DE60036803D1 - Arylmethyl-carbonylamino-thiazolderivate und ihre verwendung als antitumormittel - Google Patents

Arylmethyl-carbonylamino-thiazolderivate und ihre verwendung als antitumormittel

Info

Publication number
DE60036803D1
DE60036803D1 DE60036803T DE60036803T DE60036803D1 DE 60036803 D1 DE60036803 D1 DE 60036803D1 DE 60036803 T DE60036803 T DE 60036803T DE 60036803 T DE60036803 T DE 60036803T DE 60036803 D1 DE60036803 D1 DE 60036803D1
Authority
DE
Germany
Prior art keywords
antitum
arylmethyl
carbonylamino
thiazone
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60036803T
Other languages
English (en)
Other versions
DE60036803T2 (de
Inventor
Paolo Pevarello
Raffaella Amici
Manuela Villa
Barbara Salom
Anna Vulpetti
Mario Varasi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pfizer Italia SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Italia SRL filed Critical Pfizer Italia SRL
Application granted granted Critical
Publication of DE60036803D1 publication Critical patent/DE60036803D1/de
Publication of DE60036803T2 publication Critical patent/DE60036803T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
DE60036803T 1999-08-12 2000-08-11 Arylmethyl-carbonylamino-thiazolderivate und ihre verwendung als antitumormittel Expired - Lifetime DE60036803T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US372832 1999-08-12
US09/372,832 US6114365A (en) 1999-08-12 1999-08-12 Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents
PCT/IB2000/001423 WO2001014353A1 (en) 1999-08-12 2000-08-11 Arylmethyl-carbonylamino-thiazole derivatives and their use as antitumor agents

Publications (2)

Publication Number Publication Date
DE60036803D1 true DE60036803D1 (de) 2007-11-29
DE60036803T2 DE60036803T2 (de) 2008-07-24

Family

ID=23469806

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60036803T Expired - Lifetime DE60036803T2 (de) 1999-08-12 2000-08-11 Arylmethyl-carbonylamino-thiazolderivate und ihre verwendung als antitumormittel

Country Status (36)

