UY25965A1 - AMINOMETIL-2 3 8 9-TETRAHIDRO-7H-1 4-DIOXINO [2 3 E] -INDOL-8- ONAS AND DERIVATIVES - Google Patents
AMINOMETIL-2 3 8 9-TETRAHIDRO-7H-1 4-DIOXINO [2 3 E] -INDOL-8- ONAS AND DERIVATIVESInfo
- Publication number
- UY25965A1 UY25965A1 UY25965A UY25965A UY25965A1 UY 25965 A1 UY25965 A1 UY 25965A1 UY 25965 A UY25965 A UY 25965A UY 25965 A UY25965 A UY 25965A UY 25965 A1 UY25965 A1 UY 25965A1
- Authority
- UY
- Uruguay
- Prior art keywords
- alkyl
- optionally substituted
- hydrogen
- detailed
- indole
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Los compuestos de la fórmula l (como por ejemplo: 2-(bencilamino)metil-2,3,8,9-tetrahidro-7H-1,4-dioxino[2,3-e]-indol-8-ona) en la cual R1 y R2 son, independientemente, hidrógeno, alquilo, fenilo o benzilo; o R1 y R2, juntos, son bencilideno sustituido opcionalmente por R3 según se lo detalla más abajo, o alquilideno, o R1 y R2 tomados junto al carbono al cual se hallan unidos, forman una porción de carbonilo o un grupo cicloalquilo; R3 es hidrogeno, hidróxido, halo, trifluorometilo, trifluorometoxi, alquilo, alcoxi, aralcoxi,alcanoiloxi,amino, mono o di alquilamino, alcanamido, o alcanosulfonamido, R4 es hidrógeno o alquilo, n es un entero de 0 a 6 inclusive, Z es hidrogeno, hidroxi, alquilo, alquenilo, alquinilo, alcoxi, cicloalquilo, policiclo-alquilo, fenilo sustituido opcionalmente por R3,según se lo detalló anteriormente, fenoxi sustituido opcionalmente por R3, según se lo detalló del grupo heterarilo o heteroariloxi es seleccionado de tiofeno, furano, piridina, pirazina, pirimidina, indol, indazol, imidazo, cromano, cumarina, carboestirilo, quinolina, bencisoxazol, benzoxazol, pirazol, pirrol, tiazo, oxazol, o isoxazol y el anillo heterocíclico es sustituido opcionalmente por R3 según se lo detalló anteriormente, o una sal del mismo, farmacéuticamente aceptable, son útiles para el tratamiento de trastornos del sistema dopaminérgico. Un método para el tratamiento de enfermedades de desregulación de la dopamina cerebral, que implica la administración, oral o parental, de una cantidad de un compuesto de la fórmula l, a un sujeto que padezca ese tipo de trastorno del sistema dopaminérgico.Compounds of formula l (such as: 2- (benzylamino) methyl-2,3,8,9-tetrahydro-7H-1,4-dioxino [2,3-e] -indole-8-one) in which R1 and R2 are independently hydrogen, alkyl, phenyl or benzyl; or R1 and R2, together, are benzylidene optionally substituted by R3 as detailed below, or alkylidene, or R1 and R2 taken together with the carbon to which they are attached, form a carbonyl moiety or a cycloalkyl group; R3 is hydrogen, hydroxide, halo, trifluoromethyl, trifluoromethoxy, alkyl, alkoxy, aralkoxy, alkanoyloxy, amino, mono or di alkylamino, alkanido, or alkanesulfonamido, R4 is hydrogen or alkyl, n is an integer from 0 to 6 inclusive, Z is hydrogen, hydroxy, alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, polycycloalkyl, phenyl optionally substituted by R3, as detailed above, phenoxy optionally substituted by R3, as detailed from the heteroaryl or heteroaryloxy group is selected from thiophene, furan, pyridine, pyrazine, pyrimidine, indole, indazole, imidazo, chroman, coumarin, carbostyril, quinoline, benzisxaxazole, benzoxazole, pyrazole, pyrrole, thiazo, oxazole, or isoxazole and is optionally substituted by R3 as detailed above , or a pharmaceutically acceptable salt thereof, are useful for the treatment of disorders of the dopaminergic system. A method for the treatment of brain dopamine dysregulation diseases, involving the administration, orally or parentally, of an amount of a compound of formula I, to a subject suffering from such a disorder of the dopaminergic system.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UY25965A UY25965A1 (en) | 2000-01-17 | 2000-01-17 | AMINOMETIL-2 3 8 9-TETRAHIDRO-7H-1 4-DIOXINO [2 3 E] -INDOL-8- ONAS AND DERIVATIVES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UY25965A UY25965A1 (en) | 2000-01-17 | 2000-01-17 | AMINOMETIL-2 3 8 9-TETRAHIDRO-7H-1 4-DIOXINO [2 3 E] -INDOL-8- ONAS AND DERIVATIVES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY25965A1 true UY25965A1 (en) | 2001-08-27 |
Family
ID=38812155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY25965A UY25965A1 (en) | 2000-01-17 | 2000-01-17 | AMINOMETIL-2 3 8 9-TETRAHIDRO-7H-1 4-DIOXINO [2 3 E] -INDOL-8- ONAS AND DERIVATIVES |
Country Status (1)
| Country | Link |
|---|---|
| UY (1) | UY25965A1 (en) |
-
2000
- 2000-01-17 UY UY25965A patent/UY25965A1/en not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RDES | Application refused |
Effective date: 20110802 |