DK344488A - Hexacycliske forbindelser - Google Patents
Hexacycliske forbindelserInfo
- Publication number
- DK344488A DK344488A DK344488A DK344488A DK344488A DK 344488 A DK344488 A DK 344488A DK 344488 A DK344488 A DK 344488A DK 344488 A DK344488 A DK 344488A DK 344488 A DK344488 A DK 344488A
- Authority
- DK
- Denmark
- Prior art keywords
- compound
- hexacyclic compounds
- antitumour
- camptothecin
- chem
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Luminescent Compositions (AREA)
- Liquid Crystal Substances (AREA)
- Lubricants (AREA)
- Fats And Perfumes (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15699087 | 1987-06-24 | ||
JP550388 | 1988-01-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
DK344488D0 DK344488D0 (da) | 1988-06-23 |
DK344488A true DK344488A (da) | 1989-02-24 |
Family
ID=26339454
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK344488A DK344488A (da) | 1987-06-24 | 1988-06-23 | Hexacycliske forbindelser |
Country Status (13)
Country | Link |
---|---|
US (2) | US4939255A (da) |
EP (1) | EP0296597B1 (da) |
KR (1) | KR960002853B1 (da) |
AT (1) | ATE111913T1 (da) |
AU (1) | AU610189B2 (da) |
CA (1) | CA1304370C (da) |
DE (1) | DE3851577T2 (da) |
DK (1) | DK344488A (da) |
ES (1) | ES2064329T3 (da) |
FI (1) | FI91872C (da) |
IE (1) | IE61281B1 (da) |
NO (1) | NO167738C (da) |
PH (1) | PH27557A (da) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4939255A (en) * | 1987-06-24 | 1990-07-03 | Daiichi Pharmaceutical Co., Ltd. | Hexa-cyclic camptothecin derivatives |
US5552154A (en) * | 1989-11-06 | 1996-09-03 | The Stehlin Foundation For Cancer Research | Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof |
US6407115B1 (en) * | 1991-01-16 | 2002-06-18 | Daiichi Pharmaceutical Co., Ltd. | Hexa-cyclic compound |
JP3008226B2 (ja) * | 1991-01-16 | 2000-02-14 | 第一製薬株式会社 | 六環性化合物 |
US5658920A (en) * | 1991-01-16 | 1997-08-19 | Daiichi Pharmaceutical Co., Ltd. | Substituted 1H,12H-benz-[DE]pyrano[3',4':6,7] indolizino[1,2-B]quinoline-10,13(9H,15H)-dione compound |
US6080751A (en) * | 1992-01-14 | 2000-06-27 | The Stehlin Foundation For Cancer Research | Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof |
US5391745A (en) * | 1992-07-23 | 1995-02-21 | Sloan-Kettering Institute For Cancer Research | Methods of preparation of camptothecin analogs |
US5446047A (en) * | 1992-07-23 | 1995-08-29 | Sloan-Kettering Institute For Cancer Research | Camptothecin analogues |
US6504029B1 (en) * | 1995-04-10 | 2003-01-07 | Daiichi Pharmaceutical Co., Ltd. | Condensed-hexacyclic compounds and a process therefor |
US5663177A (en) * | 1995-05-31 | 1997-09-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs |
US5670500A (en) * | 1995-05-31 | 1997-09-23 | Smithkline Beecham Corporation | Water soluble camptothecin analogs |
EP0835303A4 (en) * | 1995-06-07 | 2000-09-13 | Univ Jefferson | ANTIFUNGAL AGENTS AND THEIR IDENTIFICATION AND UTILIZATION METHODS |
SG50747A1 (en) * | 1995-08-02 | 1998-07-20 | Tanabe Seiyaku Co | Comptothecin derivatives |
SG104284A1 (en) | 1996-10-30 | 2004-06-21 | Tanabe Seiyaku Co | S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof |
KR19980076076A (ko) * | 1997-04-04 | 1998-11-16 | 유현식 | 전선용 발포성 수지조성물 |
US6046209A (en) * | 1997-05-27 | 2000-04-04 | Smithkline Beecham Corporation | Water soluble camptothecin analogs |
IN189180B (da) * | 1997-07-09 | 2003-01-04 | Chong Kun Dang Corp | |
JP4094710B2 (ja) | 1997-11-06 | 2008-06-04 | 株式会社ヤクルト本社 | 新規なカンプトテシン誘導体 |
AU775373B2 (en) | 1999-10-01 | 2004-07-29 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
FR2801309B1 (fr) * | 1999-11-18 | 2002-01-04 | Adir | Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
KR100895746B1 (ko) | 2001-11-30 | 2009-04-30 | 추가이 세이야쿠 가부시키가이샤 | 헥사사이클릭 화합물 |
US8034831B2 (en) | 2002-11-06 | 2011-10-11 | Celgene Corporation | Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies |
US7563810B2 (en) | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
US7595400B2 (en) | 2003-02-21 | 2009-09-29 | Chugai Seiyaku Kabushiki Kaisha | Process for the preparation of hexacyclic compounds |
NZ550665A (en) | 2004-04-09 | 2010-05-28 | Chugai Pharmaceutical Co Ltd | Novel water-soluble prodrugs of camptothecin derivatives |
TW200744603A (en) | 2005-08-22 | 2007-12-16 | Chugai Pharmaceutical Co Ltd | Novel anticancer concomitant drug |
CN102060713A (zh) * | 2010-12-09 | 2011-05-18 | 中华人民共和国嘉兴出入境检验检疫局 | 用于检测偶氮类染料的芳香胺半抗原及其制备方法 |
JP7210770B2 (ja) | 2019-03-29 | 2023-01-23 | メドイミューン・リミテッド | 化合物及びその複合体 |
KR20220130749A (ko) | 2020-01-22 | 2022-09-27 | 메디뮨 리미티드 | 화합물 및 이의 접합체 |
TW202140076A (zh) | 2020-01-22 | 2021-11-01 | 英商梅迪繆思有限公司 | 化合物及其軛合物 |
US11806405B1 (en) | 2021-07-19 | 2023-11-07 | Zeno Management, Inc. | Immunoconjugates and methods |
WO2023180489A1 (en) | 2022-03-23 | 2023-09-28 | Synaffix B.V. | Antibody-conjugates for targeting of tumours expressing carcinoembyronic antigen |
WO2023180490A1 (en) | 2022-03-23 | 2023-09-28 | Synaffix B.V. | Antibody-conjugates for targeting of tumours expressing nectin-4 |
WO2023180485A1 (en) | 2022-03-23 | 2023-09-28 | Synaffix B.V. | Antibody-conjugates for targeting of tumours expressing trop-2 |
WO2023180484A1 (en) | 2022-03-23 | 2023-09-28 | Synaffix B.V. | Antibody-conjugates for targeting of tumours expressing ptk7 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US32518A (en) * | 1861-06-11 | Improvement in city railroads | ||
JPS51288A (ja) * | 1974-06-18 | 1976-01-05 | Tamura Seisakusho Kk | Hanshakyoshinhoshasochi |
US4399282A (en) * | 1979-07-10 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives |
US4399276A (en) * | 1981-01-09 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | 7-Substituted camptothecin derivatives |
US4473692A (en) * | 1981-09-04 | 1984-09-25 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives and process for preparing same |
JPS5839685A (ja) * | 1981-09-04 | 1983-03-08 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体及びその製造法 |
JPS58154582A (ja) * | 1982-03-10 | 1983-09-14 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体およびその製造法 |
JPS6019790A (ja) * | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
DE3682874D1 (de) * | 1985-10-21 | 1992-01-23 | Daiichi Seiyaku Co | Pyranoindolizinderivate und verfahren zu ihrer herstellung. |
US4939255A (en) * | 1987-06-24 | 1990-07-03 | Daiichi Pharmaceutical Co., Ltd. | Hexa-cyclic camptothecin derivatives |
US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
JPH0615547B2 (ja) * | 1988-01-20 | 1994-03-02 | 株式会社ヤクルト本社 | 新規なカンプトテシン誘導体 |
-
1988
- 1988-06-16 US US07/207,718 patent/US4939255A/en not_active Expired - Fee Related
- 1988-06-20 IE IE186088A patent/IE61281B1/en not_active IP Right Cessation
- 1988-06-21 CA CA000569969A patent/CA1304370C/en not_active Expired - Lifetime
- 1988-06-23 NO NO882785A patent/NO167738C/no unknown
- 1988-06-23 EP EP88110044A patent/EP0296597B1/en not_active Expired - Lifetime
- 1988-06-23 FI FI883050A patent/FI91872C/fi not_active IP Right Cessation
- 1988-06-23 AT AT88110044T patent/ATE111913T1/de not_active IP Right Cessation
- 1988-06-23 DE DE3851577T patent/DE3851577T2/de not_active Expired - Fee Related
- 1988-06-23 DK DK344488A patent/DK344488A/da not_active Application Discontinuation
- 1988-06-23 ES ES88110044T patent/ES2064329T3/es not_active Expired - Lifetime
- 1988-06-24 AU AU18349/88A patent/AU610189B2/en not_active Ceased
- 1988-06-24 KR KR1019880007643A patent/KR960002853B1/ko not_active IP Right Cessation
- 1988-07-22 PH PH37104A patent/PH27557A/en unknown
-
1989
- 1989-12-27 US US07/457,921 patent/US5061795A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
NO167738B (no) | 1991-08-26 |
FI91872C (fi) | 1994-08-25 |
ES2064329T3 (es) | 1995-02-01 |
FI883050A (fi) | 1988-12-25 |
EP0296597A2 (en) | 1988-12-28 |
EP0296597B1 (en) | 1994-09-21 |
CA1304370C (en) | 1992-06-30 |
DK344488D0 (da) | 1988-06-23 |
IE61281B1 (en) | 1994-10-19 |
DE3851577D1 (de) | 1994-10-27 |
NO882785L (no) | 1988-12-27 |
KR960002853B1 (ko) | 1996-02-27 |
KR890000489A (ko) | 1989-03-15 |
PH27557A (en) | 1993-08-18 |
AU1834988A (en) | 1989-01-05 |
US5061795A (en) | 1991-10-29 |
ATE111913T1 (de) | 1994-10-15 |
NO167738C (no) | 1991-12-04 |
FI883050A0 (fi) | 1988-06-23 |
US4939255A (en) | 1990-07-03 |
DE3851577T2 (de) | 1995-04-27 |
EP0296597A3 (en) | 1991-07-31 |
AU610189B2 (en) | 1991-05-16 |
IE881860L (en) | 1988-12-24 |
FI91872B (fi) | 1994-05-13 |
NO882785D0 (no) | 1988-06-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AHS | Application shelved for other reasons than non-payment |