DE69636801D1 - Dioxinoderivate und ihre Verwendung als Dopamine Agonisten - Google Patents
Dioxinoderivate und ihre Verwendung als Dopamine AgonistenInfo
- Publication number
- DE69636801D1 DE69636801D1 DE69636801T DE69636801T DE69636801D1 DE 69636801 D1 DE69636801 D1 DE 69636801D1 DE 69636801 T DE69636801 T DE 69636801T DE 69636801 T DE69636801 T DE 69636801T DE 69636801 D1 DE69636801 D1 DE 69636801D1
- Authority
- DE
- Germany
- Prior art keywords
- dopamine agonists
- dioxin derivatives
- dioxin
- derivatives
- dopamine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US730267 | 1991-07-12 | ||
US728395P | 1995-11-06 | 1995-11-06 | |
US7283P | 1995-11-06 | ||
US08/730,267 US5756532A (en) | 1995-11-06 | 1996-10-15 | Aminomethyl-2 3 8 9-tetrahydro-7H-1 4-dioxino 2 3-E!-indol-8-ones and derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69636801D1 true DE69636801D1 (de) | 2007-02-08 |
DE69636801T2 DE69636801T2 (de) | 2007-04-26 |
Family
ID=26676776
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69636801T Expired - Lifetime DE69636801T2 (de) | 1995-11-06 | 1996-10-22 | Dioxinoderivate und ihre Verwendung als Dopamine Agonisten |
Country Status (21)
Country | Link |
---|---|
US (2) | US5756532A (de) |
EP (3) | EP1375503B1 (de) |
JP (1) | JP4311770B2 (de) |
KR (1) | KR100566678B1 (de) |
CN (1) | CN1084748C (de) |
AR (2) | AR004284A1 (de) |
AT (1) | ATE349450T1 (de) |
AU (1) | AU701624B2 (de) |
CA (1) | CA2189524C (de) |
CZ (1) | CZ291731B6 (de) |
DE (1) | DE69636801T2 (de) |
DK (1) | DK1375503T3 (de) |
ES (1) | ES2277014T3 (de) |
HU (1) | HU224841B1 (de) |
IL (1) | IL119565A (de) |
MX (1) | MX9605367A (de) |
NO (1) | NO317054B1 (de) |
NZ (1) | NZ299693A (de) |
PT (1) | PT1375503E (de) |
RU (1) | RU2178416C2 (de) |
SK (1) | SK282168B6 (de) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9627005D0 (en) * | 1996-12-27 | 1997-02-12 | Knoll Ag | Therapeutic agents |
GB9704948D0 (en) | 1997-03-11 | 1997-04-30 | Knoll Ag | Therapeutic agents |
US6362009B1 (en) | 1997-11-21 | 2002-03-26 | Merck & Co., Inc. | Solid phase synthesis of heterocycles |
US6350773B1 (en) * | 1999-12-10 | 2002-02-26 | American Home Products Corporation | Therapeutic combinations of (S)-2-(benzylamino-methyl)-2,3,8,9,-tetrahydro 7H-1,4-dioxino{2,3-e}indol-8-one and neuroleptics for the treatment or prevention of psychotic disorders |
MXPA02005649A (es) | 1999-12-10 | 2004-09-10 | Wyeth Corp | Nuevas combinaciones terapeuticas de (s)-2 -(bencilamino -metil)-2, 3, 8, 9-tetrahidro-7h -1, 4-dioxino(2-3 -e]indol-8 -ona y agentes neurolepticos para el tratamiento o prevencion de trastornos psicoticos. |
US20060223824A1 (en) * | 2000-11-28 | 2006-10-05 | Wyeth | Serotonergic agents |
US20060287335A1 (en) * | 2000-11-28 | 2006-12-21 | Wyeth | Serotonergic agents for treating sexual dysfunction |
US6458802B1 (en) | 2001-03-14 | 2002-10-01 | Wyeth | Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-dioxino [2,3-f]quinoline |
US6803368B2 (en) | 2001-04-25 | 2004-10-12 | Wyeth | Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1,3-diaza-cyclopenta[a]naphthalene |
US6861427B2 (en) * | 2001-04-26 | 2005-03-01 | Wyeth | Azabicyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinoline as 5-HT1A antagonists |
US6800648B2 (en) | 2001-04-26 | 2004-10-05 | Wyeth | Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-1,6,9-trioxa-3-AZA-cyclopenta[a]naphthalen-2-one |
