ES2101291T3 - 1'-AMINO-2 - ((BENZOTIAZOLYL) METHYL) SPYRO (ISOQUINOLINE-4 (1H), 3'-PIRROLIDINE) -1.2 ', 3.5' (2H) -THERONES AND USEFUL ANALOGS AS ALDOSE INHIBITORS REDUCTASE. - Google Patents
1'-AMINO-2 - ((BENZOTIAZOLYL) METHYL) SPYRO (ISOQUINOLINE-4 (1H), 3'-PIRROLIDINE) -1.2 ', 3.5' (2H) -THERONES AND USEFUL ANALOGS AS ALDOSE INHIBITORS REDUCTASE.Info
- Publication number
- ES2101291T3 ES2101291T3 ES93900708T ES93900708T ES2101291T3 ES 2101291 T3 ES2101291 T3 ES 2101291T3 ES 93900708 T ES93900708 T ES 93900708T ES 93900708 T ES93900708 T ES 93900708T ES 2101291 T3 ES2101291 T3 ES 2101291T3
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- aryl
- lower alkyl
- therones
- benzotiazolyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
The invention concerns compounds of formula (I) wherein: R<1>, R<2> and R<3> are independently hydrogen, alkyl containing 1 to 6 carbon atoms, halogen, lower alkoxy containing 1 to 6 carbon atoms, trifluoromethyl or nitro; R<6> is (a), (b) or (c) wherein R<4> and R<5> are independently hydrogen, alkyl containing 1 to 6 carbon atoms, aryl, aryl (lower alkyl) wherein aryl contains 6 to 10 carbons atoms and lower alkyl contains 1 to 6 carbon atoms, alkanoyl of 2 to 5 carbon atoms or carboalkoxy, or R<4> and R<5> are joined to form alicyclic or heterocyclic rings selected from the group consisting of (d) wherein n = 1-10; (e) wherein X = O, S, SO, SO2; (f) wherein X = O, S; and (g) wherein R<9> = H, lower alkyl containing 1 to 6 carbon atoms, aryl or aryl (lower alkyl) wherein aryl contains 6 to 10 carbon atoms and lower alkyl contains 1 to 6 carbon atoms, and R<7> and R<8> are independently alkylsulfoxy, arylsulfoxy, alkylsulfonyl, arylsulfonyl wherein aryl contains 6 to 10 carbon atoms and alkyl contains 1 to 6 carbon atoms or R<8> may also represent one of the values for R<5> above, and the pharmaceutically acceptable salts thereof, to processes for their preparation, to methods for using the compounds, and to pharmaceutical preparations thereof. The compounds have pharmaceutical properties which render them beneficial for the prevention or treatment of diabetes mellitus associated complications.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/798,294 US5189168A (en) | 1991-11-25 | 1991-11-25 | 1'-amino-2[(benzothiazolyl)methyl]spiro-[isoquinoline-4(1H),3'-pyrrolidine]-1,2'3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors |
| US07/797,567 US5189167A (en) | 1991-11-25 | 1991-11-25 | Alkylidene analogs of 1'-amino-2-[(benzothiazolyl)-methyl]spiro [isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2101291T3 true ES2101291T3 (en) | 1997-07-01 |
Family
ID=27121893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93900708T Expired - Lifetime ES2101291T3 (en) | 1991-11-25 | 1992-11-25 | 1'-AMINO-2 - ((BENZOTIAZOLYL) METHYL) SPYRO (ISOQUINOLINE-4 (1H), 3'-PIRROLIDINE) -1.2 ', 3.5' (2H) -THERONES AND USEFUL ANALOGS AS ALDOSE INHIBITORS REDUCTASE. |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0618917B1 (en) |
| JP (1) | JPH07501342A (en) |
| AT (1) | ATE150753T1 (en) |
| AU (1) | AU665796B2 (en) |
| CA (1) | CA2122916A1 (en) |
| DE (1) | DE69218626T2 (en) |
| DK (1) | DK0618917T3 (en) |
| ES (1) | ES2101291T3 (en) |
| FI (1) | FI942401A (en) |
| GR (1) | GR3023563T3 (en) |
| HK (1) | HK108997A (en) |
| HU (1) | HUT67539A (en) |
| SG (1) | SG47554A1 (en) |
| WO (1) | WO1993011126A1 (en) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5534520A (en) * | 1990-04-10 | 1996-07-09 | Fisher; Abraham | Spiro compounds containing five-membered rings |
| US5037831A (en) * | 1990-05-21 | 1991-08-06 | American Home Products Corporation | Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors |
| US5068332A (en) * | 1990-10-12 | 1991-11-26 | American Home Products Corporation | Alkylidene analogs of 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors |
| US5102886A (en) * | 1990-10-12 | 1992-04-07 | American Home Products Corporation | 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors |
-
1992
- 1992-11-25 EP EP93900708A patent/EP0618917B1/en not_active Expired - Lifetime
- 1992-11-25 AT AT93900708T patent/ATE150753T1/en not_active IP Right Cessation
- 1992-11-25 ES ES93900708T patent/ES2101291T3/en not_active Expired - Lifetime
- 1992-11-25 JP JP5510273A patent/JPH07501342A/en active Pending
- 1992-11-25 DE DE69218626T patent/DE69218626T2/en not_active Expired - Fee Related
- 1992-11-25 WO PCT/US1992/010268 patent/WO1993011126A1/en active IP Right Grant
- 1992-11-25 SG SG1996002816A patent/SG47554A1/en unknown
- 1992-11-25 HU HU9401410A patent/HUT67539A/en unknown
- 1992-11-25 CA CA002122916A patent/CA2122916A1/en not_active Abandoned
- 1992-11-25 AU AU32284/93A patent/AU665796B2/en not_active Ceased
- 1992-11-25 DK DK93900708.4T patent/DK0618917T3/en active
-
1994
- 1994-05-24 FI FI942401A patent/FI942401A/en not_active Application Discontinuation
-
1997
- 1997-05-28 GR GR970401216T patent/GR3023563T3/en unknown
- 1997-06-26 HK HK108997A patent/HK108997A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HUT67539A (en) | 1995-04-28 |
| FI942401A0 (en) | 1994-05-24 |
| GR3023563T3 (en) | 1997-08-29 |
| EP0618917A1 (en) | 1994-10-12 |
| SG47554A1 (en) | 1998-04-17 |
| ATE150753T1 (en) | 1997-04-15 |
| CA2122916A1 (en) | 1993-06-10 |
| AU3228493A (en) | 1993-06-28 |
| HU9401410D0 (en) | 1994-08-29 |
| DE69218626D1 (en) | 1997-04-30 |
| HK108997A (en) | 1997-08-22 |
| EP0618917B1 (en) | 1997-03-26 |
| DE69218626T2 (en) | 1997-07-03 |
| WO1993011126A1 (en) | 1993-06-10 |
| DK0618917T3 (en) | 1997-10-13 |
| FI942401A (en) | 1994-05-24 |
| JPH07501342A (en) | 1995-02-09 |
| AU665796B2 (en) | 1996-01-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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