ES2101291T3 - 1'-amino-2-((benzotiazolil)metil)espiro(isoquinolina-4(1h),3'-pirrolidina)-1,2',3,5'(2h)-tetronas y sus analogos utiles como inhibidores de aldosa reductasa. - Google Patents

1'-amino-2-((benzotiazolil)metil)espiro(isoquinolina-4(1h),3'-pirrolidina)-1,2',3,5'(2h)-tetronas y sus analogos utiles como inhibidores de aldosa reductasa.

Info

Publication number
ES2101291T3
ES2101291T3 ES93900708T ES93900708T ES2101291T3 ES 2101291 T3 ES2101291 T3 ES 2101291T3 ES 93900708 T ES93900708 T ES 93900708T ES 93900708 T ES93900708 T ES 93900708T ES 2101291 T3 ES2101291 T3 ES 2101291T3
Authority
ES
Spain
Prior art keywords
carbon atoms
aryl
lower alkyl
therones
benzotiazolyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93900708T
Other languages
English (en)
Inventor
Michael Sotirios Malamas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/797,567 external-priority patent/US5189167A/en
Priority claimed from US07/798,294 external-priority patent/US5189168A/en
Application filed by American Home Products Corp filed Critical American Home Products Corp
Application granted granted Critical
Publication of ES2101291T3 publication Critical patent/ES2101291T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

EL INVENTO CONCIERNE A COMPONENTES DE FORMULA (I) EN DONDE: R1, R2 Y R3 SON INDEPENDIENTEMENTE HIDROGENO, ALQUIL, CONTENIENDO DE 1 A 6 ATOMOS DE CARBONO, HALOGENO, ALCOXI REDUCIDO CONTENIENDO DE 1 A 6 ATOMOS DE CARBONO, TRIFLUOROMETIL O NITRO; R6 ES (A), (B) O (C) EN DONDE R4 Y R5 SON INDEPENDIENTEMENTE HIDROGENO, ALQUIL CONTENIENDO DE 1 A 6 ATOMOS DE CARBONO, ARIL, ARIL(ALQUIL REDUCIDO) EN DONDE ARIL CONTIENE DE 6 A 10 ATOMOS DE CARBONO Y EL ALQUIL REDUCIDO CONTIENE DE 1 A 6 ATOMOS DE CARBONO, ALCANOIL DE 2 A 5 ATOMOS DE CARBONO O CARBOALCOXI, O R4 Y R5 ESTAN UNIDOS PARA FORMAR ANILLOS ALICICLICOS O HETEROCICLICOS SELECCIONADOS DEL GRUPO QUE CONSTA DE (D) EN DONDE N= 1-10; (E) EN DONDE X = O, S, SO, SO2; (F) EN DONDE X = O, S; Y (G)EN DONDE R9 = H, ALQUIL REDUCIDO CONTENIENDO DE 1 A 6 ATOMOS DE CARBONO, ARIL O ARIL(ALQUIL REDUCIDO) EN DONDE EL ARIL CONTIENE DE 6 A 10 ATOMOS DE CARBONO Y EL ALQUIL REDUCIDO CONTIENE DE 1 A 6 ATOMOS DE CARBONO Y R7 Y R8 SON INDEPENDIENTEMENTE ALQUILSULFOXI, ARILSULFOXI, ALQUILSULFONIL, ARILSULFONIL EN DONDE EL ARIL CONTIENE DE 6 A 10 ATOMOS DE CARBONO Y EL ALQUIL CONTIENE DE 1 A 6 ATOMOS DE CARBONO O R8 DEBE TAMBIEN REPRESENTAR UNO DE LOS VALORES PARA R5 ANTERIOR, Y LAS SALES DE ELLO ACEPTABLES FARMACEUTICAMENTE, A PROCESOS PARA SU PREPARACION, A METODOS PARA USAR LOS COMPONENTES, Y A LAS PREPARACIONES DE ELLO FARMACEUTICAS. LOS COMPONENTES TIENEN PROPIEDADES FARMACEUTICAS QUE LES DAN BENEFICIOS PARA LA PREVENCION Y EL TRATAMIENTO DE LAS COMPLICACIONES ASOCIADAS A LA DIABETES MELLITUS.
ES93900708T 1991-11-25 1992-11-25 1'-amino-2-((benzotiazolil)metil)espiro(isoquinolina-4(1h),3'-pirrolidina)-1,2',3,5'(2h)-tetronas y sus analogos utiles como inhibidores de aldosa reductasa. Expired - Lifetime ES2101291T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/797,567 US5189167A (en) 1991-11-25 1991-11-25 Alkylidene analogs of 1'-amino-2-[(benzothiazolyl)-methyl]spiro [isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors
US07/798,294 US5189168A (en) 1991-11-25 1991-11-25 1'-amino-2[(benzothiazolyl)methyl]spiro-[isoquinoline-4(1H),3'-pyrrolidine]-1,2'3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors

Publications (1)

Publication Number Publication Date
ES2101291T3 true ES2101291T3 (es) 1997-07-01

Family

ID=27121893

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93900708T Expired - Lifetime ES2101291T3 (es) 1991-11-25 1992-11-25 1'-amino-2-((benzotiazolil)metil)espiro(isoquinolina-4(1h),3'-pirrolidina)-1,2',3,5'(2h)-tetronas y sus analogos utiles como inhibidores de aldosa reductasa.

Country Status (14)

Country Link
EP (1) EP0618917B1 (es)
JP (1) JPH07501342A (es)
AT (1) ATE150753T1 (es)
AU (1) AU665796B2 (es)
CA (1) CA2122916A1 (es)
DE (1) DE69218626T2 (es)
DK (1) DK0618917T3 (es)
ES (1) ES2101291T3 (es)
FI (1) FI942401A0 (es)
GR (1) GR3023563T3 (es)
HK (1) HK108997A (es)
HU (1) HUT67539A (es)
SG (1) SG47554A1 (es)
WO (1) WO1993011126A1 (es)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5534520A (en) * 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
US5037831A (en) * 1990-05-21 1991-08-06 American Home Products Corporation Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors
US5068332A (en) * 1990-10-12 1991-11-26 American Home Products Corporation Alkylidene analogs of 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors
US5102886A (en) * 1990-10-12 1992-04-07 American Home Products Corporation 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors

Also Published As

Publication number Publication date
EP0618917B1 (en) 1997-03-26
FI942401A (fi) 1994-05-24
EP0618917A1 (en) 1994-10-12
ATE150753T1 (de) 1997-04-15
HUT67539A (en) 1995-04-28
DE69218626D1 (de) 1997-04-30
FI942401A0 (fi) 1994-05-24
DK0618917T3 (da) 1997-10-13
SG47554A1 (en) 1998-04-17
GR3023563T3 (en) 1997-08-29
AU665796B2 (en) 1996-01-18
HK108997A (en) 1997-08-22
HU9401410D0 (en) 1994-08-29
DE69218626T2 (de) 1997-07-03
WO1993011126A1 (en) 1993-06-10
CA2122916A1 (en) 1993-06-10
JPH07501342A (ja) 1995-02-09
AU3228493A (en) 1993-06-28

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