ATE52518T1 - Peptid-derivate, pepstatin-analoga, renin- und saeureprotease hemmende mittel. - Google Patents

Peptid-derivate, pepstatin-analoga, renin- und saeureprotease hemmende mittel.

Info

Publication number
ATE52518T1
ATE52518T1 AT86400272T AT86400272T ATE52518T1 AT E52518 T1 ATE52518 T1 AT E52518T1 AT 86400272 T AT86400272 T AT 86400272T AT 86400272 T AT86400272 T AT 86400272T AT E52518 T1 ATE52518 T1 AT E52518T1
Authority
AT
Austria
Prior art keywords
pepstatin
renin
analogues
peptide derivatives
protease inhibitors
Prior art date
Application number
AT86400272T
Other languages
English (en)
Inventor
Jean Wagnon
Georges Callet
Jean-Pierre Gagnol
Dino Nisato
Catherine Cazaubon
Original Assignee
Sanofi Sa
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8501981A external-priority patent/FR2577225B1/fr
Priority claimed from FR8501982A external-priority patent/FR2577226B1/fr
Application filed by Sanofi Sa, Inst Nat Sante Rech Med filed Critical Sanofi Sa
Application granted granted Critical
Publication of ATE52518T1 publication Critical patent/ATE52518T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/86—Renin inhibitors
AT86400272T 1985-02-12 1986-02-10 Peptid-derivate, pepstatin-analoga, renin- und saeureprotease hemmende mittel. ATE52518T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR8501981A FR2577225B1 (fr) 1985-02-12 1985-02-12 Derives peptidiques inhibiteurs de la renine et des proteases acides
FR8501982A FR2577226B1 (fr) 1985-02-12 1985-02-12 Analogues de pepstatine inhibiteurs de la renine et des proteases acides
EP86400272A EP0193445B1 (de) 1985-02-12 1986-02-10 Peptid-Derivate, Pepstatin-Analoga, Renin- und Säureprotease hemmende Mittel

Publications (1)

Publication Number Publication Date
ATE52518T1 true ATE52518T1 (de) 1990-05-15

Family

ID=26224369

Family Applications (2)

Application Number Title Priority Date Filing Date
AT86400272T ATE52518T1 (de) 1985-02-12 1986-02-10 Peptid-derivate, pepstatin-analoga, renin- und saeureprotease hemmende mittel.
AT86400271T ATE71111T1 (de) 1985-02-12 1986-02-10 Peptid-derivate, renin- und saeureprotease hemmende mittel.

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT86400271T ATE71111T1 (de) 1985-02-12 1986-02-10 Peptid-derivate, renin- und saeureprotease hemmende mittel.

Country Status (11)

