ATE129497T1 - Bicyclische pyranderivate und ihre verwendung als 5-lipoxygenasehemmer. - Google Patents

Bicyclische pyranderivate und ihre verwendung als 5-lipoxygenasehemmer.

Info

Publication number
ATE129497T1
ATE129497T1 AT91305532T AT91305532T ATE129497T1 AT E129497 T1 ATE129497 T1 AT E129497T1 AT 91305532 T AT91305532 T AT 91305532T AT 91305532 T AT91305532 T AT 91305532T AT E129497 T1 ATE129497 T1 AT E129497T1
Authority
AT
Austria
Prior art keywords
bicyclic
lipoxygenase inhibitors
pyrane derivatives
pyrane
derivatives
Prior art date
Application number
AT91305532T
Other languages
English (en)
Inventor
Pierre Andre Raymond Bruneau
Graham Charles Chapel Crawley
Original Assignee
Zeneca Ltd
Ici Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd, Ici Pharma filed Critical Zeneca Ltd
Application granted granted Critical
Publication of ATE129497T1 publication Critical patent/ATE129497T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
    • C07D273/04—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT91305532T 1990-06-21 1991-06-19 Bicyclische pyranderivate und ihre verwendung als 5-lipoxygenasehemmer. ATE129497T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP90401757 1990-06-21
EP91400076 1991-01-15

Publications (1)

Publication Number Publication Date
ATE129497T1 true ATE129497T1 (de) 1995-11-15

Family

ID=26127306

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91305532T ATE129497T1 (de) 1990-06-21 1991-06-19 Bicyclische pyranderivate und ihre verwendung als 5-lipoxygenasehemmer.

Country Status (26)

Country Link
US (3) US5217969A (de)
EP (1) EP0462813B1 (de)
JP (1) JP3112981B2 (de)
KR (1) KR920000738A (de)
AR (1) AR247886A1 (de)
AT (1) ATE129497T1 (de)
AU (1) AU637500B2 (de)
CA (1) CA2044219A1 (de)
CS (1) CS187491A3 (de)
DE (1) DE69114052T2 (de)
DK (1) DK0462813T3 (de)
ES (1) ES2079576T3 (de)
FI (1) FI913048A (de)
GB (1) GB9113132D0 (de)
GR (1) GR3017888T3 (de)
HU (2) HU210919B (de)
IE (1) IE911919A1 (de)
IL (1) IL98396A (de)
MY (1) MY106366A (de)
NO (1) NO912411L (de)
NZ (1) NZ238470A (de)
PL (1) PL168310B1 (de)
PT (1) PT98041A (de)
RU (1) RU2059627C1 (de)
TW (1) TW217412B (de)
ZW (1) ZW7091A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
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IE911853A1 (en) * 1990-06-21 1992-01-01 Ici Plc Heterocyclene derivatives
US5254581A (en) * 1990-06-21 1993-10-19 Imperial Chemical Industries Plc Pyran derivatives and their use as inhibitors of 5-lipoxygenase
IE913655A1 (en) * 1990-11-06 1992-05-22 Zeneca Ltd Synergistic agents
IE914005A1 (en) * 1990-12-14 1992-06-17 Zeneca Ltd Novel intermediates
EP0532239B1 (de) * 1991-09-10 1995-12-13 Zeneca Limited Benzolsulfonamidderivate als 5-Lipoxygenasehemmer
CA2094465A1 (en) * 1992-04-23 1993-10-24 Pierre Andre Raymond Bruneau Cycloalkane derivatives
CA2095006A1 (en) * 1992-05-12 1993-11-13 Philip Neil Edwards Oxime derivatives
CA2095005A1 (en) * 1992-05-12 1993-11-13 Philip Neil Edwards Hydroxylamine derivatives
AU4444393A (en) * 1992-09-01 1994-03-10 Zeneca Limited Pyrrolidine derivatives
US5354865A (en) * 1992-09-10 1994-10-11 Abbott Laboratories Phenylmethyl derivatives having lipoxygenase inhibitory activity
IL109254A (en) * 1993-04-29 1999-03-12 Zeneca Ltd History of the tetrahydropyran and tetrahydropuran site preparation and pharmaceutical preparations containing them
US5424320A (en) * 1993-06-23 1995-06-13 Merck Frosst Canada, Inc. Heteroaryl coumarins as inhibitors of leukotriene biosynthesis
US5360815A (en) * 1993-06-23 1994-11-01 Merck Frosst Canada, Inc. Heteroaryl cinnamic acids as inhibitors of leukotriene biosynthesis
US5459271A (en) * 1993-07-20 1995-10-17 Merck Frosst Canada, Inc. Arylbicyclooctanes as inhibitors of leukotriene biosynthesis
IL110280A0 (en) * 1993-07-27 1994-10-21 Zeneca Ltd Thiazole derivatives
ZA945250B (en) * 1993-07-27 1995-01-27 Zeneca Ltd Thiazole derivatives
EP0636624A1 (de) * 1993-07-27 1995-02-01 Zeneca Limited Thiazolederivative als Lipoxygenasehemmer
US5350760A (en) * 1993-08-04 1994-09-27 Merck Frosst Canada, Inc. Aza-5,5-fused hetrocyclic acids as leukotriene antagonists
ATE169298T1 (de) * 1994-03-28 1998-08-15 Pfizer Benzisothiazol-derivate als inhibitoren der 5- lipoxygenase biosynthese
WO1995030668A1 (en) * 1994-05-06 1995-11-16 Zeneca Limited Cyclic ether derivatives and pharmaceutical composition containing them
US5643933A (en) * 1995-06-02 1997-07-01 G. D. Searle & Co. Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
US5891460A (en) * 1995-06-07 1999-04-06 University Of Southern California University Park Campus Method for reducing or preventing post-surgical adhesion formation using ketotifen and analogs thereof
US6677364B2 (en) * 1998-04-20 2004-01-13 G.D. Searle & Co. Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
JP2004528335A (ja) 2001-04-23 2004-09-16 アストラゼネカ アクチボラグ 血管新生の治療に使用のベンゾオキサジノン誘導体
US7378415B2 (en) 2004-09-30 2008-05-27 Roche Palo Alto Llc Benzoxazine and quinoxaline derivatives and uses thereof
EP1978966A4 (de) * 2006-01-23 2010-11-10 Amira Pharmaceuticals Inc Tricyclische hemmer von 5-lipoxygenase
US8048977B2 (en) * 2006-04-28 2011-11-01 E. I. Du Pont De Nemours And Company Organosilicon polymers
JP2010529101A (ja) * 2007-06-04 2010-08-26 テックフィールズ インコーポレイテッド 非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用
EP3563842A1 (de) 2009-04-29 2019-11-06 Amarin Pharmaceuticals Ireland Limited Pharmazeutische zusammensetzungen mit epa und einem kardiovaskulären mittel sowie verfahren zur verwendung davon

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US3661917A (en) * 1970-05-21 1972-05-09 Smith Kline French Lab 3-sulfonamido-4-hydroxyphenyl-2-piperidylcarbinols
US3743737A (en) * 1970-05-21 1973-07-03 Smith Kline French Lab 3-sulfonamido-4-hydroxyphenyl-2-piperindinylcarbinol compositions
US4567184A (en) * 1982-12-01 1986-01-28 Usv Pharmaceutical Corporation Certain aryl or hetero-aryl derivatives of 1-hydroxy-pentane or 1-hydroxy-hexane which are useful for treating inflammation and allergies
US4794188A (en) * 1982-12-01 1988-12-27 Usv Pharmaceutical Corporation Certain unsymmetrical quinolinyl ethers having anti-inflammatory and anti-allergic activity
IE56702B1 (en) * 1982-12-01 1991-11-06 Usv Pharma Corp Antiinflammatory antiallergic compounds
NZ213986A (en) * 1984-10-30 1989-07-27 Usv Pharma Corp Heterocyclic or aromatic compounds, and pharmaceutical compositions containing such
US4625034A (en) * 1985-02-04 1986-11-25 Usv Pharmaceutical Corp. 1,2-Dihydro; 1,2,3,4-tetrahydro; 5,8 dihydro; and 5,6,7,8-tetrahydroquinoline derivatives
US4839369A (en) * 1985-04-16 1989-06-13 Rorer Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4728668A (en) * 1985-04-16 1988-03-01 Usv Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4725619A (en) * 1985-04-16 1988-02-16 Usv Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4631287A (en) * 1985-04-16 1986-12-23 Usv Pharmaceutical Corp. Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4876346A (en) * 1985-05-02 1989-10-24 American Home Products Corporation Quinoline compounds
EP0271287A3 (de) * 1986-12-11 1990-06-13 Merck Frosst Canada Inc. Chinolindicarbonsäuren und ihre Amide
US4920132A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4920130A (en) * 1987-11-02 1990-04-24 Rorer Pharamceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4920133A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4920131A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4918081A (en) * 1988-06-20 1990-04-17 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene d4
EP0349062A1 (de) * 1988-06-27 1990-01-03 Merck Frosst Canada Inc. Chinolinetheralkansäuren
GB8926981D0 (en) * 1988-12-23 1990-01-17 Ici Plc Heterocyclic derivatives
ZA9076B (en) * 1989-02-03 1990-10-31 Tanabe Seiyaku Co Limited A process for preparing a naphthalene derivative and a synthetic intermediate thereof
IL93344A0 (en) * 1989-02-28 1990-11-29 Ici Plc Heterocyclic cyclic ethers
IE70521B1 (en) * 1989-02-28 1996-12-11 Zeneca Pharma Sa Heterocycles with inhibitory activity of 5-lipoxygenase
IL93343A0 (en) * 1989-02-28 1990-11-29 Ici Plc Heterocyclic cycloalkanes
JP2996475B2 (ja) * 1989-12-22 1999-12-27 サントリー株式会社 ベンズオキサジノン誘導体及びそれを有効成分として含有する除草剤

Also Published As

Publication number Publication date
DE69114052T2 (de) 1996-10-17
EP0462813B1 (de) 1995-10-25
CS187491A3 (en) 1992-02-19
KR920000738A (ko) 1992-01-29
US5373007A (en) 1994-12-13
DE69114052D1 (de) 1995-11-30
NO912411L (no) 1991-12-23
IL98396A0 (en) 1992-07-15
AU7816191A (en) 1992-01-02
CA2044219A1 (en) 1991-12-22
EP0462813A3 (de) 1992-01-22
JP3112981B2 (ja) 2000-11-27
FI913048A0 (fi) 1991-06-20
RU2059627C1 (ru) 1996-05-10
HU211133A9 (en) 1995-10-30
HU912003D0 (en) 1991-12-30
IL98396A (en) 1995-11-27
TW217412B (de) 1993-12-11
EP0462813A2 (de) 1991-12-27
PT98041A (pt) 1992-04-30
ES2079576T3 (es) 1996-01-16
AR247886A1 (es) 1995-04-28
GR3017888T3 (en) 1996-01-31
HU210919B (en) 1995-09-28
HUT61298A (en) 1992-12-28
DK0462813T3 (da) 1996-02-05
NO912411D0 (no) 1991-06-20
PL168310B1 (pl) 1996-02-29
PL290757A1 (en) 1992-08-24
US5321025A (en) 1994-06-14
JPH04230283A (ja) 1992-08-19
ZW7091A1 (en) 1992-03-25
MY106366A (en) 1995-05-30
AU637500B2 (en) 1993-05-27
NZ238470A (en) 1993-07-27
US5217969A (en) 1993-06-08
FI913048A (fi) 1991-12-22
GB9113132D0 (en) 1991-08-07
IE911919A1 (en) 1992-01-01

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