AR025698A1 - Derivados de la quinolil propil piperidina, su preparacion y las composiciones farmaceuticas que los contienen. - Google Patents
Derivados de la quinolil propil piperidina, su preparacion y las composiciones farmaceuticas que los contienen.Info
- Publication number
- AR025698A1 AR025698A1 ARP000104875A ARP000104875A AR025698A1 AR 025698 A1 AR025698 A1 AR 025698A1 AR P000104875 A ARP000104875 A AR P000104875A AR P000104875 A ARP000104875 A AR P000104875A AR 025698 A1 AR025698 A1 AR 025698A1
- Authority
- AR
- Argentina
- Prior art keywords
- halogen
- alkyl
- alkyloxycarbonyl
- substituted
- alkyloxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Derivados de quinolil propil piperidina de formula general 1 en la que R1 es H o de halogeno, o OH, R1 es H, o puede representar halogeno cuando R1 estambién halogeno, y Rs es H, o bien R1 y Rs forman una union y R1 es H, R2 es un radical carboxi,ca rboximetilo o carboxi-2 etilo, y R3 es alquilo (C1-6)sustituido por 1 a 3 sustituyentes elegidos entre OH, halogeno, =O, COOH, alquiloxicarbonilo alquiloxi, alquiltio o entre un radical fenilo, feniltio ofenilalquiltio que pueden ellos mismosllevar 1 a 4 sustituyentes [elegidos entre halogeno, OH, alquilo, alquiloxi, trifluorometilo, trifluorometoxi, COOH,alquiloxicarbonilo, CN, acetamido o NH2] o entre cicloalquilo o cicloalquiltio (3 a 7 eslabones), o entre heterociclilo oheterocicliltio aro mático (5 a 6eslabones) que comprenden 1 a 4 heteroátomos elegidos entre N, O o S y eventualmente ellos mismos sustituidos [por halogeno, OH, alquilo alquiloxi, CF3, OCF3,=O, COOH, alquiloxicarbonilo, CN o NH2], o R3 espropargilo sustituido por feni lo que puede él mismo llevar 1 a 3 sustituyentes [elegidos entre halogneo, OH,alquilo, alquiloxi, CF3, OCF3, COOH, alquiloxicarbonilo, CN o NH2], o sustituido por un radical cicloalquilo que contiene 3 a 7 eslabones osustituido porheterociclilo arom ático (5 a 6 eslabones) que comprende 1 a 4 heteroátomos elegidos entre N, O o S y eventualmente el mismo sustituido [por halogeno, OH,alquilo, alquiloxi, CF3, OCF3, =O, COOH, alquiloxicarbonilo, CN o NH2], o R3representa cinamilo o 4-fenilbuten-3-i lo, o bien R2 es -CH2OH, alquiloxicarbonilo,alquiloxicarbonilmetilo o alquiloxicarbonil-2-etilo y R3 es alquilo (C1-6) sustituido por feniltio que puede el mismo llevar 1 a 3 sustituyentes [elegidosentrehalogeno, OH, alquilo, alquiloxi, CF3, OCF3, C OOH, alquiloxicarbonilo, CN o NH2], por cicloalquiltio (3 a 7 eslabones), o por heterocicliltio aromático(5 a 6 eslabones) que comprende 1 a 4 heteroátomos elegidos entre N, S o O y eventualmente élmismo sustituido [por halogeno, OH, alquilo, alquil oxi, CF3,OCF3, =O, COOH, alquiloxicarbonilo, CN o NH2] o R3 es propargilo sustituido por fenilo que puede el mismo llevar 1 a 3 sustituyentes [elegidos entre halogeno,
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US728395P | 1995-11-06 | 1995-11-06 | |
| US08/730,267 US5756532A (en) | 1995-11-06 | 1996-10-15 | Aminomethyl-2 3 8 9-tetrahydro-7H-1 4-dioxino 2 3-E!-indol-8-ones and derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR025698A1 true AR025698A1 (es) | 2002-12-11 |
Family
ID=26676776
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960105059A AR004284A1 (es) | 1995-11-06 | 1996-11-05 | Derivados de aminometil-2,3,8,9-tetrahidro-7h-1,4-dioxino-2,3-e-indol-8-onas y el uso de los mismos para la manufactura de un medicamento |
| ARP000104875A AR025698A1 (es) | 1995-11-06 | 2000-09-15 | Derivados de la quinolil propil piperidina, su preparacion y las composiciones farmaceuticas que los contienen. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960105059A AR004284A1 (es) | 1995-11-06 | 1996-11-05 | Derivados de aminometil-2,3,8,9-tetrahidro-7h-1,4-dioxino-2,3-e-indol-8-onas y el uso de los mismos para la manufactura de un medicamento |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US5756532A (es) |
| EP (3) | EP0771800A3 (es) |
| JP (1) | JP4311770B2 (es) |
| KR (1) | KR100566678B1 (es) |
| CN (1) | CN1084748C (es) |
| AR (2) | AR004284A1 (es) |
| AT (1) | ATE349450T1 (es) |
| AU (1) | AU701624B2 (es) |
| CA (1) | CA2189524C (es) |
| CZ (1) | CZ291731B6 (es) |
| DE (1) | DE69636801T2 (es) |
| DK (1) | DK1375503T3 (es) |
| ES (1) | ES2277014T3 (es) |
| HU (1) | HU224841B1 (es) |
| IL (1) | IL119565A (es) |
| MX (1) | MX9605367A (es) |
| NO (1) | NO317054B1 (es) |
| NZ (1) | NZ299693A (es) |
| PT (1) | PT1375503E (es) |
| RU (1) | RU2178416C2 (es) |
| SK (1) | SK282168B6 (es) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9627005D0 (en) * | 1996-12-27 | 1997-02-12 | Knoll Ag | Therapeutic agents |
| GB9704948D0 (en) | 1997-03-11 | 1997-04-30 | Knoll Ag | Therapeutic agents |
| US6362009B1 (en) | 1997-11-21 | 2002-03-26 | Merck & Co., Inc. | Solid phase synthesis of heterocycles |
| US6350773B1 (en) * | 1999-12-10 | 2002-02-26 | American Home Products Corporation | Therapeutic combinations of (S)-2-(benzylamino-methyl)-2,3,8,9,-tetrahydro 7H-1,4-dioxino{2,3-e}indol-8-one and neuroleptics for the treatment or prevention of psychotic disorders |
| MXPA02005649A (es) * | 1999-12-10 | 2004-09-10 | Wyeth Corp | Nuevas combinaciones terapeuticas de (s)-2 -(bencilamino -metil)-2, 3, 8, 9-tetrahidro-7h -1, 4-dioxino(2-3 -e]indol-8 -ona y agentes neurolepticos para el tratamiento o prevencion de trastornos psicoticos. |
| US20060223824A1 (en) * | 2000-11-28 | 2006-10-05 | Wyeth | Serotonergic agents |
| US20060287335A1 (en) * | 2000-11-28 | 2006-12-21 | Wyeth | Serotonergic agents for treating sexual dysfunction |
| US6458802B1 (en) | 2001-03-14 | 2002-10-01 | Wyeth | Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-dioxino [2,3-f]quinoline |
| US6803368B2 (en) | 2001-04-25 | 2004-10-12 | Wyeth | Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1,3-diaza-cyclopenta[a]naphthalene |
| CA2445581A1 (en) * | 2001-04-26 | 2002-11-07 | Jonathan Laird Gross | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinoxaline |
| US6821981B2 (en) | 2001-04-26 | 2004-11-23 | Wyeth | Azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]-quinoline as 5-HT1A antagonists |
| WO2002088129A1 (en) * | 2001-04-26 | 2002-11-07 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinazoline |
| US6861427B2 (en) * | 2001-04-26 | 2005-03-01 | Wyeth | Azabicyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinoline as 5-HT1A antagonists |
| US6800641B2 (en) | 2001-04-26 | 2004-10-05 | Wyeth | Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-2,3-diaza-cyclopenta[a]naphthalene |
| US6800648B2 (en) | 2001-04-26 | 2004-10-05 | Wyeth | Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-1,6,9-trioxa-3-AZA-cyclopenta[a]naphthalen-2-one |
| DE60206048T2 (de) * | 2001-04-26 | 2006-07-13 | Wyeth | Antidepressive (sssri) azaheterocyclylmethylderivate von 7,8-dihydro-3h-6,9-dioxa-1,3-diazacyclopenta [a] naphthalin |
| US6861434B2 (en) * | 2001-04-26 | 2005-03-01 | Wyeth | Antipsychotic aminomethyl derivatives of 1,3,7,8-tetrahydro-6,9-dioxa-1,3-diaza-cyclopenta[a]-naphthalen-2-one |
| US7008944B2 (en) * | 2001-04-26 | 2006-03-07 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-Dioxino[2,3-f]quinoxaline |
| US6927226B2 (en) | 2001-04-26 | 2005-08-09 | Wyeth | Antidepressant azaheterocyclymethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1,3-diazacyclopenta[a]naphthalene |
| US6800642B2 (en) | 2001-04-26 | 2004-10-05 | Wyeth | Antipsychotic aminomethyl derivatives of 7,8-dihydro-2,6,9-trioxa-3-aza-cyclopenta[a]naphthalene |
| US6555560B2 (en) | 2001-04-30 | 2003-04-29 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 1,4,5-trioxa-phenanthrene |
| US6906206B2 (en) | 2001-04-30 | 2005-06-14 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 1,4,5-trioxa-phenanthrene |
| CA2447150A1 (en) * | 2001-05-17 | 2002-11-21 | Wyeth | Processes for the synthesis of derivatives of 2,3-dihydro-1,4-dioxino-[2,3-f] quinoline |
| US6541502B1 (en) | 2001-07-20 | 2003-04-01 | Wyeth | 2-(aminomethyl)-tetrahydro-9-oxa-1,3-diaza-cyclopenta[a]-naphthalenyl derivatives with antipsychotic activity |
| US6541501B2 (en) | 2001-07-20 | 2003-04-01 | Wyeth | 2-(aminomethyl)-tetrahydro-9-oxa-1,3-diaza-cyclopenta[a]-naphthalenyl derivatives with antipsychotic activity |
| WO2003010169A1 (en) * | 2001-07-25 | 2003-02-06 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 7, 8-dihydro-6h-5-oxa-1-aza-phenanthrene |
| US7135479B2 (en) | 2002-09-12 | 2006-11-14 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans |
| US6800637B2 (en) * | 2002-09-12 | 2004-10-05 | Wyeth | Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines |
| CN100352820C (zh) * | 2002-09-12 | 2007-12-05 | 惠氏公司 | 抗抑郁的杂环稠合的苯并二噁烷的氮杂环甲基衍生物 |
| US6939877B2 (en) * | 2002-09-12 | 2005-09-06 | Wyeth | Antidepressant piperidine derivatives of heterocycle-fused benzodioxans |
| US7153849B2 (en) * | 2002-09-12 | 2006-12-26 | Wyeth | Antidepressant arylpiperazine derivatives of hetrocycle-fused benzodioxans |
| SG147450A1 (en) * | 2003-10-29 | 2008-11-28 | Wyeth Corp | Sustained release pharmaceutical compositions comprising aplindore and derivatives thereof |
| CA2597616A1 (en) | 2005-02-17 | 2006-08-24 | Wyeth | Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives |
| JP2008531694A (ja) * | 2005-03-01 | 2008-08-14 | ワイス | 結晶性および非晶性４−シアノ−ｎ−｛（２ｒ）−２−［４−（２，３−ジヒドロ−ベンゾ［１，４］ジオキシン−５−イル）−ピペラジン−１−イル］−プロピル｝−ｎ−ピリジン−２−イル−ベンズアミド塩酸塩 |
| PE20061327A1 (es) * | 2005-04-22 | 2007-01-02 | Wyeth Corp | Combinaciones de derivados de benzofurano y un antidepresivo para el tratamiento o la prevencion de la depresion |
| TW200811182A (en) * | 2006-05-25 | 2008-03-01 | Wyeth Corp | Oxindoledioxans, synthesis thereof, and intermediates thereto |
| US8466296B2 (en) * | 2007-03-26 | 2013-06-18 | Ligand Pharmaceuticals | Compounds and processes for preparing substituted aminomethyl-2,3,8,9-tetrahydro-7H-1,4-dioxino[2,3-e]indol-8-ones |
| JP5755217B2 (ja) * | 2009-03-30 | 2015-07-29 | トランステック・ファーマ，エルエルシー | 置換アゾアントラセン誘導体、その医薬組成物とその使用の方法 |
| RU2554883C1 (ru) * | 2014-05-27 | 2015-06-27 | Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Казанский (Приволжский) Федеральный Университет" (ФГАОУ ВПО КФУ) | Применение производных ацеталей пиридоксина в качестве антагонистов пуринорецепторов |
| RU2554885C1 (ru) * | 2014-05-27 | 2015-06-27 | Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Казанский (Приволжский) Федеральный Университет" (ФГАОУ ВПО КФУ) | Антагонисты пуринорецепторов на основе новых производных пиридоксина |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991013872A1 (en) * | 1990-03-15 | 1991-09-19 | The Upjohn Company | Therapeutically useful heterocyclic indole compounds |
| US5166367A (en) * | 1991-06-21 | 1992-11-24 | American Home Products Corporation | Antipsychotic benzodioxan derivatives |
| US5189171A (en) * | 1991-06-21 | 1993-02-23 | American Home Products Corporation | Antipsychotic benzodioxan derivatives |
| US5126366A (en) * | 1991-06-21 | 1992-06-30 | American Home Products Corporation | Aminophenoxyalkyl derivatives of benzodioxan |
| DE4135474A1 (de) * | 1991-10-28 | 1993-04-29 | Bayer Ag | 2-aminomethyl-chromane |
| US5235055A (en) * | 1992-09-02 | 1993-08-10 | American Home Products Corporation | Antipsychotic quinoline derivatives of benzodioxanmethylamine |
| US5245051A (en) * | 1992-09-03 | 1993-09-14 | American Home Products Corporation | Antipsychotic chroman derivatives of benzodioxanmethylamine |
-
1996
- 1996-10-15 US US08/730,267 patent/US5756532A/en not_active Expired - Lifetime
- 1996-10-22 DE DE69636801T patent/DE69636801T2/de not_active Expired - Lifetime
- 1996-10-22 PT PT03021780T patent/PT1375503E/pt unknown
- 1996-10-22 AT AT03021780T patent/ATE349450T1/de active
- 1996-10-22 EP EP96307616A patent/EP0771800A3/en not_active Ceased
- 1996-10-22 EP EP03021780A patent/EP1375503B1/en not_active Expired - Lifetime
- 1996-10-22 DK DK03021780T patent/DK1375503T3/da active
- 1996-10-22 ES ES03021780T patent/ES2277014T3/es not_active Expired - Lifetime
- 1996-10-22 EP EP06015712A patent/EP1726592A1/en not_active Withdrawn
- 1996-10-31 SK SK1414-96A patent/SK282168B6/sk not_active IP Right Cessation
- 1996-11-01 AU AU70553/96A patent/AU701624B2/en not_active Ceased
- 1996-11-04 CA CA002189524A patent/CA2189524C/en not_active Expired - Fee Related
- 1996-11-04 RU RU96121824/04A patent/RU2178416C2/ru not_active IP Right Cessation
- 1996-11-04 NZ NZ299693A patent/NZ299693A/xx not_active IP Right Cessation
- 1996-11-05 MX MX9605367A patent/MX9605367A/es unknown
- 1996-11-05 KR KR1019960051969A patent/KR100566678B1/ko not_active IP Right Cessation
- 1996-11-05 NO NO19964686A patent/NO317054B1/no not_active IP Right Cessation
- 1996-11-05 IL IL11956596A patent/IL119565A/en not_active IP Right Cessation
- 1996-11-05 HU HU9603057A patent/HU224841B1/hu not_active IP Right Cessation
- 1996-11-05 CN CN96121650A patent/CN1084748C/zh not_active Expired - Fee Related
- 1996-11-05 CZ CZ19963241A patent/CZ291731B6/cs not_active IP Right Cessation
- 1996-11-05 AR ARP960105059A patent/AR004284A1/es active IP Right Grant
- 1996-11-05 JP JP29247996A patent/JP4311770B2/ja not_active Expired - Fee Related
-
1998
- 1998-01-29 US US09/015,149 patent/US5962465A/en not_active Expired - Lifetime
-
2000
- 2000-09-15 AR ARP000104875A patent/AR025698A1/es unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |