BR0008491A - Inibidores de metaloprotease de ácido hidrox mico de sulfona aromática - Google Patents

Inibidores de metaloprotease de ácido hidrox mico de sulfona aromática

Info

Publication number
BR0008491A
BR0008491A BR0008491-3A BR0008491A BR0008491A BR 0008491 A BR0008491 A BR 0008491A BR 0008491 A BR0008491 A BR 0008491A BR 0008491 A BR0008491 A BR 0008491A
Authority
BR
Brazil
Prior art keywords
mmp
hydroxamic acid
aromatic sulfone
aromatic
sulfone hydroxamic
Prior art date
Application number
BR0008491-3A
Other languages
English (en)
Inventor
Thomas E Barta
Daniel P Becker
Louis J Bedell
Terri L Boehm
Jeffery N Carroll
Gary
De Crescenzo
Yvette M Fobian
John N Freskos
Daniel P Getman
Joseph J Mcdonald
Gunnar J Hanson
Susan L Hockerman
Susan C Howard
Steve A Kolodziej
Hui Li
Deborah A Mischke
Joseph G Rico
Nathan W Stehle
Michael B Tollefson
William F Vernier
Clara I Villamil
Shashidahar N Rao
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of BR0008491A publication Critical patent/BR0008491A/pt

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
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Abstract

"INIBIDORES DE METALOPROTEASE DE áCIDO HIDROX MICO DE SULFONA AROMáTICA". A invenção descreve um processo de tratamento que compreende administrar uma quantidade eficaz de um ácido hidroxâmico de sulfona aromática que apresenta excelente atividade inibidora de uma ou mais enzimas de metaloprotease de matriz (MMP), tal como MMP-2, MMP-9 e MMP-13, ao mesmo tempo em que apresenta substancialmente menos inibição pelo menos de MMP-1 a uma hospedeiro tendo uma condição associada com atividade de metaloprotease de matriz patológica. Também estão descritos compostos inibidores de metaloprotease tendo essas atividades seletivas, processos de produção de tais compostos e composições farmacêuticas utilizando um inibidor.
BR0008491-3A 1999-02-24 2000-02-22 Inibidores de metaloprotease de ácido hidrox mico de sulfona aromática BR0008491A (pt)

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US09/256,948 US20010039287A1 (en) 1997-11-14 1999-02-24 Aromatic sulfone hydroxamic acid metalloprotease inhibitor
PCT/US2000/002518 WO2000050396A1 (en) 1999-02-24 2000-02-22 Aromatic sulfone hydroxamic acid metalloprotease inhibitor

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NZ513648A (en) 2004-02-27
HUP0200239A2 (en) 2002-06-29
NO20013963L (no) 2001-10-23
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EP1230219A1 (en) 2002-08-14
US6750233B2 (en) 2004-06-15
WO2000050396A1 (en) 2000-08-31
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