FI883050A - Menetelmä terapeuttisesti aktiivisten pyranoindolitsinokinoliinijohdannaisten valmistamiseksi - Google Patents

Menetelmä terapeuttisesti aktiivisten pyranoindolitsinokinoliinijohdannaisten valmistamiseksi Download PDF

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Publication number
FI883050A
FI883050A FI883050A FI883050A FI883050A FI 883050 A FI883050 A FI 883050A FI 883050 A FI883050 A FI 883050A FI 883050 A FI883050 A FI 883050A FI 883050 A FI883050 A FI 883050A
Authority
FI
Finland
Prior art keywords
compound
pyranoindolequinoquinoline
derivatives
preparation
therapeutically active
Prior art date
Application number
FI883050A
Other languages
English (en)
Swedish (sv)
Other versions
FI883050A0 (fi
FI91872C (fi
FI91872B (fi
Inventor
Hiroaki Tagawa
Masamichi Sugimori
Hirofumi Terasawa
Akio Ejima
Satoru Ohsuki
Original Assignee
Daiichi Seiyaku Co
Yakult Honsha Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Seiyaku Co, Yakult Honsha Kk filed Critical Daiichi Seiyaku Co
Publication of FI883050A0 publication Critical patent/FI883050A0/fi
Publication of FI883050A publication Critical patent/FI883050A/fi
Application granted granted Critical
Publication of FI91872B publication Critical patent/FI91872B/fi
Publication of FI91872C publication Critical patent/FI91872C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Luminescent Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Lubricants (AREA)
  • Fats And Perfumes (AREA)
  • Liquid Crystal Substances (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
FI883050A 1987-06-24 1988-06-23 Menetelmä terapeuttisesti aktiivisten pyranoindolitsinokinoliinijohdannaisten valmistamiseksi FI91872C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP15699087 1987-06-24
JP15699087 1987-06-24
JP550388 1988-01-13
JP550388 1988-01-13

Publications (4)

Publication Number Publication Date
FI883050A0 FI883050A0 (fi) 1988-06-23
FI883050A true FI883050A (fi) 1988-12-25
FI91872B FI91872B (fi) 1994-05-13
FI91872C FI91872C (fi) 1994-08-25

Family

ID=26339454

Family Applications (1)

Application Number Title Priority Date Filing Date
FI883050A FI91872C (fi) 1987-06-24 1988-06-23 Menetelmä terapeuttisesti aktiivisten pyranoindolitsinokinoliinijohdannaisten valmistamiseksi

Country Status (13)

Country Link
US (2) US4939255A (fi)
EP (1) EP0296597B1 (fi)
KR (1) KR960002853B1 (fi)
AT (1) ATE111913T1 (fi)
AU (1) AU610189B2 (fi)
CA (1) CA1304370C (fi)
DE (1) DE3851577T2 (fi)
DK (1) DK344488A (fi)
ES (1) ES2064329T3 (fi)
FI (1) FI91872C (fi)
IE (1) IE61281B1 (fi)
NO (1) NO167738C (fi)
PH (1) PH27557A (fi)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4939255A (en) * 1987-06-24 1990-07-03 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic camptothecin derivatives
US5552154A (en) 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
JP3008226B2 (ja) * 1991-01-16 2000-02-14 第一製薬株式会社 六環性化合物
US5637770A (en) * 1991-01-16 1997-06-10 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic compound
US6407115B1 (en) * 1991-01-16 2002-06-18 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic compound
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
US5446047A (en) * 1992-07-23 1995-08-29 Sloan-Kettering Institute For Cancer Research Camptothecin analogues
US5391745A (en) * 1992-07-23 1995-02-21 Sloan-Kettering Institute For Cancer Research Methods of preparation of camptothecin analogs
US6504029B1 (en) * 1995-04-10 2003-01-07 Daiichi Pharmaceutical Co., Ltd. Condensed-hexacyclic compounds and a process therefor
US5670500A (en) * 1995-05-31 1997-09-23 Smithkline Beecham Corporation Water soluble camptothecin analogs
US5663177A (en) * 1995-05-31 1997-09-02 Smithkline Beecham Corporation Water soluble camptothecin analogs
EP0835303A4 (en) * 1995-06-07 2000-09-13 Univ Jefferson ANTIFUNGAL AGENTS AND THEIR IDENTIFICATION AND UTILIZATION METHODS
SG50747A1 (en) * 1995-08-02 1998-07-20 Tanabe Seiyaku Co Comptothecin derivatives
SG104284A1 (en) 1996-10-30 2004-06-21 Tanabe Seiyaku Co S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof
KR19980076076A (ko) * 1997-04-04 1998-11-16 유현식 전선용 발포성 수지조성물
US6046209A (en) * 1997-05-27 2000-04-04 Smithkline Beecham Corporation Water soluble camptothecin analogs
IN189180B (fi) * 1997-07-09 2003-01-04 Chong Kun Dang Corp
JP4094710B2 (ja) 1997-11-06 2008-06-04 株式会社ヤクルト本社 新規なカンプトテシン誘導体
EP2266607A3 (en) 1999-10-01 2011-04-20 Immunogen, Inc. Immunoconjugates for treating cancer
FR2801309B1 (fr) * 1999-11-18 2002-01-04 Adir Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
BR0214615A (pt) * 2001-11-30 2004-09-14 Chugai Pharmaceutical Co Ltd Composto hexacìclico
US8034831B2 (en) 2002-11-06 2011-10-11 Celgene Corporation Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies
US7563810B2 (en) 2002-11-06 2009-07-21 Celgene Corporation Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
EP1599484A2 (en) * 2003-02-21 2005-11-30 Chugai Seiyaku Kabushiki Kaisha Process for the preparation of hexacyclic camptothecin derivatives
BRPI0509732A (pt) 2004-04-09 2007-09-25 Chugai Pharmaceutical Co Ltd pró-fármaco solúvel em água, composição farmacêutica, agente terapêutico, agente antifungo e uso do referido pró-fármaco
TW200744603A (en) 2005-08-22 2007-12-16 Chugai Pharmaceutical Co Ltd Novel anticancer concomitant drug
CN102060713A (zh) * 2010-12-09 2011-05-18 中华人民共和国嘉兴出入境检验检疫局 用于检测偶氮类染料的芳香胺半抗原及其制备方法
RS63715B1 (sr) 2019-03-29 2022-11-30 Medimmune Ltd Jedinjenja i njihovi konjugati
TW202140076A (zh) 2020-01-22 2021-11-01 英商梅迪繆思有限公司 化合物及其軛合物
AU2021210570A1 (en) 2020-01-22 2022-09-01 Medimmune Limited Compounds and conjugates thereof
US11806405B1 (en) 2021-07-19 2023-11-07 Zeno Management, Inc. Immunoconjugates and methods
WO2023180489A1 (en) 2022-03-23 2023-09-28 Synaffix B.V. Antibody-conjugates for targeting of tumours expressing carcinoembyronic antigen
WO2023180484A1 (en) 2022-03-23 2023-09-28 Synaffix B.V. Antibody-conjugates for targeting of tumours expressing ptk7
WO2023180490A1 (en) 2022-03-23 2023-09-28 Synaffix B.V. Antibody-conjugates for targeting of tumours expressing nectin-4
WO2023180485A1 (en) 2022-03-23 2023-09-28 Synaffix B.V. Antibody-conjugates for targeting of tumours expressing trop-2

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US32518A (en) * 1861-06-11 Improvement in city railroads
JPS51288A (ja) * 1974-06-18 1976-01-05 Tamura Seisakusho Kk Hanshakyoshinhoshasochi
US4399282A (en) 1979-07-10 1983-08-16 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives
US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
US4473692A (en) * 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPS5839685A (ja) * 1981-09-04 1983-03-08 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体及びその製造法
JPS58154582A (ja) * 1982-03-10 1983-09-14 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体およびその製造法
JPS6019790A (ja) * 1983-07-14 1985-01-31 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
DE3682874D1 (de) * 1985-10-21 1992-01-23 Daiichi Seiyaku Co Pyranoindolizinderivate und verfahren zu ihrer herstellung.
US4939255A (en) * 1987-06-24 1990-07-03 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic camptothecin derivatives
US5004758A (en) * 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JPH0615547B2 (ja) * 1988-01-20 1994-03-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体

Also Published As

Publication number Publication date
DE3851577D1 (de) 1994-10-27
IE881860L (en) 1988-12-24
NO167738C (no) 1991-12-04
NO882785D0 (no) 1988-06-23
FI883050A0 (fi) 1988-06-23
US4939255A (en) 1990-07-03
US5061795A (en) 1991-10-29
FI91872C (fi) 1994-08-25
CA1304370C (en) 1992-06-30
EP0296597A2 (en) 1988-12-28
KR960002853B1 (ko) 1996-02-27
EP0296597A3 (en) 1991-07-31
DK344488D0 (da) 1988-06-23
ES2064329T3 (es) 1995-02-01
ATE111913T1 (de) 1994-10-15
EP0296597B1 (en) 1994-09-21
FI91872B (fi) 1994-05-13
PH27557A (en) 1993-08-18
KR890000489A (ko) 1989-03-15
AU610189B2 (en) 1991-05-16
NO167738B (no) 1991-08-26
AU1834988A (en) 1989-01-05
IE61281B1 (en) 1994-10-19
DK344488A (da) 1989-02-24
NO882785L (no) 1988-12-27
DE3851577T2 (de) 1995-04-27

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Legal Events

Date Code Title Description
BB Publication of examined application
MM Patent lapsed
MM Patent lapsed

Owner name: DAIICHI SEIYAKU CO., LTD.

Owner name: KABUSHIKI KAISHA YAKULT HONSHA