Country Link
US (3) US6114365A (de)
EP (1) EP1204649B1 (de)
JP (1) JP4864260B2 (de)
KR (2) KR100827563B1 (de)
CN (1) CN100410245C (de)
AP (1) AP1853A (de)
AT (1) ATE375987T1 (de)
AU (1) AU782882B2 (de)
BG (1) BG65484B1 (de)
BR (1) BR0013281A (de)
CA (1) CA2381097C (de)
CY (1) CY1107108T1 (de)
CZ (1) CZ303138B6 (de)
DE (1) DE60036803T2 (de)
DK (1) DK1204649T3 (de)
EA (1) EA005375B1 (de)
EE (1) EE04939B1 (de)
ES (1) ES2295056T3 (de)
GE (1) GEP20053475B (de)
HK (1) HK1054233B (de)
HR (1) HRP20020127B1 (de)
HU (1) HUP0202492A3 (de)
IL (2) IL147924A0 (de)
IS (1) IS2594B (de)
MA (1) MA25433A1 (de)
MX (1) MXPA02001508A (de)
NO (1) NO323576B1 (de)
NZ (1) NZ517236A (de)
OA (1) OA12047A (de)
PT (1) PT1204649E (de)
RS (1) RS50300B (de)
SI (1) SI1204649T1 (de)
SK (1) SK287373B6 (de)
UA (1) UA72538C2 (de)
WO (1) WO2001014353A1 (de)
ZA (1) ZA200201117B (de)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020150921A1 (en) * 1996-02-09 2002-10-17 Francis Barany Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US6407103B2 (en) 1998-04-21 2002-06-18 Bristol-Myers Squibb Pharma Company Indeno [1,2-c] pyrazol-4-ones and their uses
US6610846B1 (en) * 1999-03-29 2003-08-26 Hoffman-La Roche Inc. Heteroaromatic glucokinase activators
US6320050B1 (en) * 1999-03-29 2001-11-20 Hoffmann-La Roche Inc. Heteroaromatic glucokinase activators
ID30460A (id) * 1999-04-15 2001-12-06 Bristol Myers Squibb Co Inhibitor-inhibitor protein siklik tirosin kinase
US7125875B2 (en) * 1999-04-15 2006-10-24 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
US6114365A (en) * 1999-08-12 2000-09-05 Pharmacia & Upjohn S.P.A. Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents
EP2266607A3 (de) 1999-10-01 2011-04-20 Immunogen, Inc. Immunokonjugate für Krebsbehandlung
US6291504B1 (en) 1999-10-20 2001-09-18 Dupont Pharmaceuticals Company Acylsemicarbazides and their uses
US20040048844A1 (en) * 1999-10-20 2004-03-11 Bristol-Myers Squibb Pharma Company Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents
AU2002215053A1 (en) * 2000-11-27 2002-06-24 Pharmacia Italia S.P.A. Phenylacetamido- pyrazole derivatives and their use as antitumor agents
AU2002228692A1 (en) * 2000-12-01 2002-06-11 Bristol-Myers Squibb Pharma Company 3-(2,4-dimethylthiazol-5-yl) indeno(1,2-c)pyrazol-4-one derivatives as cdk inhibitors
CA2430376A1 (en) 2000-12-08 2002-06-13 David J. Carini Semicarbazides and their uses as cyclin dependent kinase inhibitors
AU3113902A (en) * 2000-12-21 2002-07-01 Bristol Myers Squibb Co Thiazolyl inhibitors of tec family tyrosine kinases
ES2254611T3 (es) 2001-05-11 2006-06-16 Pfizer Products Inc. Derivados de tiazol.
EP1724270A3 (de) 2001-07-19 2007-01-03 Pfizer Italia S.r.l. Phenylacetamido-thiazole Verbindungen, Verfahren zu ihren Herstellung und ihre Anwendung als antitumor Mittel
KR100908794B1 (ko) * 2001-07-19 2009-07-22 파마시아 이탈리아 에스.피.에이. 페닐아세트아미도-티아졸 유도체, 이의 제조방법 및 이를 포함하는 항종양제로서의 약제학적 조성물
EP1436286B1 (de) * 2001-09-27 2009-08-19 Equispharm Co., Ltd. Fumagillolderivate und verfahren zu deren herstellung
RU2374236C2 (ru) * 2001-12-21 2009-11-27 Ново Нордиск А/С Амидные производные в качестве активаторов gk
WO2004002481A1 (en) * 2002-06-27 2004-01-08 Novo Nordisk A/S Aryl carbonyl derivatives as therapeutic agents
EP1594866A1 (de) * 2003-02-12 2005-11-16 Pfizer Inc. Antiproliferative 2-(sulfophenyl)aminothiazolderivate
BRPI0407618A (pt) * 2003-02-21 2006-02-21 Pfizer derivados de tiazole amino substituidos com cicloalquilo contendo n e composições farmacêuticas para inibição da proliferação celular e métodos para a sua utilização
CN1794988B (zh) * 2003-03-31 2010-07-28 株式会社·R-技术上野 用于治疗血管渗透性过高疾病的组合物
WO2005014591A1 (en) * 2003-07-15 2005-02-17 L'oreal 2-acylamino or 2-sulfonylamino-1, 3-thiazoles as couplers for the oxidation dyeing of keratin fibres
FR2857664B1 (fr) * 2003-07-15 2007-12-14 Oreal Nouveaux derives thiazoles et utilisation de ces derives pour la teinture des fibres keratiniques
US7351727B2 (en) * 2003-09-02 2008-04-01 Bristol-Myers Squibb Company Inhibitors of 15-lipoxygenase
US20050074424A1 (en) * 2003-10-03 2005-04-07 Lev Salnikov Using polyion polymers with glucose infusion for a cancer selective chemotherapy compound and method
US20070196395A1 (en) * 2003-12-12 2007-08-23 Mackerell Alexander Immunomodulatory compounds that target and inhibit the py'binding site of tyrosene kinase p56 lck sh2 domain
RU2386622C9 (ru) * 2004-01-06 2021-04-21 Ново Нордиск А/С Гетероароматические производные мочевины и их применение в качестве активаторов глюкокиназы
CA2584493A1 (en) 2004-06-18 2006-01-05 Gpc Biotech, Inc. Kinase inhibitors for treating cancers
EP1621539A1 (de) * 2004-07-27 2006-02-01 Aventis Pharma S.A. Heterocyclische-substituirte cyclische Harnstoffderivate, Verfaren zu ihrer Herstellung, und ihre pharmaceutische Verwendung als Kinase Inhibitoren
EP1621536A1 (de) * 2004-07-27 2006-02-01 Aventis Pharma S.A. Amino zyklische Urea-Derivaten, ihre Herstellung und deren pharmazeutische Verwendungen als Kinase Inhibitoren
MX2007001727A (es) * 2004-08-13 2007-04-20 Genentech Inc Compuestos a base de 2-amido-tiazol que exhiben actividad inhibidora de enzima que utiliza atp y composiciones y usos de los mismos.
EP2096107A1 (de) 2004-12-23 2009-09-02 GPC Biotech AG Derivate von Quadratsäure mit Wirkung gegen Proliferation
WO2007130075A1 (en) * 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
EP1904438B1 (de) * 2005-07-08 2012-02-29 Novo Nordisk A/S Dicycloalkylcarbamoyl-harnstoffe als glucokinase-aktivatoren
EP2377856A1 (de) * 2005-07-14 2011-10-19 Novo Nordisk A/S Harnstoff-Glucokinase-Aktivatoren
EP1914234A1 (de) * 2006-10-16 2008-04-23 GPC Biotech Inc. Pyrido[2,3-d]pyrimidinen und ihre Verwendung als kinase Inhibitoren
JP2010515701A (ja) * 2007-01-09 2010-05-13 ノボ・ノルデイスク・エー／エス ウレアグルコキナーゼアクチベーター
US8318778B2 (en) * 2007-01-11 2012-11-27 Novo Nordisk A/S Urea glucokinase activators
JP5568312B2 (ja) * 2007-02-13 2014-08-06 アーべー・シオンス キナーゼ阻害剤としての２−アミノチアゾール化合物の合成方法
US8450348B2 (en) * 2007-02-21 2013-05-28 Forma Tm, Llc Derivatives of squaric acid with anti-proliferative activity
TWI437986B (zh) * 2008-01-31 2014-05-21 R Tech Ueno Ltd 噻唑衍生物及使用該衍生物作為ｖａｐ－１抑制劑之用途
US8232402B2 (en) 2008-03-12 2012-07-31 Link Medicine Corporation Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
EP2112152A1 (de) 2008-04-22 2009-10-28 GPC Biotech AG Dihydropteridinones als Plk-Inhibitoren
EP2112150B1 (de) 2008-04-22 2013-10-16 Forma Therapeutics, Inc. Verbesserte Raf-Inhibitoren
CA2743717A1 (en) 2008-11-13 2010-05-20 Link Medicine Corporation Azaquinolinone derivatives and uses thereof
UA103918C2 (en) * 2009-03-02 2013-12-10 Айерем Элелси N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators
TWI504598B (zh) * 2009-03-20 2015-10-21 Onyx Therapeutics Inc 結晶性三肽環氧酮蛋白酶抑制劑
EP2440556A1 (de) * 2009-06-10 2012-04-18 Vertex Pharmaceuticals Incorporated Phosphatidylinositol 3-kinasehemmer
DE102009043260A1 (de) * 2009-09-28 2011-04-28 Merck Patent Gmbh Pyridinyl-imidazolonderivate
EP2325185A1 (de) 2009-10-28 2011-05-25 GPC Biotech AG Plk-Inhibitor
HU0900798D0 (en) 2009-12-21 2010-03-01 Vichem Chemie Kutato Kft 4-phenylamino-pyrimidine derivatives having protein kinase inhibitor activity
TWI450891B (zh) * 2010-12-29 2014-09-01 Dev Center Biotechnology 新穎微管蛋白抑制劑
RU2011122942A (ru) 2011-06-08 2012-12-20 Общество С Ограниченной Ответственностью "Асинэкс Медхим" Новые ингибиторы киназ
CN103387551B (zh) 2012-05-11 2015-05-20 中国人民解放军军事医学科学院毒物药物研究所 噻唑类化合物及其用途
PL2887943T3 (pl) 2012-08-23 2018-05-30 Virostatics Srl Nowe 4,6-dipodstawione pochodne aminopirymidyny
EA202191466A1 (ru) 2016-04-11 2021-12-31 Женфит Способы лечения холестатических и фибротических заболеваний
JP7319977B2 (ja) 2017-12-06 2023-08-02 リン バイオサイエンス，インコーポレイテッド チューブリン阻害剤
JP7184383B2 (ja) * 2018-02-01 2022-12-06 ザ・ユニバーシティ・オブ・シドニー 抗癌性化合物
JP2021526130A (ja) 2018-06-12 2021-09-30 ブイティーブイ・セラピューティクス・エルエルシー インスリンまたはインスリン類似体と組み合わせたグルコキナーゼ活性化薬の治療的使用
WO2020193431A1 (en) 2019-03-22 2020-10-01 Deutsches Krebsforschungszentrum Novel inhibitors of histone deacetylase 10
EP3712127A1 (de) 2019-03-22 2020-09-23 Deutsches Krebsforschungszentrum Neuartige inhibitoren der histon-deacetylase 10
US20230150952A1 (en) * 2020-02-10 2023-05-18 Juntendo Educational Foundation Type 2 ryanodine receptor activity inhibitor
CN115322208B (zh) * 2021-05-10 2023-04-11 中国药科大学 2-氨基噻唑类衍生物及其制备方法和医药用途
WO2023182780A1 (ko) * 2022-03-22 2023-09-28 오토텔릭바이오 주식회사 티아졸 유도체 화합물 및 이의 용도

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1252204B (de) * 1960-04-20 1967-10-19 Ortho Pharmaceutical Corporation, Raritan, N. J. (V. St. A.) Verfahren zur Herstellung von 2,4-Dinitropyrrolderivaten
JPH1095777A (ja) * 1996-07-31 1998-04-14 Otsuka Pharmaceut Co Ltd チアゾール誘導体
TW513418B (en) * 1996-07-31 2002-12-11 Otsuka Pharma Co Ltd Thiazole derivatives, their production and use
US6794392B1 (en) * 1996-09-30 2004-09-21 Schering Aktiengesellschaft Cell differentiation inducer
KR20010082501A (ko) * 1997-10-27 2001-08-30 개리 이. 프라이드만 4-아미노티아졸 유도체, 그 제조방법 및 싸이클린-의존성키나아제의 억제제로서의 이용방법
US6040321A (en) * 1997-11-12 2000-03-21 Bristol-Myers Squibb Company Aminothiazole inhibitors of cyclin dependent kinases
WO1999065884A1 (en) * 1998-06-18 1999-12-23 Bristol-Myers Squibb Company Carbon substituted aminothiazole inhibitors of cyclin dependent kinases
GB9823871D0 (en) * 1998-10-30 1998-12-23 Pharmacia & Upjohn Spa 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents
ID30460A (id) * 1999-04-15 2001-12-06 Bristol Myers Squibb Co Inhibitor-inhibitor protein siklik tirosin kinase
US6114365A (en) 1999-08-12 2000-09-05 Pharmacia & Upjohn S.P.A. Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents
US6992081B2 (en) * 2000-03-23 2006-01-31 Elan Pharmaceuticals, Inc. Compounds to treat Alzheimer's disease
SE0102440D0 (sv) * 2001-07-05 2001-07-05 Astrazeneca Ab New compound
DE60221627D1 (de) * 2001-12-21 2007-09-20 Virochem Pharma Inc Thiazolderivate und ihre Verwendung zur Behandlung oder Vorbeugung von Infektionen durch Flaviviren
US7125901B2 (en) * 2003-01-27 2006-10-24 Astellas Pharma Inc. Thiazole derivatives

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Publication number Publication date
CZ303138B6 (cs) 2012-04-25
HK1054233A1 (en) 2003-11-21
US20050004120A1 (en) 2005-01-06
CZ2002486A3 (cs) 2002-11-13
CA2381097A1 (en) 2001-03-01
AP1853A (en) 2008-05-29
GEP20053475B (en) 2005-03-25
DE60036803T2 (de) 2008-07-24
NZ517236A (en) 2004-11-26
WO2001014353A1 (en) 2001-03-01
EE04939B1 (et) 2007-12-17
CA2381097C (en) 2009-06-16
NO20020683L (no) 2002-04-10
JP2003507461A (ja) 2003-02-25
AU7440000A (en) 2001-03-19
RS50300B (sr) 2009-09-08
CN100410245C (zh) 2008-08-13
BG65484B1 (bg) 2008-09-30
SK287373B6 (sk) 2010-08-09
EE200200064A (et) 2003-04-15
MXPA02001508A (es) 2003-07-21
IS6264A (is) 2002-02-11
BG106481A (en) 2002-09-30
HUP0202492A2 (hu) 2002-11-28
NO323576B1 (no) 2007-06-11
AU782882B2 (en) 2005-09-08
KR20070074003A (ko) 2007-07-10
AP2002002441A0 (en) 2002-03-31
EA200200247A1 (ru) 2002-08-29
IL147924A0 (en) 2002-08-14
PT1204649E (pt) 2008-01-10
UA72538C2 (en) 2005-03-15
US6784198B1 (en) 2004-08-31
SI1204649T1 (sl) 2008-02-29
EP1204649B1 (de) 2007-10-17
JP4864260B2 (ja) 2012-02-01
YU9702A (sh) 2004-11-25
ZA200201117B (en) 2003-04-30
HRP20020127A2 (en) 2003-04-30
IL147924A (en) 2008-03-20
IS2594B (is) 2010-03-15
ATE375987T1 (de) 2007-11-15
SK1802002A3 (en) 2003-05-02
HRP20020127B1 (en) 2010-08-31
HK1054233B (zh) 2009-05-29
US6114365A (en) 2000-09-05
ES2295056T3 (es) 2008-04-16
NO20020683D0 (no) 2002-02-11
CY1107108T1 (el) 2012-10-24
KR100773709B1 (ko) 2007-11-09
HUP0202492A3 (en) 2004-12-28
KR100827563B1 (ko) 2008-05-07
BR0013281A (pt) 2002-06-18
PL353588A1 (en) 2003-12-01
MA25433A1 (fr) 2002-04-01
EP1204649A1 (de) 2002-05-15
EA005375B1 (ru) 2005-02-24
DK1204649T3 (da) 2007-12-03
KR20020060159A (ko) 2002-07-16
OA12047A (en) 2006-05-02
CN1425009A (zh) 2003-06-18

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