KR950702976A - 벤조피란 및 벤족사진 유도체[benzopyran and benzoxazine derivatives] - Google Patents

벤조피란 및 벤족사진 유도체[benzopyran and benzoxazine derivatives] Download PDF

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KR950702976A
KR950702976A KR1019950700620A KR19950700620A KR950702976A KR 950702976 A KR950702976 A KR 950702976A KR 1019950700620 A KR1019950700620 A KR 1019950700620A KR 19950700620 A KR19950700620 A KR 19950700620A KR 950702976 A KR950702976 A KR 950702976A
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group
hydrogen atom
represent
benzopyran
same
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KR1019950700620A
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KR100231634B1 (ko
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히로시 고가
하루히꼬 사또
다께노리 이시자와
히로유끼 나바따
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나가야마 오사무
쥬우가이세이야꾸 가부시끼가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

일반식
(식중, R1및 R2는 저급할로알킬기를 나타내며, R3은 수소원자 등을 나타내며, R4는 복소환기 또는 A-O-(A는 환상구조) 등을 나타내며, R5및 R6은 저급할로알킬기를 나타내며, X는 =N-, N→0 등을 나타낸다.)로 나타내는, 신규 벤조피란 또는 벤족사진 유도체를 개시한다. 이들 화합물은, K+챤넬 적용활성화 작용을 나타내며, 향천식제, 간질치료 등에 폭넓게 응용할 수 있는 화합물이다.

Description

벤조피란 및 벤족사진 유도체[BENZOPYRAN AND BENZOXAZINE DERIVATIVES]
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 하기 일반식으로 나타내는, 벤조피란 또는 벤조사진 유도체:
    [식중, R1및 R2는 동일하거나 상이하며 저급할로알킬기를 나타내고; R3은 수소원자 등을 나타내거나, 또는 X와 직접 결합하여서 단결합을 나타내고; R4는 치환 또는 무치환의 아미노기, 포화 또는 불포화의 복소환기, 또는 A-O-(A는, 포화 또는 불포화의 탄소환기, 또는 포화 또는 불포화기의 복소환기)를 나타내고; R5및 R8은 동일하거나 상이하며 수소원자, 할로겐, 저급알킬기, 저급 할로알킬기, 니트로기 또는 시아노기를 나타내고; X는 =N-, N+-O-또는
    을 나타내며, 여기서 R7및 R8은 동일하거나 상이하며 수소원자, 수산기 또는 저급아실옥시기를 나타내거나, 또는 R7은 R8과 직접결합하여서 단결합을 형성한다].
  2. 제1항에 있어서, R1및 R2가 동일한 저급할로알킬기를 나타내며; R3가 수소원자를 나타내거나, 또는 X와 직접 결합하여서 단결합을 나타내며; R4가 포착 또는 불포화의 복소환기를 나타내며; R5가 저급할로알킬기, 6-니트로기 또는 6-시아노기를 나타내며; R6가 수소원자를 나타내며; X가
    (식중, R7은 수소원자 또는 수산기를 나타내거나, 또는 R3과 직접결합하여서 단결합을 형성하며, R8은 수소 원자를 나타낸다)을 나타내는 벤조피란 또는 벤족사진 유도체.
  3. 제1항에 있어서, R1및 R2가 CH2F인 벤조피란 또는 벤족사진 유도체.
  4. 제1항에 있어서, R5가 6 위치에 결합한 할로겐, 저급알킬기, 저급합로알킬기, 니트로기 또는 시아노기인 벤조피란 또는 벤족사진 유도체.
  5. 하기 일반식으로 나타내는 벤조피란 또는 벤족사진 유도체 및 약학적으로 허용되는 담체를 함유하는 K+찬넬 활성화제.
    [식중, R1및 R2는 동일하거나 상이하며 저급 할로알킬기를 나타내고; R3은 수소원자를 나타내거나, 또는 X와 직접 결합하여서 단결합을 나타내고; R4는 치환 또는 무치환의 아미노기, 포화 또모는 불포화의 복소환기, 또는 A-O-(A는, 포화 또는 불포화의 탄소환기, 또는 포화 또는 불포화의 복소환기)를 나타내고; R5및 R6은, 동일하거나 상이하며 수소원자, 할로겐, 저급알킬기, 저급 할로알킬기, 니트로기 또는 시아노기를 나타내고; X는 =N-, N+-O-또는
    을 나타내며, 여기서 R7및 R8은 동일하거나 상이하며 수소원자, 수산기 또는 저급아실옥시기를 나타내거나, 또는 R7은 R3과 직접결합하여서 단결합을 형성한다].
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950700620A 1992-08-17 1993-08-17 벤조피란 및 벤족사진 유도체 KR100231634B1 (ko)

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JP21797592 1992-08-17
JP92-217975 1992-08-17
JP8846293 1993-04-15
JP93-88462 1993-04-15
PCT/JP1993/001150 WO1994004521A1 (en) 1992-08-17 1993-08-17 Benzopyran and benzoxazine derivatives

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KR100231634B1 KR100231634B1 (ko) 1999-11-15

