ES483854A1 - Proceso para la obtencion de un derivado de 2-deoxi-5-fluo- rouridina. - Google Patents

Proceso para la obtencion de un derivado de 2-deoxi-5-fluo- rouridina.

Info

Publication number
ES483854A1
ES483854A1 ES483854A ES483854A ES483854A1 ES 483854 A1 ES483854 A1 ES 483854A1 ES 483854 A ES483854 A ES 483854A ES 483854 A ES483854 A ES 483854A ES 483854 A1 ES483854 A1 ES 483854A1
Authority
ES
Spain
Prior art keywords
same
deoxy
antitumor agents
fluorouridine
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES483854A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Funai Pharmaceutical Industries Ltd
Original Assignee
Funai Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Funai Pharmaceutical Industries Ltd filed Critical Funai Pharmaceutical Industries Ltd
Publication of ES483854A1 publication Critical patent/ES483854A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Proceso para la obtención de un derivado de 2-deoxi-5- fluorouridina, representado por la fórmula-01 (I): **(Fórmula-01)** donde: R representa un átomo de hidrógeno, un grupo alquilo que tiene de la 5 átomos de carbono, un grupo alcoxilo que tiene de 1 a 4 átomos de carbono, un grupo acetiloxilo o un átomo de halógeno, y n es un entero de 1 a 3, que comprende reaccionar 2-deoxi-3'',5''-di-0-acetil-5-fluorouridina con un haluro de benzoil representado por la fórmula-02 (II): **(Fórmula-02)** donde hal representa un átomo de halógeno, y R y n son iguales tal y como se ha definido antes.
ES483854A 1978-09-05 1979-09-03 Proceso para la obtencion de un derivado de 2-deoxi-5-fluo- rouridina. Expired ES483854A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10895578A JPS5535057A (en) 1978-09-05 1978-09-05 2'-deoxy-5-fluorouridine derivative, its preparation, and antitumor agent comprising it

Publications (1)

Publication Number Publication Date
ES483854A1 true ES483854A1 (es) 1980-09-01

Family

ID=14497883

Family Applications (1)

Application Number Title Priority Date Filing Date
ES483854A Expired ES483854A1 (es) 1978-09-05 1979-09-03 Proceso para la obtencion de un derivado de 2-deoxi-5-fluo- rouridina.

Country Status (7)

Country Link
US (2) US4599404A (es)
EP (1) EP0009882B1 (es)
JP (1) JPS5535057A (es)
AT (1) ATE733T1 (es)
CA (1) CA1121811A (es)
DE (1) DE2962235D1 (es)
ES (1) ES483854A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5924999B2 (ja) * 1978-06-10 1984-06-13 富山化学工業株式会社 新規な５−フルオロ−２′−デオキシ−β−ウリジン誘導体の製造法
GB2072164B (en) * 1980-02-15 1983-12-21 Funai Pharmaceutical Ind Ltd 2'-deoxy-3',5'-di-o-alkylcarbonyl-5-fluorouridine derivatives a process for the preparation of the derivatives and antitumor agents containing the derivatives
EP0082668A1 (en) * 1981-12-18 1983-06-29 Beecham Group Plc 5-(2-Halogenovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in treating viral infections
JPS6041922A (ja) * 1984-07-17 1985-03-05 松下電器産業株式会社 飲料製造機
JPS6041924A (ja) * 1984-07-17 1985-03-05 松下電器産業株式会社 飲料製造機
DE3588036T2 (de) * 1984-10-30 1995-11-16 Otsuka Pharma Co Ltd 5-Fluoruracilderivate.
US4864021A (en) * 1984-10-30 1989-09-05 Otsuka Pharmaceutical Co., Ltd. 5-fluorouracil derivatives
JPH0678478B2 (ja) * 1986-03-19 1994-10-05 ユニチカ株式会社 熱可塑性樹脂組成物
DE3786834T2 (de) * 1986-04-30 1994-03-03 Otsuka Pharma Co Ltd 5-Fluoro-Uracil-Derivate.
AU610913B2 (en) * 1987-07-31 1991-05-30 Taiho Pharmaceutical Co., Ltd. 2'-deoxy-5-fluorouridine derivatives
US4992534A (en) * 1987-08-12 1991-02-12 Otsuka Pharmaceutical Co., Ltd. 3'-O-,5'-O-derivatives of 2'-deoxy-5-fluorouridine
US4981908A (en) * 1988-02-02 1991-01-01 E. I. Du Pont De Nemours And Company Thermoplastic elastomer blends
AU610344B2 (en) * 1988-02-29 1991-05-16 Taiho Pharmaceutical Co., Ltd. 2'-deoxy-5-fluorouridine derivatives
US20050131224A1 (en) * 2003-12-15 2005-06-16 Cti Pet Systems, Inc. Method for preparing radiolabeled thymidine
US7160537B2 (en) * 2003-12-15 2007-01-09 Siemens Medical Solutions Usa, Inc. Method for preparing radiolabeled thymidine having low chromophoric byproducts
CN113234064B (zh) * 2021-05-27 2022-03-29 西南医科大学附属中医医院 一种替加氟衍生物及其制备方法与应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3168513A (en) * 1962-03-02 1965-02-02 Hoffmann La Roche Derivative of 2'-deoxy-5-fluorouridine
US3309359A (en) * 1965-10-22 1967-03-14 Hoffmann La Roche N-mono-acyl-5-fluorocytosine derivatives and process
US3975367A (en) * 1971-06-08 1976-08-17 The Upjohn Company Arabinofuranosyl N4 -aminoacyl cytosine containing compounds
FR2306701A1 (fr) * 1975-04-08 1976-11-05 Asahi Chemical Ind Derives de nucleotides
DE2658672A1 (de) * 1976-12-23 1978-06-29 Robugen Gmbh Neue nucleosid-verbindungen und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
JPS5611718B2 (es) 1981-03-16
US4599404A (en) 1986-07-08
EP0009882A1 (en) 1980-04-16
DE2962235D1 (en) 1982-04-01
CA1121811A (en) 1982-04-13
EP0009882B1 (en) 1982-03-03
US4490366A (en) 1984-12-25
ATE733T1 (de) 1982-03-15
JPS5535057A (en) 1980-03-11

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970505