RU92016545A - Гетероциклические соединения, способ их получения и фармацевтическая композиция - Google Patents
Гетероциклические соединения, способ их получения и фармацевтическая композицияInfo
- Publication number
- RU92016545A RU92016545A RU92016545/04A RU92016545A RU92016545A RU 92016545 A RU92016545 A RU 92016545A RU 92016545/04 A RU92016545/04 A RU 92016545/04A RU 92016545 A RU92016545 A RU 92016545A RU 92016545 A RU92016545 A RU 92016545A
- Authority
- RU
- Russia
- Prior art keywords
- optionally substituted
- production
- pharmaceutical composition
- heterocyclic compounds
- alkyl
- Prior art date
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000004433 nitrogen atoms Chemical group N* 0.000 claims 2
- 206010012601 Diabetes mellitus Diseases 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 125000004432 carbon atoms Chemical group C* 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atoms Chemical class [H]* 0.000 claims 1
- 201000001421 hyperglycemia Diseases 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Claims (1)
- Предлагаются соединения формулы
и их фармацевтически приемлемые соли, где R1 является необязательно замещенным фенилом, R2 является необязательно замещенным амином, либо R2 и R3 вместе с атомами азота и углерода, к которым они присоединены, образуют необязательно замещенное гетероциклическое кольцо, либо R3 и R4 вместе с атомом азота, к которому они присоединены, образуют необязательно замещенное гетероциклическое кольцо, и R5-водородом, галоидом, алкил, алкокси, трифторметил или группой формулы S(O)mR8, где m = 0, 1 или 2, и R8 является алкилом. Данные соединения применимы для лечения диабетов, особенно для лечения гипергликемии.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN126BO1990 IN172842B (ru) | 1990-05-17 | 1990-05-17 | |
GB9014456.9 | 1990-06-28 | ||
GB909014456A GB9014456D0 (en) | 1990-06-28 | 1990-06-28 | Therapeutic agents |
PCT/EP1991/000911 WO1992000273A1 (en) | 1990-05-17 | 1991-05-15 | Orthosubstituted biphenyl amidine and biphenyl guanidine derivatives and antidiabetic or hypoglycaemic agents containing them |
Publications (2)
Publication Number | Publication Date |
---|---|
RU92016545A true RU92016545A (ru) | 1995-05-20 |
RU2099323C1 RU2099323C1 (ru) | 1997-12-20 |
Family
ID=26297257
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU9292016545A RU2099323C1 (ru) | 1990-05-17 | 1991-05-15 | Производные гуанидина, способ их получения и фармацевтическая композиция, обладающая гипогликемической активностью |
Country Status (27)
Country | Link |
---|---|
US (1) | US5302720A (ru) |
EP (1) | EP0536151B1 (ru) |
JP (1) | JPH089589B2 (ru) |
KR (1) | KR920005714A (ru) |
CN (1) | CN1028521C (ru) |
AT (1) | ATE111445T1 (ru) |
AU (1) | AU637695B2 (ru) |
BG (1) | BG61260B1 (ru) |
CA (1) | CA2041846A1 (ru) |
CZ (1) | CZ280182B6 (ru) |
DE (1) | DE69104041T4 (ru) |
DK (1) | DK0536151T3 (ru) |
ES (1) | ES2064103T3 (ru) |
FI (1) | FI95566C (ru) |
GB (1) | GB2244486B (ru) |
HR (1) | HRP930699A2 (ru) |
HU (1) | HU210200B (ru) |
IE (1) | IE64485B1 (ru) |
IL (1) | IL98029A (ru) |
IN (1) | IN172842B (ru) |
MX (1) | MX25770A (ru) |
NO (1) | NO179204C (ru) |
NZ (1) | NZ238119A (ru) |
PL (1) | PL167657B1 (ru) |
PT (1) | PT97700B (ru) |
RU (1) | RU2099323C1 (ru) |
WO (1) | WO1992000273A1 (ru) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992004054A1 (en) * | 1990-08-30 | 1992-03-19 | STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of THE OREGON HEALTH SCIENCES UNIVERSITY, PORTLAND, OREGON, and THE UNIVERSITY OF OREGON, EUGENE, OREGON, Johnson Hall, University of Oregon | Substituted amidines having high binding to the sigma receptor and the use thereof |
US5298657A (en) * | 1992-03-20 | 1994-03-29 | Cambridge Neuroscience Inc. | Preparation of substituted guanidines |
ATE180255T1 (de) * | 1993-03-23 | 1999-06-15 | Astra Ab | Guanidinderivate mit therapeutischer wirkung |
US5512596A (en) * | 1994-09-02 | 1996-04-30 | Gilead Sciences, Inc. | Aromatic compounds |
WO1996017612A1 (en) * | 1994-12-08 | 1996-06-13 | Knoll Aktiengesellschaft | Use of substituted phenylamidine and phenylguanidine compounds for the treatment of cerebral and cardiac ischaemia, convulsion and sickle cell anaemia |
ATE208767T1 (de) * | 1996-04-30 | 2001-11-15 | Pfizer | Muscarinische rezeptor-agonisten |
US6756389B2 (en) * | 1996-08-09 | 2004-06-29 | Cambridge Neuroscience, Inc. | Pharmaceutically active compounds and methods of use |
KR19990017013A (ko) * | 1997-08-20 | 1999-03-15 | 윤종용 | 가변단속주기의 오디오신호 발생장치 |
DE19737463A1 (de) * | 1997-08-28 | 1999-03-04 | Hoechst Marion Roussel De Gmbh | Verwendung von Inhibitoren des Natrium-Wasserstoff-Austauschers zur Herstellung eines Arzneimittels zur Behandlung von Erkrankungen, die durch Protozoen verursacht werden |
AU7672698A (en) | 1998-06-11 | 1999-12-30 | S.P.O. Medical Equipment Ltd. | Physiological stress detector device and method |
WO2002008197A1 (de) * | 2000-07-24 | 2002-01-31 | Bayer Cropscience Ag | Biphenylcarboxamide |
HUP0301189A3 (en) * | 2000-07-24 | 2003-11-28 | Bayer Cropscience Ag | Pyrazolyl biphenyl carboxamides, intermediates, preparation and use thereof for controlling undesired microorganisms |
DE10258314A1 (de) * | 2002-12-13 | 2004-06-24 | Bayer Cropscience Ag | Biphenyloximether |
PE20070341A1 (es) * | 2005-07-29 | 2007-04-13 | Wyeth Corp | Derivados de pirrol como moduladores del receptor de progesterona |
PE20070182A1 (es) * | 2005-07-29 | 2007-03-06 | Wyeth Corp | Derivados cianopirrol-fenil amida como moduladores del receptor de progesterona |
EP1926718B1 (en) | 2005-09-13 | 2012-09-05 | Bayer CropScience AG | Pesticide thiazolyloxy substituted phenylamidine derivatives |
CN104945287B (zh) * | 2015-06-12 | 2017-06-13 | 苏州大学张家港工业技术研究院 | 一种脒的磺酸内盐化合物的合成方法 |
AR101498A1 (es) * | 2015-08-11 | 2016-12-21 | Chemo Res S L | Procedimiento para la preparación del compuesto n-(3,5-dimetilfenil)-n-(2-trifluorometilfenil)guanidina y su forma cristalina a |
GB201809295D0 (en) | 2018-06-06 | 2018-07-25 | Institute Of Cancer Res Royal Cancer Hospital | Lox inhibitors |
GB201818750D0 (en) | 2018-11-16 | 2019-01-02 | Institute Of Cancer Res Royal Cancer Hospital | Lox inhibitors |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1850682A (en) * | 1927-01-10 | 1932-03-22 | Ig Farbenindustrie Ag | Substituted guanidines |
GB614072A (en) * | 1946-07-01 | 1948-12-09 | Boots Pure Drug Co Ltd | Manufacture of phenanthridine compounds |
NL299929A (ru) * | 1962-10-30 | |||
US3252982A (en) * | 1963-10-16 | 1966-05-24 | Ciba Geigy Corp | Benzhydryl compounds |
US3669974A (en) * | 1971-03-25 | 1972-06-13 | Usv Pharma Corp | N,n1-disubstituted benzamidines |
BE788767A (fr) * | 1971-09-13 | 1973-01-02 | Richardson Merrell Inc | Compositions hypoglycemiques contenant des derives de benzhydryllactamimide |
FR2223361B1 (ru) * | 1973-03-27 | 1977-04-29 | Philagro Sa | |
DE2417669A1 (de) * | 1974-04-11 | 1975-10-16 | Hoechst Ag | Verfahren zur herstellung von n(halogenaryl)-n',n'-dialkylamidinen |
US4061746A (en) * | 1976-04-23 | 1977-12-06 | Richardson-Merrell Inc. | Lactamimide inhibitors of gastrointestinal hypersecretion |
JPS604829B2 (ja) * | 1977-03-28 | 1985-02-06 | 日本曹達株式会社 | イミダゾール誘導体、その製造方法及び農園芸用殺菌剤 |
US4101659A (en) * | 1977-08-29 | 1978-07-18 | Mcneil Laboratories, Incorporated | Benzhydryl guanidines |
US4414211A (en) * | 1978-09-18 | 1983-11-08 | Mcneilab, Inc. | Heterocyclic derivatives of guanidine |
NL7810350A (nl) * | 1978-10-16 | 1980-04-18 | Duphar Int Res | Preparaat met groeiregulerende werking en gebruik van dit preparaat in land- en tuinbouw. |
ZA801680B (en) * | 1979-04-03 | 1981-03-25 | Fujisawa Pharmaceutical Co | 2-imidazoline derivatives,process for the preparation thereof and the pharmaceutical composition of the same |
AU538963B2 (en) * | 1979-07-09 | 1984-09-06 | Seth Thomas Shaw Jr. | Drug for use with an iud |
