EP0296597A3 - Hexa-cyclic compound - Google Patents
Hexa-cyclic compound Download PDFInfo
- Publication number
- EP0296597A3 EP0296597A3 EP19880110044 EP88110044A EP0296597A3 EP 0296597 A3 EP0296597 A3 EP 0296597A3 EP 19880110044 EP19880110044 EP 19880110044 EP 88110044 A EP88110044 A EP 88110044A EP 0296597 A3 EP0296597 A3 EP 0296597A3
- Authority
- EP
- European Patent Office
- Prior art keywords
- compound
- hexa
- cyclic compound
- antitumour
- camptothecin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Luminescent Compositions (AREA)
- Lubricants (AREA)
- Fats And Perfumes (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Liquid Crystal Substances (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP156990/87 | 1987-06-24 | ||
JP15699087 | 1987-06-24 | ||
JP5503/88 | 1988-01-13 | ||
JP550388 | 1988-01-13 |
Publications (3)
Publication Number | Publication Date |
---|---|
EP0296597A2 EP0296597A2 (en) | 1988-12-28 |
EP0296597A3 true EP0296597A3 (en) | 1991-07-31 |
EP0296597B1 EP0296597B1 (en) | 1994-09-21 |
Family
ID=26339454
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP88110044A Expired - Lifetime EP0296597B1 (en) | 1987-06-24 | 1988-06-23 | Hexa-cyclic compound |
Country Status (13)
Country | Link |
---|---|
US (2) | US4939255A (en) |
EP (1) | EP0296597B1 (en) |
KR (1) | KR960002853B1 (en) |
AT (1) | ATE111913T1 (en) |
AU (1) | AU610189B2 (en) |
CA (1) | CA1304370C (en) |
DE (1) | DE3851577T2 (en) |
DK (1) | DK344488A (en) |
ES (1) | ES2064329T3 (en) |
FI (1) | FI91872C (en) |
IE (1) | IE61281B1 (en) |
NO (1) | NO167738C (en) |
PH (1) | PH27557A (en) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4939255A (en) * | 1987-06-24 | 1990-07-03 | Daiichi Pharmaceutical Co., Ltd. | Hexa-cyclic camptothecin derivatives |
US5552154A (en) * | 1989-11-06 | 1996-09-03 | The Stehlin Foundation For Cancer Research | Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof |
JP3008226B2 (en) * | 1991-01-16 | 2000-02-14 | 第一製薬株式会社 | Hexacyclic compounds |
US5658920A (en) * | 1991-01-16 | 1997-08-19 | Daiichi Pharmaceutical Co., Ltd. | Substituted 1H,12H-benz-[DE]pyrano[3',4':6,7] indolizino[1,2-B]quinoline-10,13(9H,15H)-dione compound |
US6407115B1 (en) * | 1991-01-16 | 2002-06-18 | Daiichi Pharmaceutical Co., Ltd. | Hexa-cyclic compound |
US6080751A (en) * | 1992-01-14 | 2000-06-27 | The Stehlin Foundation For Cancer Research | Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof |
US5446047A (en) * | 1992-07-23 | 1995-08-29 | Sloan-Kettering Institute For Cancer Research | Camptothecin analogues |
US5391745A (en) * | 1992-07-23 | 1995-02-21 | Sloan-Kettering Institute For Cancer Research | Methods of preparation of camptothecin analogs |
US6504029B1 (en) * | 1995-04-10 | 2003-01-07 | Daiichi Pharmaceutical Co., Ltd. | Condensed-hexacyclic compounds and a process therefor |
US5663177A (en) * | 1995-05-31 | 1997-09-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs |
US5670500A (en) * | 1995-05-31 | 1997-09-23 | Smithkline Beecham Corporation | Water soluble camptothecin analogs |
EP0835303A4 (en) * | 1995-06-07 | 2000-09-13 | Univ Jefferson | Anti-fungal agents and methods of identifying and using the same |
SG50747A1 (en) * | 1995-08-02 | 1998-07-20 | Tanabe Seiyaku Co | Comptothecin derivatives |
