DK0688315T3 - Pyrrolidin- og oxazolidinderivater, deres fremstilling og deres anvendelse som trombocytaggregationsinhibitorer - Google Patents

Pyrrolidin- og oxazolidinderivater, deres fremstilling og deres anvendelse som trombocytaggregationsinhibitorer

Info

Publication number
DK0688315T3
DK0688315T3 DK94908350T DK94908350T DK0688315T3 DK 0688315 T3 DK0688315 T3 DK 0688315T3 DK 94908350 T DK94908350 T DK 94908350T DK 94908350 T DK94908350 T DK 94908350T DK 0688315 T3 DK0688315 T3 DK 0688315T3
Authority
DK
Denmark
Prior art keywords
pct
pyrrolidine
preparation
platelet aggregation
aggregation inhibitors
Prior art date
Application number
DK94908350T
Other languages
English (en)
Inventor
Gerhard Breipohl
Gerhard Zoller
Melitta Just
Jochen Knolle
Otmar Klingler
Bernd Jablonka
Wolfgang Kinig
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Application granted granted Critical
Publication of DK0688315T3 publication Critical patent/DK0688315T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK94908350T 1993-03-13 1994-02-19 Pyrrolidin- og oxazolidinderivater, deres fremstilling og deres anvendelse som trombocytaggregationsinhibitorer DK0688315T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4308034A DE4308034A1 (de) 1993-03-13 1993-03-13 Neue Heterocyclen, ihre Herstellung und ihre Verwendung
PCT/EP1994/000481 WO1994021607A1 (de) 1993-03-13 1994-02-19 Neue heterocyclen, ihre herstellung und ihre verwendung

Publications (1)

Publication Number Publication Date
DK0688315T3 true DK0688315T3 (da) 1999-11-01

Family

ID=6482724

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94908350T DK0688315T3 (da) 1993-03-13 1994-02-19 Pyrrolidin- og oxazolidinderivater, deres fremstilling og deres anvendelse som trombocytaggregationsinhibitorer

Country Status (15)

Country Link
US (1) US5658935A (da)
EP (1) EP0688315B1 (da)
JP (1) JP3547745B2 (da)
KR (1) KR100379051B1 (da)
AT (1) ATE179698T1 (da)
AU (1) AU678438B2 (da)
CA (1) CA2155842A1 (da)
DE (2) DE4308034A1 (da)
DK (1) DK0688315T3 (da)
ES (1) ES2133543T3 (da)
GR (1) GR3030699T3 (da)
HU (1) HUT72756A (da)
IL (1) IL108943A (da)
WO (1) WO1994021607A1 (da)
ZA (1) ZA941714B (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4427979A1 (de) * 1993-11-15 1996-02-15 Cassella Ag Substituierte 5-Ring-Heterocyclen, ihre Herstellung und ihre Verwendung
DE59706273D1 (de) 1996-03-20 2002-03-21 Hoechst Ag Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
US5925635A (en) * 1996-04-17 1999-07-20 Dupont Pharmaceuticals Company N-(amidinophenyl) cyclourea analogs as factor XA inhibitors
DE19622489A1 (de) 1996-06-05 1997-12-11 Hoechst Ag Salze des 3-(2-(4-(4-(Amino-imino-methyl)-phenyl)-4- methyl-2,5-dioxo-imidazolidin-1-yl)-acetylamino)-3- phenyl-propionsäure-ethylesters
DE19647380A1 (de) * 1996-11-15 1998-05-20 Hoechst Ag 5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten
DE19741235A1 (de) * 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19741873A1 (de) * 1997-09-23 1999-03-25 Hoechst Marion Roussel De Gmbh Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19751251A1 (de) 1997-11-19 1999-05-20 Hoechst Marion Roussel De Gmbh Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
DE19821483A1 (de) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19922462A1 (de) 1999-05-17 2000-11-23 Aventis Pharma Gmbh Spiro-imidazolidinderivate, ihre Herstellung ihre Verwendung und sie enthaltende pharmazeutische Präparate
JP2001316361A (ja) 2000-05-01 2001-11-13 Ethyl Corp スクシンイミド−酸化合物およびそれの誘導体
DE10111877A1 (de) 2001-03-10 2002-09-12 Aventis Pharma Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE10137595A1 (de) * 2001-08-01 2003-02-13 Aventis Pharma Gmbh Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung
TWI329105B (en) * 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
US20060039949A1 (en) * 2004-08-20 2006-02-23 Nycz Jeffrey H Acetabular cup with controlled release of an osteoinductive formulation
US20060045902A1 (en) * 2004-09-01 2006-03-02 Serbousek Jon C Polymeric wrap for in vivo delivery of osteoinductive formulations
US20060057184A1 (en) * 2004-09-16 2006-03-16 Nycz Jeffrey H Process to treat avascular necrosis (AVN) with osteoinductive materials
US8414907B2 (en) 2005-04-28 2013-04-09 Warsaw Orthopedic, Inc. Coatings on medical implants to guide soft tissue healing
US9119901B2 (en) * 2005-04-28 2015-09-01 Warsaw Orthopedic, Inc. Surface treatments for promoting selective tissue attachment to medical impants
US20070179615A1 (en) * 2006-01-31 2007-08-02 Sdgi Holdings, Inc. Intervertebral prosthetic disc
US20070280986A1 (en) * 2006-06-01 2007-12-06 Carlos Gil Intra-operative coating of implants
US8133553B2 (en) 2007-06-18 2012-03-13 Zimmer, Inc. Process for forming a ceramic layer
US8309521B2 (en) 2007-06-19 2012-11-13 Zimmer, Inc. Spacer with a coating thereon for use with an implant device
US8608049B2 (en) 2007-10-10 2013-12-17 Zimmer, Inc. Method for bonding a tantalum structure to a cobalt-alloy substrate
WO2009096945A1 (en) * 2008-01-29 2009-08-06 Zimmer, Inc. Implant device for use in an implant system
US11020160B2 (en) 2016-03-21 2021-06-01 Warsaw Orthopedic, Inc. Surgical injection system and method
US10709814B2 (en) 2016-04-22 2020-07-14 Warsaw Orthopedic, Inc. Osteoimplant comprising an insoluble fibrous polymer
CA3121202A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
US11292782B2 (en) 2018-11-30 2022-04-05 Nuvation Bio Inc. Diarylhydantoin compounds and methods of use thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1539817A (en) * 1976-10-22 1979-02-07 Ucb Sa N-substituted lactams
GB2032419B (en) * 1978-09-05 1983-01-19 Wellcome Found Hydantoin prostaglandin analogues
AU561156B2 (en) * 1983-02-18 1987-04-30 Wellcome Foundation Limited, The Hydantoin derivatives
CA1279643C (en) * 1985-02-07 1991-01-29 Hiroyuki Kouji N-substituted-phenylteraconimide compound, herbicidal composition, and method for the destruction of undesirable weeds
DE4009506A1 (de) * 1990-03-24 1991-09-26 Hoechst Ag Hydantoinderivate
HUT68769A (en) * 1991-05-07 1995-07-28 Merck & Co Inc FIBRINOGéN RECEPTOR ANTAGONIST COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AS EFFECTIVE SUBSTANCE
DE4126277A1 (de) * 1991-08-08 1993-02-11 Cassella Ag Hydantoinderivate
DE4213634A1 (de) * 1992-04-24 1993-10-28 Cassella Ag 2,4-Dioxo-imidazolidin-Derivate
DE4224414A1 (de) * 1992-07-24 1994-01-27 Cassella Ag Phenylimidazolidin-derivate, ihre Herstellung und ihre Verwendung

