PT939628E - Inibidores tiolsulfona de metaloproteases - Google Patents
Inibidores tiolsulfona de metaloproteasesInfo
- Publication number
- PT939628E PT939628E PT97936169T PT97936169T PT939628E PT 939628 E PT939628 E PT 939628E PT 97936169 T PT97936169 T PT 97936169T PT 97936169 T PT97936169 T PT 97936169T PT 939628 E PT939628 E PT 939628E
- Authority
- PT
- Portugal
- Prior art keywords
- inhibitors
- tiolsulfone
- metaloprotease
- proteinase
- mmp
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
- C07C323/65—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfone or sulfoxide groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/24—Esters of monothiocarboxylic acids having carbon atoms of esterified thiocarboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/26—Esters of monothiocarboxylic acids having carbon atoms of esterified thiocarboxyl groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2204396P | 1996-07-22 | 1996-07-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT939628E true PT939628E (pt) | 2003-07-31 |
Family
ID=21807522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT97936169T PT939628E (pt) | 1996-07-22 | 1997-07-22 | Inibidores tiolsulfona de metaloproteases |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6013649A (pt) |
| EP (1) | EP0939628B1 (pt) |
| JP (1) | JP2001505869A (pt) |
| KR (1) | KR20000067963A (pt) |
| CN (1) | CN1230884A (pt) |
| AT (1) | ATE233552T1 (pt) |
| AU (1) | AU714687B2 (pt) |
| BR (1) | BR9710758A (pt) |
| CA (1) | CA2260859A1 (pt) |
| CZ (1) | CZ16799A3 (pt) |
| DE (1) | DE69719538T2 (pt) |
| DK (1) | DK0939628T3 (pt) |
| ES (1) | ES2194209T3 (pt) |
| IL (1) | IL128079A0 (pt) |
| NO (1) | NO990262L (pt) |
| NZ (1) | NZ333824A (pt) |
| PL (1) | PL331369A1 (pt) |
| PT (1) | PT939628E (pt) |
| RU (1) | RU2221781C2 (pt) |
| WO (1) | WO1998003164A1 (pt) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6747027B1 (en) | 1996-07-22 | 2004-06-08 | Pharmacia Corporation | Thiol sulfonamide metalloprotease inhibitors |
| US6794511B2 (en) | 1997-03-04 | 2004-09-21 | G. D. Searle | Sulfonyl aryl or heteroaryl hydroxamic acid compounds |
| US6696449B2 (en) | 1997-03-04 | 2004-02-24 | Pharmacia Corporation | Sulfonyl aryl hydroxamates and their use as matrix metalloprotease inhibitors |
| US7115632B1 (en) | 1999-05-12 | 2006-10-03 | G. D. Searle & Co. | Sulfonyl aryl or heteroaryl hydroxamic acid compounds |
| CN1279669A (zh) * | 1997-11-14 | 2001-01-10 | G·D·瑟尔公司 | 芳族砜异羟肟酸金属蛋白酶抑制剂 |
| US20010039287A1 (en) | 1997-11-14 | 2001-11-08 | Thomas E Barta | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
| US6750228B1 (en) | 1997-11-14 | 2004-06-15 | Pharmacia Corporation | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
| US6420415B1 (en) | 1998-09-21 | 2002-07-16 | Takeda Chemical Industries, Ltd. | Thiol compounds, their production and use |
| US6288261B1 (en) * | 1998-12-18 | 2001-09-11 | Abbott Laboratories | Inhibitors of matrix metalloproteinases |
| US20040122011A1 (en) * | 1998-12-23 | 2004-06-24 | Pharmacia Corporation | Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy |
| US6313123B1 (en) | 1999-01-27 | 2001-11-06 | American Cyanamid Company | Acetylenic sulfonamide thiol tace inhibitors |
| HUP0105282A3 (en) * | 1999-01-27 | 2005-04-28 | Wyeth Holdings Corp Madison | Acetylenic sulfonamide thiol tace inhibitors process for their preparation and pharmaceutical compositions containing the same |
| US6800646B1 (en) | 1999-02-08 | 2004-10-05 | Pharmacia Corporation | Sulfamato hydroxamic acid metalloprotease inhibitor |
| US6583299B1 (en) * | 1999-05-20 | 2003-06-24 | G.D. Searle & Co. | α-amino-β-sulfonyl hydroxamic acid compounds |
| US6683093B2 (en) * | 2000-05-12 | 2004-01-27 | Pharmacia Corporation | Aromatic sulfone hydroxamic acids and their use as protease inhibitors |