SG104284A1 (en) * | 1996-10-30 | 2004-06-21 | Tanabe Seiyaku Co | S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof |
KR19980076076A (en) * | 1997-04-04 | 1998-11-16 | 유현식 | Expandable resin composition for electric wire |
US6046209A (en) * | 1997-05-27 | 2000-04-04 | Smithkline Beecham Corporation | Water soluble camptothecin analogs |
IN189180B (en) * | 1997-07-09 | 2003-01-04 | Chong Kun Dang Corp | |
JP4094710B2 (en) | 1997-11-06 | 2008-06-04 | 株式会社ヤクルト本社 | New camptothecin derivatives |
AU775373B2 (en) | 1999-10-01 | 2004-07-29 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
FR2801309B1 (en) * | 1999-11-18 | 2002-01-04 | Adir | NOVEL CAMPTOTHECIN-LIKE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
JP4305909B2 (en) * | 2001-11-30 | 2009-07-29 | 中外製薬株式会社 | Hexacyclic compounds |
US7563810B2 (en) | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
US8034831B2 (en) | 2002-11-06 | 2011-10-11 | Celgene Corporation | Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies |
EP1599484A2 (en) | 2003-02-21 | 2005-11-30 | Chugai Seiyaku Kabushiki Kaisha | Process for the preparation of hexacyclic camptothecin derivatives |
BRPI0509732A (en) | 2004-04-09 | 2007-09-25 | Chugai Pharmaceutical Co Ltd | water soluble prodrug, pharmaceutical composition, therapeutic agent, antifungal agent and use of said prodrug |
TW200744603A (en) | 2005-08-22 | 2007-12-16 | Chugai Pharmaceutical Co Ltd | Novel anticancer concomitant drug |
CN102060713A (en) * | 2010-12-09 | 2011-05-18 | 中华人民共和国嘉兴出入境检验检疫局 | Aromatic amine hapten for detecting azo dyes and preparation method thereof |
CN118240003A (en) | 2019-03-29 | 2024-06-25 | 免疫医疗有限公司 | Compounds and conjugates thereof |
BR112022014391A2 (en) | 2020-01-22 | 2022-09-13 | Medimmune Ltd | COMPOUNDS AND CONJUGATIONS THEREOF |
TW202140076A (en) | 2020-01-22 | 2021-11-01 | 英商梅迪繆思有限公司 | Compounds and conjugates thereof |
US11806405B1 (en) | 2021-07-19 | 2023-11-07 | Zeno Management, Inc. | Immunoconjugates and methods |
WO2023180490A1 (en) | 2022-03-23 | 2023-09-28 | Synaffix B.V. | Antibody-conjugates for targeting of tumours expressing nectin-4 |
WO2023180485A1 (en) | 2022-03-23 | 2023-09-28 | Synaffix B.V. | Antibody-conjugates for targeting of tumours expressing trop-2 |
WO2023180484A1 (en) | 2022-03-23 | 2023-09-28 | Synaffix B.V. | Antibody-conjugates for targeting of tumours expressing ptk7 |
WO2023180489A1 (en) | 2022-03-23 | 2023-09-28 | Synaffix B.V. | Antibody-conjugates for targeting of tumours expressing carcinoembyronic antigen |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0056692A1 (en) * | 1981-01-09 | 1982-07-28 | Kabushiki Kaisha Yakult Honsha | 7-Substituted camptothecin derivatives and process for their preparation |
EP0074256A1 (en) * | 1981-09-04 | 1983-03-16 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives, processes for preparing same, formulations containing such derivatives and their use |
EP0088642A2 (en) * | 1982-03-10 | 1983-09-14 | Kabushiki Kaisha Yakult Honsha | New camptothecin derivatives and process for their preparation |
EP0137145A1 (en) * | 1983-07-14 | 1985-04-17 | Kabushiki Kaisha Yakult Honsha | New camptothecin derivatives and process for preparing same |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US32518A (en) * | 1861-06-11 | Improvement in city railroads | ||
