ATE150753T1 - 1'-amino-2((benzothiazolyl)methyl> spiro (isochinolin-4(1h), 3'-pyrrolidine>-1,2',3,5'- tetrone und analoge davon verwendbar als aldosereduktase luhibitoren - Google Patents

1'-amino-2((benzothiazolyl)methyl> spiro (isochinolin-4(1h), 3'-pyrrolidine>-1,2',3,5'- tetrone und analoge davon verwendbar als aldosereduktase luhibitoren

Info

Publication number
ATE150753T1
ATE150753T1 AT93900708T AT93900708T ATE150753T1 AT E150753 T1 ATE150753 T1 AT E150753T1 AT 93900708 T AT93900708 T AT 93900708T AT 93900708 T AT93900708 T AT 93900708T AT E150753 T1 ATE150753 T1 AT E150753T1
Authority
AT
Austria
Prior art keywords
carbon atoms
aryl
lower alkyl
luhibitors
tetrones
Prior art date
Application number
AT93900708T
Other languages
English (en)
Inventor
Michael Sotirios Malamas
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/797,567 external-priority patent/US5189167A/en
Priority claimed from US07/798,294 external-priority patent/US5189168A/en
Application filed by American Home Prod filed Critical American Home Prod
Application granted granted Critical
Publication of ATE150753T1 publication Critical patent/ATE150753T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT93900708T 1991-11-25 1992-11-25 1'-amino-2((benzothiazolyl)methyl> spiro (isochinolin-4(1h), 3'-pyrrolidine>-1,2',3,5'- tetrone und analoge davon verwendbar als aldosereduktase luhibitoren ATE150753T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/797,567 US5189167A (en) 1991-11-25 1991-11-25 Alkylidene analogs of 1'-amino-2-[(benzothiazolyl)-methyl]spiro [isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors
US07/798,294 US5189168A (en) 1991-11-25 1991-11-25 1'-amino-2[(benzothiazolyl)methyl]spiro-[isoquinoline-4(1H),3'-pyrrolidine]-1,2'3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors
PCT/US1992/010268 WO1993011126A1 (en) 1991-11-25 1992-11-25 1'-amino-2-[(benzothiazolyl)methyl]spiro [isoquinoline-4(1h),3'-pyrrolidine]-1,2',3,5'(2h)-tetrones and analogs thereof useful as aldose reductase inhibitors

Publications (1)

Publication Number Publication Date
ATE150753T1 true ATE150753T1 (de) 1997-04-15

Family

ID=27121893

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93900708T ATE150753T1 (de) 1991-11-25 1992-11-25 1'-amino-2((benzothiazolyl)methyl> spiro (isochinolin-4(1h), 3'-pyrrolidine>-1,2',3,5'- tetrone und analoge davon verwendbar als aldosereduktase luhibitoren

Country Status (14)

Country Link
EP (1) EP0618917B1 (de)
JP (1) JPH07501342A (de)
AT (1) ATE150753T1 (de)
AU (1) AU665796B2 (de)
CA (1) CA2122916A1 (de)
DE (1) DE69218626T2 (de)
DK (1) DK0618917T3 (de)
ES (1) ES2101291T3 (de)
FI (1) FI942401A7 (de)
GR (1) GR3023563T3 (de)
HK (1) HK108997A (de)
HU (1) HUT67539A (de)
SG (1) SG47554A1 (de)
WO (1) WO1993011126A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220144510A (ko) * 2021-04-20 2022-10-27 에스케이이노베이션 주식회사 신규한 디아자스피로 화합물 및 이의 용도

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5534520A (en) * 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
US5037831A (en) * 1990-05-21 1991-08-06 American Home Products Corporation Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors
US5068332A (en) * 1990-10-12 1991-11-26 American Home Products Corporation Alkylidene analogs of 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors
US5102886A (en) * 1990-10-12 1992-04-07 American Home Products Corporation 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors

Also Published As

Publication number Publication date
GR3023563T3 (en) 1997-08-29
DE69218626T2 (de) 1997-07-03
DK0618917T3 (da) 1997-10-13
DE69218626D1 (de) 1997-04-30
WO1993011126A1 (en) 1993-06-10
EP0618917B1 (de) 1997-03-26
FI942401A0 (fi) 1994-05-24
HU9401410D0 (en) 1994-08-29
EP0618917A1 (de) 1994-10-12
CA2122916A1 (en) 1993-06-10
FI942401A7 (fi) 1994-05-24
HUT67539A (en) 1995-04-28
SG47554A1 (en) 1998-04-17
AU3228493A (en) 1993-06-28
ES2101291T3 (es) 1997-07-01
HK108997A (en) 1997-08-22
JPH07501342A (ja) 1995-02-09
AU665796B2 (en) 1996-01-18

Similar Documents

Publication Publication Date Title
AU572405B2 (en) Heterocyclic-substituted indole
CA2042113A1 (en) Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors
ATE53032T1 (de) 2-thiazolylimidazo(1,2-a)pyrimidine und ihre salze, verfahren zu ihrer herstellung, ihre anwendung als arzneimittel und diese enthaltende zubereitungen.
DK160308C (da) Analogifremgangsmaade til fremstilling af 1,2,4-triazolo(4,3-a)quinazolin-5-(4h)-oner eller deres syreadditionssalte
NO161493C (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive 1,6-nafthyridinderivater.
ATE150753T1 (de) 1'-amino-2((benzothiazolyl)methyl> spiro (isochinolin-4(1h), 3'-pyrrolidine>-1,2',3,5'- tetrone und analoge davon verwendbar als aldosereduktase luhibitoren
DK0553263T3 (da) 1'-Aminospiro[isoquinolin-4(1H),3'-pyrrolidin]-1,2',3,5'(2H)-tetroner samt analoge deraf til anvendelse som inhibitorer af
KR930702347A (ko) 알도스 리덕타제 억제제로서 유용한 1'-아미노스피로[이소퀴놀린-4(1h),3'-피롤리딘]-1,2',3,5'(2h)-테트론의 알킬리덴 동족체
CA2042112A1 (en) N'-alkyl-spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
NO911998L (no) Pyrido(3,4-b)(pyrrolo(1,2-e)(1,4,5)oksadiazepin og beslektede analoger og fremgangsmaate for fremstilling derav.
ATE96803T1 (de) Indolo(3,2,1-de>(1,4>-oxazino(2,3,4ij>(1,5>naphthyridinderivate, verfahren zu ihrer herstellung und zwischenprodukte, ihre verwendung als arzneimittel und diese enthaltende zubereitungen.
ZA872925B (en) Heterocyclic compounds

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee