MX9605367A - Aminometil-2,3,8,9-tetrahidro-7h-1, 4-dioxino[2,3-e]-indol-8 onas y derivados. - Google Patents

Aminometil-2,3,8,9-tetrahidro-7h-1, 4-dioxino[2,3-e]-indol-8 onas y derivados.

Info

Publication number
MX9605367A
MX9605367A MX9605367A MX9605367A MX9605367A MX 9605367 A MX9605367 A MX 9605367A MX 9605367 A MX9605367 A MX 9605367A MX 9605367 A MX9605367 A MX 9605367A MX 9605367 A MX9605367 A MX 9605367A
Authority
MX
Mexico
Prior art keywords
optionally substituted
alkyl
defined above
hydrogen
heteroaryl
Prior art date
Application number
MX9605367A
Other languages
English (en)
Inventor
Gary Paul Stack
Richard Eric Mewshaw
Byron Abel Bravo
Young Hee Kang
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of MX9605367A publication Critical patent/MX9605367A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Se describen los compuestos de la formula I: en donde R1 y R2 son, independientemente, hidrogeno, alquilo, fenilo o bencilo; o R1 y R2 tomados conjuntamente, son bencilideno opcionalmente substituidos con R3 como se define anteriormente o alquilideno, o R1 y R2, tomados conjuntamente con el átomo de carbono al cual están unidos, forman una porcion carbonilo o un grupo cicloalquilo; R3 es hidrogeno, hidroxi, halo, trifluorometilo, trifluorometoxi, alquilo, alcoxi, aralcoxi, alcanoiloxi, amino, mono-o di-alquilamino, alcanamido o alcansulfonamido; R4 es hidrogeno o alquilo; m es un numero entero 0, 1 o 2; n es un numero entero de 0 a 6, inclusive; Z es hidrogeno, hidroxi, alquilo, alquenilo, alquinilo, alcoxi, cicloalquilo, alquilo policíclico, fenilo opcionalmente substituido con R3 como se define anteriormente, fenoxi opcionalmente substituido con R3 como se define anteriormente, naftilo opcionalmente substituido con R3 como se define anteriormente, o naftiloxi opcionalmente substituido con R3 como se define anteriormente, heteroarilo o heteroariloxi, en los cuales el anillo heterocíclico el grupo heteroarilo o heteroariloxi se seleccionan de tiofeno, furano, piridina, pirazina, pirimidina, indol, indazol, imidazol, cromano, cumarina, carbostirilo, quinolina, bencisoxazol, benzoxazol, pirazol, pirrol, tiazol, oxazol, o isoxazol y el anillo heterocíclico está opcionalmente substituido con R3 como se define anteriormente; o una sal farmacéuticamente aceptable de los mismos, que son utiles en el tratamiento de desordenes del sistema dopaminérgico.
MX9605367A 1995-11-06 1996-11-05 Aminometil-2,3,8,9-tetrahidro-7h-1, 4-dioxino[2,3-e]-indol-8 onas y derivados. MX9605367A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US728395P 1995-11-06 1995-11-06
US08/730,267 US5756532A (en) 1995-11-06 1996-10-15 Aminomethyl-2 3 8 9-tetrahydro-7H-1 4-dioxino 2 3-E!-indol-8-ones and derivatives

Publications (1)

Publication Number Publication Date
MX9605367A true MX9605367A (es) 1997-10-31

Family

ID=26676776

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9605367A MX9605367A (es) 1995-11-06 1996-11-05 Aminometil-2,3,8,9-tetrahidro-7h-1, 4-dioxino[2,3-e]-indol-8 onas y derivados.

Country Status (21)

Country Link
US (2) US5756532A (es)
EP (3) EP1375503B1 (es)
JP (1) JP4311770B2 (es)
KR (1) KR100566678B1 (es)
CN (1) CN1084748C (es)
AR (2) AR004284A1 (es)
AT (1) ATE349450T1 (es)
AU (1) AU701624B2 (es)
CA (1) CA2189524C (es)
CZ (1) CZ291731B6 (es)
DE (1) DE69636801T2 (es)
DK (1) DK1375503T3 (es)
ES (1) ES2277014T3 (es)
HU (1) HU224841B1 (es)
IL (1) IL119565A (es)
MX (1) MX9605367A (es)
NO (1) NO317054B1 (es)
NZ (1) NZ299693A (es)
PT (1) PT1375503E (es)
RU (1) RU2178416C2 (es)
SK (1) SK282168B6 (es)

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GB9704948D0 (en) 1997-03-11 1997-04-30 Knoll Ag Therapeutic agents
US6362009B1 (en) 1997-11-21 2002-03-26 Merck & Co., Inc. Solid phase synthesis of heterocycles
US6350773B1 (en) * 1999-12-10 2002-02-26 American Home Products Corporation Therapeutic combinations of (S)-2-(benzylamino-methyl)-2,3,8,9,-tetrahydro 7H-1,4-dioxino{2,3-e}indol-8-one and neuroleptics for the treatment or prevention of psychotic disorders
JP5557409B2 (ja) * 1999-12-10 2014-07-23 ワイス・エルエルシー （ｓ）−２−（ベンジルアミノメチル）−２，３，８，９−テトラヒドロ−７ｈ−１，４−ジオキシノ（２，３）ｅインドール−８−オンと神経遮断薬との組合せ
US20060287335A1 (en) * 2000-11-28 2006-12-21 Wyeth Serotonergic agents for treating sexual dysfunction
US20060223824A1 (en) * 2000-11-28 2006-10-05 Wyeth Serotonergic agents
US6458802B1 (en) 2001-03-14 2002-10-01 Wyeth Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-dioxino [2,3-f]quinoline
US6803368B2 (en) 2001-04-25 2004-10-12 Wyeth Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1,3-diaza-cyclopenta[a]naphthalene
EP1381612A1 (en) 2001-04-26 2004-01-21 Wyeth Antidepressant aza-heterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinazoline
US6821981B2 (en) 2001-04-26 2004-11-23 Wyeth Azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]-quinoline as 5-HT1A antagonists
US6573283B2 (en) 2001-04-26 2003-06-03 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1,3-diazacyclopenta[a]naphthalene
US6800648B2 (en) 2001-04-26 2004-10-05 Wyeth Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-1,6,9-trioxa-3-AZA-cyclopenta[a]naphthalen-2-one
US6861427B2 (en) * 2001-04-26 2005-03-01 Wyeth Azabicyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinoline as 5-HT1A antagonists
US6800642B2 (en) 2001-04-26 2004-10-05 Wyeth Antipsychotic aminomethyl derivatives of 7,8-dihydro-2,6,9-trioxa-3-aza-cyclopenta[a]naphthalene
US7008944B2 (en) * 2001-04-26 2006-03-07 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-Dioxino[2,3-f]quinoxaline
US6927226B2 (en) 2001-04-26 2005-08-09 Wyeth Antidepressant azaheterocyclymethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1,3-diazacyclopenta[a]naphthalene
US6800641B2 (en) 2001-04-26 2004-10-05 Wyeth Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-2,3-diaza-cyclopenta[a]naphthalene
BR0209342A (pt) 2001-04-26 2004-06-15 Wyeth Corp Antidepressivos de azaheterociclilmetila derivados de 2,3 dihidro-1,4-dioxino[2,3-f]quinoxalina; método de tratamento usando tais compostos; processo para prepará-los
US6861434B2 (en) 2001-04-26 2005-03-01 Wyeth Antipsychotic aminomethyl derivatives of 1,3,7,8-tetrahydro-6,9-dioxa-1,3-diaza-cyclopenta[a]-naphthalen-2-one
US6555560B2 (en) * 2001-04-30 2003-04-29 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 1,4,5-trioxa-phenanthrene
US6906206B2 (en) 2001-04-30 2005-06-14 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 1,4,5-trioxa-phenanthrene
MXPA03010524A (es) * 2001-05-17 2005-03-07 Wyeth Corp Proceso para la sintesis de derivados de la 2,3-dihidro-1,4-dioxino-[2,3-f]-quinolina.
US6541501B2 (en) 2001-07-20 2003-04-01 Wyeth 2-(aminomethyl)-tetrahydro-9-oxa-1,3-diaza-cyclopenta[a]-naphthalenyl derivatives with antipsychotic activity
US6541502B1 (en) 2001-07-20 2003-04-01 Wyeth 2-(aminomethyl)-tetrahydro-9-oxa-1,3-diaza-cyclopenta[a]-naphthalenyl derivatives with antipsychotic activity
WO2003010169A1 (en) * 2001-07-25 2003-02-06 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 7, 8-dihydro-6h-5-oxa-1-aza-phenanthrene
US6800637B2 (en) * 2002-09-12 2004-10-05 Wyeth Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines
CN100352820C (zh) * 2002-09-12 2007-12-05 惠氏公司 抗抑郁的杂环稠合的苯并二噁烷的氮杂环甲基衍生物
US6939877B2 (en) * 2002-09-12 2005-09-06 Wyeth Antidepressant piperidine derivatives of heterocycle-fused benzodioxans
US7153849B2 (en) * 2002-09-12 2006-12-26 Wyeth Antidepressant arylpiperazine derivatives of hetrocycle-fused benzodioxans
US7135479B2 (en) 2002-09-12 2006-11-14 Wyeth Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans
US20050095292A1 (en) * 2003-10-29 2005-05-05 Wyeth Sustained release pharmaceutical compositions
CA2597616A1 (en) 2005-02-17 2006-08-24 Wyeth Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives
MX2007010524A (es) * 2005-03-01 2008-01-16 Wyeth Corp Formas cristalinas y amorfas del clorhidrato 4-ciano-n-{(2r)-2-[4- (2,3-dihidro-benzo[1-4]dioxin-5-il)-piperazin-1-il]-propil}-n- piridin-2-il-benzamida.
TW200722081A (en) * 2005-04-22 2007-06-16 Wyeth Corp New therapeutic combinations for the treatment or prevention of depression
TW200811182A (en) * 2006-05-25 2008-03-01 Wyeth Corp Oxindoledioxans, synthesis thereof, and intermediates thereto
WO2008118935A1 (en) * 2007-03-26 2008-10-02 Neurogen Corporation Compounds and processes for preparing substituted aminomethyl-2,3,8,9-tetrahydro-7h-1,4-dioxino[2,3-e]indol-8-ones
MA33219B1 (fr) * 2009-03-30 2012-04-02 Transtech Pharma Inc Derives d'azoanthracene substitues, compositions pharmaceutiques et leurs procedes d'utilisation
RU2554885C1 (ru) * 2014-05-27 2015-06-27 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Казанский (Приволжский) Федеральный Университет" (ФГАОУ ВПО КФУ) Антагонисты пуринорецепторов на основе новых производных пиридоксина
RU2554883C1 (ru) * 2014-05-27 2015-06-27 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Казанский (Приволжский) Федеральный Университет" (ФГАОУ ВПО КФУ) Применение производных ацеталей пиридоксина в качестве антагонистов пуринорецепторов

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Also Published As

Publication number Publication date
NO964686D0 (no) 1996-11-05
EP1375503A1 (en) 2004-01-02
CA2189524C (en) 2007-05-01
NO964686L (no) 1997-05-07
IL119565A (en) 2002-11-10
HU9603057D0 (en) 1996-12-30
NO317054B1 (no) 2004-08-02
HU224841B1 (en) 2006-03-28
DK1375503T3 (da) 2007-01-22
CN1155546A (zh) 1997-07-30
AU7055396A (en) 1997-05-15
AR004284A1 (es) 1998-11-04
JP4311770B2 (ja) 2009-08-12
US5962465A (en) 1999-10-05
AR025698A1 (es) 2002-12-11
PT1375503E (pt) 2007-03-30
ATE349450T1 (de) 2007-01-15
DE69636801T2 (de) 2007-04-26
CA2189524A1 (en) 1997-05-07
IL119565A0 (en) 1997-03-18
HUP9603057A2 (en) 1997-05-28
HUP9603057A3 (en) 1998-12-28
SK282168B6 (sk) 2001-11-06
JPH09249671A (ja) 1997-09-22
RU2178416C2 (ru) 2002-01-20
SK141496A3 (en) 1997-08-06
EP1726592A1 (en) 2006-11-29
EP0771800A2 (en) 1997-05-07
NZ299693A (en) 1997-09-22
CZ291731B6 (cs) 2003-05-14
AU701624B2 (en) 1999-02-04
US5756532A (en) 1998-05-26
EP1375503B1 (en) 2006-12-27
CZ324196A3 (en) 1997-12-17
ES2277014T3 (es) 2007-07-01
KR970027068A (ko) 1997-06-24
CN1084748C (zh) 2002-05-15
EP0771800A3 (en) 1998-01-28
KR100566678B1 (ko) 2006-11-30
DE69636801D1 (de) 2007-02-08

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