CA2198875A1 - Quinazolinone pharmaceuticals and use thereof - Google Patents

Quinazolinone pharmaceuticals and use thereof

Info

Publication number
CA2198875A1
CA2198875A1 CA002198875A CA2198875A CA2198875A1 CA 2198875 A1 CA2198875 A1 CA 2198875A1 CA 002198875 A CA002198875 A CA 002198875A CA 2198875 A CA2198875 A CA 2198875A CA 2198875 A1 CA2198875 A1 CA 2198875A1
Authority
CA
Canada
Prior art keywords
group
hydrogen
quinazolinone
pharmaceuticals
lower alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002198875A
Other languages
French (fr)
Other versions
CA2198875C (en
Inventor
Arnon Nagler
Shimon Slavin
Israel Vlodavsky
Mark Pines
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hadasit Medical Research Services and Development Co
Agricultural Research Organization of Israel Ministry of Agriculture
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL11083194A external-priority patent/IL110831A/en
Application filed by Individual filed Critical Individual
Publication of CA2198875A1 publication Critical patent/CA2198875A1/en
Application granted granted Critical
Publication of CA2198875C publication Critical patent/CA2198875C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides a pharmaceutical composition for preventing restenosis by the inhibition of vascular smooth muscle cell proliferation, comprising a compound of formula I:
wherein: n=1 or 2 R1 is a member of the group consisting of hydrogen, halogen, nitro, benzo, lower alkyl, phenyl and lower alkoxy;
R2 is a member of the group consisting of hydroxy, acetoxy, and lower alkoxy, and R3 is a member of the group consisting of hydrogen and lower alkenoxy-carbonyl as active ingredient therein, or a physiologically acceptable salt thereof, in combination with a pharmaceutically acceptable carrier.
CA002198875A 1994-08-31 1995-08-29 Quinazolinone pharmaceuticals and use thereof Expired - Fee Related CA2198875C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL11083194A IL110831A (en) 1994-08-31 1994-08-31 Pharmaceutical compositions containing quinazolinone derivatives for preventing restenosis
IL110831 1994-08-31
PCT/US1995/011186 WO1996006616A1 (en) 1994-08-31 1995-08-29 Quinazolinone pharmaceuticals and use thereof

Publications (2)

Publication Number Publication Date
CA2198875A1 true CA2198875A1 (en) 1996-03-07
CA2198875C CA2198875C (en) 2005-11-15

Family

ID=35530890

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002198875A Expired - Fee Related CA2198875C (en) 1994-08-31 1995-08-29 Quinazolinone pharmaceuticals and use thereof

Country Status (1)

Country Link
CA (1) CA2198875C (en)

Also Published As

Publication number Publication date
CA2198875C (en) 2005-11-15

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed