EA200200247A1 - Производные арилметилкарбониламинотиазола и их применение в качестве противоопухолевых средств - Google Patents

Производные арилметилкарбониламинотиазола и их применение в качестве противоопухолевых средств

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Publication number
EA200200247A1
EA200200247A1 EA200200247A EA200200247A EA200200247A1 EA 200200247 A1 EA200200247 A1 EA 200200247A1 EA 200200247 A EA200200247 A EA 200200247A EA 200200247 A EA200200247 A EA 200200247A EA 200200247 A1 EA200200247 A1 EA 200200247A1
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EA
Eurasian Patent Office
Prior art keywords
application
carbonylaminothiazole
arylmethyl
derivatives
tumor medicine
Prior art date
Application number
EA200200247A
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English (en)
Other versions
EA005375B1 (ru
Inventor
Паоло Певарелло
Раффаэлла Амичи
Мануэла Вилла
Барбара Салом
Анна Вульпетти
Марио Варази
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Фармация Италия, С.П.А.
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Publication date
Application filed by Фармация Италия, С.П.А. filed Critical Фармация Италия, С.П.А.
Publication of EA200200247A1 publication Critical patent/EA200200247A1/ru
Publication of EA005375B1 publication Critical patent/EA005375B1/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/4261,3-Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/08Antiseborrheics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38Nitrogen atoms
    • C07D277/44Acylated amino or imino radicals
    • C07D277/46Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Производные 2-амино-1,3-тиазола, представленные формулой (I) или (II), где R, R, Rи Rописаны здесь, или их фармацевтически приемлемые соли применимы, например, для лечения злокачественных опухолей, нарушений клеточной пролиферации, болезни Альцгеймера, вирусных инфекций, аутоиммунных заболеваний или нейродегенеративных заболеваний.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200200247A 1999-08-12 2000-08-11 Производные арилметилкарбониламинотиазола и их применение в качестве противоопухолевых средств EA005375B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/372,832 US6114365A (en) 1999-08-12 1999-08-12 Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents
PCT/IB2000/001423 WO2001014353A1 (en) 1999-08-12 2000-08-11 Arylmethyl-carbonylamino-thiazole derivatives and their use as antitumor agents

Publications (2)

Publication Number Publication Date
EA200200247A1 true EA200200247A1 (ru) 2002-08-29
EA005375B1 EA005375B1 (ru) 2005-02-24

Family

ID=23469806

Family Applications (1)

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EA200200247A EA005375B1 (ru) 1999-08-12 2000-08-11 Производные арилметилкарбониламинотиазола и их применение в качестве противоопухолевых средств

Country Status (36)

Country Link
US (3) US6114365A (ru)
EP (1) EP1204649B1 (ru)
JP (1) JP4864260B2 (ru)
KR (2) KR100827563B1 (ru)
CN (1) CN100410245C (ru)
AP (1) AP1853A (ru)
AT (1) ATE375987T1 (ru)
AU (1) AU782882B2 (ru)
BG (1) BG65484B1 (ru)
BR (1) BR0013281A (ru)
CA (1) CA2381097C (ru)
CY (1) CY1107108T1 (ru)
CZ (1) CZ303138B6 (ru)
DE (1) DE60036803T2 (ru)
DK (1) DK1204649T3 (ru)
EA (1) EA005375B1 (ru)
EE (1) EE04939B1 (ru)
ES (1) ES2295056T3 (ru)
GE (1) GEP20053475B (ru)
HK (1) HK1054233B (ru)
HR (1) HRP20020127B1 (ru)
HU (1) HUP0202492A3 (ru)
IL (2) IL147924A0 (ru)
IS (1) IS2594B (ru)
MA (1) MA25433A1 (ru)
MX (1) MXPA02001508A (ru)
NO (1) NO323576B1 (ru)
NZ (1) NZ517236A (ru)
OA (1) OA12047A (ru)
PT (1) PT1204649E (ru)
RS (1) RS50300B (ru)
SI (1) SI1204649T1 (ru)
SK (1) SK287373B6 (ru)
UA (1) UA72538C2 (ru)
WO (1) WO2001014353A1 (ru)
ZA (1) ZA200201117B (ru)

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CN100410245C (zh) 2008-08-13
CN1425009A (zh) 2003-06-18
HK1054233A1 (en) 2003-11-21
AU782882B2 (en) 2005-09-08
AU7440000A (en) 2001-03-19
DE60036803D1 (de) 2007-11-29
JP4864260B2 (ja) 2012-02-01
US6114365A (en) 2000-09-05
AP1853A (en) 2008-05-29
HUP0202492A2 (hu) 2002-11-28
EE200200064A (et) 2003-04-15
EP1204649B1 (en) 2007-10-17
MA25433A1 (fr) 2002-04-01
US20050004120A1 (en) 2005-01-06
KR20020060159A (ko) 2002-07-16
RS50300B (sr) 2009-09-08
HUP0202492A3 (en) 2004-12-28
DK1204649T3 (da) 2007-12-03
NZ517236A (en) 2004-11-26
BG106481A (en) 2002-09-30
CA2381097A1 (en) 2001-03-01
HRP20020127B1 (en) 2010-08-31
HK1054233B (zh) 2009-05-29
AP2002002441A0 (en) 2002-03-31
WO2001014353A1 (en) 2001-03-01
NO323576B1 (no) 2007-06-11
BR0013281A (pt) 2002-06-18
KR100827563B1 (ko) 2008-05-07
IL147924A (en) 2008-03-20
OA12047A (en) 2006-05-02
ES2295056T3 (es) 2008-04-16
IS6264A (is) 2002-02-11
CY1107108T1 (el) 2012-10-24
NO20020683L (no) 2002-04-10
CZ2002486A3 (cs) 2002-11-13
IS2594B (is) 2010-03-15
NO20020683D0 (no) 2002-02-11
US6784198B1 (en) 2004-08-31
ATE375987T1 (de) 2007-11-15
EE04939B1 (et) 2007-12-17
IL147924A0 (en) 2002-08-14
SI1204649T1 (sl) 2008-02-29
CA2381097C (en) 2009-06-16
SK1802002A3 (en) 2003-05-02
KR20070074003A (ko) 2007-07-10
ZA200201117B (en) 2003-04-30
YU9702A (sh) 2004-11-25
EP1204649A1 (en) 2002-05-15
HRP20020127A2 (en) 2003-04-30
UA72538C2 (en) 2005-03-15
BG65484B1 (bg) 2008-09-30
PL353588A1 (en) 2003-12-01
SK287373B6 (sk) 2010-08-09
MXPA02001508A (es) 2003-07-21
DE60036803T2 (de) 2008-07-24
JP2003507461A (ja) 2003-02-25
KR100773709B1 (ko) 2007-11-09
EA005375B1 (ru) 2005-02-24
PT1204649E (pt) 2008-01-10
GEP20053475B (en) 2005-03-25
CZ303138B6 (cs) 2012-04-25

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