KR900018006A - 인간 신경 성장인자의 촉진용 페놀 유도체 - Google Patents
인간 신경 성장인자의 촉진용 페놀 유도체 Download PDFInfo
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- KR900018006A KR900018006A KR1019900007439A KR900007439A KR900018006A KR 900018006 A KR900018006 A KR 900018006A KR 1019900007439 A KR1019900007439 A KR 1019900007439A KR 900007439 A KR900007439 A KR 900007439A KR 900018006 A KR900018006 A KR 900018006A
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Abstract
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Claims (13)
- 하기 일반식(Ia) 및 (Ib)의 페놀 유도체 및 그의 약학적으로 허용가능한 염.[상기식에서, R1은 동일 또는 상이하며 수소원자 또는 히드록시-보호기를 나타내고;R2는 알킬기, 시클로알킬기, 아릴기와 축합된 시클로알킬기, 아릴기, 아르알킬기 또는 헤테로환기를 나타내고;R3는 수소원자 또는 R2기를 나타내거나;또는 R2및 R3는 그들이 부착된 질소원자와 함께 환식 아미노기를 나타내고;m은 1 내지 6의 정수를 나타내고;n은 1 내지 3의 정수를 나타내고;단, n이 2 또는 3이면, 인접하는 두개의 R1기는 함께 조인트(joint) 히드록시-보호기를 형성할수 있고;p는 0이거나 1내지 3의 정수를 나타내고;q는 0이거나 1내지 3의 정수를 나타내고; 및 점선으로 표시된 겨랍은 단일결합 또는 이중결합일 수 있다.]
- 제1항에 있어서, R1이 수소원자 또는 예비 약물용 히드록시-보호기로부터 선택되는 화합물.
- 제2항에 있어서, R1이 1 내지 20의 탄소원자를 갖는 알킬기, 아릴카르보니기, 아실기가 1 내지 6의 탄소원자를 가지며 알콕시기가 1 내지 6의 탄소원자를 가지는 지방족 아실옥시알콕시카르보닐기, 카르복실기로 치환된 지방족 아실기, 또는 아미노산 아실기로부터 선택되는 화합물.
- 제1,2 또는 3항에 있어서, R2가 시클로알킬기, 2 내지 3의 염소 또는 브롬원자로 치환된 아릴기, 또튼 메톡시카르보닐기로 치환된 헤테로환기로부터 선택되는 화합물.
- 제1 내지 4항중 어느 한 항에 있어서, R2가 수소원자를 나타내는 화합물.
- 제1 내지 5항중 어느 한 항에 있어서, m이 2,3 또는 4인 화합물.
- 제1 내지 6항중 어느 한 항에 있어서, n이 2 또는 3인 화합물.
- 제1 내지 7항 중 어느 한 항에 있어서, p가 0 또는 1인 화합물.
- 제1 내지 8항중 어느 한 항에 있어서, q가 1,2 또는 3인 화합물.
- 하기 화합물;3-(3,4-디아세톡시페닐)-N-(2,4,5-트리크로로페닐)프로피온아마이드, 3-(3,4-디아세톡시페닐)-N-(2,3-디클로로페닐)프로피온아마이드, 3-(3,4-디아세톡시페닐)-N-(2,4-디클로로페닐)부티르아마이드, N-(2,4-디클로로페닐)-3-(4-히드록시-3-디메틸카르바모일옥시페닐)ㅡ프로피온아마이드, N-(2,4-디클로로페닐)-3-(3,4-디-[3-에톡시카르보닐프로파노일옥시]페닐)프로피온아마이드, N-(2,4-디클로로페닐)-3-(3-카르복시프로파노일옥시-4-히드록시페닐)프로피온아마이드, N-(2,4-디클로로페닐)-3-(3,4-디글리실옥시페닐)프로피온아마이드, N-(1-아다만틸)-3-(2,3-디아세톡시페닐)프로피온아마이드, N-(2,4-디클로로페닐)-3-(3,4-디히드로시페닐)프로피온아마이드, N-(2,4-디클로로페닐)-6,7-디아세톡시-1,2,3,4-테트라히드로-2-나트타마이드, N-(3-퀴놀릴)-6,7-디아세톡시-1,2,3,4-테트라히드로-2-나프타마이드, N-(1-아다만틸)-6,7-디아세톡시-1,2,3,4-테트라히드로-2-나프타마이드, N-(2,4-디클로로페닐)-6,7-디아세톡시-3,4,-디히드로-2-나프타마이드, N-(3-퀴놀릴)-6,7,-디아세톡시-3,4-디히드로-2-나프타마이드, N-(1-아다만틸)-6,7-디아세톡시-3,4-디히드로-2-타프타마이드, N-(1-아다만틸)-6,7-디아세톡시-1,2,3,4-테트라히드로-2-나프타마이드, N-(2,4-디클로로페닐)-6,7-디아세톡시-3,4-디히드로-2-나프타마이드, 또는 N-(2,4-디크로로페닐)-6,7-디글리실옥시-1,2,3,4-테트라히드로-2-나프타마이드 및 이들의 약학적으로 허용가능한 염으로부터 선택되는 화합물.
