YU110692A - TETRAHYDROIZOHINOLINE UNITS - Google Patents
TETRAHYDROIZOHINOLINE UNITSInfo
- Publication number
- YU110692A YU110692A YU110692A YU110692A YU110692A YU 110692 A YU110692 A YU 110692A YU 110692 A YU110692 A YU 110692A YU 110692 A YU110692 A YU 110692A YU 110692 A YU110692 A YU 110692A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- groups
- alkyl
- alkoxy
- optionally substituted
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Pronalazak se odnosi na tetrahidroizohinolinska jedinjenja formule (I) i njihove farmaceutski prihvatljive soli, u kojima R1 predstavlja jedan ili vise supstituenata odabranih od H, halogena, hidroksi, alkil grupa koje su po potrebi supstituisane sa hidroksi, alkoksi, alkiltio, alkilsulfinil, alkilsulfonil, nitro, cijano, polihaloalkil, polihaloalkok-si, fenil grupa koje su po potrebi supstituisane jednom ili vise grupa odarbranih medju halogenima, alkil ili alkoksi grupama, ili je R1 po potrebi alkilovana karbamoil grupa; R2 predstavlja alifatičnu grupu koja je po potrebi supstituisana sa hidroksi ili alkoksi; E je alkilenski niz koji je po potrebi supstituisan jednom ili vise alkil grupa; i G predstavlja fenil grupu ili fenil supstituisan jednom ili vise alkil, alkoksi, halogene, hidroksi, polihaloalkil, polihaloalkoksi, cijano, alkiltio, alkilsulf inil, alkilsulfonil grupe, fenil grupe koje su po potrebi supstituisane jednim ili vise halogena, alkil ili alkoksi grupa, po potrebi alkilovane karbamoil grupe, ili G predstavlja fenil prsten koji je kondenzovan sa heterocikličnim ili aromatifnim karbocikličnim prstenom. Pronalazak obuhvata i O-acilovane derivate jedinjenja formule (I), koji predstavljaju lipofilne estre korisne u analgeziji i u tretiranju psihoza (na primer Šizofrenije), Parkinsonove bolesti, Lesch-Nyan-ovog sindroma, poremećaja pažnje, saznajnog poremećaja, kao i zavisnosti od lekova ili poznog poremećaja pokretljivosti.The invention relates to tetrahydroisoquinoline compounds of formula (I) and their pharmaceutically acceptable salts, in which R 1 represents one or more substituents selected from H, halogens, hydroxy, alkyl groups optionally substituted by hydroxy, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, nitro, cyano, polyhaloalkyl, polyhaloalkoxy, phenyl groups optionally substituted by one or more groups selected from halogens, alkyl or alkoxy groups, or R1 is an alkyl carbamoyl group optionally; R 2 represents an aliphatic group optionally substituted by hydroxy or alkoxy; E is an alkylene sequence optionally substituted by one or more alkyl groups; and G represents a phenyl group or phenyl substituted by one or more alkyl, alkoxy, halogens, hydroxy, polyhaloalkyl, polyhaloalkoxy, cyano, alkylthio, alkylsulfinyl, alkylsulfonyl groups, phenyl groups optionally substituted by one or more halogens, alkyl or alkoxy groups. optionally alkylated carbamoyl groups, or G represents a phenyl ring which is fused to a heterocyclic or aromatic carbocyclic ring. The invention also encompasses O-acylated derivatives of the compounds of formula (I), which are lipophilic esters useful in analgesia and in the treatment of psychoses (for example, schizophrenia), Parkinson's disease, Lesch-Nyan syndrome, attention deficit disorder, cognitive disorder and drug dependence or late impaired mobility.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919127306A GB9127306D0 (en) | 1991-12-23 | 1991-12-23 | Therapeutic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU110692A true YU110692A (en) | 1996-01-08 |
| YU48648B YU48648B (en) | 1999-06-15 |
Family
ID=47521612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU110692A YU48648B (en) | 1991-12-23 | 1992-12-23 | Tetrahydroyisoquinolinic compounds and methods of preparation thereof |
Country Status (5)
| Country | Link |
|---|---|
| KR (1) | KR100248558B1 (en) |
| MY (1) | MY108027A (en) |
| TW (1) | TW300889B (en) |
| UA (1) | UA32423C2 (en) |
| YU (1) | YU48648B (en) |
-
1992
- 1992-12-12 UA UA94005505A patent/UA32423C2/en unknown
- 1992-12-12 KR KR1019940702189A patent/KR100248558B1/en not_active IP Right Cessation
- 1992-12-22 MY MYPI92002362A patent/MY108027A/en unknown
- 1992-12-23 YU YU110692A patent/YU48648B/en unknown
-
1993
- 1993-06-22 TW TW082104999A patent/TW300889B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| KR940703812A (en) | 1994-12-12 |
| TW300889B (en) | 1997-03-21 |
| KR100248558B1 (en) | 2000-04-01 |
| UA32423C2 (en) | 2000-12-15 |
| MY108027A (en) | 1996-07-30 |
| YU48648B (en) | 1999-06-15 |
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