PT81991B - Processo para a preparacao de derivados peptidicos, analogos a pepestatina, inibidores darenina e das proteases acidas - Google Patents

Processo para a preparacao de derivados peptidicos, analogos a pepestatina, inibidores darenina e das proteases acidas

Info

Publication number
PT81991B
PT81991B PT81991A PT8199186A PT81991B PT 81991 B PT81991 B PT 81991B PT 81991 A PT81991 A PT 81991A PT 8199186 A PT8199186 A PT 8199186A PT 81991 B PT81991 B PT 81991B
Authority
PT
Portugal
Prior art keywords
pepestatin
darenine
analogs
inhibitors
preparation
Prior art date
Application number
PT81991A
Other languages
English (en)
Other versions
PT81991A (fr
Inventor
Dino Nisato
Jean Wagnon
Georges Callet
Jean-Pierre Gagnol
Catherine Cazaubon
Original Assignee
Sanofi Sa
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8501982A external-priority patent/FR2577226B1/fr
Priority claimed from FR8501981A external-priority patent/FR2577225B1/fr
Application filed by Sanofi Sa, Inst Nat Sante Rech Med filed Critical Sanofi Sa
Publication of PT81991A publication Critical patent/PT81991A/pt
Publication of PT81991B publication Critical patent/PT81991B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/86—Renin inhibitors
PT81991A 1985-02-12 1986-02-07 Processo para a preparacao de derivados peptidicos, analogos a pepestatina, inibidores darenina e das proteases acidas PT81991B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8501982A FR2577226B1 (fr) 1985-02-12 1985-02-12 Analogues de pepstatine inhibiteurs de la renine et des proteases acides
FR8501981A FR2577225B1 (fr) 1985-02-12 1985-02-12 Derives peptidiques inhibiteurs de la renine et des proteases acides

Publications (2)

Publication Number Publication Date
PT81991A PT81991A (fr) 1986-03-01
PT81991B true PT81991B (pt) 1988-03-03

Family

ID=26224369

Family Applications (2)

Application Number Title Priority Date Filing Date
PT81990A PT81990B (pt) 1985-02-12 1986-02-07 Processo para a preparacao de derivados peptidicos inibidores da renina e das proteases acidas
PT81991A PT81991B (pt) 1985-02-12 1986-02-07 Processo para a preparacao de derivados peptidicos, analogos a pepestatina, inibidores darenina e das proteases acidas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT81990A PT81990B (pt) 1985-02-12 1986-02-07 Processo para a preparacao de derivados peptidicos inibidores da renina e das proteases acidas

Country Status (11)

