PT83045B - Processo para a obtencao de derivados aminoalcoois peptidicos contendo um atomo de carbono tetrasubstituido inibidores da renina e das proteases acidas - Google Patents

Processo para a obtencao de derivados aminoalcoois peptidicos contendo um atomo de carbono tetrasubstituido inibidores da renina e das proteases acidas

Info

Publication number
PT83045B
PT83045B PT83045A PT8304586A PT83045B PT 83045 B PT83045 B PT 83045B PT 83045 A PT83045 A PT 83045A PT 8304586 A PT8304586 A PT 8304586A PT 83045 B PT83045 B PT 83045B
Authority
PT
Portugal
Prior art keywords
renin
aminoalcoal
peptidal
atomus
inhibitors
Prior art date
Application number
PT83045A
Other languages
English (en)
Other versions
PT83045A (fr
Inventor
Dino Nisato
Jean Wagnon
Remy Chegan
Colette Lacour
Original Assignee
Sanofi Sa
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa, Inst Nat Sante Rech Med filed Critical Sanofi Sa
Publication of PT83045A publication Critical patent/PT83045A/pt
Publication of PT83045B publication Critical patent/PT83045B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/86—Renin inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT83045A 1985-07-31 1986-07-23 Processo para a obtencao de derivados aminoalcoois peptidicos contendo um atomo de carbono tetrasubstituido inibidores da renina e das proteases acidas PT83045B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8511728A FR2585708B1 (fr) 1985-07-31 1985-07-31 Derives aminoalcools peptidiques inhibiteurs de la resine et des proteases acides, leur procede de preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
PT83045A PT83045A (fr) 1986-08-01
PT83045B true PT83045B (pt) 1988-07-01

Family

ID=9321828

Family Applications (1)

Application Number Title Priority Date Filing Date
PT83045A PT83045B (pt) 1985-07-31 1986-07-23 Processo para a obtencao de derivados aminoalcoois peptidicos contendo um atomo de carbono tetrasubstituido inibidores da renina e das proteases acidas

Country Status (17)

Country Link
US (1) US4840935A (pt)
EP (1) EP0211744B1 (pt)
JP (1) JP2505164B2 (pt)
KR (1) KR930008111B1 (pt)
AT (1) ATE70067T1 (pt)
AU (1) AU600907B2 (pt)
CA (1) CA1293839C (pt)
DE (1) DE3682721D1 (pt)
DK (1) DK172011B1 (pt)
ES (1) ES2001863A6 (pt)
FR (1) FR2585708B1 (pt)
GR (1) GR862021B (pt)
IE (1) IE59400B1 (pt)
IL (1) IL79442A (pt)
NZ (1) NZ217007A (pt)
PT (1) PT83045B (pt)
ZA (1) ZA865696B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ222755A (en) * 1986-12-23 1989-11-28 Warner Lambert Co Renin inhibiting acyl peptide derivatives containing two to four amino acid residues, and pharmaceutical compositions
DE3815913A1 (de) * 1988-05-10 1989-11-23 Sandoz Ag Neue reninhemmer, verfahren zu deren herstellung und deren verwendung
DE3841520A1 (de) * 1988-12-09 1990-06-13 Hoechst Ag Enzymhemmende harnstoffderivate von dipeptiden, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
FR2646354B1 (fr) * 1989-04-27 1994-06-10 Sanofi Sa Utilisation de peptides inhibiteurs de proteases acides pour la preparation de medicaments utiles pour le traitement de maladies virales
FR2647675B1 (fr) * 1989-06-05 1994-05-20 Sanofi Utilisation d'un derive de la statine dans le traitement des affections oculaires
JPH0765456B2 (ja) * 1989-12-09 1995-07-19 株式会社奥村組 拡大トンネル部の構築方法
JPH0768844B2 (ja) * 1990-08-24 1995-07-26 鉄建建設株式会社 シールドトンネルの拡巾方法
US5672717A (en) * 1993-10-26 1997-09-30 Iowa State University Research Foundation, Inc. Preparation of pyrrol and oxazole compounds; formation of porphyrins and C-acyl-α-amino acid esters therefrom
US5367084A (en) * 1993-10-26 1994-11-22 Iowa State University Research Foundation, Inc. Preparation of pyrrol and oxazole compounds: formation of porphyrins and c-acyl-α-amino acid esters therefrom
US5872101A (en) * 1995-01-06 1999-02-16 Sibia Neurosciences, Inc. Methods of treating neurodegenerative disorders using protease inhibitors
US5804560A (en) * 1995-01-06 1998-09-08 Sibia Neurosciences, Inc. Peptide and peptide analog protease inhibitors
US5833946A (en) * 1995-06-06 1998-11-10 Bayer Corporation Dissemination of fungal infections: animal model and method of prophylaxis
ATE360011T1 (de) * 2000-07-13 2007-05-15 Sankyo Co Aminoalkoholderivate
WO2005105069A1 (en) * 2004-04-26 2005-11-10 Alcon, Inc. Statins for the treatment of ocular hypertension and glaucoma

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1245217A (en) * 1981-12-10 1988-11-22 Joshua S. Boger Renin inhibitory peptides having phe su13 xx deletion
US4595677A (en) * 1982-12-03 1986-06-17 Ciba-Geigy Corporation Substituted tetrapeptides
US4661473A (en) * 1984-03-27 1987-04-28 Merck & Co., Inc. Renin inhibitors containing peptide isosteres
US4668663A (en) * 1984-03-27 1987-05-26 Merck & Co., Inc. Renin inhibitors containing homophe8
US4636491A (en) * 1984-03-27 1987-01-13 Merck & Co., Inc. Renin inhibitory peptides having improved solubility
DE3418491A1 (de) * 1984-05-18 1985-11-21 Merck Patent Gmbh, 6100 Darmstadt Diaminosaeurederivate
CA1286846C (en) * 1985-02-12 1991-07-23 Catherine Cazaubon Peptide derivatives which inhibit renin and acid proteases

Also Published As

Publication number Publication date
IE862031L (en) 1987-01-31
EP0211744A1 (fr) 1987-02-25
ES2001863A6 (es) 1988-07-01
FR2585708A1 (fr) 1987-02-06
US4840935A (en) 1989-06-20
DK364486D0 (da) 1986-07-31
IL79442A (en) 1991-06-10
AU600907B2 (en) 1990-08-30
KR930008111B1 (ko) 1993-08-26
IL79442A0 (en) 1986-10-31
JP2505164B2 (ja) 1996-06-05
FR2585708B1 (fr) 1989-07-07
IE59400B1 (en) 1994-02-23
DK172011B1 (da) 1997-09-15
EP0211744B1 (fr) 1991-12-04
DK364486A (da) 1987-02-01
GR862021B (en) 1986-12-31
JPS6229596A (ja) 1987-02-07
ATE70067T1 (de) 1991-12-15
AU6052086A (en) 1987-02-05
ZA865696B (en) 1987-03-25
NZ217007A (en) 1988-06-30
CA1293839C (en) 1991-12-31
KR880001697A (ko) 1988-04-26
PT83045A (fr) 1986-08-01
DE3682721D1 (de) 1992-01-16

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