- 제1 내지 10항중 어느 한 항에 따른 화합물 1종 이상을 약학적으로 허용가능한 담체와 함께 포함하는 약학 조성물.
- 하기식(Ⅱa) 또는 (Ⅱb)의 산할라이드를 하기식(Ⅲ)의 아민과 반응시키고, 이 화합물을 염류화시킬 수 있으며, 그리고, R1'로 나타내는 히드록시-보호기를 제거할 수 있음을 포함하는 하기식(Ia) 및 (Ib)의 화합물 및 그의 야학적으로 허용가능한 염의 제조방법.[상기식에서, R1'은 하이드록시-보호기이고;Y는 할로겐원자이고;R1은 동일 또는 상이하며 수소원자 또는 히드록시-보호기를 나타내고;R2는 알킬기, 시클로알킬기, 아릴기와 축합된 시클로알킬기, 아릴기, 아르알킬기 또는 헤테로원자를 나타내고;R3는 수소원자 또는 R2기를 나타내거나;또는 R2및 R3는 그들이 부착된 질소원자와 함께 환식 아미노기를 나타내고;m은 1 내지 6의 정수를 나타내고;n은 1 내지 3의 정수를 나타내고; 단, n이 2 또는 3이면 인접한 두개의 R1기는 함께 조인트 히드록시-보호기를 형성할수있고;p는 0이거나 1 내지 3의 정수를 나타내고;q는 0이거나 1 내지 3의 정수를 나타내고; 및 점선으로 표시된 결합은 단일결합 또는 이중결합일 수 있다.]
- 약학적으로 허용가능한 담체와 혼합함에 의하여 약학 조성물의 제조를 위한 제1항에 따른 화합물의 용도.※ 참고사항 : 최초출원내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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JP1-129344 | 1989-05-23 | ||
JP12934489 | 1989-05-23 | ||
JP20422289 | 1989-08-07 | ||
JP1-204222 | 1989-08-07 |
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KR900018006A true KR900018006A (ko) | 1990-12-20 |
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KR1019900007439A KR900018006A (ko) | 1989-05-23 | 1990-05-23 | 인간 신경 성장인자의 촉진용 페놀 유도체 |
Country Status (7)
Country | Link |
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EP (1) | EP0399814A3 (ko) |
KR (1) | KR900018006A (ko) |
CN (1) | CN1048030A (ko) |
CA (1) | CA2017287A1 (ko) |
DD (1) | DD299424A5 (ko) |
HU (1) | HU208111B (ko) |
PT (1) | PT94121A (ko) |
Cited By (1)
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KR100459917B1 (ko) * | 2001-12-14 | 2004-12-03 | (주)바이오뉴트리젠 | 페놀릭산 유도체 및 이를 포함하는 혈중 지질 농도 관련질환의 예방 및 치료용 조성물 |
Families Citing this family (19)
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EP0495998A1 (en) * | 1990-08-10 | 1992-07-29 | MITSUI TOATSU CHEMICALS, Inc. | Dihydrocaffeic acid amide derivative and application thereof as medicine |
US5643925A (en) * | 1991-02-21 | 1997-07-01 | Sankyo Company, Limited | Benzene derivatives having NGF production-promoting activity |
JPH05148202A (ja) * | 1991-04-10 | 1993-06-15 | Tsumura & Co | 新規な化合物およびその医薬としての用途 |
US5480907A (en) * | 1991-05-16 | 1996-01-02 | Takeda Chemical Industries, Ltd. | Aromatic amide compounds and their production and use |
US5591776A (en) * | 1994-06-24 | 1997-01-07 | Euro-Celtique, S.A. | Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV |
WO1998049155A1 (en) * | 1997-04-25 | 1998-11-05 | Takeda Chemical Industries, Ltd. | Cell differentiation inducing amide derivatives, their production and use |
US6037340A (en) * | 1997-05-28 | 2000-03-14 | Cadus Pharmaceutical Corporation | Synthesis and use of thiophene- and pyrrole-based heteroaromatic compounds |
US20030203857A1 (en) * | 2000-04-11 | 2003-10-30 | Hiromu Ohnogi | Remedies |
US7049333B2 (en) | 2002-06-04 | 2006-05-23 | Sanofi-Aventis Deutschland Gmbh | Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis |
DE10254872A1 (de) | 2002-11-25 | 2004-06-03 | Symrise Gmbh & Co. Kg | Anthranilsäureamide und deren Derivate als kosmetische und pharmazeutische Wirkstoffe |
WO2004056744A1 (en) * | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors |
US9012494B2 (en) | 2004-05-07 | 2015-04-21 | Janssen Pharmaceutica N.V. | Pyrrolidin-2-one and piperidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
ES2334246T3 (es) | 2004-08-30 | 2010-03-08 | Janssen Pharmaceutica Nv | Derivados triciclos de adamantilamida como inhibidores de la 11-beta-hidroxiesteroide-deshidrogenasa. |
MX2007002449A (es) | 2004-08-30 | 2007-10-10 | Janssen Pharmaceutica Nv | Derivados de n-2 adamantanil-2-fenoxi-acetamida como inhibidores de deshidrogenasa 11-beta hidroxiesteroide. |
DE602005017159D1 (de) | 2004-08-30 | 2009-11-26 | Janssen Pharmaceutica Nv | Oxysteroid-dehydrogenase-inhibitoren |
KR100957465B1 (ko) * | 2006-08-10 | 2010-05-14 | (주)아모레퍼시픽 | 히드록시신남산 유도체 화합물과 그 제조방법 및 이를함유하는 화장료 조성물 |
DE102010002558A1 (de) * | 2009-11-20 | 2011-06-01 | Symrise Ag | Verwendung physiologischer Kühlwirkstoffe und Mittel enthaltend solche Wirkstoffe |
US20130287727A1 (en) * | 2012-04-25 | 2013-10-31 | Inscent, Inc. | Psyllid Attractants and Their Uses |
MX2020002347A (es) | 2017-08-31 | 2020-10-28 | Basf Se | Uso de principios activos refrescantes fisiologicos y agentes que contienen dichos principios activos. |
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US4529604A (en) * | 1977-03-28 | 1985-07-16 | Smithkline Beckman Corporation | N,N-Di-(n-Propyl)dopamine derivatives |
US4424205A (en) * | 1982-03-18 | 1984-01-03 | The Procter & Gamble Company | Hydroxyphenylacetamides having analgesic and anti-irritant activity |
FI874163A (fi) * | 1986-09-26 | 1988-03-27 | Mitsui Toatsu Chemicals | Katekolderivat samt preparat innehaollande desamma foer haemmande och botande av regressiva sjukdomar i det centrala nervsystemet. |
NZ228329A (en) * | 1988-03-18 | 1991-12-23 | Mitsui Toatsu Chemicals | Catechol derivatives and pharmaceutical compositions thereof |
-
1990
- 1990-05-22 CA CA002017287A patent/CA2017287A1/en not_active Abandoned
- 1990-05-22 DD DD90340912A patent/DD299424A5/de unknown
- 1990-05-22 PT PT94121A patent/PT94121A/pt not_active Application Discontinuation
- 1990-05-23 EP EP19900305633 patent/EP0399814A3/en not_active Withdrawn
- 1990-05-23 HU HU903164A patent/HU208111B/hu not_active IP Right Cessation
- 1990-05-23 CN CN90103242A patent/CN1048030A/zh active Pending
- 1990-05-23 KR KR1019900007439A patent/KR900018006A/ko not_active Application Discontinuation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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KR100459917B1 (ko) * | 2001-12-14 | 2004-12-03 | (주)바이오뉴트리젠 | 페놀릭산 유도체 및 이를 포함하는 혈중 지질 농도 관련질환의 예방 및 치료용 조성물 |
Also Published As
Publication number | Publication date |
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EP0399814A2 (en) | 1990-11-28 |
HU208111B (en) | 1993-08-30 |
PT94121A (pt) | 1991-02-08 |
EP0399814A3 (en) | 1992-01-08 |
HUT54108A (en) | 1991-01-28 |
CN1048030A (zh) | 1990-12-26 |
DD299424A5 (de) | 1992-04-16 |
CA2017287A1 (en) | 1990-11-23 |
HU903164D0 (en) | 1990-10-28 |
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