JPS51288A (en) * | 1974-06-18 | 1976-01-05 | Tamura Seisakusho Kk | HANSHAKYOSHI NHOSHASOCHI |
US4399282A (en) * | 1979-07-10 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives |
JPS5839685A (en) * | 1981-09-04 | 1983-03-08 | Yakult Honsha Co Ltd | Novel camptothecin derivative and its preparation |
EP0220601B1 (en) * | 1985-10-21 | 1991-12-11 | Daiichi Seiyaku Co., Ltd. | Pyranoindolizine derivatives and preparation process thereof |
US4939255A (en) * | 1987-06-24 | 1990-07-03 | Daiichi Pharmaceutical Co., Ltd. | Hexa-cyclic camptothecin derivatives |
US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
JPH0615547B2 (en) * | 1988-01-20 | 1994-03-02 | 株式会社ヤクルト本社 | Novel camptothecin derivative |
-
1988
- 1988-06-16 US US07/207,718 patent/US4939255A/en not_active Expired - Fee Related
- 1988-06-20 IE IE186088A patent/IE61281B1/en not_active IP Right Cessation
- 1988-06-21 CA CA000569969A patent/CA1304370C/en not_active Expired - Lifetime
- 1988-06-23 ES ES88110044T patent/ES2064329T3/en not_active Expired - Lifetime
- 1988-06-23 EP EP88110044A patent/EP0296597B1/en not_active Expired - Lifetime
- 1988-06-23 DK DK344488A patent/DK344488A/en not_active Application Discontinuation
- 1988-06-23 FI FI883050A patent/FI91872C/en not_active IP Right Cessation
- 1988-06-23 AT AT88110044T patent/ATE111913T1/en not_active IP Right Cessation
- 1988-06-23 NO NO882785A patent/NO167738C/en unknown
- 1988-06-23 DE DE3851577T patent/DE3851577T2/en not_active Expired - Fee Related
- 1988-06-24 AU AU18349/88A patent/AU610189B2/en not_active Ceased
- 1988-06-24 KR KR1019880007643A patent/KR960002853B1/en not_active IP Right Cessation
- 1988-07-22 PH PH37104A patent/PH27557A/en unknown
-
1989
- 1989-12-27 US US07/457,921 patent/US5061795A/en not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0056692A1 (en) * | 1981-01-09 | 1982-07-28 | Kabushiki Kaisha Yakult Honsha | 7-Substituted camptothecin derivatives and process for their preparation |
EP0074256A1 (en) * | 1981-09-04 | 1983-03-16 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives, processes for preparing same, formulations containing such derivatives and their use |
EP0088642A2 (en) * | 1982-03-10 | 1983-09-14 | Kabushiki Kaisha Yakult Honsha | New camptothecin derivatives and process for their preparation |
EP0137145A1 (en) * | 1983-07-14 | 1985-04-17 | Kabushiki Kaisha Yakult Honsha | New camptothecin derivatives and process for preparing same |
Also Published As
Publication number | Publication date |
---|---|
DE3851577T2 (en) | 1995-04-27 |
US5061795A (en) | 1991-10-29 |
AU1834988A (en) | 1989-01-05 |
IE61281B1 (en) | 1994-10-19 |
DE3851577D1 (en) | 1994-10-27 |
FI91872B (en) | 1994-05-13 |
IE881860L (en) | 1988-12-24 |
ATE111913T1 (en) | 1994-10-15 |
DK344488D0 (en) | 1988-06-23 |
ES2064329T3 (en) | 1995-02-01 |
NO167738B (en) | 1991-08-26 |
US4939255A (en) | 1990-07-03 |
PH27557A (en) | 1993-08-18 |
KR890000489A (en) | 1989-03-15 |
NO882785D0 (en) | 1988-06-23 |
EP0296597A2 (en) | 1988-12-28 |
CA1304370C (en) | 1992-06-30 |
AU610189B2 (en) | 1991-05-16 |
NO167738C (en) | 1991-12-04 |
NO882785L (en) | 1988-12-27 |
FI883050A0 (en) | 1988-06-23 |
EP0296597B1 (en) | 1994-09-21 |
DK344488A (en) | 1989-02-24 |
FI883050A (en) | 1988-12-25 |
FI91872C (en) | 1994-08-25 |
KR960002853B1 (en) | 1996-02-27 |
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