TW337523B - Aminomethyl-2, 3, 8,9-tetrahydro-7H-1, 4-dioxino (2, 3-e)-indol-8-ones and derivatives - Google Patents
Aminomethyl-2, 3, 8,9-tetrahydro-7H-1, 4-dioxino (2, 3-e)-indol-8-ones and derivativesInfo
- Publication number
- TW337523B TW337523B TW085113550A TW85113550A TW337523B TW 337523 B TW337523 B TW 337523B TW 085113550 A TW085113550 A TW 085113550A TW 85113550 A TW85113550 A TW 85113550A TW 337523 B TW337523 B TW 337523B
- Authority
- TW
- Taiwan
- Prior art keywords
- optionally substituted
- alkyl
- defined above
- hydrogen
- heteroaryl
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The compounds of formula I: wherein R1 and R2 are, independently, hydrogen, C1-6 alkyl, benzyl or phenzyl; or R1 and R2, taken together, are benylidene optionally substituted with R3 and as many as 6 carbon atoms to which they are attached, form a carbonyl moiety of a cycloalkyl group; R3 is hydrogen, hydroxy, halo, trifluoromethyl, trifluoromethoxy, alkyl, alkoxy, aralkoxy, alkanoyloxy, amino, mono- or di-alkylamino, alkanamido or alkanesfulfonamido; R4 is hydrogen or alkyl; m is an integer 0, 1, or 2; n is an integer from 0 to 6, inclusive; Z is hydrogen, hydroxy, alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, polycyclo-alkyl, phenyl optionally substituted with R3 as defined above, phenoxy optionally substituted with R3 as defined above, naphthyl optionally substituted with R3 as defined above or naphthyloxy optionally substituted with R3 as defined above, heteroaryl or heteoroaryloxy, in which the heterocyclic ring of the heteroaryl or heteroaryloxy group is selected from thiophene, furan, pydridine, pyrazine, pyrimidine, indole, indazole, imidazole, chroman, coumarin, carbostyril, quinoline, benziosoxazole, benzoxazole, pyrazole, pyrrole, thiazole, oxazole, or isoxazole and the heterocyclic ring is optionally substituted by R3 as defined above; or a pharmaceutically acceptable salt thereof, are useful in treating disorders of the dopaminergic system.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/730,267 US5756532A (en) | 1995-11-06 | 1996-10-15 | Aminomethyl-2 3 8 9-tetrahydro-7H-1 4-dioxino 2 3-E!-indol-8-ones and derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
TW337523B true TW337523B (en) | 1998-08-01 |
Family
ID=24934632
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW085113550A TW337523B (en) | 1996-10-15 | 1996-11-06 | Aminomethyl-2, 3, 8,9-tetrahydro-7H-1, 4-dioxino (2, 3-e)-indol-8-ones and derivatives |
Country Status (3)
Country | Link |
---|---|
BR (1) | BR9605440B1 (en) |
TW (1) | TW337523B (en) |
ZA (1) | ZA969018B (en) |
-
1996
- 1996-10-25 ZA ZA9609018A patent/ZA969018B/en unknown
- 1996-11-06 BR BR9605440A patent/BR9605440B1/en active IP Right Grant
- 1996-11-06 TW TW085113550A patent/TW337523B/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
BR9605440B1 (en) | 2010-08-10 |
BR9605440A (en) | 1998-08-04 |
ZA969018B (en) | 1998-04-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Annulment or lapse of patent due to non-payment of fees |