YU48648B - Tetrahydroyisoquinolinic compounds and methods of preparation thereof - Google Patents
Tetrahydroyisoquinolinic compounds and methods of preparation thereofInfo
- Publication number
- YU48648B YU48648B YU110692A YU110692A YU48648B YU 48648 B YU48648 B YU 48648B YU 110692 A YU110692 A YU 110692A YU 110692 A YU110692 A YU 110692A YU 48648 B YU48648 B YU 48648B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- 3alkoxy
- groups
- 3alkyl
- carbon atoms
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Tetrahidroizohinolinska jedinjenja formule (I): gde: R1 predstavlja jedan ili vise supstituenata odabranih od vodonika, halogena, hidroksi, C1-3alkil grupa koje su po potrebi supstituisane sa hidroksi, C1-3alkoksi, C1-3alkiltio, C1-3alkilsulfinil, C1-3alkilsulfonil, nitro, cijano, polihalogenovan C1-3alkil, polihalogenovan C1-3alkoksi, fenil grupe koje su po potrebi supstituisane jednim ili vise supstituenata odabranih medu halogenima, C1-3alkil ili C1-3alkoksi grupama, ili je R1 karbamoil grupa koja je po potrebi alkilovana sa jednom ili dve alkil grupe koje svaka nezavisno sadrze 1 do 3 ugljenikova atoma; R2 predstavlja alifaticnu grupu sa 1 do 3 ugljenikova atoma, po potrebi supstituisana sa hidroksi ili C1-3alkoksi; E je alkilenski niz sa 2 do 5 ugljenikovih atoma, po potrebi supstituisan jednom ili vise C1-3alkil grupa i G predstavlja fenil grupu ili fenil supstituisan jednim ili vise supstituenata kojji mogu biti isti ili razliciti i koji nezavisno predstavljaju C1-3alkil, C1-3alkoksi, halogene, hidroksi, polihalogenovane C1-3alkil, polihalogenovani C1-3alkoksi, cijano, C1-3alkiltio, C1-3alkilsulfinil, C1-3alkilsulfonil grupe, fenil grupe koje su po potrebi supstituisane jednim ili vise supstituenata odabranih medu halogenima, C1-3alkil ili C1-3alkoksi grupama, karbamoil grupe koje se po potrebi alkilovane sa jednom ili dve alkil grupe koje svaka nezavisno sadrze od 1 do 3 ugljenikova atoma ili G predstavlja fenil prsten koji je kondenzovan sa heterociklicnim ili aromaticnim karbociklicnim prstenom; i njihovi O-acilovani derivati formule (III): gde R7 predstavlja jednu acil grupu izvedenu iz jedne karboksilne kiseline koja ima 6 do 20 atoma ugljenika, a R1, R2, E i G su kako je definisano napred, pri cemu je O-acil grupa u polozaju 5, 6, 7 ili 8 tetrahidroizohinolinskog prstena. - Prijava sadrzi jos 1 nezavisan i 12 zavisnih zahteva.Tetrahydroisoquinoline Compounds of Formula (I): wherein: R1 represents one or more substituents selected from hydrogen, halogen, hydroxy, C1-3alkyl groups optionally substituted by hydroxy, C1-3alkoxy, C1-3alkylthio, C1-3alkylsulfonyl, C1-3alkylsulfonyl , nitro, cyano, polyhalogenated C1-3alkyl, polyhalogenated C1-3alkoxy, phenyl groups optionally substituted by one or more substituents selected from halogens, C1-3alkyl or C1-3alkoxy groups, or R1 is a carbamoyl group optionally alkylated with one or two alkyl groups each independently containing 1 to 3 carbon atoms; R2 represents an aliphatic group of 1 to 3 carbon atoms, optionally substituted by hydroxy or C1-3alkoxy; E is an alkylene sequence of 2 to 5 carbon atoms optionally substituted by one or more C1-3 alkyl groups and G represents a phenyl group or phenyl substituted by one or more substituents which may be the same or different and independently represent C1-3alkyl, C1-3alkoxy , halogens, hydroxy, polyhalogenated C1-3alkyl, polyhalogenated C1-3alkoxy, cyano, C1-3alkylthio, C1-3alkylsulfinyl, C1-3alkylsulfonyl groups, phenyl groups optionally substituted by one or more substituents selected from halogens, C1-3alkyl or C1 -3alkoxy groups, carbamoyl groups optionally alkylated with one or two alkyl groups each independently containing from 1 to 3 carbon atoms or G represents a phenyl ring fused to a heterocyclic or aromatic carbocyclic ring; and their O-acylated derivatives of formula (III): wherein R7 represents an acyl group derived from one carboxylic acid having 6 to 20 carbon atoms, and R1, R2, E and G are as defined above, with O-acyl group at the 5, 6, 7 or 8 position of the tetrahydroisoquinoline ring. - The application contains 1 more independent and 12 dependent requests.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919127306A GB9127306D0 (en) | 1991-12-23 | 1991-12-23 | Therapeutic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU110692A YU110692A (en) | 1996-01-08 |
| YU48648B true YU48648B (en) | 1999-06-15 |
Family
ID=47521612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU110692A YU48648B (en) | 1991-12-23 | 1992-12-23 | Tetrahydroyisoquinolinic compounds and methods of preparation thereof |
Country Status (5)
| Country | Link |
|---|---|
| KR (1) | KR100248558B1 (en) |
| MY (1) | MY108027A (en) |
| TW (1) | TW300889B (en) |
| UA (1) | UA32423C2 (en) |
| YU (1) | YU48648B (en) |
-
1992
- 1992-12-12 KR KR1019940702189A patent/KR100248558B1/en not_active IP Right Cessation
- 1992-12-12 UA UA94005505A patent/UA32423C2/en unknown
- 1992-12-22 MY MYPI92002362A patent/MY108027A/en unknown
- 1992-12-23 YU YU110692A patent/YU48648B/en unknown
-
1993
- 1993-06-22 TW TW082104999A patent/TW300889B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| MY108027A (en) | 1996-07-30 |
| KR940703812A (en) | 1994-12-12 |
| KR100248558B1 (en) | 2000-04-01 |
| TW300889B (en) | 1997-03-21 |
| YU110692A (en) | 1996-01-08 |
| UA32423C2 (en) | 2000-12-15 |
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