BR0008491A - Inibidores de metaloprotease de ácido hidrox mico de sulfona aromática - Google Patents
Inibidores de metaloprotease de ácido hidrox mico de sulfona aromáticaInfo
- Publication number
- BR0008491A BR0008491A BR0008491-3A BR0008491A BR0008491A BR 0008491 A BR0008491 A BR 0008491A BR 0008491 A BR0008491 A BR 0008491A BR 0008491 A BR0008491 A BR 0008491A
- Authority
- BR
- Brazil
- Prior art keywords
- mmp
- hydroxamic acid
- aromatic sulfone
- aromatic
- sulfone hydroxamic
- Prior art date
Links
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
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- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4
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- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract
"INIBIDORES DE METALOPROTEASE DE áCIDO HIDROX MICO DE SULFONA AROMáTICA". A invenção descreve um processo de tratamento que compreende administrar uma quantidade eficaz de um ácido hidroxâmico de sulfona aromática que apresenta excelente atividade inibidora de uma ou mais enzimas de metaloprotease de matriz (MMP), tal como MMP-2, MMP-9 e MMP-13, ao mesmo tempo em que apresenta substancialmente menos inibição pelo menos de MMP-1 a uma hospedeiro tendo uma condição associada com atividade de metaloprotease de matriz patológica. Também estão descritos compostos inibidores de metaloprotease tendo essas atividades seletivas, processos de produção de tais compostos e composições farmacêuticas utilizando um inibidor.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/256,948 US20010039287A1 (en) | 1997-11-14 | 1999-02-24 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
PCT/US2000/002518 WO2000050396A1 (en) | 1999-02-24 | 2000-02-22 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0008491A true BR0008491A (pt) | 2002-09-17 |
Family
ID=22974260
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0008491-3A BR0008491A (pt) | 1999-02-24 | 2000-02-22 | Inibidores de metaloprotease de ácido hidrox mico de sulfona aromática |
Country Status (19)
Country | Link |
---|---|
US (2) | US20010039287A1 (pt) |
EP (1) | EP1230219A1 (pt) |
JP (1) | JP2002537378A (pt) |
KR (1) | KR20020092157A (pt) |
CN (1) | CN1370144A (pt) |
AR (1) | AR043676A1 (pt) |
AU (1) | AU3478500A (pt) |
BR (1) | BR0008491A (pt) |
CA (1) | CA2371876A1 (pt) |
CZ (1) | CZ20013038A3 (pt) |
EA (1) | EA200100804A1 (pt) |
HU (1) | HUP0200239A3 (pt) |
IL (1) | IL144945A0 (pt) |
MX (1) | MXPA01008568A (pt) |
NO (1) | NO20013963L (pt) |
NZ (1) | NZ513648A (pt) |
PL (1) | PL351204A1 (pt) |
WO (1) | WO2000050396A1 (pt) |
ZA (1) | ZA200106780B (pt) |
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US6794511B2 (en) | 1997-03-04 | 2004-09-21 | G. D. Searle | Sulfonyl aryl or heteroaryl hydroxamic acid compounds |
US6638952B1 (en) | 1997-03-04 | 2003-10-28 | Pharmacia Corporation | Aromatic sulfonyl alpha-cycloamino hydroxamic acid compounds |
WO1999025687A1 (en) * | 1997-11-14 | 1999-05-27 | G.D. Searle & Co. | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
US6750228B1 (en) | 1997-11-14 | 2004-06-15 | Pharmacia Corporation | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
US20010039287A1 (en) | 1997-11-14 | 2001-11-08 | Thomas E Barta | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
PL350193A1 (en) | 1999-02-08 | 2002-11-18 | Searle & Co | Sulfamato hydroxamic acid metalloprotease inhibitor |
US6800646B1 (en) | 1999-02-08 | 2004-10-05 | Pharmacia Corporation | Sulfamato hydroxamic acid metalloprotease inhibitor |
US20010049449A1 (en) * | 1999-12-23 | 2001-12-06 | Becker Daniel P. | Aromatic sulfonyl alpha-cycloamino hydroxamates and their use as MMP inhibitors |
US6683093B2 (en) * | 2000-05-12 | 2004-01-27 | Pharmacia Corporation | Aromatic sulfone hydroxamic acids and their use as protease inhibitors |
PL367487A1 (en) | 2001-05-11 | 2005-02-21 | Pharmacia Corporation | Aromatic sulfone hydroxamates and their use as protease inhibitors |
US20040024024A1 (en) * | 2001-05-11 | 2004-02-05 | Freskos John N. | Aromatic sulfone hydroxamates and their use as protease inhibitors |
WO2003006006A1 (en) * | 2001-07-09 | 2003-01-23 | The Regents Of The University Of California | Use of matrix metalloproteinase inhibitors to mitigate nerve damage |
US6683078B2 (en) | 2001-07-19 | 2004-01-27 | Pharmacia Corporation | Use of sulfonyl aryl or heteroaryl hydroxamic acids and derivatives thereof as aggrecanase inhibitors |
WO2003042176A1 (fr) * | 2001-11-13 | 2003-05-22 | Shiseido Co., Ltd. | Compose azabicyclo, inhibiteur de metalloprotease matricielle et preparation cutanee |
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ITTO20060575A1 (it) | 2006-08-02 | 2008-02-03 | Univ Pisa | Inibitori di zinco proteinasi tioaril sostituiti e loro usi |
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-
1999
- 1999-02-24 US US09/256,948 patent/US20010039287A1/en not_active Abandoned
-
2000
- 2000-02-22 EA EA200100804A patent/EA200100804A1/ru unknown
- 2000-02-22 CZ CZ20013038A patent/CZ20013038A3/cs unknown
- 2000-02-22 MX MXPA01008568A patent/MXPA01008568A/es unknown
- 2000-02-22 EP EP00913317A patent/EP1230219A1/en not_active Withdrawn
- 2000-02-22 CA CA002371876A patent/CA2371876A1/en not_active Abandoned
- 2000-02-22 AU AU34785/00A patent/AU3478500A/en not_active Abandoned
- 2000-02-22 BR BR0008491-3A patent/BR0008491A/pt not_active Application Discontinuation
- 2000-02-22 JP JP2000600979A patent/JP2002537378A/ja active Pending
- 2000-02-22 PL PL00351204A patent/PL351204A1/xx not_active Application Discontinuation
- 2000-02-22 HU HU0200239A patent/HUP0200239A3/hu unknown
- 2000-02-22 CN CN00806608A patent/CN1370144A/zh active Pending
- 2000-02-22 KR KR1020017010886A patent/KR20020092157A/ko not_active Application Discontinuation
- 2000-02-22 WO PCT/US2000/002518 patent/WO2000050396A1/en not_active Application Discontinuation
- 2000-02-22 NZ NZ513648A patent/NZ513648A/xx unknown
- 2000-02-22 IL IL14494500A patent/IL144945A0/xx unknown
- 2000-02-24 AR ARP000100800A patent/AR043676A1/es unknown
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2001
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- 2001-08-16 ZA ZA200106780A patent/ZA200106780B/en unknown
- 2001-09-17 US US09/954,451 patent/US6750233B2/en not_active Expired - Fee Related
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CA2371876A1 (en) | 2000-08-31 |
NZ513648A (en) | 2004-02-27 |
HUP0200239A2 (en) | 2002-06-29 |
NO20013963L (no) | 2001-10-23 |
AR043676A1 (es) | 2005-08-10 |
EP1230219A1 (en) | 2002-08-14 |
US6750233B2 (en) | 2004-06-15 |
WO2000050396A1 (en) | 2000-08-31 |
MXPA01008568A (es) | 2002-04-08 |
US20010039287A1 (en) | 2001-11-08 |
AU3478500A (en) | 2000-09-14 |
ZA200106780B (en) | 2002-08-16 |
CZ20013038A3 (cs) | 2002-07-17 |
PL351204A1 (en) | 2003-03-24 |
KR20020092157A (ko) | 2002-12-11 |
CN1370144A (zh) | 2002-09-18 |
EA200100804A1 (ru) | 2002-04-25 |
US20020177588A1 (en) | 2002-11-28 |
JP2002537378A (ja) | 2002-11-05 |
NO20013963D0 (no) | 2001-08-15 |
HUP0200239A3 (en) | 2003-04-28 |
IL144945A0 (en) | 2002-06-30 |
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