ES8609212A1 - Un procedimiento para la preparacion de derivados de etanolamina. - Google Patents

Un procedimiento para la preparacion de derivados de etanolamina.

Info

Publication number
ES8609212A1
ES8609212A1 ES544221A ES544221A ES8609212A1 ES 8609212 A1 ES8609212 A1 ES 8609212A1 ES 544221 A ES544221 A ES 544221A ES 544221 A ES544221 A ES 544221A ES 8609212 A1 ES8609212 A1 ES 8609212A1
Authority
ES
Spain
Prior art keywords
amines
beta
bis
chem
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES544221A
Other languages
English (en)
Other versions
ES544221A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES544221A0 publication Critical patent/ES544221A0/es
Publication of ES8609212A1 publication Critical patent/ES8609212A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis

Abstract

OBTENCION DEL COMPUESTO (I) O DE UNA DE SUS SALES, EN DONDE R1 Y R2 PUEDEN SER IGUALES O DIFERENTES Y SON HIDROGENO, HALOGENO O TRIFLUORMETILO, R3 ES HIDROGENO O METILO, R4 ES -O(CH2)ACO2H, -O(CH2)B U -O(CH2)-N O UN DERIVADO DE ESTER O AMIDA DEL MISMO SIENDO A UN ENTERO DE 1 A 6, B UN ENTERO DE 2 A 7, R5 Y R6 HIDROGENO O UN ALQUILO C1-C6 O N FORMAN JUNTOS UN ANILLO PENTAGONAL O HEXAGONAL, X ES UN ENLACE U -O- Y N ES 1 O 2. LAS SALES DE (I) SON SALES DE ADICION CON ACIDOS INORGANICOS FUERTES, ARIL-SULFONICOS, ALIFATICOS MONO-, DI- O TRICARBOXILICOS O HIDROXIAROMATICOS Y LOS ESTERES SON ESTERES ALQUILICOS C1-C6. EL COMPUESTO (I) SE OBTIENE POR REACCION DE (II) CON (III) EN SULFOXIDO DE DIMETILO O EN UN ALCANOL INFERIOR A TEMPERATURA ELEVADA, EN PRESENCIA OPTATIVA DE UN CATALIZADOR DE AMINA TERCIARIA O POR REACCION DE (II) CON (IV) EN SULFOXIDO DE DIMETILO. LOS COMPUESTOS SON ANTIHIPERGLICEMICOS.
ES544221A 1984-06-15 1985-06-14 Un procedimiento para la preparacion de derivados de etanolamina. Expired ES8609212A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848415377A GB8415377D0 (en) 1984-06-15 1984-06-15 Compounds

Publications (2)

Publication Number Publication Date
ES544221A0 ES544221A0 (es) 1986-09-01
ES8609212A1 true ES8609212A1 (es) 1986-09-01

Family

ID=10562528

Family Applications (1)

Application Number Title Priority Date Filing Date
ES544221A Expired ES8609212A1 (es) 1984-06-15 1985-06-14 Un procedimiento para la preparacion de derivados de etanolamina.

Country Status (9)

Country Link
EP (1) EP0164700B1 (es)
JP (1) JPS6117544A (es)
AU (1) AU4363285A (es)
DE (1) DE3567450D1 (es)
DK (1) DK268185A (es)
ES (1) ES8609212A1 (es)
GB (1) GB8415377D0 (es)
GR (1) GR851445B (es)
ZA (1) ZA854446B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE41655T1 (de) * 1985-04-16 1989-04-15 Hoffmann La Roche Phenaethanolaminderivate.
GB8519154D0 (en) * 1985-07-30 1985-09-04 Ici Plc Aromatic ethers
GB8528633D0 (en) * 1985-11-21 1985-12-24 Beecham Group Plc Compounds
DK9987A (da) * 1986-01-11 1987-07-12 Beecham Group Plc Ethanolaminderivater
CA1287061C (en) * 1986-06-27 1991-07-30 Roche Holding Ltd. Pyridine ethanolamine derivatives
IT1204416B (it) * 1986-06-27 1989-03-01 Midy Spa Medicamenti a base di analoghi di feniletanolammine per il trattamento di disturbi gastro-intestinali ed uterini
GB8925032D0 (en) * 1989-11-06 1989-12-28 Ici Plc Chemical compounds
WO1994025427A1 (en) * 1993-04-26 1994-11-10 Fujisawa Pharmaceutical Co., Ltd. Ethanolamine derivatives useful for the treatment of gastrointestinal disorders
US5578638A (en) * 1993-11-05 1996-11-26 American Cyanamid Company Treatment of glaucoma and ocular hypertension with β3 -adrenergic agonists
US5563171A (en) * 1993-11-05 1996-10-08 American Cyanamid Company Treatment of glaucoma and ocular hypertension with β3-adrenergic agonists

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4338333A (en) * 1979-06-16 1982-07-06 Beecham Group Limited Ethanamine derivatives their preparation and use in pharmaceutical compositions
DE3271132D1 (en) * 1981-07-11 1986-06-19 Beecham Group Plc Secondary phenylethanol amines, processes for their preparation and their pharmaceutical application
EP0099707B1 (en) * 1982-07-16 1986-12-10 Beecham Group Plc 2-aminoethyl ether derivatives, processes for their preparation and pharmaceutical compositions containing them
CA1258454A (en) * 1982-08-10 1989-08-15 Leo Alig Phenethanolamines

Also Published As

Publication number Publication date
ES544221A0 (es) 1986-09-01
GR851445B (es) 1985-11-25
EP0164700A3 (en) 1986-01-29
ZA854446B (en) 1986-04-30
AU4363285A (en) 1985-12-19
JPS6117544A (ja) 1986-01-25
EP0164700A2 (en) 1985-12-18
DK268185D0 (da) 1985-06-13
EP0164700B1 (en) 1989-01-11
GB8415377D0 (en) 1984-07-18
DK268185A (da) 1985-12-16
DE3567450D1 (de) 1989-02-16

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