UA32423C2 - Tetrahydroisoquinoline compounds or their pharmaceutically acceptable salts, method of their synthesis, pharmaceutical composition based on thereof and method of dophamine receptor d1 and d2 binding - Google Patents

Tetrahydroisoquinoline compounds or their pharmaceutically acceptable salts, method of their synthesis, pharmaceutical composition based on thereof and method of dophamine receptor d1 and d2 binding

Info

Publication number
UA32423C2
UA32423C2 UA94005505A UA94005505A UA32423C2 UA 32423 C2 UA32423 C2 UA 32423C2 UA 94005505 A UA94005505 A UA 94005505A UA 94005505 A UA94005505 A UA 94005505A UA 32423 C2 UA32423 C2 UA 32423C2
Authority
UA
Ukraine
Prior art keywords
compounds
dophamine
receptor
synthesis
binding
Prior art date
Application number
UA94005505A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Ентонін Козлік
Энтонин Козлик
Брюс Джеремі Саргент
Брюс Джереми Саргент
Патрісія Леслі Нідхем
Патрисия Лесли Нидхем
Original Assignee
Дзе Бутс Компані Плс
Дзе Бутс Компани ПЛС
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919127306A external-priority patent/GB9127306D0/en
Application filed by Дзе Бутс Компані Плс, Дзе Бутс Компани ПЛС filed Critical Дзе Бутс Компані Плс
Publication of UA32423C2 publication Critical patent/UA32423C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to novel tetrahydroisoquinoline compounds, to pharmaceutical compositions containing the compounds, methods of preparing the compounds and the use of the compounds in analgesia and in the treatment of psychoses, Parkinsons's disease, Lesch-Nyan syndrome, attention deficit disorder or cognitive impairment or in the relief of drug dependence or tardive dyskinesia.
UA94005505A 1991-12-23 1992-12-12 Tetrahydroisoquinoline compounds or their pharmaceutically acceptable salts, method of their synthesis, pharmaceutical composition based on thereof and method of dophamine receptor d1 and d2 binding UA32423C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919127306A GB9127306D0 (en) 1991-12-23 1991-12-23 Therapeutic agents
PCT/EP1992/002900 WO1993013073A1 (en) 1991-12-23 1992-12-12 Substituted tetrahydroisoquinolines and their use as therapeutic agents

Publications (1)

Publication Number Publication Date
UA32423C2 true UA32423C2 (en) 2000-12-15

Family

ID=47521612

Family Applications (1)

Application Number Title Priority Date Filing Date
UA94005505A UA32423C2 (en) 1991-12-23 1992-12-12 Tetrahydroisoquinoline compounds or their pharmaceutically acceptable salts, method of their synthesis, pharmaceutical composition based on thereof and method of dophamine receptor d1 and d2 binding

Country Status (5)

Country Link
KR (1) KR100248558B1 (en)
MY (1) MY108027A (en)
TW (1) TW300889B (en)
UA (1) UA32423C2 (en)
YU (1) YU48648B (en)

Also Published As

Publication number Publication date
MY108027A (en) 1996-07-30
YU48648B (en) 1999-06-15
KR100248558B1 (en) 2000-04-01
YU110692A (en) 1996-01-08
TW300889B (en) 1997-03-21
KR940703812A (en) 1994-12-12

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