ES2133543T3 - Derivados de pirrolidina y oxazolidina, su preparacion y su uso como inhibidores de la agregacion de trombocitos. - Google Patents
Derivados de pirrolidina y oxazolidina, su preparacion y su uso como inhibidores de la agregacion de trombocitos.Info
- Publication number
- ES2133543T3 ES2133543T3 ES94908350T ES94908350T ES2133543T3 ES 2133543 T3 ES2133543 T3 ES 2133543T3 ES 94908350 T ES94908350 T ES 94908350T ES 94908350 T ES94908350 T ES 94908350T ES 2133543 T3 ES2133543 T3 ES 2133543T3
- Authority
- ES
- Spain
- Prior art keywords
- pct
- inhibitors
- pirrolidine
- preparation
- thrombocyte aggregation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A COMPUESTOS HETEROCICLICOS DE LA FORMULA GENERAL (I), DONDE A, B, R, R{SUP,2}, R{SUP,3},W, Y, Z{SUP,1}, Z{SUP,2} ASI COMO R TIENEN EL SIGNIFICADO DADO EN LA DESCRIPCION, PROCESO PARA SU ELABORACION Y SU UTILIZACION COMO SUSTANCIA INHIBIDORA DE LA AGREGACION DE TROMBOCITOS, DE LA METASTASIS DE CELULAS CANCERIGENAS ASI COMO DE UNION OSTEOCLASTA EN LA SUPERFICIE DE LOS HUESOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4308034A DE4308034A1 (de) | 1993-03-13 | 1993-03-13 | Neue Heterocyclen, ihre Herstellung und ihre Verwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2133543T3 true ES2133543T3 (es) | 1999-09-16 |
Family
ID=6482724
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94908350T Expired - Lifetime ES2133543T3 (es) | 1993-03-13 | 1994-02-19 | Derivados de pirrolidina y oxazolidina, su preparacion y su uso como inhibidores de la agregacion de trombocitos. |
Country Status (15)
Country | Link |
---|---|
US (1) | US5658935A (es) |
EP (1) | EP0688315B1 (es) |
JP (1) | JP3547745B2 (es) |
KR (1) | KR100379051B1 (es) |
AT (1) | ATE179698T1 (es) |
AU (1) | AU678438B2 (es) |
CA (1) | CA2155842A1 (es) |
DE (2) | DE4308034A1 (es) |
DK (1) | DK0688315T3 (es) |
ES (1) | ES2133543T3 (es) |
GR (1) | GR3030699T3 (es) |
HU (1) | HUT72756A (es) |
IL (1) | IL108943A (es) |
WO (1) | WO1994021607A1 (es) |
ZA (1) | ZA941714B (es) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4427979A1 (de) * | 1993-11-15 | 1996-02-15 | Cassella Ag | Substituierte 5-Ring-Heterocyclen, ihre Herstellung und ihre Verwendung |
PT796855E (pt) | 1996-03-20 | 2002-07-31 | Hoechst Ag | Inibicao da reabsorcao nos ossos e antagonistas de vitronectina |
US5925635A (en) * | 1996-04-17 | 1999-07-20 | Dupont Pharmaceuticals Company | N-(amidinophenyl) cyclourea analogs as factor XA inhibitors |
DE19622489A1 (de) | 1996-06-05 | 1997-12-11 | Hoechst Ag | Salze des 3-(2-(4-(4-(Amino-imino-methyl)-phenyl)-4- methyl-2,5-dioxo-imidazolidin-1-yl)-acetylamino)-3- phenyl-propionsäure-ethylesters |
DE19647380A1 (de) * | 1996-11-15 | 1998-05-20 | Hoechst Ag | 5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
DE19741235A1 (de) * | 1997-09-18 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE19741873A1 (de) * | 1997-09-23 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE19751251A1 (de) | 1997-11-19 | 1999-05-20 | Hoechst Marion Roussel De Gmbh | Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate |
DE19821483A1 (de) | 1998-05-14 | 1999-11-18 | Hoechst Marion Roussel De Gmbh | Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE19922462A1 (de) | 1999-05-17 | 2000-11-23 | Aventis Pharma Gmbh | Spiro-imidazolidinderivate, ihre Herstellung ihre Verwendung und sie enthaltende pharmazeutische Präparate |
EP1151994A1 (en) * | 2000-05-01 | 2001-11-07 | Ethyl Corporation | Succinimide-acid compounds and derivatives thereof |
DE10111877A1 (de) | 2001-03-10 | 2002-09-12 | Aventis Pharma Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE10137595A1 (de) * | 2001-08-01 | 2003-02-13 | Aventis Pharma Gmbh | Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung |
TWI329105B (en) * | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
US20060039949A1 (en) * | 2004-08-20 | 2006-02-23 | Nycz Jeffrey H | Acetabular cup with controlled release of an osteoinductive formulation |
US20060045902A1 (en) * | 2004-09-01 | 2006-03-02 | Serbousek Jon C | Polymeric wrap for in vivo delivery of osteoinductive formulations |
US20060057184A1 (en) * | 2004-09-16 | 2006-03-16 | Nycz Jeffrey H | Process to treat avascular necrosis (AVN) with osteoinductive materials |
US8414907B2 (en) | 2005-04-28 | 2013-04-09 | Warsaw Orthopedic, Inc. | Coatings on medical implants to guide soft tissue healing |
US9119901B2 (en) * | 2005-04-28 | 2015-09-01 | Warsaw Orthopedic, Inc. | Surface treatments for promoting selective tissue attachment to medical impants |
US20070179615A1 (en) * | 2006-01-31 | 2007-08-02 | Sdgi Holdings, Inc. | Intervertebral prosthetic disc |
US20070280986A1 (en) * | 2006-06-01 | 2007-12-06 | Carlos Gil | Intra-operative coating of implants |
US8133553B2 (en) | 2007-06-18 | 2012-03-13 | Zimmer, Inc. | Process for forming a ceramic layer |
US8309521B2 (en) | 2007-06-19 | 2012-11-13 | Zimmer, Inc. | Spacer with a coating thereon for use with an implant device |
US8608049B2 (en) | 2007-10-10 | 2013-12-17 | Zimmer, Inc. | Method for bonding a tantalum structure to a cobalt-alloy substrate |
US20090192609A1 (en) * | 2008-01-29 | 2009-07-30 | Zimmer, Inc. | Implant device for use in an implant system |
US11020160B2 (en) | 2016-03-21 | 2021-06-01 | Warsaw Orthopedic, Inc. | Surgical injection system and method |
US10709814B2 (en) | 2016-04-22 | 2020-07-14 | Warsaw Orthopedic, Inc. | Osteoimplant comprising an insoluble fibrous polymer |
US11292782B2 (en) | 2018-11-30 | 2022-04-05 | Nuvation Bio Inc. | Diarylhydantoin compounds and methods of use thereof |
WO2020113094A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1539817A (en) * | 1976-10-22 | 1979-02-07 | Ucb Sa | N-substituted lactams |
GB2032419B (en) * | 1978-09-05 | 1983-01-19 | Wellcome Found | Hydantoin prostaglandin analogues |
DK75884A (da) * | 1983-02-18 | 1984-08-19 | Wellcome Found | Heterocycliske forbindelser, deres syntese, praeparater, der indeholder dem, og deres medicinske anvendelse |
CA1279643C (en) * | 1985-02-07 | 1991-01-29 | Hiroyuki Kouji | N-substituted-phenylteraconimide compound, herbicidal composition, and method for the destruction of undesirable weeds |
DE4009506A1 (de) * | 1990-03-24 | 1991-09-26 | Hoechst Ag | Hydantoinderivate |
HUT68769A (en) * | 1991-05-07 | 1995-07-28 | Merck & Co Inc | FIBRINOGéN RECEPTOR ANTAGONIST COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AS EFFECTIVE SUBSTANCE |
DE4126277A1 (de) * | 1991-08-08 | 1993-02-11 | Cassella Ag | Hydantoinderivate |
DE4213634A1 (de) * | 1992-04-24 | 1993-10-28 | Cassella Ag | 2,4-Dioxo-imidazolidin-Derivate |
DE4224414A1 (de) * | 1992-07-24 | 1994-01-27 | Cassella Ag | Phenylimidazolidin-derivate, ihre Herstellung und ihre Verwendung |
-
1993
- 1993-03-13 DE DE4308034A patent/DE4308034A1/de not_active Withdrawn
-
1994
- 1994-02-19 JP JP52055994A patent/JP3547745B2/ja not_active Expired - Fee Related
- 1994-02-19 CA CA002155842A patent/CA2155842A1/en not_active Abandoned
- 1994-02-19 AT AT94908350T patent/ATE179698T1/de not_active IP Right Cessation
- 1994-02-19 HU HU9502660A patent/HUT72756A/hu unknown
- 1994-02-19 US US08/513,897 patent/US5658935A/en not_active Expired - Lifetime
- 1994-02-19 DE DE59408213T patent/DE59408213D1/de not_active Expired - Lifetime
- 1994-02-19 ES ES94908350T patent/ES2133543T3/es not_active Expired - Lifetime
- 1994-02-19 KR KR1019950703843A patent/KR100379051B1/ko not_active IP Right Cessation
- 1994-02-19 AU AU61423/94A patent/AU678438B2/en not_active Ceased
- 1994-02-19 DK DK94908350T patent/DK0688315T3/da active
- 1994-02-19 WO PCT/EP1994/000481 patent/WO1994021607A1/de active IP Right Grant
- 1994-02-19 EP EP94908350A patent/EP0688315B1/de not_active Expired - Lifetime
- 1994-03-11 ZA ZA941714A patent/ZA941714B/xx unknown
- 1994-03-11 IL IL10894394A patent/IL108943A/en active IP Right Grant
-
1999
- 1999-07-07 GR GR990401782T patent/GR3030699T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
KR960701008A (ko) | 1996-02-24 |
DE4308034A1 (de) | 1994-09-15 |
IL108943A (en) | 2001-04-30 |
ZA941714B (en) | 1994-10-05 |
HU9502660D0 (en) | 1995-11-28 |
IL108943A0 (en) | 1994-06-24 |
EP0688315A1 (de) | 1995-12-27 |
HUT72756A (en) | 1996-05-28 |
JP3547745B2 (ja) | 2004-07-28 |
KR100379051B1 (ko) | 2003-08-21 |
AU678438B2 (en) | 1997-05-29 |
US5658935A (en) | 1997-08-19 |
EP0688315B1 (de) | 1999-05-06 |
ATE179698T1 (de) | 1999-05-15 |
JPH08509209A (ja) | 1996-10-01 |
DK0688315T3 (da) | 1999-11-01 |
CA2155842A1 (en) | 1994-09-29 |
WO1994021607A1 (de) | 1994-09-29 |
AU6142394A (en) | 1994-10-11 |
DE59408213D1 (de) | 1999-06-10 |
GR3030699T3 (en) | 1999-11-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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