NO990080L - Indolderivater for behandling av osteoporose - Google Patents
Indolderivater for behandling av osteoporoseInfo
- Publication number
- NO990080L NO990080L NO990080A NO990080A NO990080L NO 990080 L NO990080 L NO 990080L NO 990080 A NO990080 A NO 990080A NO 990080 A NO990080 A NO 990080A NO 990080 L NO990080 L NO 990080L
- Authority
- NO
- Norway
- Prior art keywords
- sub
- alkyl
- optionally substituted
- group
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
En forbindelse med formel (I) eller et salt derav eller et solvat derav, hvor Ra representerer en gruppe R5 som er hydrogen, alkyl eller eventuelt substituert aryl og Rb representerer en andel med formel (a) f2 = c ¿ c = c, OR, o hvor X representerer en hydroksy- eller en alkoksygruppe hvor alkylgruppen kan være substituert eller usubstituert eller X representerer en gruppe RsRt hvor Rs og Rt hver uavhengig representerer hydrogen, alkyl, substituert alkyl, eventuelt substituert alkenyl, eventuelt substituert aryl, eventuelt substituert arylalkyl, en eventuelt substituert heterocyklisk gruppe eller en eventuelt substituert hetero- cyklyalkylgruppe, eller Rs og Rt danner, sammen med det nitrogengen til hvilket de er bundet, en heterocyklisk gruppe; RI representerer en alkyl- eller en sub- stituert eller usubstituert arylgruppe; og R2, Rs og R4 representerer hver uavhen- gig hydrogen, alkyl, aryl eller substituert aryl, R6 og R7 representerer hver uavhen- gig hydrogen, hydroksy, amino, alkoksy, eventuelt substituert aryloksy, eventuelt substituert benzyloksy, alkylamino, dialkylamino, halogen, trifluormetyl, trifluor- metoksy, nitro, alkyl, karboksy, karbalkoksy, karbamoyl, alkylkarbamoyl, eller R6 og R? representerer sammen metylendioksy, karbonyldioksy eller karbonyldi- amino; og R8 representerer hydrogen, hydroksy, alkanoyl, alkyl, aminoalkyl, hydroksyalkyl, karboksyalkyl, karbalkoksyalkyl, karbamoyl eller aminosulfonyl, en fremgangsmåte for fremstilling av en slik forbindelse, et farmasøytisk preparat som inneholder en slik forbindelse og anvendelse av en slik forbindelse i medisin.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9614367.2A GB9614367D0 (en) | 1996-07-09 | 1996-07-09 | Novel compounds |
GBGB9626697.8A GB9626697D0 (en) | 1996-12-23 | 1996-12-23 | Novel compounds |
GBGB9626700.0A GB9626700D0 (en) | 1996-12-23 | 1996-12-23 | Novel compounds |
PCT/EP1997/003577 WO1998001443A1 (en) | 1996-07-09 | 1997-07-03 | Indole derivatives for the treatment of osteoporosis |
Publications (2)
Publication Number | Publication Date |
---|---|
NO990080L true NO990080L (no) | 1999-01-08 |
NO990080D0 NO990080D0 (no) | 1999-01-08 |
Family
ID=27268385
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO990080A NO990080D0 (no) | 1996-07-09 | 1999-01-08 | Indolderivater for behandling av osteoporose |
Country Status (21)
Country | Link |
---|---|
US (2) | US20020173659A1 (no) |
EP (1) | EP0914321B1 (no) |
JP (1) | JP2000514074A (no) |
KR (1) | KR20000023646A (no) |
AT (1) | ATE277037T1 (no) |
AU (1) | AU3620597A (no) |
BR (1) | BR9710230A (no) |
CA (1) | CA2259598A1 (no) |
CZ (1) | CZ3799A3 (no) |
DE (1) | DE69730837T2 (no) |
ES (1) | ES2229375T3 (no) |
ID (1) | ID18181A (no) |
IL (1) | IL127668A0 (no) |
MA (1) | MA24349A1 (no) |
NO (1) | NO990080D0 (no) |
PE (1) | PE46699A1 (no) |
PL (1) | PL330994A1 (no) |
TR (1) | TR199900138T2 (no) |
TW (1) | TW397684B (no) |
UY (2) | UY24608A1 (no) |
WO (1) | WO1998001443A1 (no) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0974584B1 (en) | 1997-02-21 | 2003-01-15 | Takeda Chemical Industries, Ltd. | Fused ring compounds, process for producing the same and use thereof |
HU226587B1 (en) * | 1998-05-15 | 2009-04-28 | Wyeth Corp | Pharmaceutical composition containing 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole in combination with estrogens |
US6479535B1 (en) | 1998-05-15 | 2002-11-12 | Wyeth | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations |
GB9914371D0 (en) | 1999-06-18 | 1999-08-18 | Smithkline Beecham Plc | Novel compounds |
SE9903610D0 (sv) * | 1999-10-06 | 1999-10-06 | Astra Ab | Novel compounds II |
SE9903611D0 (sv) * | 1999-10-06 | 1999-10-06 | Astra Ab | Novel compounds III |
SE9903760D0 (sv) * | 1999-10-18 | 1999-10-18 | Astra Ab | New compounds |
DE10022925A1 (de) * | 2000-05-11 | 2001-11-15 | Basf Ag | Substituierte Indole als PARP-Inhibitoren |
WO2002007721A2 (en) | 2000-07-20 | 2002-01-31 | Lauras As | Use of cox-2 inhibitors for preventing immunodeficiency |
MXPA03008143A (es) | 2001-03-09 | 2005-08-16 | Johnson & Johnson | Compuestos heterociclicos. |
JP2005510482A (ja) * | 2001-10-16 | 2005-04-21 | アストラゼネカ・アクチエボラーグ | 線維筋痛症候群の治療方法 |
WO2004022060A2 (en) | 2002-09-06 | 2004-03-18 | Janssen Pharmaceutica, N.V. | (1h-benzoimidazol-2-yl)-(piperazinyl)-methanone derivatives and related compounds as histamine h4-receptor antagonists for the treatment of inflammatory and allergic disorders |
JP4384052B2 (ja) * | 2002-11-25 | 2009-12-16 | エフ.ホフマン−ラ ロシュ アーゲー | インドリル誘導体 |
US6916852B2 (en) * | 2003-05-12 | 2005-07-12 | University Of Tennessee Research Foundation | Method for regulation of microvascular tone |
ITMI20040875A1 (it) * | 2004-04-30 | 2004-07-30 | Ist Naz Stud Cura Dei Tumori | Derivati indolici utili per il trattamento della resistenza agli agenti antitumorali |
EP1779848A1 (en) | 2005-10-28 | 2007-05-02 | Nikem Research S.R.L. | V-ATPase inhibitors for the treatment of inflammatory and autoimmune diseases |
EP1779849A1 (en) | 2005-10-28 | 2007-05-02 | Nikem Research S.R.L. | V-ATPase inhibitors for the treatment of septic shock |
WO2010144611A2 (en) * | 2009-06-10 | 2010-12-16 | 3-V Biosciences, Inc. | Antivirals that target transporters, carriers, and ion channels |
WO2012045451A1 (en) | 2010-10-05 | 2012-04-12 | Ludwig-Maximilians-Universitaet Muenchen | Novel therapeutic treatment of progranulin-dependent diseases |
CA2877474A1 (en) * | 2011-06-20 | 2012-12-27 | Myrexis, Inc. | Compounds and therapeutic uses thereof |
US20230219881A1 (en) * | 2022-01-11 | 2023-07-13 | Compound Solutions Inc. | Synthesis of Spermidine, Spermine, and Free Bases Thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2038925A1 (en) * | 1990-03-26 | 1991-09-27 | Takashi Sohda | Indole derivatives, their production and use |
WO1993001280A1 (en) * | 1991-07-08 | 1993-01-21 | Roland Baron | Inhibition of proton pump in osteoclast cells |
JPH07223945A (ja) * | 1994-02-10 | 1995-08-22 | Snow Brand Milk Prod Co Ltd | 骨疾患治療剤 |
SK93297A3 (en) | 1995-01-10 | 1998-02-04 | Smithkline Beecham Spa | Indole derivatives, method for their producing, pharmaceutical comosition containing the same, and their use |
-
1997
- 1997-07-03 PL PL97330994A patent/PL330994A1/xx unknown
- 1997-07-03 DE DE69730837T patent/DE69730837T2/de not_active Expired - Lifetime
- 1997-07-03 WO PCT/EP1997/003577 patent/WO1998001443A1/en active IP Right Grant
- 1997-07-03 EP EP97932778A patent/EP0914321B1/en not_active Expired - Lifetime
- 1997-07-03 AU AU36205/97A patent/AU3620597A/en not_active Abandoned
- 1997-07-03 IL IL12766897A patent/IL127668A0/xx unknown
- 1997-07-03 CZ CZ9937A patent/CZ3799A3/cs unknown
- 1997-07-03 JP JP10504784A patent/JP2000514074A/ja not_active Ceased
- 1997-07-03 AT AT97932778T patent/ATE277037T1/de not_active IP Right Cessation
- 1997-07-03 BR BR9710230A patent/BR9710230A/pt not_active IP Right Cessation
- 1997-07-03 TR TR1999/00138T patent/TR199900138T2/xx unknown
- 1997-07-03 CA CA002259598A patent/CA2259598A1/en not_active Abandoned
- 1997-07-03 ES ES97932778T patent/ES2229375T3/es not_active Expired - Lifetime
- 1997-07-07 ID IDP972341A patent/ID18181A/id unknown
- 1997-07-07 PE PE1997000586A patent/PE46699A1/es not_active Application Discontinuation
- 1997-07-07 UY UY24608A patent/UY24608A1/es unknown
- 1997-07-07 MA MA24706A patent/MA24349A1/fr unknown
- 1997-07-08 TW TW086109710A patent/TW397684B/zh not_active IP Right Cessation
- 1997-12-05 UY UY24802A patent/UY24802A1/es unknown
-
1999
- 1999-01-08 KR KR1019997000099A patent/KR20000023646A/ko not_active Application Discontinuation
- 1999-01-08 NO NO990080A patent/NO990080D0/no not_active Application Discontinuation
-
2001
- 2001-12-04 US US10/005,491 patent/US20020173659A1/en not_active Abandoned
-
2002
- 2002-11-20 US US10/300,332 patent/US6903117B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0914321B1 (en) | 2004-09-22 |
IL127668A0 (en) | 1999-10-28 |
CA2259598A1 (en) | 1998-01-15 |
CZ3799A3 (cs) | 1999-08-11 |
UY24608A1 (es) | 1997-12-19 |
ATE277037T1 (de) | 2004-10-15 |
US6903117B2 (en) | 2005-06-07 |
EP0914321A1 (en) | 1999-05-12 |
ES2229375T3 (es) | 2005-04-16 |
AU3620597A (en) | 1998-02-02 |
US20040010012A1 (en) | 2004-01-15 |
US20020173659A1 (en) | 2002-11-21 |
BR9710230A (pt) | 1999-08-10 |
MA24349A1 (fr) | 1998-07-01 |
KR20000023646A (ko) | 2000-04-25 |
UY24802A1 (es) | 2001-03-16 |
PE46699A1 (es) | 1999-06-12 |
WO1998001443A1 (en) | 1998-01-15 |
JP2000514074A (ja) | 2000-10-24 |
TW397684B (en) | 2000-07-11 |
PL330994A1 (en) | 1999-06-21 |
TR199900138T2 (xx) | 1999-04-21 |
NO990080D0 (no) | 1999-01-08 |
ID18181A (id) | 1998-03-12 |
DE69730837D1 (de) | 2004-10-28 |
DE69730837T2 (de) | 2005-09-29 |
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Legal Events
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FC2A | Withdrawal, rejection or dismissal of laid open patent application |