US6800642B2 (en) | 2001-04-26 | 2004-10-05 | Wyeth | Antipsychotic aminomethyl derivatives of 7,8-dihydro-2,6,9-trioxa-3-aza-cyclopenta[a]naphthalene |
US6927226B2 (en) | 2001-04-26 | 2005-08-09 | Wyeth | Antidepressant azaheterocyclymethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1,3-diazacyclopenta[a]naphthalene |
US6861434B2 (en) * | 2001-04-26 | 2005-03-01 | Wyeth | Antipsychotic aminomethyl derivatives of 1,3,7,8-tetrahydro-6,9-dioxa-1,3-diaza-cyclopenta[a]-naphthalen-2-one |
US6821981B2 (en) | 2001-04-26 | 2004-11-23 | Wyeth | Azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]-quinoline as 5-HT1A antagonists |
US6800641B2 (en) | 2001-04-26 | 2004-10-05 | Wyeth | Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-2,3-diaza-cyclopenta[a]naphthalene |
DE60206048T2 (de) * | 2001-04-26 | 2006-07-13 | Wyeth | Antidepressive (sssri) azaheterocyclylmethylderivate von 7,8-dihydro-3h-6,9-dioxa-1,3-diazacyclopenta [a] naphthalin |
US7008944B2 (en) * | 2001-04-26 | 2006-03-07 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-Dioxino[2,3-f]quinoxaline |
ATE334989T1 (de) * | 2001-04-26 | 2006-08-15 | Wyeth Corp | Antidepressive azaheterocyclylmethyl-derivate von 2,3-dihydro-1,4-dioxino 2,3-föchinoxalin |
US6656947B2 (en) | 2001-04-26 | 2003-12-02 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinazoline |
US6555560B2 (en) * | 2001-04-30 | 2003-04-29 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 1,4,5-trioxa-phenanthrene |
US6906206B2 (en) | 2001-04-30 | 2005-06-14 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 1,4,5-trioxa-phenanthrene |
MXPA03010524A (es) * | 2001-05-17 | 2005-03-07 | Wyeth Corp | Proceso para la sintesis de derivados de la 2,3-dihidro-1,4-dioxino-[2,3-f]-quinolina. |
US6541502B1 (en) | 2001-07-20 | 2003-04-01 | Wyeth | 2-(aminomethyl)-tetrahydro-9-oxa-1,3-diaza-cyclopenta[a]-naphthalenyl derivatives with antipsychotic activity |
US6541501B2 (en) | 2001-07-20 | 2003-04-01 | Wyeth | 2-(aminomethyl)-tetrahydro-9-oxa-1,3-diaza-cyclopenta[a]-naphthalenyl derivatives with antipsychotic activity |
US6903110B2 (en) | 2001-07-25 | 2005-06-07 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene |
US7135479B2 (en) | 2002-09-12 | 2006-11-14 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans |
US6800637B2 (en) * | 2002-09-12 | 2004-10-05 | Wyeth | Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines |
US7153849B2 (en) * | 2002-09-12 | 2006-12-26 | Wyeth | Antidepressant arylpiperazine derivatives of hetrocycle-fused benzodioxans |
US6939877B2 (en) * | 2002-09-12 | 2005-09-06 | Wyeth | Antidepressant piperidine derivatives of heterocycle-fused benzodioxans |
CN100352820C (zh) * | 2002-09-12 | 2007-12-05 | 惠氏公司 | 抗抑郁的杂环稠合的苯并二噁烷的氮杂环甲基衍生物 |
CN1874767A (zh) * | 2003-10-29 | 2006-12-06 | 惠氏公司 | 包含aplindore和其衍生物的缓释药物组合物 |
GT200600078A (es) | 2005-02-17 | 2007-04-12 | Derivados de indol, benzotiofeno, benzofurano e indeno cicloalquil condensados | |
JP2008531694A (ja) * | 2005-03-01 | 2008-08-14 | ワイス | 結晶性および非晶性4−シアノ−n−{(2r)−2−[4−(2,3−ジヒドロ−ベンゾ[1,4]ジオキシン−5−イル)−ピペラジン−1−イル]−プロピル}−n−ピリジン−2−イル−ベンズアミド塩酸塩 |
EP1871355A1 (de) * | 2005-04-22 | 2008-01-02 | Wyeth | Neue therapeutische kombinationen zur behandlung oder prävention von depression |
TW200811182A (en) | 2006-05-25 | 2008-03-01 | Wyeth Corp | Oxindoledioxans, synthesis thereof, and intermediates thereto |
WO2008118935A1 (en) * | 2007-03-26 | 2008-10-02 | Neurogen Corporation | Compounds and processes for preparing substituted aminomethyl-2,3,8,9-tetrahydro-7h-1,4-dioxino[2,3-e]indol-8-ones |
EA023430B1 (ru) | 2009-03-30 | 2016-06-30 | виТиви ТЕРАПЬЮТИКС ЭлЭлСи | Замещенные производные азоантрацена, фармацевтические композиции и способы их применения |
RU2554885C1 (ru) * | 2014-05-27 | 2015-06-27 | Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Казанский (Приволжский) Федеральный Университет" (ФГАОУ ВПО КФУ) | Антагонисты пуринорецепторов на основе новых производных пиридоксина |
RU2554883C1 (ru) * | 2014-05-27 | 2015-06-27 | Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Казанский (Приволжский) Федеральный Университет" (ФГАОУ ВПО КФУ) | Применение производных ацеталей пиридоксина в качестве антагонистов пуринорецепторов |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05505599A (ja) * | 1990-03-15 | 1993-08-19 | ジ・アップジョン・カンパニー | 治療上有用な複素環インドール化合物類 |
US5126366A (en) * | 1991-06-21 | 1992-06-30 | American Home Products Corporation | Aminophenoxyalkyl derivatives of benzodioxan |
US5189171A (en) * | 1991-06-21 | 1993-02-23 | American Home Products Corporation | Antipsychotic benzodioxan derivatives |
US5166367A (en) * | 1991-06-21 | 1992-11-24 | American Home Products Corporation | Antipsychotic benzodioxan derivatives |
DE4135474A1 (de) * | 1991-10-28 | 1993-04-29 | Bayer Ag | 2-aminomethyl-chromane |
US5235055A (en) * | 1992-09-02 | 1993-08-10 | American Home Products Corporation | Antipsychotic quinoline derivatives of benzodioxanmethylamine |
US5245051A (en) * | 1992-09-03 | 1993-09-14 | American Home Products Corporation | Antipsychotic chroman derivatives of benzodioxanmethylamine |
-
1996
- 1996-10-15 US US08/730,267 patent/US5756532A/en not_active Expired - Lifetime
- 1996-10-22 EP EP03021780A patent/EP1375503B1/de not_active Expired - Lifetime
- 1996-10-22 ES ES03021780T patent/ES2277014T3/es not_active Expired - Lifetime
- 1996-10-22 AT AT03021780T patent/ATE349450T1/de active
- 1996-10-22 EP EP06015712A patent/EP1726592A1/de not_active Withdrawn
- 1996-10-22 EP EP96307616A patent/EP0771800A3/de not_active Ceased
- 1996-10-22 DK DK03021780T patent/DK1375503T3/da active
- 1996-10-22 DE DE69636801T patent/DE69636801T2/de not_active Expired - Lifetime
- 1996-10-22 PT PT03021780T patent/PT1375503E/pt unknown
- 1996-10-31 SK SK1414-96A patent/SK282168B6/sk not_active IP Right Cessation
- 1996-11-01 AU AU70553/96A patent/AU701624B2/en not_active Ceased
- 1996-11-04 RU RU96121824/04A patent/RU2178416C2/ru not_active IP Right Cessation
- 1996-11-04 NZ NZ299693A patent/NZ299693A/xx not_active IP Right Cessation
- 1996-11-04 CA CA002189524A patent/CA2189524C/en not_active Expired - Fee Related
- 1996-11-05 NO NO19964686A patent/NO317054B1/no not_active IP Right Cessation
- 1996-11-05 AR ARP960105059A patent/AR004284A1/es active IP Right Grant
- 1996-11-05 MX MX9605367A patent/MX9605367A/es unknown
- 1996-11-05 KR KR1019960051969A patent/KR100566678B1/ko not_active IP Right Cessation
- 1996-11-05 CZ CZ19963241A patent/CZ291731B6/cs not_active IP Right Cessation
- 1996-11-05 CN CN96121650A patent/CN1084748C/zh not_active Expired - Fee Related
- 1996-11-05 JP JP29247996A patent/JP4311770B2/ja not_active Expired - Fee Related
- 1996-11-05 HU HU9603057A patent/HU224841B1/hu not_active IP Right Cessation
- 1996-11-05 IL IL11956596A patent/IL119565A/en not_active IP Right Cessation
-
1998
- 1998-01-29 US US09/015,149 patent/US5962465A/en not_active Expired - Lifetime
-
2000
- 2000-09-15 AR ARP000104875A patent/AR025698A1/es unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |