PE46699A1 - Compuesto derivado de indol - Google Patents

Compuesto derivado de indol

Info

Publication number
PE46699A1
PE46699A1 PE1997000586A PE00058697A PE46699A1 PE 46699 A1 PE46699 A1 PE 46699A1 PE 1997000586 A PE1997000586 A PE 1997000586A PE 00058697 A PE00058697 A PE 00058697A PE 46699 A1 PE46699 A1 PE 46699A1
Authority
PE
Peru
Prior art keywords
sub
alkyl
optionally substituted
group
compound
Prior art date
Application number
PE1997000586A
Other languages
English (en)
Inventor
Carlo Farina
Stefania Gagliardi
Guy Nadler
Marguerite Marie Gerard Nadler
Original Assignee
Smithkline Beecham Spa
Smithkline Beecham Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9614367.2A external-priority patent/GB9614367D0/en
Priority claimed from GBGB9626697.8A external-priority patent/GB9626697D0/en
Priority claimed from GBGB9626700.0A external-priority patent/GB9626700D0/en
Application filed by Smithkline Beecham Spa, Smithkline Beecham Lab filed Critical Smithkline Beecham Spa
Publication of PE46699A1 publication Critical patent/PE46699A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I) O UNA SAL O SOLVATO, DONDE: Ra ES R5 QUE ES H, ALQUILO O ARILO; Rb ES (a) DONDE "X" ES DE PREFERENCIA NRsRt DONDE Rs Y Rt SON H, ALQUILO O ARILO O Rs Y Rt JUNTO CON N FORMAN UN GRUPO HETEROCICLICO; R1 ES ALQUILO O ARILO; R2, R3 Y R4 SON H, ALQUILO O ARILO; R6 Y R7 SON H, ALCOXILO, HALO O TRIFLUOROMETILO, DE PREFERENCIA R7 ES 6-CLORO Y R6 ES 5-CLORO; R8 ES H, OH, ALQUILO, ENTRE OTROS. EL COMPUESTO DE FORMULA (I) ACTUA COMO INHIBIDOR SELECTIVO DE LA H+ ATPASA VACUOLAR SITUADA EN EL BORDE FRUNCIDO DE OSTEOCLASTOS DE HUMANO, QUE INTERACTUA ESPECIFICAMENTE CON LA SUBUNIDAD 16KDa O 116KDa. TAMBIEN SE REFIERE AL PROCEDIMIENTO DE PREPARACION DEL COMPUESTO DE FORMULA (I) Y A LOS COMPUESTOS INTERMEDIOS EN SU PREPARACION. EL COMPUESTO DE FORMULA (I) ES UTIL EN EL TRATAMIENTO DE OSTEOPOROSIS, DE ENFERMEDADES ASOCIADAS CON UNA ACTIVIDAD EXCESIVA DE OSTEOCLASTOS EN MAMIFEROS, ENFERMEDADES OSTEOPENICAS, ENFERMEDADES ANGIOGENICAS, ENFERMEDAD DE PAGET, TUMORES RELACIONADOS CON CANCER RENAL, MELANOMA
PE1997000586A 1996-07-09 1997-07-07 Compuesto derivado de indol PE46699A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9614367.2A GB9614367D0 (en) 1996-07-09 1996-07-09 Novel compounds
GBGB9626697.8A GB9626697D0 (en) 1996-12-23 1996-12-23 Novel compounds
GBGB9626700.0A GB9626700D0 (en) 1996-12-23 1996-12-23 Novel compounds

Publications (1)

Publication Number Publication Date
PE46699A1 true PE46699A1 (es) 1999-06-12

Family

ID=27268385

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1997000586A PE46699A1 (es) 1996-07-09 1997-07-07 Compuesto derivado de indol

Country Status (21)

