TW337523B - Aminomethyl-2, 3, 8,9-tetrahydro-7H-1, 4-dioxino (2, 3-e)-indol-8-ones and derivatives - Google Patents

Aminomethyl-2, 3, 8,9-tetrahydro-7H-1, 4-dioxino (2, 3-e)-indol-8-ones and derivatives

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Publication number
TW337523B
TW337523B TW085113550A TW85113550A TW337523B TW 337523 B TW337523 B TW 337523B TW 085113550 A TW085113550 A TW 085113550A TW 85113550 A TW85113550 A TW 85113550A TW 337523 B TW337523 B TW 337523B
Authority
TW
Taiwan
Prior art keywords
optionally substituted
alkyl
defined above
hydrogen
heteroaryl
Prior art date
Application number
TW085113550A
Other languages
Chinese (zh)
Inventor
Paul Stack Gary
Eric Mewshaw Richard
Abel Bravo Byron
Hee Kang Young
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24934632&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW337523(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/730,267 external-priority patent/US5756532A/en
Application filed by American Home Prod filed Critical American Home Prod
Application granted granted Critical
Publication of TW337523B publication Critical patent/TW337523B/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The compounds of formula I: wherein R1 and R2 are, independently, hydrogen, C1-6 alkyl, benzyl or phenzyl; or R1 and R2, taken together, are benylidene optionally substituted with R3 and as many as 6 carbon atoms to which they are attached, form a carbonyl moiety of a cycloalkyl group; R3 is hydrogen, hydroxy, halo, trifluoromethyl, trifluoromethoxy, alkyl, alkoxy, aralkoxy, alkanoyloxy, amino, mono- or di-alkylamino, alkanamido or alkanesfulfonamido; R4 is hydrogen or alkyl; m is an integer 0, 1, or 2; n is an integer from 0 to 6, inclusive; Z is hydrogen, hydroxy, alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, polycyclo-alkyl, phenyl optionally substituted with R3 as defined above, phenoxy optionally substituted with R3 as defined above, naphthyl optionally substituted with R3 as defined above or naphthyloxy optionally substituted with R3 as defined above, heteroaryl or heteoroaryloxy, in which the heterocyclic ring of the heteroaryl or heteroaryloxy group is selected from thiophene, furan, pydridine, pyrazine, pyrimidine, indole, indazole, imidazole, chroman, coumarin, carbostyril, quinoline, benziosoxazole, benzoxazole, pyrazole, pyrrole, thiazole, oxazole, or isoxazole and the heterocyclic ring is optionally substituted by R3 as defined above; or a pharmaceutically acceptable salt thereof, are useful in treating disorders of the dopaminergic system.
TW085113550A 1996-10-15 1996-11-06 Aminomethyl-2, 3, 8,9-tetrahydro-7H-1, 4-dioxino (2, 3-e)-indol-8-ones and derivatives TW337523B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/730,267 US5756532A (en) 1995-11-06 1996-10-15 Aminomethyl-2 3 8 9-tetrahydro-7H-1 4-dioxino 2 3-E!-indol-8-ones and derivatives

Publications (1)

Publication Number Publication Date
TW337523B true TW337523B (en) 1998-08-01

Family

ID=24934632

Family Applications (1)

Application Number Title Priority Date Filing Date
TW085113550A TW337523B (en) 1996-10-15 1996-11-06 Aminomethyl-2, 3, 8,9-tetrahydro-7H-1, 4-dioxino (2, 3-e)-indol-8-ones and derivatives

Country Status (3)

Country Link
BR (1) BR9605440B1 (en)
TW (1) TW337523B (en)
ZA (1) ZA969018B (en)

Also Published As

Publication number Publication date
BR9605440B1 (en) 2010-08-10
BR9605440A (en) 1998-08-04
ZA969018B (en) 1998-04-25

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MM4A Annulment or lapse of patent due to non-payment of fees