ATE26839T1 - Aminonaphtacen derivate und ihre herstellung. - Google Patents
Aminonaphtacen derivate und ihre herstellung.Info
- Publication number
- ATE26839T1 ATE26839T1 AT83306384T AT83306384T ATE26839T1 AT E26839 T1 ATE26839 T1 AT E26839T1 AT 83306384 T AT83306384 T AT 83306384T AT 83306384 T AT83306384 T AT 83306384T AT E26839 T1 ATE26839 T1 AT E26839T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- hydrogen atom
- hydroxy
- aminophtacene
- derivatives
- Prior art date
Links
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 125000004066 1-hydroxyethyl group Chemical group [H]OC([H])([*])C([H])([H])[H] 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 239000013043 chemical agent Substances 0.000 abstract 1
- 230000007794 irritation Effects 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- FUIJBTPGTRUBJJ-UHFFFAOYSA-N tetracen-2-amine Chemical class C1=CC=CC2=CC3=CC4=CC(N)=CC=C4C=C3C=C21 FUIJBTPGTRUBJJ-UHFFFAOYSA-N 0.000 abstract 1
- -1 tetrahydropyranyloxy group Chemical group 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57186514A JPS5976099A (ja) | 1982-10-22 | 1982-10-22 | アミノナフタセン誘導体とその製造方法 |
| EP83306384A EP0107486B1 (de) | 1982-10-22 | 1983-10-20 | Aminonaphtacen Derivate und ihre Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE26839T1 true ATE26839T1 (de) | 1987-05-15 |
Family
ID=16189827
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT83306384T ATE26839T1 (de) | 1982-10-22 | 1983-10-20 | Aminonaphtacen derivate und ihre herstellung. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4673668A (de) |
| EP (1) | EP0107486B1 (de) |
| JP (1) | JPS5976099A (de) |
| AT (1) | ATE26839T1 (de) |
| CA (1) | CA1245642A (de) |
| DE (1) | DE3371205D1 (de) |
| ES (2) | ES8602836A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2603480B2 (ja) * | 1987-08-05 | 1997-04-23 | 住友製薬株式会社 | 安定化されたアンスラサイクリン系製剤 |
| AU1259899A (en) * | 1997-11-28 | 1999-06-16 | Sumitomo Pharmaceuticals Company, Limited | Crystalline amrubicin hydrochloride |
| KR101114790B1 (ko) * | 2001-01-30 | 2012-02-28 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | 폐암 치료제 |
| WO2003035660A1 (fr) * | 2001-10-23 | 2003-05-01 | Sumitomo Chemical Company, Limited | Stabilisation d'hydrochlorure d'amrubicine |
| AU2003284478A1 (en) | 2002-11-29 | 2004-06-23 | Sumitomo Pharmaceuticals Co., Ltd. | Freeze-dried preparation of stabilized anthracycline compound |
| US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
| AR074977A1 (es) | 2008-12-23 | 2011-03-02 | Pharmasset Inc | Sintesis de nucleosidos de purina |
| CN102753563A (zh) | 2008-12-23 | 2012-10-24 | 吉利德制药有限责任公司 | 核苷类似物 |
| PT2376088T (pt) | 2008-12-23 | 2017-05-02 | Gilead Pharmasset Llc | Fosforamidatos de nucleósidos de 2-amino-purina 6-osubstituída |
| EP2436386B1 (de) | 2009-05-27 | 2014-09-24 | Dainippon Sumitomo Pharma Co., Ltd. | Stabilisierte und lyophilisierte Formulierung von Anthracyclin-Verbindungen |
| CN102858790A (zh) | 2010-03-31 | 2013-01-02 | 吉利德制药有限责任公司 | 核苷氨基磷酸酯 |
| CN103421059B (zh) * | 2012-05-22 | 2016-04-06 | 重庆圣华曦药业股份有限公司 | 一种氨柔比星的合成方法 |
| CN105367418A (zh) * | 2014-08-14 | 2016-03-02 | 上海科胜药物研发有限公司 | 一种四氢萘类化合物及其合成方法 |
| WO2017207540A1 (en) * | 2016-05-30 | 2017-12-07 | Toxinvent Oü | Antibody-drug-conjugates comprising novel anthracycline-derivatives for cancer treatment |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2314726A1 (fr) * | 1975-06-16 | 1977-01-14 | Rhone Poulenc Ind | Nouveaux derives du naphtagene, leur preparation et les compositions qui les contiennent |
| IT1098211B (it) * | 1978-05-09 | 1985-09-07 | Farmaceutici Italia | Deossiantracicline antitumorali |
| US4540695A (en) * | 1981-08-12 | 1985-09-10 | Sumitomo Chemical Co., Ltd. | Aminonaphthacene derivatives and their use |
-
1982
- 1982-10-22 JP JP57186514A patent/JPS5976099A/ja active Pending
-
1983
- 1983-10-17 CA CA000439091A patent/CA1245642A/en not_active Expired
- 1983-10-20 EP EP83306384A patent/EP0107486B1/de not_active Expired
- 1983-10-20 AT AT83306384T patent/ATE26839T1/de not_active IP Right Cessation
- 1983-10-20 DE DE8383306384T patent/DE3371205D1/de not_active Expired
- 1983-10-21 ES ES526641A patent/ES8602836A1/es not_active Expired
-
1985
- 1985-04-10 US US06/721,606 patent/US4673668A/en not_active Expired - Lifetime
- 1985-05-30 ES ES543672A patent/ES8603858A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE3371205D1 (en) | 1987-06-04 |
| ES526641A0 (es) | 1985-11-01 |
| ES543672A0 (es) | 1986-01-01 |
| EP0107486A1 (de) | 1984-05-02 |
| US4673668A (en) | 1987-06-16 |
| CA1245642A (en) | 1988-11-29 |
| JPS5976099A (ja) | 1984-04-28 |
| ES8602836A1 (es) | 1985-11-01 |
| EP0107486B1 (de) | 1987-04-29 |
| ES8603858A1 (es) | 1986-01-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |