DE69408674D1 - Phenylpyrrol-derivate und ihre verwendung als dopamin d3 antagonisten - Google Patents

Phenylpyrrol-derivate und ihre verwendung als dopamin d3 antagonisten

Info

Publication number
DE69408674D1
DE69408674D1 DE69408674T DE69408674T DE69408674D1 DE 69408674 D1 DE69408674 D1 DE 69408674D1 DE 69408674 T DE69408674 T DE 69408674T DE 69408674 T DE69408674 T DE 69408674T DE 69408674 D1 DE69408674 D1 DE 69408674D1
Authority
DE
Germany
Prior art keywords
phenylpyrrol
dopamine
antagonists
derivatives
phenylpyrrol derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69408674T
Other languages
English (en)
Other versions
DE69408674T2 (de
Inventor
Geoffrey Stemp
Christopher Norbert Johnson
Roger Edward Markwell
Harry John Wadsworth
Eric Alfred Watts
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939313185A external-priority patent/GB9313185D0/en
Priority claimed from GB9402196A external-priority patent/GB9402196D0/en
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Application granted granted Critical
Publication of DE69408674D1 publication Critical patent/DE69408674D1/de
Publication of DE69408674T2 publication Critical patent/DE69408674T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69408674T 1993-06-25 1994-06-20 Phenylpyrrol-derivate und ihre verwendung als dopamin d3 antagonisten Expired - Fee Related DE69408674T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939313185A GB9313185D0 (en) 1993-06-25 1993-06-25 Compounds
GB9402196A GB9402196D0 (en) 1994-02-04 1994-02-04 Compounds
PCT/EP1994/002027 WO1995000508A1 (en) 1993-06-25 1994-06-20 Phenyrrole derivatives and their use as dopamine d3 antagonists

Publications (2)

Publication Number Publication Date
DE69408674D1 true DE69408674D1 (de) 1998-04-02
DE69408674T2 DE69408674T2 (de) 1998-09-10

Family

ID=26303123

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69408674T Expired - Fee Related DE69408674T2 (de) 1993-06-25 1994-06-20 Phenylpyrrol-derivate und ihre verwendung als dopamin d3 antagonisten

Country Status (5)

Country Link
EP (1) EP0705259B1 (de)
JP (1) JPH08511789A (de)
AU (1) AU7186994A (de)
DE (1) DE69408674T2 (de)
WO (1) WO1995000508A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9402197D0 (en) * 1994-02-04 1994-03-30 Smithkline Beecham Plc Compounds
GB9403199D0 (en) * 1994-02-19 1994-04-13 Smithkline Beecham Plc Compounds
GB9512129D0 (en) * 1995-06-15 1995-08-16 Smithkline Beecham Plc Compounds
GB9708805D0 (en) 1997-05-01 1997-06-25 Smithkline Beecham Plc Compounds
DK0984943T3 (da) * 1997-05-30 2003-03-17 Neurosearch As Azacycloalkan og -alkenderivater, deres fremstilling og anvendelse
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
MA26696A1 (fr) 1998-10-08 2004-12-20 Smithkline Beecham Plc Derives de tetrahydrobenzazepine nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
ES2364488T3 (es) * 2004-10-14 2011-09-05 ABBOTT GMBH & CO. KG Compuestos heterocíclicos adecuados para el tratamiento de trastornos que responden a la modulación del receptor de dopamina.
WO2012117048A1 (en) 2011-03-02 2012-09-07 Lead Discovery Center Gmbh Pharmaceutically active disubstituted triazine derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA871335B (en) * 1986-02-27 1987-09-30 Duphar Int Res New aryl-substituted(n-piperidinyl)methyl-and(n-piperazinyl)-methylazoles having antipsychotic properties
PH23898A (en) * 1986-09-12 1989-12-18 Duphar Int Res New phenyl pyrrolidin-2-yl substituted-2-yl substituted 5-ring heterocycles having antipsycotic properties
JPH07509705A (ja) * 1992-08-06 1995-10-26 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ドーパミンｄ３レセプター拮抗薬用５−（２−オキシフェニル）−ピロール誘導体

Also Published As

Publication number Publication date
WO1995000508A1 (en) 1995-01-05
DE69408674T2 (de) 1998-09-10
AU7186994A (en) 1995-01-17
EP0705259A1 (de) 1996-04-10
EP0705259B1 (de) 1998-02-25
JPH08511789A (ja) 1996-12-10

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee