IT8224380A0 - Amminoacidi fosfinilalcanoici utili come agenti ipotensivi. - Google Patents
Amminoacidi fosfinilalcanoici utili come agenti ipotensivi.Info
- Publication number
- IT8224380A0 IT8224380A0 IT8224380A IT2438082A IT8224380A0 IT 8224380 A0 IT8224380 A0 IT 8224380A0 IT 8224380 A IT8224380 A IT 8224380A IT 2438082 A IT2438082 A IT 2438082A IT 8224380 A0 IT8224380 A0 IT 8224380A0
- Authority
- IT
- Italy
- Prior art keywords
- phosphynylalkanoic
- amino acids
- acids useful
- hypotensive agents
- hypotensive
- Prior art date
Links
- 150000001413 amino acids Chemical class 0.000 title 1
- 239000002220 antihypertensive agent Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids R2P(=O)(OH); Thiophosphinic acids, i.e. R2P(=X)(XH) (X = S, Se)
- C07F9/32—Esters thereof
- C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3211—Esters of acyclic saturated acids which can have further substituents on alkyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids R2P(=O)(OH); Thiophosphinic acids, i.e. R2P(=X)(XH) (X = S, Se)
- C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/323,859 US4396772A (en) | 1981-11-23 | 1981-11-23 | Phosphinylalkanoyl amino acids |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IT8224380A0 true IT8224380A0 (it) | 1982-11-23 |
| IT8224380A1 IT8224380A1 (it) | 1984-05-23 |
| IT1153356B IT1153356B (it) | 1987-01-14 |
Family
ID=23261036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT24380/82A IT1153356B (it) | 1981-11-23 | 1982-11-23 | Amminoacidi fosfinilalcanoici utili come agenti ipotensivi |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4396772A (it) |
| JP (1) | JPS5892684A (it) |
| CA (1) | CA1185248A (it) |
| DE (1) | DE3243057A1 (it) |
| FR (1) | FR2516924B1 (it) |
| GB (1) | GB2109793B (it) |
| IT (1) | IT1153356B (it) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4432972A (en) * | 1981-08-03 | 1984-02-21 | E. R. Squibb & Sons, Inc. | Phosphonamidate compounds |
| NZ201997A (en) * | 1981-09-25 | 1985-12-13 | Wellcome Found | Phosphorus-containing amides and pharmaceutical compositions |
| US4555506A (en) * | 1981-12-24 | 1985-11-26 | E. R. Squibb & Sons, Inc. | Phosphorus containing compounds and use as hypotensives |
| US4427665A (en) | 1982-05-19 | 1984-01-24 | E. R. Squibb & Sons, Inc. | Phosphinylalkanoyl substituted imino acids and their use in hypotensive compositions |
| DK31784A (da) * | 1983-01-28 | 1984-07-29 | Schering Corp | Phosphorholdige amidforbindelser, farmaceutiske kompositioner indeholdende disse, og fremgangsmaader til forbindelsernes fremstilling |
| US4873356A (en) * | 1987-09-30 | 1989-10-10 | E. R. Squibb & Sons, Inc. | Method for preparing phosphinic acids used in preparing ace inhibitors and intermediates produced thereby |
| IT1270260B (it) * | 1994-06-21 | 1997-04-29 | Zambon Spa | Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4105776A (en) * | 1976-06-21 | 1978-08-08 | E. R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
| US4053651A (en) * | 1976-05-10 | 1977-10-11 | E. R. Squibb & Sons, Inc. | Compounds and method for alleviating angiotensin related hypertension |
| US4179464A (en) * | 1977-11-14 | 1979-12-18 | Schultz Robert J | Preparation of N-(phosphonoacetyl)-L-aspartic acid |
| US4316896A (en) * | 1978-09-07 | 1982-02-23 | Merck & Co., Inc. | Aminoacid derivatives as antihypertensives |
| US4168267A (en) * | 1978-10-23 | 1979-09-18 | E. R. Squibb & Sons, Inc. | Phosphinylalkanoyl prolines |
| US4371526A (en) * | 1981-08-21 | 1983-02-01 | E. R. Squibb & Sons, Inc. | Phosphinylalkanoyl substituted 4,5-dihydropyrazole-5-carboxylic acid derivatives and hypotensive method and composition |
-
1981
- 1981-11-23 US US06/323,859 patent/US4396772A/en not_active Expired - Fee Related
-
1982
- 1982-10-21 CA CA000413953A patent/CA1185248A/en not_active Expired
- 1982-11-02 GB GB08231345A patent/GB2109793B/en not_active Expired
- 1982-11-18 FR FR8219281A patent/FR2516924B1/fr not_active Expired
- 1982-11-19 JP JP57204431A patent/JPS5892684A/ja active Pending
- 1982-11-22 DE DE19823243057 patent/DE3243057A1/de not_active Withdrawn
- 1982-11-23 IT IT24380/82A patent/IT1153356B/it active
Also Published As
| Publication number | Publication date |
|---|---|
| CA1185248A (en) | 1985-04-09 |
| GB2109793A (en) | 1983-06-08 |
| FR2516924B1 (fr) | 1985-05-31 |
| US4396772A (en) | 1983-08-02 |
| JPS5892684A (ja) | 1983-06-02 |
| DE3243057A1 (de) | 1983-05-26 |
| IT1153356B (it) | 1987-01-14 |
| GB2109793B (en) | 1985-09-04 |
| IT8224380A1 (it) | 1984-05-23 |
| FR2516924A1 (fr) | 1983-05-27 |
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