DK0689549T3 - Nye urinstofderivater, deres fremstilling og anvendelse - Google Patents
Nye urinstofderivater, deres fremstilling og anvendelseInfo
- Publication number
- DK0689549T3 DK0689549T3 DK94911129T DK94911129T DK0689549T3 DK 0689549 T3 DK0689549 T3 DK 0689549T3 DK 94911129 T DK94911129 T DK 94911129T DK 94911129 T DK94911129 T DK 94911129T DK 0689549 T3 DK0689549 T3 DK 0689549T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- preparation
- urea derivatives
- sec
- new urea
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Closures For Containers (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4309867A DE4309867A1 (de) | 1993-03-26 | 1993-03-26 | Neue Harnstoffderivate, ihre Herstellung und Verwendung |
| PCT/EP1994/000713 WO1994022907A1 (de) | 1993-03-26 | 1994-03-09 | Neue harnstoffderivate, ihre herstellung und verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0689549T3 true DK0689549T3 (da) | 1999-02-01 |
Family
ID=6483938
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94911129T DK0689549T3 (da) | 1993-03-26 | 1994-03-09 | Nye urinstofderivater, deres fremstilling og anvendelse |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5703050A (da) |
| EP (1) | EP0689549B1 (da) |
| JP (1) | JP3597862B2 (da) |
| KR (1) | KR100418144B1 (da) |
| AT (1) | ATE167483T1 (da) |
| AU (1) | AU679509B2 (da) |
| CA (1) | CA2155843C (da) |
| DE (2) | DE4309867A1 (da) |
| DK (1) | DK0689549T3 (da) |
| ES (1) | ES2119187T3 (da) |
| HU (1) | HU219483B (da) |
| IL (1) | IL109135A (da) |
| WO (1) | WO1994022907A1 (da) |
| ZA (1) | ZA942124B (da) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4427979A1 (de) | 1993-11-15 | 1996-02-15 | Cassella Ag | Substituierte 5-Ring-Heterocyclen, ihre Herstellung und ihre Verwendung |
| US6248713B1 (en) * | 1995-07-11 | 2001-06-19 | Biogen, Inc. | Cell adhesion inhibitors |
| RO118289B1 (ro) | 1995-08-30 | 2003-04-30 | Gd Searle & Co Chicago | Derivati de fenilcarboniluree si compozitie farmaceutica |
| WO1997026250A1 (en) * | 1996-01-16 | 1997-07-24 | Merck & Co., Inc. | Integrin receptor antagonists |
| DE19622489A1 (de) | 1996-06-05 | 1997-12-11 | Hoechst Ag | Salze des 3-(2-(4-(4-(Amino-imino-methyl)-phenyl)-4- methyl-2,5-dioxo-imidazolidin-1-yl)-acetylamino)-3- phenyl-propionsäure-ethylesters |
| US6239108B1 (en) | 1996-07-11 | 2001-05-29 | Biogen, Inc. | Cell adhesion inhibitors |
| ATE363658T1 (de) | 1996-07-25 | 2007-06-15 | Biogen Idec Inc | Molekülmodell für vla-4-inhibitoren |
| US6686350B1 (en) | 1996-07-25 | 2004-02-03 | Biogen, Inc. | Cell adhesion inhibitors |
| YU75500A (sh) | 1998-05-28 | 2002-12-10 | Biogen Inc. | NOVI VLA-4 INHIBITORI oMePUPA-V |
| US6420403B1 (en) * | 1998-10-29 | 2002-07-16 | Edwin J. Iwanowicz | Inhibitors of IMPDH enzyme |
| IL148014A0 (en) | 1999-08-13 | 2002-09-12 | Biogen Inc | Cell adhesion inhibitors |
| CN1352641A (zh) * | 1999-09-29 | 2002-06-05 | 奥索-麦克尼尔药品公司 | 用于治疗整联蛋白介导的疾病的异哌啶甲酰胺 |
| EP1162194A1 (en) * | 2000-06-06 | 2001-12-12 | Aventis Pharma Deutschland GmbH | Factor VIIa inhibitory (thio)urea derivatives, their preparation and their use |
| US6875743B1 (en) | 2000-11-28 | 2005-04-05 | Biogen, Inc. | Cell adhesion inhibitors |
| DE10063008A1 (de) * | 2000-12-16 | 2002-06-20 | Merck Patent Gmbh | Carbonsäureamidderivate |
| US7081460B2 (en) * | 2001-04-09 | 2006-07-25 | Ortho-Mcneil Pharmaceutical, Inc. | Quinazoline and quinazoline-like compounds for the treatment of integrin-mediated disorders |