US4281004A (en) * | 1980-03-31 | 1981-07-28 | Pfizer Inc. | Phenylguanidine therapeutic agents |
DE3108564A1 (de) * | 1981-03-06 | 1982-11-18 | Bayer Ag, 5090 Leverkusen | N-tert-butyl-phenyl-n'-cyclohexyl-quanidine, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide |
ATE19880T1 (de) * | 1981-08-24 | 1986-06-15 | Merck & Co Inc | Thiadiazole oxyde mit antisekretorischer wirkung. |
DE3220828A1 (de) * | 1982-06-03 | 1983-12-08 | Hoechst Ag, 6230 Frankfurt | Bisamidin-derivate von dephenyl, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
IN158084B (ru) * | 1982-06-25 | 1986-08-30 | Council Scient Ind Res | |
DE3343815A1 (de) * | 1983-12-03 | 1985-06-13 | Hoechst Ag, 6230 Frankfurt | Neue bisamidindiphenylderivate, ein verfahren zu ihrer herstellung und ihre verwendung als chemotherapeutika |
US4680300A (en) * | 1985-01-10 | 1987-07-14 | Syntex (U.S.A.) Inc. | Anti-inflammatory guanidines |
US4693850A (en) * | 1985-03-15 | 1987-09-15 | Mcneilab, Inc. | Methane sulfonic acid derivatives |
US4656270A (en) * | 1985-03-15 | 1987-04-07 | Mcneilab, Inc. | Process for producing guanidines such as linogliride |
US4781866A (en) * | 1985-03-15 | 1988-11-01 | Mcneilab, Inc. | Process for producing amidine sulfonic acid intermediates for guanidines |
SG47583A1 (en) * | 1986-01-13 | 1998-04-17 | American Cyanamid Co | 4,5,6-Substituted-n- (substituted-phenyl) -2- pyrimidinamines |
US4709094A (en) * | 1986-07-10 | 1987-11-24 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Sigma brain receptor ligands and their use |
GB8903592D0 (en) * | 1989-02-16 | 1989-04-05 | Boots Co Plc | Therapeutic agents |
IE62023B1 (en) * | 1989-01-02 | 1994-12-14 | Boots Co Plc | Therapeutic agents |
DE3922232A1 (de) * | 1989-07-06 | 1991-01-17 | Basf Ag | Fungizide guanidine |
EP0418199A3 (en) * | 1989-09-13 | 1991-06-12 | Ciba-Geigy Ag | Guanidine derivatives |
-
1990
- 1990-05-17 IN IN126BO1990 patent/IN172842B/en unknown
-
1991
- 1991-04-29 IE IE143991A patent/IE64485B1/en not_active IP Right Cessation
- 1991-05-02 IL IL9802991A patent/IL98029A/en active IP Right Grant
- 1991-05-06 CA CA002041846A patent/CA2041846A1/en not_active Abandoned
- 1991-05-07 CZ CS911334A patent/CZ280182B6/cs not_active IP Right Cessation
- 1991-05-07 AU AU76394/91A patent/AU637695B2/en not_active Ceased
- 1991-05-10 NZ NZ238119A patent/NZ238119A/en unknown
- 1991-05-13 GB GB9110306A patent/GB2244486B/en not_active Expired - Fee Related
- 1991-05-14 MX MX25770A patent/MX25770A/es unknown
- 1991-05-15 JP JP3508950A patent/JPH089589B2/ja not_active Expired - Lifetime
- 1991-05-15 DE DE69104041A patent/DE69104041T4/de not_active Expired - Fee Related
- 1991-05-15 DK DK91909161.1T patent/DK0536151T3/da active
- 1991-05-15 PL PL91297374A patent/PL167657B1/pl unknown
- 1991-05-15 EP EP91909161A patent/EP0536151B1/en not_active Expired - Lifetime
- 1991-05-15 KR KR1019910007829A patent/KR920005714A/ko not_active Application Discontinuation
- 1991-05-15 ES ES91909161T patent/ES2064103T3/es not_active Expired - Lifetime
- 1991-05-15 RU RU9292016545A patent/RU2099323C1/ru active
- 1991-05-15 WO PCT/EP1991/000911 patent/WO1992000273A1/en active IP Right Grant
- 1991-05-15 AT AT91909161T patent/ATE111445T1/de not_active IP Right Cessation
- 1991-05-16 HU HU911650A patent/HU210200B/hu not_active IP Right Cessation
- 1991-05-16 PT PT97700A patent/PT97700B/pt not_active IP Right Cessation
- 1991-11-14 CN CN91110775A patent/CN1028521C/zh not_active Expired - Fee Related
-
1992
- 1992-06-17 US US07/899,939 patent/US5302720A/en not_active Expired - Fee Related
- 1992-12-10 NO NO924783A patent/NO179204C/no unknown
- 1992-12-22 BG BG97221A patent/BG61260B1/bg unknown
- 1992-12-23 FI FI925871A patent/FI95566C/fi active
-
1993
- 1993-04-02 HR HR930699A patent/HRP930699A2/hr not_active Application Discontinuation
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