-14 1985-01-31 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
EP0220601B1 (en) * 1985-10-21 1991-12-11 Daiichi Seiyaku Co., Ltd. Pyranoindolizine derivatives and preparation process thereof
US4939255A (en) * 1987-06-24 1990-07-03 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic camptothecin derivatives
US5004758A (en) * 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JPH0615547B2 (ja) * 1988-01-20 1994-03-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19980076076A (ko) * 1997-04-04 1998-11-16 유현식 전선용 발포성 수지조성물

Also Published As

Publication number Publication date
AU610189B2 (en) 1991-05-16
DK344488D0 (da) 1988-06-23
FI91872C (fi) 1994-08-25
EP0296597A3 (en) 1991-07-31
CA1304370C (en) 1992-06-30
NO882785D0 (no) 1988-06-23
FI91872B (fi) 1994-05-13
DK344488A (da) 1989-02-24
EP0296597B1 (en) 1994-09-21
US4939255A (en) 1990-07-03
NO167738B (no) 1991-08-26
PH27557A (en) 1993-08-18
AU1834988A (en) 1989-01-05
KR960002853B1 (ko) 1996-02-27
US5061795A (en) 1991-10-29
DE3851577D1 (de) 1994-10-27
FI883050A (fi) 1988-12-25
NO167738C (no) 1991-12-04
IE881860L (en) 1988-12-24
ATE111913T1 (de) 1994-10-15
FI883050A0 (fi) 1988-06-23
EP0296597A2 (en) 1988-12-28
ES2064329T3 (es) 1995-02-01
IE61281B1 (en) 1994-10-19
NO882785L (no) 1988-12-27
DE3851577T2 (de) 1995-04-27

Similar Documents

Publication Publication Date Title
KR890000489A (ko) 6 환 화합물
KR920014816A (ko) 6환 화합물
KR890011884A (ko) 캠프토데신 유도체
PT1140851E (pt) 4-oxo-1,4-di-hidro-3-quinolinacarboxamidas como agentes antivirais
FI950016A0 (fi) Heterosykliset yhdisteet lääkeaineena
BR1101017A (pt) Distamicina a análoga; processo para a apresentação de um composto; composição farmacêutica contendo um composto; e uso de um composto
HUP9903707A2 (hu) 17Béta-karboxi-,-tio-karboxi-vagy -amido-androsztánszármazékok laktonszármazékai, előállításuk, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények
PT99134A (pt) Processo para a preparacao de derivados da piperazina
ES550933A0 (es) Un procedimiento para preparar derivados de arilciclobutilalquilamina
KR950702976A (ko) 벤조피란 및 벤족사진 유도체[benzopyran and benzoxazine derivatives]
KR910002873A (ko) 티아졸로[5,4-b] 아제핀 화합물
YU48136B (sh) Morfolinil derivati doksorubicina i postupak za njihovo dobijanje
PT89935A (pt) Processo para a preparacao de novos compostos cefem
AU539177B2 (en) Amino alkoxy pyrazoles
ATE106891T1 (de) 2'-deoxy-5-fluorouridin-derivate.
AU546679B2 (en) Hydrogenated 1,4 thiazepine (thiazine) dione derivatives
ATE149352T1 (de) Thiadiazol-derivate zur behandlung von depressiven zuständen
DK0686641T3 (da) 2'-Deoxy-5-fluoruridinderivat, farmaceutisk acceptabelt salt deraf, fremgangsmåde til fremstilling deraf, og antitumorlægem
DK0410224T3 (da) Pyrrolo(2,1-b)thiazol-derivater

Legal Events

Date Code Title Description
A201 Request for examination
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
LAPS Lapse due to unpaid annual fee