Country Link
US (2) US4746648A (de)
EP (2) EP0193445B1 (de)
AT (2) ATE52518T1 (de)
AU (2) AU606572B2 (de)
CA (2) CA1286846C (de)
DE (2) DE3671021D1 (de)
DK (2) DK64086A (de)
ES (2) ES8701782A1 (de)
GR (2) GR860398B (de)
NZ (2) NZ215097A (de)
PT (2) PT81990B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2585708B1 (fr) * 1985-07-31 1989-07-07 Sanofi Sa Derives aminoalcools peptidiques inhibiteurs de la resine et des proteases acides, leur procede de preparation et leur application en therapeutique
US4599198A (en) * 1985-08-02 1986-07-08 Pfizer Inc. Intermediates in polypeptide synthesis
DE3626130A1 (de) * 1986-08-01 1988-02-11 Merck Patent Gmbh Aminosaeurederivate
DE3640535A1 (de) * 1986-11-27 1988-06-01 Merck Patent Gmbh Peptide
EP0284510A3 (de) * 1987-03-24 1990-08-22 Asahi Breweries, Ltd. N-[N-alpha-(1(S)-carboxy-3-cyclohexylpropyl)-L-lysyl]-N-cyclopentylglycin als antihypertensives Mittel
US4980283A (en) * 1987-10-01 1990-12-25 Merck & Co., Inc. Renin-inhibitory pepstatin phenyl derivatives
US4874745A (en) * 1987-10-01 1989-10-17 Merck & Co., Inc. Renin-inhibitory pepstatin phenyl derivatives
US5162527A (en) * 1987-10-26 1992-11-10 Warner-Lambert Company Renin inhibitors, processes for preparing them, methods for using them, and compositions containing them
EP0314060A3 (de) * 1987-10-26 1991-06-19 Warner-Lambert Company Renin-Hemmer, Verfahren zu ihrer Herstellung, Methoden zu ihrer Verwendung und Zubereitungen, die sie enthalten
IL92011A0 (en) * 1988-10-19 1990-07-12 Abbott Lab Heterocyclic peptide renin inhibitors
US5164388A (en) * 1988-10-19 1992-11-17 Abbott Laboratories Heterocyclic peptide renin inhibitors
ES2077021T3 (es) * 1989-02-16 1995-11-16 Sankyo Co Peptidos que tienen actividad inhibidora de renina, su preparacion y uso.
FR2646354B1 (fr) * 1989-04-27 1994-06-10 Sanofi Sa Utilisation de peptides inhibiteurs de proteases acides pour la preparation de medicaments utiles pour le traitement de maladies virales
US5238923A (en) * 1989-05-26 1993-08-24 Warner-Lambert Company Amino-substituted heterocycles as renin inhibitors
US5149692A (en) * 1989-12-21 1992-09-22 Warner-Lambert Company Bisalkoxyphosphinyl compounds as renin inhibitors
US5071837A (en) * 1990-11-28 1991-12-10 Warner-Lambert Company Novel renin inhibiting peptides
US5833946A (en) * 1995-06-06 1998-11-10 Bayer Corporation Dissemination of fungal infections: animal model and method of prophylaxis
AT407043B (de) * 1998-01-23 2000-11-27 Martin Dr Kratzel Simplifizierte pepstatin-a-analoga, deren herstellung und verwendung
US7247704B2 (en) * 2000-12-18 2007-07-24 Arriva Pharmaceuticals, Inc. Multifunctional protease inhibitors and their use in treatment of disease
US7929913B2 (en) 2002-12-16 2011-04-19 Intel Corporation Adaptive receiver architecture
CN103370331B (zh) 2011-02-08 2017-02-15 默克专利股份有限公司 用于治疗关节病的氨基他汀衍生物
WO2014015934A1 (de) 2012-07-24 2014-01-30 Merck Patent Gmbh Hydroxystatin-derivate zur behandlung von arthrose
CA2902080A1 (en) 2013-02-25 2014-08-28 Merck Patent Gmbh 2-amino-3,4-dihydroquinazoline derivatives and the use thereof as cathepsin d inhibitors
US9750784B2 (en) 2013-08-06 2017-09-05 Merck Patent Gmbh Intraarticular application of pepstatin in the case of arthrosis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1245217A (en) * 1981-12-10 1988-11-22 Joshua S. Boger Renin inhibitory peptides having phe su13 xx deletion
FR2531951A1 (fr) * 1982-08-17 1984-02-24 Sanofi Sa Derives peptidiques inhibiteurs de proteases acides, procede pour leur preparation et medicaments qui en contiennent
EP0114993B1 (de) * 1982-12-27 1990-05-16 Merck & Co. Inc. Reninhemmende Tripeptide

Also Published As

Publication number Publication date
AU5327386A (en) 1986-08-21
DK64186D0 (da) 1986-02-10
EP0192554B1 (de) 1992-01-02
PT81991A (fr) 1986-03-01
GR860398B (en) 1986-06-12
US4725580A (en) 1988-02-16
NZ215097A (en) 1990-04-26
PT81990B (pt) 1988-03-03
US4746648A (en) 1988-05-24
PT81990A (fr) 1986-03-01
ATE71111T1 (de) 1992-01-15
CA1286846C (en) 1991-07-23
NZ215096A (en) 1989-10-27
AU606572B2 (en) 1991-02-14
DK64086A (da) 1986-08-13
ES551821A0 (es) 1987-01-01
DE3683170D1 (de) 1992-02-13
CA1286847C (en) 1991-07-23
AU606312B2 (en) 1991-02-07
EP0192554A1 (de) 1986-08-27
DK64086D0 (da) 1986-02-10
EP0193445B1 (de) 1990-05-09
ES551820A0 (es) 1986-12-16
DE3671021D1 (de) 1990-06-13
DK64186A (da) 1986-08-13
ES8701782A1 (es) 1986-12-16
AU5327286A (en) 1986-08-14
EP0193445A1 (de) 1986-09-03
PT81991B (pt) 1988-03-03
GR860399B (en) 1986-06-12
ES8701783A1 (es) 1987-01-01

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee