DK0618917T3 - 1Amino-2- (benzothiazolyl)methyl spiro isoquinolin-4(1h),3-pyrrolidin -1,2,3,5(2h)-tetroner og analoger deraf, der kan anvendes som aldosereduktaseinhibitorer. - Google Patents
1Amino-2- (benzothiazolyl)methyl spiro isoquinolin-4(1h),3-pyrrolidin -1,2,3,5(2h)-tetroner og analoger deraf, der kan anvendes som aldosereduktaseinhibitorer.Info
- Publication number
- DK0618917T3 DK0618917T3 DK93900708.4T DK93900708T DK0618917T3 DK 0618917 T3 DK0618917 T3 DK 0618917T3 DK 93900708 T DK93900708 T DK 93900708T DK 0618917 T3 DK0618917 T3 DK 0618917T3
- Authority
- DK
- Denmark
- Prior art keywords
- carbon atoms
- aryl
- lower alkyl
- tetrons
- 1amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/797,567 US5189167A (en) | 1991-11-25 | 1991-11-25 | Alkylidene analogs of 1'-amino-2-[(benzothiazolyl)-methyl]spiro [isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors |
| US07/798,294 US5189168A (en) | 1991-11-25 | 1991-11-25 | 1'-amino-2[(benzothiazolyl)methyl]spiro-[isoquinoline-4(1H),3'-pyrrolidine]-1,2'3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0618917T3 true DK0618917T3 (da) | 1997-10-13 |
Family
ID=27121893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93900708.4T DK0618917T3 (da) | 1991-11-25 | 1992-11-25 | 1Amino-2- (benzothiazolyl)methyl spiro isoquinolin-4(1h),3-pyrrolidin -1,2,3,5(2h)-tetroner og analoger deraf, der kan anvendes som aldosereduktaseinhibitorer. |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0618917B1 (da) |
| JP (1) | JPH07501342A (da) |
| AT (1) | ATE150753T1 (da) |
| AU (1) | AU665796B2 (da) |
| CA (1) | CA2122916A1 (da) |
| DE (1) | DE69218626T2 (da) |
| DK (1) | DK0618917T3 (da) |
| ES (1) | ES2101291T3 (da) |
| FI (1) | FI942401A0 (da) |
| GR (1) | GR3023563T3 (da) |
| HK (1) | HK108997A (da) |
| HU (1) | HUT67539A (da) |
| SG (1) | SG47554A1 (da) |
| WO (1) | WO1993011126A1 (da) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5534520A (en) * | 1990-04-10 | 1996-07-09 | Fisher; Abraham | Spiro compounds containing five-membered rings |
| US5037831A (en) * | 1990-05-21 | 1991-08-06 | American Home Products Corporation | Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors |
| US5068332A (en) * | 1990-10-12 | 1991-11-26 | American Home Products Corporation | Alkylidene analogs of 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors |
| US5102886A (en) * | 1990-10-12 | 1992-04-07 | American Home Products Corporation | 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors |
-
1992
- 1992-11-25 ES ES93900708T patent/ES2101291T3/es not_active Expired - Lifetime
- 1992-11-25 EP EP93900708A patent/EP0618917B1/en not_active Expired - Lifetime
- 1992-11-25 WO PCT/US1992/010268 patent/WO1993011126A1/en active IP Right Grant
- 1992-11-25 CA CA002122916A patent/CA2122916A1/en not_active Abandoned
- 1992-11-25 HU HU9401410A patent/HUT67539A/hu unknown
- 1992-11-25 SG SG1996002816A patent/SG47554A1/en unknown
- 1992-11-25 DK DK93900708.4T patent/DK0618917T3/da active
- 1992-11-25 AU AU32284/93A patent/AU665796B2/en not_active Ceased
- 1992-11-25 DE DE69218626T patent/DE69218626T2/de not_active Expired - Fee Related
- 1992-11-25 AT AT93900708T patent/ATE150753T1/de not_active IP Right Cessation
- 1992-11-25 JP JP5510273A patent/JPH07501342A/ja active Pending
-
1994
- 1994-05-24 FI FI942401A patent/FI942401A0/fi not_active Application Discontinuation
-
1997
- 1997-05-28 GR GR970401216T patent/GR3023563T3/el unknown
- 1997-06-26 HK HK108997A patent/HK108997A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SG47554A1 (en) | 1998-04-17 |
| FI942401A (fi) | 1994-05-24 |
| EP0618917B1 (en) | 1997-03-26 |
| HUT67539A (en) | 1995-04-28 |
| AU665796B2 (en) | 1996-01-18 |
| JPH07501342A (ja) | 1995-02-09 |
| EP0618917A1 (en) | 1994-10-12 |
| ES2101291T3 (es) | 1997-07-01 |
| DE69218626T2 (de) | 1997-07-03 |
| WO1993011126A1 (en) | 1993-06-10 |
| AU3228493A (en) | 1993-06-28 |
| ATE150753T1 (de) | 1997-04-15 |
| DE69218626D1 (de) | 1997-04-30 |
| HU9401410D0 (en) | 1994-08-29 |
| CA2122916A1 (en) | 1993-06-10 |
| FI942401A0 (fi) | 1994-05-24 |
| GR3023563T3 (en) | 1997-08-29 |
| HK108997A (en) | 1997-08-22 |
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