| GB0108592D0 (en) * | 2001-04-05 | 2001-05-23 | Merck Sharp & Dohme | Therapeutic agents |
| US6689794B2 (en) | 2001-05-11 | 2004-02-10 | Pharmacia Corporation | Aromatic sulfone hydroxamates and their use as protease inhibitors |
| US6683078B2 (en) | 2001-07-19 | 2004-01-27 | Pharmacia Corporation | Use of sulfonyl aryl or heteroaryl hydroxamic acids and derivatives thereof as aggrecanase inhibitors |
| FR2827859B1 (fr) * | 2001-07-30 | 2005-09-23 | Lipha | Derives 4-(arylthio) - ou 4-(heteroarylthio) -butyrique dans la preparation de medicaments destines au traitement du diabete |
| JP2003081838A (ja) * | 2001-09-11 | 2003-03-19 | Rohto Pharmaceut Co Ltd | グルコサミン製剤 |
| DE10201392A1 (de) * | 2002-01-16 | 2003-07-31 | Bayer Ag | Phenylsulfoxide und-sulfone |
| AU2003221786A1 (en) * | 2002-04-25 | 2003-11-10 | Pharmacia Corporation | Piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors |
| US20050209278A1 (en) * | 2002-04-25 | 2005-09-22 | Mcdonald Joseph J | Piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors |
| CA2490646A1 (en) * | 2002-06-25 | 2003-12-31 | Pharmacia Corporation | Arylsulfonylhydroxamic acid and amide derivatives and their use as protease inhibitors |
| CA2509060A1 (en) * | 2002-12-27 | 2004-07-22 | Angiotech International Ag | Compositions and methods of using collagen and mmpi |
| ATE457716T1 (de) | 2002-12-30 | 2010-03-15 | Angiotech Int Ag | Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung |
| US20050043533A1 (en) * | 2003-03-25 | 2005-02-24 | Babiak Kevin A. | Process for making alpha-substituted hydroxamic acids |
| SE0301010D0 (sv) | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| SA04250253B1 (ar) | 2003-08-21 | 2009-11-10 | استرازينيكا ايه بي | احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن |
| US20050277897A1 (en) * | 2004-06-14 | 2005-12-15 | Ghannoum Ziad R | Handpiece tip |
| GB0415320D0 (en) | 2004-07-08 | 2004-08-11 | Astrazeneca Ab | Novel compounds |
| GB0418830D0 (en) | 2004-08-24 | 2004-09-22 | Astrazeneca Ab | Novel compounds |
| SI1817282T1 (sl) | 2004-11-23 | 2011-10-28 | Astrazeneca Ab | Derivati fenoksiocetne kisline, uporabni za zdravljenje respiratornih bolezni |
| TW200745003A (en) | 2005-10-06 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| US8148572B2 (en) * | 2005-10-06 | 2012-04-03 | Astrazeneca Ab | Compounds |
| WO2007141029A1 (en) * | 2006-06-08 | 2007-12-13 | Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) | Specific protease inhibitors and their use in cancer therapy |
| WO2009045761A1 (en) * | 2007-09-28 | 2009-04-09 | Absolute Science, Inc. | Compounds and methods for treating zinc matrix metalloprotease dependent diseases |
| CA2737437A1 (en) * | 2008-09-19 | 2010-03-25 | Absolute Science, Inc. | Methods of treating a botulinum toxin related condition in a subject |
| EP3542629A3 (en) | 2009-06-15 | 2020-01-01 | Encore Health, LLC | Dithiol compounds, derivatives, and uses therefor |
| FR2950890B1 (fr) * | 2009-10-06 | 2011-12-30 | Tetrahedron | Procede de synthese de la 2-thiohistidine et analogues |
| GB201313238D0 (en) * | 2013-07-24 | 2013-09-04 | Avexxin As | Process for the preparation of a polyunsaturated ketone compound |
| CN116785450A (zh) | 2017-02-28 | 2023-09-22 | 伊缪诺金公司 | 具有自分解肽接头的类美登素衍生物和其缀合物 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4595700A (en) * | 1984-12-21 | 1986-06-17 | G. D. Searle & Co. | Thiol based collagenase inhibitors |
| US5274094A (en) * | 1990-08-15 | 1993-12-28 | British Bio-Technology Limited | Production of heterobicyclic containing benzene sulfonamides |
| CA2110514A1 (en) * | 1991-07-05 | 1993-01-21 | Raymond Baker | Aromatic compounds, pharmaceutical compositions containing them and their use in therapy |
| GB9200210D0 (en) * | 1992-01-07 | 1992-02-26 | British Bio Technology | Compounds |
| US5376664A (en) * | 1992-07-27 | 1994-12-27 | The Du Pont Merck Pharmaceutical Company | Unsymmetrical mono-3-nitro bis-naphthalimides as anticancer agents |
| GB9307956D0 (en) * | 1993-04-17 | 1993-06-02 | Walls Alan J | Hydroxamic acid derivatives |
| SG52229A1 (en) * | 1993-08-10 | 1998-09-28 | Black James Foundation | Gastrin and cck receptor ligands |
| AU8130894A (en) * | 1993-11-04 | 1995-05-23 | Liposome Company, Inc., The | Methods of treatment using unilamellar liposomal arachidonic acid metabolite formulations |
| GB9323162D0 (en) * | 1993-11-10 | 1994-01-05 | British Bio Technology | 4-(1h-2-methylimidazo(4,5-c)pyridinylmethyl)phenylsulphonamid e derivatives as antagonists of paf |
| GB9323165D0 (en) * | 1993-11-10 | 1994-01-05 | Chiros Ltd | Compounds |
| US5475138A (en) * | 1994-07-07 | 1995-12-12 | Pharm-Eco Laboratories Incorporated | Method preparing amino acid-derived diaminopropanols |
| BR9509237A (pt) * | 1994-10-05 | 1997-10-21 | Chiroscience Ltd | Compostos peptidila e seu uso terapêutico como inibidores de metaloproteases |
| WO1997005865A1 (en) * | 1995-08-08 | 1997-02-20 | Fibrogen, Inc. | C-proteinase inhibitors for the treatment of disorders related to the overproduction of collagen |
| DK0874830T3 (da) * | 1995-12-08 | 2003-04-22 | Agouron Pharma | Metalloproteinaseinhibitor, farmaceutisk præparat indeholdende denne og den farmaceutiske anvendelse samt en fremgangsmåde til fremstilling deraf |
-
1997
- 1997-07-22 PT PT97936169T patent/PT939628E/pt unknown
- 1997-07-22 US US08/900,028 patent/US6013649A/en not_active Expired - Fee Related
- 1997-07-22 PL PL97331369A patent/PL331369A1/xx unknown
- 1997-07-22 CA CA002260859A patent/CA2260859A1/en not_active Abandoned
- 1997-07-22 NZ NZ333824A patent/NZ333824A/xx unknown
- 1997-07-22 KR KR1019997000465A patent/KR20000067963A/ko not_active Application Discontinuation
- 1997-07-22 JP JP50719698A patent/JP2001505869A/ja not_active Abandoned
- 1997-07-22 EP EP97936169A patent/EP0939628B1/en not_active Expired - Lifetime
- 1997-07-22 ES ES97936169T patent/ES2194209T3/es not_active Expired - Lifetime
- 1997-07-22 RU RU99103642/04A patent/RU2221781C2/ru not_active IP Right Cessation
- 1997-07-22 CZ CZ99167A patent/CZ16799A3/cs unknown
- 1997-07-22 DK DK97936169T patent/DK0939628T3/da active
- 1997-07-22 BR BR9710758A patent/BR9710758A/pt not_active IP Right Cessation
- 1997-07-22 WO PCT/US1997/012874 patent/WO1998003164A1/en not_active Application Discontinuation
- 1997-07-22 IL IL12807997A patent/IL128079A0/xx unknown
- 1997-07-22 CN CN97198098A patent/CN1230884A/zh active Pending
- 1997-07-22 AT AT97936169T patent/ATE233552T1/de not_active IP Right Cessation
- 1997-07-22 AU AU38904/97A patent/AU714687B2/en not_active Ceased
- 1997-07-22 DE DE69719538T patent/DE69719538T2/de not_active Expired - Fee Related
-
1999
- 1999-01-21 NO NO990262A patent/NO990262L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE233552T1 (de) | 2003-03-15 |
| RU2221781C2 (ru) | 2004-01-20 |
| US6013649A (en) | 2000-01-11 |
| PL331369A1 (en) | 1999-07-05 |
| KR20000067963A (ko) | 2000-11-25 |
| ES2194209T3 (es) | 2003-11-16 |
| CA2260859A1 (en) | 1998-01-29 |
| EP0939628A4 (en) | 1999-12-22 |
| NO990262D0 (no) | 1999-01-21 |
| DE69719538T2 (de) | 2004-02-19 |
| AU714687B2 (en) | 2000-01-06 |
| BR9710758A (pt) | 1999-08-17 |
| AU3890497A (en) | 1998-02-10 |
| DE69719538D1 (en) | 2003-04-10 |
| NO990262L (no) | 1999-03-17 |
| EP0939628A1 (en) | 1999-09-08 |
| CN1230884A (zh) | 1999-10-06 |
| JP2001505869A (ja) | 2001-05-08 |
| NZ333824A (en) | 2000-08-25 |
| EP0939628B1 (en) | 2003-03-05 |
| CZ16799A3 (cs) | 1999-06-16 |
| DK0939628T3 (da) | 2003-07-07 |
| WO1998003164A1 (en) | 1998-01-29 |
| IL128079A0 (en) | 1999-11-30 |
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