EA200100804A1 - Сульфоароматические производные гидроксамовой кислоты как ингибиторы металлопротеаз - Google Patents

Сульфоароматические производные гидроксамовой кислоты как ингибиторы металлопротеаз

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Publication number
EA200100804A1
EA200100804A1 EA200100804A EA200100804A EA200100804A1 EA 200100804 A1 EA200100804 A1 EA 200100804A1 EA 200100804 A EA200100804 A EA 200100804A EA 200100804 A EA200100804 A EA 200100804A EA 200100804 A1 EA200100804 A1 EA 200100804A1
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EA
Eurasian Patent Office
Prior art keywords
mmp
sulphooromatic
proteasis
methype
inhibitors
Prior art date
Application number
EA200100804A
Other languages
English (en)
Inventor
Томас Э. Барта
Даниэль П. Бекер
Луи Дж. Биделл
Терри Л. Бем
Джеффери Н. Кэррол
Гари А. Де Крещенцо
Иветт М. Фобиан
Джон Н. Фрескос
Даниэль П. Гетман
Джозеф Дж. Макдональд
Гуннар Дж. Хэнсон
Сузан Л. Хокерман
Сузан С. Говард
Стив А. Колодзей
Хью Ли
Дебора А. Мишке
Джозеф Дж. Рико
Натан В. Стели
Майкл Б. Толлефсон
Уильям Ф. Верньер
Клара И. Вилламил
Шашидхар Н. Рао
Original Assignee
Дж.Д.Сирл Энд Ко
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Дж.Д.Сирл Энд Ко filed Critical Дж.Д.Сирл Энд Ко
Publication of EA200100804A1 publication Critical patent/EA200100804A1/ru

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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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Abstract

Раскрывают способ лечения, включающий введение эффективного количества ароматической сульфонгидроксамовой кислоты, которая демонстрирует великолепную угнетающую активность в отношении одной или нескольких матричных металлопротеазных (ММР) ферментов, например ММР-2, ММР-9 и ММР-13, демонстрируя значительно меньшее угнетение, по крайней мере ММР-1, хозяину, имеющему состояние, связанное с патологической активностью матричной металлопротеазы. Раскрываются также соединения-ингибиторы металлопротеаз, обладающие указанной избирательной активностью, способы получения таких соединений и фармацевтические композиции, в которых используется ингибитор.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200100804A 1999-02-24 2000-02-22 Сульфоароматические производные гидроксамовой кислоты как ингибиторы металлопротеаз EA200100804A1 (ru)

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US09/256,948 US20010039287A1 (en) 1997-11-14 1999-02-24 Aromatic sulfone hydroxamic acid metalloprotease inhibitor
PCT/US2000/002518 WO2000050396A1 (en) 1999-02-24 2000-02-22 Aromatic sulfone hydroxamic acid metalloprotease inhibitor

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