KR960029312A - N-아릴알킬페닐아세트아미드 유도체와 그의 제조방법 - Google Patents

N-아릴알킬페닐아세트아미드 유도체와 그의 제조방법 Download PDF

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KR960029312A
KR960029312A KR1019950000299A KR19950000299A KR960029312A KR 960029312 A KR960029312 A KR 960029312A KR 1019950000299 A KR1019950000299 A KR 1019950000299A KR 19950000299 A KR19950000299 A KR 19950000299A KR 960029312 A KR960029312 A KR 960029312A
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compound
alkyl
integer
formula
pharmaceutically acceptable
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KR1019950000299A
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KR0147963B1 (ko
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박노상
정영식
성철민
이종철
최진일
최승원
최연주
이광숙
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강박광
재단법인 한국화학연구소
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Priority to KR1019950000299A priority Critical patent/KR0147963B1/ko
Priority to EP96100223A priority patent/EP0721939B1/en
Priority to AT96100223T priority patent/ATE165083T1/de
Priority to DE69600231T priority patent/DE69600231T2/de
Priority to JP8002636A priority patent/JP2661892B2/ja
Priority to US08/584,025 priority patent/US5670546A/en
Publication of KR960029312A publication Critical patent/KR960029312A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)

Abstract

본 발명은 진통 및 소염 작용이 우수한 하기 일반식(Ⅰ)로 표시되는 N-아릴알킬페닐아세트아미드 유도체 또는 그의 약제학적으로 허용가능한 염 및 그의 제조방법에 관한 것이다.
상기 식에서, X는 수소, 할로겐, 히드록시 또는 메톡시이고, Y는 수소, 알킬, 아실, 알킬히드록시, 니트릴, 카르복실, 아미드, 카바메이트 또는 치환되거나 치환도지 않는 아미노 알킬이며, Z는 서로 같거나 다를 수 있으며, 수소, 할로겐, 히드록시, 메틸렌디옥시, 트리플루오로메틸, R1또는 OR1이고, 이때 R1은 C1-5의 치환되지 않은 알킬이나 고리알킬, 페닐 또는 벤질기이며, n은 2 내지 5의 정수이고, p는 0 내지 5의 정수이다.

Description

N-아릴알킬페닐아세트아미드 유도체와 그의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 하기 일반식(Ⅰ)로 표시되는 N-아릴알킬페닐아세트아미드 유도체 또는 그의 약제학적으로 허용가능한 염.
    상기 식에서, X는 수소, 할로겐, 히드록시 또는 메톡시이고, Y는 수소, 알킬, 아실, 알킬히드록시, 니트릴, 카르복실, 아미드, 카바메이트 또는 아미노 알킬(여기서, 아미노알킬의 경우에는 아미노기가 하나 이상의 알킬, 아실, 알킬히드록시 또는 아미노 알킬로 치환될 수도 있다)이며, Z는 서로 같거나 다를 수 있으며, 수소, 할로겐, 히드록시, 메틸렌디옥시, 트리플루오로메틸, R1또는 OR1이고, 이때 R1은 C1-5의 치환되지 않은 알킬이나 고리알킬, 페닐 또는 벤질기이며, n은 2 내지 5의 정수이고, p는 0 내지 5의 정수이다.
  2. 제1항에 있어서, n이 3 내지 4의 정수이고, p가 1 내지 2의 정수인 유도체 또는 그의 약제학적으로 허용가능한 염.
  3. 제2항에 있어서, X가 메톡시인 유도체 또는 그의 약제학적으로 허용가능한 염.
  4. 하기 일반식(Ⅱ)의 화합물과 하기 일반식(Ⅲ)의 아민화합물을 반응시켜 하기 일반식(Ⅳ)의 화합물을 수득하고, 이를 Y기 함유 화합물과 반응시키는 단계를 포함하는 하기 일반식(Ⅰ)의 화합물의 제조방법.
    H2N-(CH2)n-
    상기 식에서, X, Y, Z, n 및 p는 제1항에서 정의한 바와 같고, R은 H, CH2CH2Cl, CH2CH2Br, CH2CH2N3또는 CH2CH2NH2이다.
  5. 제1항 내지 제3항중 어느 한 항의 화합물 효과량과 약학적 담체를 포함하는 약학 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950000299A 1995-01-10 1995-01-10 엔-아릴알킬페닐아세트아미드 유도체와 그의 제조방법 KR0147963B1 (ko)

Priority Applications (6)

Application Number Priority Date Filing Date Title
KR1019950000299A KR0147963B1 (ko) 1995-01-10 1995-01-10 엔-아릴알킬페닐아세트아미드 유도체와 그의 제조방법
EP96100223A EP0721939B1 (en) 1995-01-10 1996-01-09 N-arylalkylphenylacetamide derivatives
AT96100223T ATE165083T1 (de) 1995-01-10 1996-01-09 N-arylalkylphenylacetamidderivate
DE69600231T DE69600231T2 (de) 1995-01-10 1996-01-09 N-Arylalkylphenylacetamidderivate
JP8002636A JP2661892B2 (ja) 1995-01-10 1996-01-10 Ｎ−アリールアルキルフェニルアセトアミド化合物
US08/584,025 US5670546A (en) 1995-01-10 1996-01-11 N-Arylalkylphenylacetamide derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019950000299A KR0147963B1 (ko) 1995-01-10 1995-01-10 엔-아릴알킬페닐아세트아미드 유도체와 그의 제조방법

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KR960029312A true KR960029312A (ko) 1996-08-17
KR0147963B1 KR0147963B1 (ko) 1998-08-17

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KR1019950000299A KR0147963B1 (ko) 1995-01-10 1995-01-10 엔-아릴알킬페닐아세트아미드 유도체와 그의 제조방법

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US (1) US5670546A (ko)
EP (1) EP0721939B1 (ko)
JP (1) JP2661892B2 (ko)
KR (1) KR0147963B1 (ko)
AT (1) ATE165083T1 (ko)
DE (1) DE69600231T2 (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9727521D0 (en) * 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Substituted 2-benzylamino-2-phenyl-acetamide compounds
GB9727523D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
TWI239942B (en) 2001-06-11 2005-09-21 Dainippon Pharmaceutical Co N-arylphenylacetamide derivative and pharmaceutical composition containing the same
ATE317280T1 (de) 2001-09-03 2006-02-15 Newron Pharm Spa Pharmazeutische zusammensetzung mit gabapentin oder deren analog und einem alpha-aminoamid und analgetische verwendung dieser zusammensetzung
EP1438956A1 (en) * 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful as antimigraine agents
US20060047171A1 (en) * 2003-12-22 2006-03-02 Harold Meckler Catalytic hydrogenation of nitriles to produce capsaicinoid derivatives and amine compounds, and methods for purifying and obtaining the polymorphs thereof
CN101018546B (zh) * 2004-09-10 2013-06-12 纽朗制药有限公司 作为钠和/或钙通道选择性调节剂的(卤代苄氧基)苄氨基-丙酰胺类
GB0526123D0 (en) * 2005-12-22 2006-02-01 Univ Gent Synephrine derivatives useful as anti-inflammatory agents

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4562201A (en) * 1982-07-26 1985-12-31 American Hospital Supply Corporation Aminomethyl benzanilides
US5013759A (en) * 1985-06-10 1991-05-07 The Procter & Gamble Company Compounds and compositions having anti-inflammatory and analgesic activity
DE3887544T2 (de) * 1987-03-09 1994-06-01 Procter & Gamble Beta-aminoethyl-substituierte Phenyl-Verbindungen, diese enthaltende entzündungshemmende oder analgetische Zusammensetzungen.
YU46706B (sh) * 1987-09-05 1994-04-05 Hokuriku Pharmaceutical Co. Ltd. Postupak za dobijanje amidnih jedinjenja
DE3830054A1 (de) * 1988-09-03 1990-03-15 Boehringer Mannheim Gmbh Phenylamide - verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
GB9016978D0 (en) * 1990-08-02 1990-09-19 Ici Plc Acetamide derivatives
US5242944A (en) * 1991-06-20 1993-09-07 Korea Research Institute Of Chemical Technology Phenylacetamide derivatives and pharmaceutical compositions thereof
EP0525360B1 (en) * 1991-07-30 1998-03-25 Korea Research Institute Of Chemical Technology Novel phenylacetamide derivatives and processes for the preparation thereof

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Publication number Publication date
KR0147963B1 (ko) 1998-08-17
US5670546A (en) 1997-09-23
DE69600231T2 (de) 1998-12-17
EP0721939B1 (en) 1998-04-15
EP0721939A1 (en) 1996-07-17
JPH08283220A (ja) 1996-10-29
DE69600231D1 (de) 1998-05-20
JP2661892B2 (ja) 1997-10-08
ATE165083T1 (de) 1998-05-15

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