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EP (1) EP0655448B1 (ko)
KR (1) KR100231634B1 (ko)
CN (1) CN1044605C (ko)
AT (1) ATE191716T1 (ko)
AU (1) AU4761693A (ko)
CA (1) CA2142471A1 (ko)
DE (1) DE69328366T2 (ko)
ES (1) ES2145129T3 (ko)
TW (1) TW258735B (ko)
WO (1) WO1994004521A1 (ko)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9309716D0 (en) * 1993-05-12 1993-06-23 Zeneca Ltd Heterocyclic derivatives
WO1995013272A1 (fr) * 1993-11-10 1995-05-18 Japan Tobacco Inc. Derive de chromanne et utilisation therapeutique de ce dernier
NZ329200A (en) * 1996-12-16 1999-05-28 Hoechst Ag Sulphonamide substituted quinazoline, isoquinoline, quinoline or benzo[1,3-]oxazine derivatives and medicaments
TW533073B (en) 1997-03-03 2003-05-21 Chugai Pharmaceutical Co Ltd Therapeutic agents for peripheral vascular disease
JP5198707B2 (ja) * 2000-05-23 2013-05-15 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト ベンゾキサジンを合成し、かつ、アシル化することによるアシルアミドの製造方法
US7161001B2 (en) * 2000-05-23 2007-01-09 Syngenta Crop Protection, Inc. Method for making acylamides by synthesizing and acylating benzoxazines
MXPA04003087A (es) * 2001-10-04 2004-09-06 Wyeth Corp Derivados de cromano como ligados de 5-hidroxitriptamina-6.
NZ550441A (en) * 2004-05-05 2009-07-31 Hoffmann La Roche Arylsulfonyl benzodioxanes useful for modulating the 5-HT6 receptor, the 5-HT2A receptor or both
WO2006002470A1 (en) * 2004-06-30 2006-01-12 Monash University Chiral ligands for asymmetric catalysis
ATE448216T1 (de) * 2004-12-21 2009-11-15 Hoffmann La Roche Tetralin- und indanderivate und anwendungen davon
JP4738418B2 (ja) 2004-12-21 2011-08-03 エフ．ホフマン−ラ ロシュ アーゲー クロマン誘導体及びｃｎｓ障害の処置におけるその使用
MX2007007480A (es) * 2004-12-21 2007-07-20 Hoffmann La Roche Derivados de cromano y su uso como ligandos del receptor 5-ht.
KR100889185B1 (ko) * 2004-12-21 2009-03-16 에프. 호프만-라 로슈 아게 테트랄린 및 인단 유도체 및 5-ｈｔ 길항제로서의 이의용도
SI1831159T1 (sl) * 2004-12-21 2010-04-30 Hoffmann La Roche Derivati tetralina in indana ter njune uporabe
CA2620846A1 (en) * 2005-09-01 2007-03-08 Janssen Pharmaceutica N.V. Benzopyran and pyranopyridine derivatives as potassium channel openers
RU2008115032A (ru) * 2005-11-03 2009-12-10 Ф. Хоффманн-Ля Рош Аг (Ch) Арилсульфонилхроманы в качестве ингибиторов 5-нт6
JP2009541249A (ja) * 2006-06-20 2009-11-26 エフ．ホフマン−ラ ロシュ アーゲー アリールスルホニルナフタレン誘導体およびその使用
BRPI0713736A2 (pt) * 2006-06-20 2014-11-18 Hoffmann La Roche Derivados de tetralina e indano e emprego destes
CN101472883A (zh) * 2006-06-20 2009-07-01 弗·哈夫曼-拉罗切有限公司 芳基磺酰氨基四氢萘衍生物以及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3046300A (en) * 1960-10-21 1962-07-24 Merck & Co Inc alpha-trifluoromethyloxyphenylalanines
FR2615191B1 (fr) * 1987-05-16 1991-01-11 Sandoz Sa Nouveaux benzo(b)pyrannes et pyrannopyridines, leur preparation et leur utilisation comme medicaments
FI90343C (fi) * 1987-06-23 1994-01-25 Merck Patent Gmbh Menetelmä korkeaa verenpainetta alentavien ja rytmihäiriöitä vastustavien trans-2,2-dimetyylikroman-3-olijohdannaisten valmistamiseksi
US4971982A (en) * 1987-07-06 1990-11-20 Hoffmann-La Roche Inc. Benzopyran derivatives
IL88035A0 (en) * 1987-10-27 1989-06-30 American Home Prod Benzopyran derivatives,their preparation and pharmaceutical compositions containing them
US5021432A (en) * 1988-04-26 1991-06-04 Yoshitomi Pharmaceutical Industries, Ltd. Benzopyran compound and its pharmaceutical use
DE68921972T2 (de) * 1988-12-13 1995-11-16 Beecham Group Plc Benzopyran und verwandte Verbindungen.
FR2657872B2 (fr) * 1989-11-06 1992-06-12 Sanofi Sa Derive d'amidino-4 chromanne, procede d'obtention et compositions pharmaceutiques le contenant.
DE4018552A1 (de) * 1990-06-09 1991-12-12 Sandoz Ag Asthma-prophylaktische verwendung von k(pfeil hoch)+(pfeil hoch) kanal-activatoren
CN1060467A (zh) * 1990-09-25 1992-04-22 武田药品工业株式会社 1，3-苯并嗪衍生物、其生产方法和用途

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TW258735B (ko) 1995-10-01
CN1044605C (zh) 1999-08-11
CN1086817A (zh) 1994-05-18
US5874446A (en) 1999-02-23
AU4761693A (en) 1994-03-15
ATE191716T1 (de) 2000-04-15
WO1994004521A1 (en) 1994-03-03
US5977167A (en) 1999-11-02
US5614633A (en) 1997-03-25
ES2145129T3 (es) 2000-07-01
CA2142471A1 (en) 1994-03-03
EP0655448A1 (en) 1995-05-31
EP0655448B1 (en) 2000-04-12
DE69328366T2 (de) 2000-08-10
EP0655448A4 (ko) 1995-06-07
KR100231634B1 (ko) 1999-11-15
DE69328366D1 (de) 2000-05-18

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