Also Published As

Publication number Publication date
JPH08509209A (ja) 1996-10-01
WO1994021607A1 (de) 1994-09-29
CA2155842A1 (en) 1994-09-29
KR960701008A (ko) 1996-02-24
GR3030699T3 (en) 1999-11-30
US5658935A (en) 1997-08-19
HU9502660D0 (en) 1995-11-28
DE59408213D1 (de) 1999-06-10
HUT72756A (en) 1996-05-28
KR100379051B1 (ko) 2003-08-21
JP3547745B2 (ja) 2004-07-28
ATE179698T1 (de) 1999-05-15
ES2133543T3 (es) 1999-09-16
IL108943A0 (en) 1994-06-24
EP0688315B1 (de) 1999-05-06
DE4308034A1 (de) 1994-09-15
EP0688315A1 (de) 1995-12-27
AU6142394A (en) 1994-10-11
ZA941714B (en) 1994-10-05
IL108943A (en) 2001-04-30
AU678438B2 (en) 1997-05-29

Similar Documents

Publication Publication Date Title
DK0688315T3 (da) Pyrrolidin- og oxazolidinderivater, deres fremstilling og deres anvendelse som trombocytaggregationsinhibitorer
AP2001002204A0 (en) Pyrazole derivatives.
DK41193D0 (da) Ionkanalaabnere
TR199901765T2 (xx) S�lfomid-metalloproteaz inhibit�rleri
NO990667D0 (no) Depeptid-benzamidin som kinogenase-inhibitor
DK0766696T3 (da) Thiazolidinderivater, fremstilling af disse forbindelser og lægemidler indeholdende disse forbindelser
ATE416157T1 (de) Inhibitoren von integrin alpha-v-beta-6
DK0839041T3 (da) Salte af amidinderivater og cyclooxygenaseinhibitorer, deres fremstillingsmåde og anvendelse som medikamenter og farmaceutiske sammensætninger indeholdende disse
DK0689549T3 (da) Nye urinstofderivater, deres fremstilling og anvendelse
IL116231A (en) Dipeptide p-amidinobenzylamides with n-terminal sulfonyl or aminosulfonyl radicals as thrombin inhibitors
AU2001263278A1 (en) Cyclic gmp-specific phosphodiesterase inhibitors
NO20022123L (no) Osoksazolderivater for anvendelse som inhibitorer for fosfodiesterase VII
DK0490816T3 (da) Fluorforbindelser som aromatase-inhibitorer.
TR200100133T2 (tr) FKBP İnhibitörleri
AU2001296699A1 (en) Condensed pyrazindione derivatives as pde inhibitors
DK0775113T3 (da) N-substituerede azabicycloheptan-derivater som neuroleptika osv.
CA2423357A1 (en) Fused heterocyclic derivatives as phosphodiesterase inhibitors
ATE149159T1 (de) Heteroarylmethylbenzole-aromatasehemmer
DK0687257T3 (da) 4-amino-2-(hetero)aryl-butanamider anvendelige som 5HT1A-antagonister
MXPA04001442A (es) Derivados de m-aminofenol y agentes colorantes que contienen estos compuestos.
DK0662081T3 (da) Ureidoacetamidderivater, deres fremstilling og lægemidler indeholdende disse derivater
ZA955052B (en) Pyrrolidine derivatives their preparation and compositions containing them