Country Link
US (2) US4725580A (pt)
EP (2) EP0192554B1 (pt)
AT (2) ATE71111T1 (pt)
AU (2) AU606572B2 (pt)
CA (2) CA1286846C (pt)
DE (2) DE3671021D1 (pt)
DK (2) DK64086A (pt)
ES (2) ES8701783A1 (pt)
GR (2) GR860398B (pt)
NZ (2) NZ215096A (pt)
PT (2) PT81990B (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2585708B1 (fr) * 1985-07-31 1989-07-07 Sanofi Sa Derives aminoalcools peptidiques inhibiteurs de la resine et des proteases acides, leur procede de preparation et leur application en therapeutique
US4599198A (en) * 1985-08-02 1986-07-08 Pfizer Inc. Intermediates in polypeptide synthesis
DE3626130A1 (de) * 1986-08-01 1988-02-11 Merck Patent Gmbh Aminosaeurederivate
DE3640535A1 (de) * 1986-11-27 1988-06-01 Merck Patent Gmbh Peptide
EP0284510A3 (en) * 1987-03-24 1990-08-22 Asahi Breweries, Ltd. N-[N alpha-(1(S)-carboxy-3-cyclohexyl-propyl)-1-lysyl] N-cyclopentylglycine as antihypertensives
US4874745A (en) * 1987-10-01 1989-10-17 Merck & Co., Inc. Renin-inhibitory pepstatin phenyl derivatives
US4980283A (en) * 1987-10-01 1990-12-25 Merck & Co., Inc. Renin-inhibitory pepstatin phenyl derivatives
EP0314060A3 (en) * 1987-10-26 1991-06-19 Warner-Lambert Company Renin inhibitors, processes for preparing them, methods for using them, and compositions containing them
US5162527A (en) * 1987-10-26 1992-11-10 Warner-Lambert Company Renin inhibitors, processes for preparing them, methods for using them, and compositions containing them
US5164388A (en) * 1988-10-19 1992-11-17 Abbott Laboratories Heterocyclic peptide renin inhibitors
IL92011A0 (en) * 1988-10-19 1990-07-12 Abbott Lab Heterocyclic peptide renin inhibitors
EP0383635B1 (en) * 1989-02-16 1995-07-12 Sankyo Company Limited Peptides having renin inhibitory activity their preparation and use
FR2646354B1 (fr) * 1989-04-27 1994-06-10 Sanofi Sa Utilisation de peptides inhibiteurs de proteases acides pour la preparation de medicaments utiles pour le traitement de maladies virales
US5238923A (en) * 1989-05-26 1993-08-24 Warner-Lambert Company Amino-substituted heterocycles as renin inhibitors
US5149692A (en) * 1989-12-21 1992-09-22 Warner-Lambert Company Bisalkoxyphosphinyl compounds as renin inhibitors
US5071837A (en) * 1990-11-28 1991-12-10 Warner-Lambert Company Novel renin inhibiting peptides
US5833946A (en) * 1995-06-06 1998-11-10 Bayer Corporation Dissemination of fungal infections: animal model and method of prophylaxis
AT407043B (de) * 1998-01-23 2000-11-27 Martin Dr Kratzel Simplifizierte pepstatin-a-analoga, deren herstellung und verwendung
US7247704B2 (en) 2000-12-18 2007-07-24 Arriva Pharmaceuticals, Inc. Multifunctional protease inhibitors and their use in treatment of disease
US7929913B2 (en) 2002-12-16 2011-04-19 Intel Corporation Adaptive receiver architecture
KR20140053855A (ko) 2011-02-08 2014-05-08 메르크 파텐트 게엠베하 관절증의 치료를 위한 아미노스타틴 유도체
CN104507957B (zh) 2012-07-24 2018-12-25 默克专利股份有限公司 用于治疗关节病的羟基他汀衍生物
US9663475B2 (en) 2013-02-25 2017-05-30 Merck Patent Gmbh 2 amino-3,4-dihydrcquinazoline derivatives and the use thereof as cathepsin D inhibitors
WO2015018472A1 (de) 2013-08-06 2015-02-12 Merck Patent Gmbh Intraartikuläre applikation von pepstatin bei arthrose

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1245217A (en) * 1981-12-10 1988-11-22 Joshua S. Boger Renin inhibitory peptides having phe su13 xx deletion
FR2531951A1 (fr) * 1982-08-17 1984-02-24 Sanofi Sa Derives peptidiques inhibiteurs de proteases acides, procede pour leur preparation et medicaments qui en contiennent
DE3381565D1 (de) * 1982-12-27 1990-06-21 Merck & Co Inc Reninhemmende tripeptide.

Also Published As

Publication number Publication date
DK64086D0 (da) 1986-02-10
ES551821A0 (es) 1987-01-01
US4746648A (en) 1988-05-24
AU606572B2 (en) 1991-02-14
EP0193445A1 (fr) 1986-09-03
PT81990B (pt) 1988-03-03
CA1286846C (en) 1991-07-23
DK64086A (da) 1986-08-13
CA1286847C (en) 1991-07-23
AU5327286A (en) 1986-08-14
DE3671021D1 (de) 1990-06-13
DK64186A (da) 1986-08-13
ES8701783A1 (es) 1987-01-01
ATE52518T1 (de) 1990-05-15
NZ215097A (en) 1990-04-26
PT81990A (fr) 1986-03-01
ATE71111T1 (de) 1992-01-15
GR860399B (en) 1986-06-12
AU606312B2 (en) 1991-02-07
EP0192554A1 (fr) 1986-08-27
EP0193445B1 (fr) 1990-05-09
DK64186D0 (da) 1986-02-10
DE3683170D1 (de) 1992-02-13
ES8701782A1 (es) 1986-12-16
GR860398B (en) 1986-06-12
US4725580A (en) 1988-02-16
EP0192554B1 (fr) 1992-01-02
AU5327386A (en) 1986-08-21
NZ215096A (en) 1989-10-27
PT81991A (fr) 1986-03-01
ES551820A0 (es) 1986-12-16

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Legal Events

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Effective date: 19940331