Country Link
US (2) US20020173659A1 (es)
EP (1) EP0914321B1 (es)
JP (1) JP2000514074A (es)
KR (1) KR20000023646A (es)
AT (1) ATE277037T1 (es)
AU (1) AU3620597A (es)
BR (1) BR9710230A (es)
CA (1) CA2259598A1 (es)
CZ (1) CZ3799A3 (es)
DE (1) DE69730837T2 (es)
ES (1) ES2229375T3 (es)
ID (1) ID18181A (es)
IL (1) IL127668A0 (es)
MA (1) MA24349A1 (es)
NO (1) NO990080D0 (es)
PE (1) PE46699A1 (es)
PL (1) PL330994A1 (es)
TR (1) TR199900138T2 (es)
TW (1) TW397684B (es)
UY (2) UY24608A1 (es)
WO (1) WO1998001443A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998037070A1 (fr) * 1997-02-21 1998-08-27 Takeda Chemical Industries, Ltd. Composes a anneaux condenses, leur procede de production et leur utilisation
US6479535B1 (en) 1998-05-15 2002-11-12 Wyeth 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations
CZ299334B6 (cs) * 1998-05-15 2008-06-25 Wyeth Farmaceutický prostredek
GB9914371D0 (en) 1999-06-18 1999-08-18 Smithkline Beecham Plc Novel compounds
SE9903611D0 (sv) * 1999-10-06 1999-10-06 Astra Ab Novel compounds III
SE9903610D0 (sv) * 1999-10-06 1999-10-06 Astra Ab Novel compounds II
SE9903760D0 (sv) * 1999-10-18 1999-10-18 Astra Ab New compounds
DE10022925A1 (de) * 2000-05-11 2001-11-15 Basf Ag Substituierte Indole als PARP-Inhibitoren
DK1303265T3 (da) 2000-07-20 2007-11-12 Lauras As Anvendelse af COX-2-inhibitorer, som immunostimulerende midler ved behandling af HIV eller AIDS
JP4544820B2 (ja) 2001-03-09 2010-09-15 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 複素環化合物
EP1453828A2 (en) * 2001-10-16 2004-09-08 AstraZeneca AB Azabicyclic compounds for the treatment of fibromyalgia syndrome
AU2003265886A1 (en) 2002-09-06 2004-03-29 Janssen Pharmaceutica N.V. (1H-Benzoimidazol-2-yl)-(piperazinyl)-methanone derivatives and related compounds as histamine H4-receptor antagonists for the treatment of inflammatory and allergic disorders
RU2315767C2 (ru) * 2002-11-25 2008-01-27 Ф.Хоффманн-Ля Рош Аг Индолилпроизводные, способ их получения, фармацевтическая композиция, способ лечения и/или профилактики заболеваний
US6916852B2 (en) * 2003-05-12 2005-07-12 University Of Tennessee Research Foundation Method for regulation of microvascular tone
ITMI20040875A1 (it) * 2004-04-30 2004-07-30 Ist Naz Stud Cura Dei Tumori Derivati indolici utili per il trattamento della resistenza agli agenti antitumorali
EP1779849A1 (en) 2005-10-28 2007-05-02 Nikem Research S.R.L. V-ATPase inhibitors for the treatment of septic shock
EP1779848A1 (en) 2005-10-28 2007-05-02 Nikem Research S.R.L. V-ATPase inhibitors for the treatment of inflammatory and autoimmune diseases
US20110038852A1 (en) * 2009-06-10 2011-02-17 3-V Biosciences, Inc. Antivirals that target transporters, carriers, and ion channels
WO2012045451A1 (en) 2010-10-05 2012-04-12 Ludwig-Maximilians-Universitaet Muenchen Novel therapeutic treatment of progranulin-dependent diseases
EP2739144A4 (en) * 2011-06-20 2015-04-01 Alzheimer S Inst Of America Inc COMPOUNDS AND ITS THERAPEUTIC USE

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2038925A1 (en) * 1990-03-26 1991-09-27 Takashi Sohda Indole derivatives, their production and use
WO1993001280A1 (en) * 1991-07-08 1993-01-21 Roland Baron Inhibition of proton pump in osteoclast cells
JPH07223945A (ja) * 1994-02-10 1995-08-22 Snow Brand Milk Prod Co Ltd 骨疾患治療剤
PL321263A1 (en) 1995-01-10 1997-11-24 Smithkline Beecham Spa Derivatives of indole useful in treating osteoporosis

Also Published As

Publication number Publication date
NO990080L (no) 1999-01-08
IL127668A0 (en) 1999-10-28
US20040010012A1 (en) 2004-01-15
CZ3799A3 (cs) 1999-08-11
ATE277037T1 (de) 2004-10-15
DE69730837D1 (de) 2004-10-28
PL330994A1 (en) 1999-06-21
WO1998001443A1 (en) 1998-01-15
NO990080D0 (no) 1999-01-08
US20020173659A1 (en) 2002-11-21
ES2229375T3 (es) 2005-04-16
TW397684B (en) 2000-07-11
AU3620597A (en) 1998-02-02
EP0914321B1 (en) 2004-09-22
US6903117B2 (en) 2005-06-07
UY24802A1 (es) 2001-03-16
UY24608A1 (es) 1997-12-19
MA24349A1 (fr) 1998-07-01
ID18181A (id) 1998-03-12
JP2000514074A (ja) 2000-10-24
KR20000023646A (ko) 2000-04-25
EP0914321A1 (en) 1999-05-12
TR199900138T2 (xx) 1999-04-21
BR9710230A (pt) 1999-08-10
DE69730837T2 (de) 2005-09-29
CA2259598A1 (en) 1998-01-15

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Legal Events

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