KR880005077A - 우울증 억제제로서 1-벤질-아미노알킬-피롤리디논의 용도 - Google Patents
우울증 억제제로서 1-벤질-아미노알킬-피롤리디논의 용도 Download PDFInfo
- Publication number
- KR880005077A KR880005077A KR870011159A KR870011159A KR880005077A KR 880005077 A KR880005077 A KR 880005077A KR 870011159 A KR870011159 A KR 870011159A KR 870011159 A KR870011159 A KR 870011159A KR 880005077 A KR880005077 A KR 880005077A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- alkyl group
- substituted
- alkyl
- benzyl
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
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- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (4)
- 일반식(Ⅰ)의 화합물 및 이의 약물학적으로 허용된는 산부가염의 우울증 억제제로서의 용도.상기식에서 R1은 수소 또는 알킬그룹을 나타내고, R2는 알콕시, 불소, 염소, 브롬, 트리플루오로메틸, 알킬, 하이드록시 또는 니트로에 의해 일-또는 이치환 될수 있는 페닐그룹을 나타내거나 피리딜그룹을 나타내며, R3는 수소 또는 알킬그룹을 나타내고, R4는 수소 또는 알킬그룹을 나타낼 수 있거나, R3및 R4두그룹이 질소원자와 함께, 추가로 헤테로원자로서 O 또는 N 원자를 함유할 수 있고 메틸에 의해 임으로 치환될 수 있거나 이미다졸 환을 형성할수 있는 포환된 5- 또는 6-원 환을 나타낼수 있으며, 한편 아미노알킬그룹은 4 또는 5위치에 존재한다.
- 1-벤질-4-아미노메틸-피롤리딘-2-온 및 임의적인 이의 약물학적으로 허용되는 산부가염의 우울증억제제로서의 용도.
- 우울증 치료하는 약학적 조성물을 제조하기 위한 일반식(Ⅰ) 화합물의 용도.상기식에서 R1은 수소 또는 알킬그룹을 나타내고, R2는 알콕시, 불소, 염소, 브롬, 트리플루오로메틸, 알킬, 하이드록시 또는 니트로에 의해 일-또는 이치환 될수 있는 페닐그룹을 나타내거나 피리딜그룹을 나타내며, R3는 수소 또는 알킬그룹을 나타내고, R4는 수소 또는 알킬그룹을 나타낼 수 있거나, R3및 R4두그룹이 질소원자와 함께, 추가로 헤테로 원자로서 O 또는 N 원자를 함유할 수 있고 메틸에 의해 임의로 치환될 수 있거나 이미다졸 환을 형성할수 있는 포화된 5- 또는 6-원 환을 나타낼수 있으며, 한편 아미노알킬그룹은 4 또는 5위치에 존재한다.
- 우울증을 치료하는 약학적 조성물을 제조하기 위한 1-벤질-4-아미노메틸-피롤리딘-2-온 및 임의적인 이의 약물학적으로 허용되는 산부가염의 용도.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19863634220 DE3634220A1 (de) | 1986-10-08 | 1986-10-08 | Verwendung von 1-benzyl-aminoalkyl-pyrrolidinonen als antidepressiva |
DEP3634220.3 | 1986-10-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR880005077A true KR880005077A (ko) | 1988-06-27 |
KR950009091B1 KR950009091B1 (en) | 1995-08-14 |
Family
ID=6311269
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR87011159A KR950009091B1 (en) | 1986-10-08 | 1987-10-06 | Antidepressants containing 1-benzyl-aminoalkyl-pyrrolidinones |
Country Status (8)
Country | Link |
---|---|
US (3) | US4812453A (ko) |
EP (1) | EP0266563B1 (ko) |
JP (1) | JPH0737382B2 (ko) |
KR (1) | KR950009091B1 (ko) |
AT (1) | ATE72112T1 (ko) |
DE (2) | DE3634220A1 (ko) |
IE (1) | IE60263B1 (ko) |
PH (1) | PH25506A (ko) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4638333A (en) * | 1985-10-25 | 1987-01-20 | Xerox Corporation | Thermal printing circuit |
FR2696744B1 (fr) * | 1992-10-12 | 1994-12-30 | Logeais Labor Jacques | Dérivés de 2-pyrrolidone, leur procédé de préparation et leurs applications en thérapeutique. |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3336024A1 (de) * | 1983-10-04 | 1985-04-18 | Boehringer Ingelheim KG, 6507 Ingelheim | 4-amino-l-benzyl-pyrrolidinone und ihre saeureadditionssalze, verfahren zu ihrer herstellung und arzneimittel |
-
1986
- 1986-10-08 DE DE19863634220 patent/DE3634220A1/de not_active Withdrawn
-
1987
- 1987-09-29 US US07/102,074 patent/US4812453A/en not_active Expired - Lifetime
- 1987-10-03 DE DE87114443T patent/DE3776488D1/de not_active Expired - Lifetime
- 1987-10-03 EP EP87114443A patent/EP0266563B1/de not_active Expired - Lifetime
- 1987-10-03 AT AT87114443T patent/ATE72112T1/de not_active IP Right Cessation
- 1987-10-06 KR KR87011159A patent/KR950009091B1/ko not_active IP Right Cessation
- 1987-10-07 PH PH35902A patent/PH25506A/en unknown
- 1987-10-07 IE IE267687A patent/IE60263B1/en not_active IP Right Cessation
- 1987-10-07 JP JP62253445A patent/JPH0737382B2/ja not_active Expired - Lifetime
-
1989
- 1989-07-20 US US07/383,105 patent/US4954516A/en not_active Expired - Lifetime
- 1989-08-07 US US07/394,102 patent/US4912129A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
IE60263B1 (en) | 1994-06-29 |
US4912129A (en) | 1990-03-27 |
PH25506A (en) | 1991-07-24 |
JPS6396125A (ja) | 1988-04-27 |
IE872676L (en) | 1988-04-08 |
US4954516A (en) | 1990-09-04 |
EP0266563A2 (de) | 1988-05-11 |
EP0266563B1 (de) | 1992-01-29 |
DE3634220A1 (de) | 1988-04-14 |
KR950009091B1 (en) | 1995-08-14 |
JPH0737382B2 (ja) | 1995-04-26 |
DE3776488D1 (ko) | 1992-03-12 |
US4812453A (en) | 1989-03-14 |
EP0266563A3 (en) | 1990-06-13 |
ATE72112T1 (de) | 1992-02-15 |
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