| EP1270551A1 (en) * | 2001-06-26 | 2003-01-02 | Aventis Pharma Deutschland GmbH | Urea derivatives with antiproteolytic activity |
| CN113717079B (zh) * | 2021-09-30 | 2023-03-31 | 内蒙古康普药业有限公司 | 一种甲氧氯普胺双胺新杂质的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5051405A (en) * | 1989-10-10 | 1991-09-24 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Anti-thrombotic peptides and pseudopeptides |
| US5053392A (en) * | 1989-12-01 | 1991-10-01 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Novel arginine, glycine, aspartic acid derivatives as platelet-aggregation inhibitors |
| DE4009506A1 (de) * | 1990-03-24 | 1991-09-26 | Hoechst Ag | Hydantoinderivate |
| JPH06505978A (ja) * | 1991-02-05 | 1994-07-07 | スミスクライン・ビーチャム・コーポレイション | 芳香族エステルまたはアミドを含有する抗凝集性ペプチド |
| US5321034A (en) * | 1991-05-07 | 1994-06-14 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| EP0513675B1 (en) * | 1991-05-13 | 1996-09-11 | Fujisawa Pharmaceutical Co., Ltd. | New peptide compound and a process for the preparation thereof |
| DE4126277A1 (de) * | 1991-08-08 | 1993-02-11 | Cassella Ag | Hydantoinderivate |
| US5272162A (en) * | 1992-07-02 | 1993-12-21 | G. D. Searle & Co. | Platelet aggregation inhibitors |
| US5314902A (en) * | 1993-01-27 | 1994-05-24 | Monsanto Company | Urea derivatives useful as platelet aggregation inhibitors |
-
1993
- 1993-03-26 DE DE4309867A patent/DE4309867A1/de not_active Withdrawn
-
1994
- 1994-03-09 DE DE59406279T patent/DE59406279D1/de not_active Expired - Lifetime
- 1994-03-09 AT AT94911129T patent/ATE167483T1/de not_active IP Right Cessation
- 1994-03-09 EP EP94911129A patent/EP0689549B1/de not_active Expired - Lifetime
- 1994-03-09 AU AU63754/94A patent/AU679509B2/en not_active Ceased
- 1994-03-09 HU HU9502792A patent/HU219483B/hu not_active IP Right Cessation
- 1994-03-09 WO PCT/EP1994/000713 patent/WO1994022907A1/de active IP Right Grant
- 1994-03-09 US US08/513,815 patent/US5703050A/en not_active Expired - Lifetime
- 1994-03-09 DK DK94911129T patent/DK0689549T3/da active
- 1994-03-09 CA CA002155843A patent/CA2155843C/en not_active Expired - Fee Related
- 1994-03-09 JP JP52159194A patent/JP3597862B2/ja not_active Expired - Lifetime
- 1994-03-09 KR KR1019950704123A patent/KR100418144B1/ko not_active IP Right Cessation
- 1994-03-09 ES ES94911129T patent/ES2119187T3/es not_active Expired - Lifetime
- 1994-03-25 ZA ZA942124A patent/ZA942124B/xx unknown
- 1994-03-25 IL IL10913594A patent/IL109135A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CA2155843A1 (en) | 1994-10-13 |
| ZA942124B (en) | 1994-11-10 |
| US5703050A (en) | 1997-12-30 |
| EP0689549A1 (de) | 1996-01-03 |
| AU6375494A (en) | 1994-10-24 |
| IL109135A0 (en) | 1994-06-24 |
| DE59406279D1 (de) | 1998-07-23 |
| EP0689549B1 (de) | 1998-06-17 |
| AU679509B2 (en) | 1997-07-03 |
| DE4309867A1 (de) | 1994-09-29 |
| ATE167483T1 (de) | 1998-07-15 |
| KR960701087A (ko) | 1996-02-24 |
| ES2119187T3 (es) | 1998-10-01 |
| CA2155843C (en) | 2004-09-21 |
| WO1994022907A1 (de) | 1994-10-13 |
| JP3597862B2 (ja) | 2004-12-08 |
| HUT73409A (en) | 1996-07-29 |
| HU219483B (hu) | 2001-04-28 |
| KR100418144B1 (ko) | 2004-05-07 |
| IL109135A (en) | 1999-03-12 |
| JPH08508267A (ja) | 1996-09-03 |
| HU9502792D0 (en) | 1995-11-28 |
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