MY108027A - Substitute tetrahydroisoquinolines and use as therepuetic agents - Google Patents

Substitute tetrahydroisoquinolines and use as therepuetic agents

Info

Publication number
MY108027A
MY108027A MYPI92002362A MYPI19922362A MY108027A MY 108027 A MY108027 A MY 108027A MY PI92002362 A MYPI92002362 A MY PI92002362A MY PI19922362 A MYPI19922362 A MY PI19922362A MY 108027 A MY108027 A MY 108027A
Authority
MY
Malaysia
Prior art keywords
alkyl
alkoxy
phenyl
optionally substituted
halo
Prior art date
Application number
MYPI92002362A
Inventor
Jeremy Sargent Bruce
Kozlik Antonin
Lesley Needham Patricia
Original Assignee
Boots Co Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919127306A external-priority patent/GB9127306D0/en
Application filed by Boots Co Plc filed Critical Boots Co Plc
Publication of MY108027A publication Critical patent/MY108027A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

TETRAHYDROISOQUINOLINE COMPOUND OF FORMULA 1 AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, IN WHICH:-R1 REPRESENTS ONE OR MORE SUBSTITUENTS SELECTED FROM H, HALO, HYDROXY, ALKYL (OPTIONALLY SUBSTITUTED BY HYDROXY), ALKOXY, ALKYLTHIO, ALKYLSULPHINYL, ALKYL-SULPHONYL, NITRO, CYANO, POLYHALOALKYL, POLYHALOALKOXY, PHENYL (OPTIONALLY SUBSTITUTED BY ONE OR MORE OF HALO, ALKYL OR ALKOXY), OR R1 IS OPTIONALLY ALKYLATED CARBAMOYL;R2 REPRESENTS AN ALIPHATIC GROUP OPTIONALLY SUBSTITUTED BY HYDROXY OR ALKOXY; E REPRESENTS AN ALKYLANE CHAIN OPTIONALLY SUBSTITUTED BY ONE OR MORE ALKYL GROUPS;AND G REPRESENTS PHENYL OR PHENYL SUBSTITUTED BY ONE OR MORE OF ALKYL, ALKOXY, HALO, HYDROXY, POLYHALOALKYL, POLYHALOALKOXY, CYANO, ALKYLTHIO, ALKYLSULPHINYL, ALKYLSULPHONYL, PHENYL (OPTIONALLY SUBSTITUTED BY ONE OR MORE OF HALO, ALKYL OR ALKOXY), OPTIONALLY ALKYLATED CARBAMOYL, OR G REPRESENTS A PHENYL RING HAVING FUSED THERETO A HETEROCYLIC OR AROMATIC CARBOCYCLIC RING; AND 0-ACYLATED DERIVATIVES THEREOF WHICH PROVIDE LIPOPHILIC ESTERS HAVE UTILITY ANALGESIA AND IN THE TREATMENT OF PSYCHOSES (E.G SCHIZAPHRENIA), PARKINSON'S DISEASE, LESCH-NYAN SYNDROME, ATTENTION DEFICIT DISORDER OR COGNITIVE IMPAIRMENT OR IN THE RELIEF OF DRUG DEPENDENCE OR TARDIVE DYSKINESIA.
MYPI92002362A 1991-12-23 1992-12-22 Substitute tetrahydroisoquinolines and use as therepuetic agents MY108027A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919127306A GB9127306D0 (en) 1991-12-23 1991-12-23 Therapeutic agents

Publications (1)

Publication Number Publication Date
MY108027A true MY108027A (en) 1996-07-30

Family

ID=47521612

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI92002362A MY108027A (en) 1991-12-23 1992-12-22 Substitute tetrahydroisoquinolines and use as therepuetic agents

Country Status (5)

Country Link
KR (1) KR100248558B1 (en)
MY (1) MY108027A (en)
TW (1) TW300889B (en)
UA (1) UA32423C2 (en)
YU (1) YU48648B (en)

Also Published As

Publication number Publication date
YU110692A (en) 1996-01-08
UA32423C2 (en) 2000-12-15
YU48648B (en) 1999-06-15
KR100248558B1 (en) 2000-04-01
KR940703812A (en) 1994-12-12
TW300889B (en) 1997-03-21

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