ES532380A0 - Acidos 7-amino-1-ciclopropil-6,8-difluor-1,4-dihidro-4-oxo-quinolincarboxilicos - Google Patents

Acidos 7-amino-1-ciclopropil-6,8-difluor-1,4-dihidro-4-oxo-quinolincarboxilicos

Info

Publication number
ES532380A0
ES532380A0 ES532380A ES532380A ES532380A0 ES 532380 A0 ES532380 A0 ES 532380A0 ES 532380 A ES532380 A ES 532380A ES 532380 A ES532380 A ES 532380A ES 532380 A0 ES532380 A0 ES 532380A0
Authority
ES
Spain
Prior art keywords
cyclopropil
difluor
dihydro
oxo
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES532380A
Other languages
English (en)
Other versions
ES8507535A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6199330&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES532380(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES532380A0 publication Critical patent/ES532380A0/es
Publication of ES8507535A1 publication Critical patent/ES8507535A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Fodder In General (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Hydrogenated Pyridines (AREA)
ES532380A 1983-05-18 1984-05-10 Acidos 7-amino-1-ciclopropil-6,8-difluor-1,4-dihidro-4-oxo-quinolincarboxilicos Expired ES8507535A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833318145 DE3318145A1 (de) 1983-05-18 1983-05-18 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel

Publications (2)

Publication Number Publication Date
ES532380A0 true ES532380A0 (es) 1985-09-01
ES8507535A1 ES8507535A1 (es) 1985-09-01

Family

ID=6199330

Family Applications (4)

Application Number Title Priority Date Filing Date
ES532380A Expired ES8507535A1 (es) 1983-05-18 1984-05-10 Acidos 7-amino-1-ciclopropil-6,8-difluor-1,4-dihidro-4-oxo-quinolincarboxilicos
ES540890A Expired ES8602753A1 (es) 1983-05-18 1985-03-01 Un procedimiento para la obtencion de agentes antibacteria- nos a base de acidos 7-amino-1-ciclopropil-6,8-difluor-1, 4-dihidro-4-oxo-3-quinolincarboxilicos
ES540891A Granted ES540891A0 (es) 1983-05-18 1985-03-01 Un procedimiento para la obtencion de agentes antibacteria- nos a base de acidos 7-amino-1-ciclopropil-6,8-difluor-1, 4-dihidro-4-oxo-3-quinolincarboxilicos
ES540892A Expired ES8602755A1 (es) 1983-05-18 1985-03-01 Un procedimiento para la obtencion de agentes antibacteria- nos a base de acidos 7-amino-1-ciclopropil-6,8-difluor-1, 4-dihidro-4-oxo-3-quinolincarboxilicos

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES540890A Expired ES8602753A1 (es) 1983-05-18 1985-03-01 Un procedimiento para la obtencion de agentes antibacteria- nos a base de acidos 7-amino-1-ciclopropil-6,8-difluor-1, 4-dihidro-4-oxo-3-quinolincarboxilicos
ES540891A Granted ES540891A0 (es) 1983-05-18 1985-03-01 Un procedimiento para la obtencion de agentes antibacteria- nos a base de acidos 7-amino-1-ciclopropil-6,8-difluor-1, 4-dihidro-4-oxo-3-quinolincarboxilicos
ES540892A Expired ES8602755A1 (es) 1983-05-18 1985-03-01 Un procedimiento para la obtencion de agentes antibacteria- nos a base de acidos 7-amino-1-ciclopropil-6,8-difluor-1, 4-dihidro-4-oxo-3-quinolincarboxilicos

Country Status (13)

Country Link
US (2) US4556658A (es)
EP (1) EP0126355B1 (es)
JP (3) JPH0643402B2 (es)
KR (1) KR870000921B1 (es)
AU (1) AU573765B2 (es)
CA (1) CA1304738C (es)
CY (1) CY1487A (es)
DE (2) DE3318145A1 (es)
DK (2) DK164902C (es)
ES (4) ES8507535A1 (es)
GR (1) GR79952B (es)
HK (1) HK27088A (es)
PT (1) PT78588B (es)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4665079A (en) * 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
US5281612A (en) * 1982-09-09 1994-01-25 Warner-Lambert Company Naphthyridine antibacterial agents
EP0154780B1 (en) * 1984-01-26 1990-04-11 Abbott Laboratories Quinoline antibacterial compounds
IL74244A (en) * 1984-02-17 1988-06-30 Warner Lambert Co Quinoline derivatives,their preparation and pharmaceutical compositions containing them
DE3409922A1 (de) * 1984-03-17 1985-09-26 Bayer Ag, 5090 Leverkusen 1,7-diamino-1,4-dihydro-4-oxo-3-(aza)chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie ihre verwendung bei der bekaempfung bakterieller erkrankungen
DE3420116A1 (de) * 1984-05-30 1985-12-05 Bayer Ag, 5090 Leverkusen Immunstimulierende mittel
DE3420743A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US5468861A (en) * 1984-06-04 1995-11-21 Bayer Aktiengesellschaft 8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and alkyl esters thereof
US5530158A (en) * 1984-06-04 1996-06-25 Bayer Aktiengesellschaft 2,4,5-trihalogeno- and 2,3,4,5-tetrahalogenobenzene derivatives
US5200548A (en) * 1984-06-04 1993-04-06 Bayer Aktiengesellschaft 2,4,5-Trihalogeno- and 2,3,4,5-tetrahalogenobenzene derivatives
DE3420798A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-(3-aryl-l-piperazinyl)- sowie 7-(3-cyclohexyl-l-piperazinyl)-3-chinoloncarbonsaeuren
JPS6191183A (ja) * 1984-10-11 1986-05-09 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
IN162769B (es) * 1984-11-13 1988-07-09 Kyorin Seiyaku Kk
DE3441788A1 (de) * 1984-11-15 1986-05-15 Bayer Ag, 5090 Leverkusen Alkyl-1-cyclopropyl-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3576335D1 (de) * 1984-12-14 1990-04-12 Daiichi Seiyaku Co Chinolincarbonsaeure-derivate.
US4771054A (en) * 1985-01-23 1988-09-13 Warner-Lambert Company Antibacterial agents
DE3504643A1 (de) * 1985-02-12 1986-08-14 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-1,4-dihydro-4-oxo-7-(4-(2-oxo-1,3-dioxol-4-yl-methyl)-1-piperazinyl)-3-chinolin carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3509546A1 (de) * 1985-03-16 1986-09-25 Bayer Ag, 5090 Leverkusen 7-amino-1-(subst.cyclopropyl)-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
IL77846A (en) * 1985-03-25 1989-08-15 Warner Lambert Co Process for the preparation of 7-amino-quinolin-4-oxy-3-carboxylic acid derivatives
US4578473A (en) * 1985-04-15 1986-03-25 Warner-Lambert Company Process for quinoline-3-carboxylic acid antibacterial agents
IL79189A (en) * 1985-06-26 1990-07-12 Daiichi Seiyaku Co Quinoline and/or naphthyridine-4-oxo-3-carboxylic acid derivatives,process for their preparation and pharmaceutical compositions comprising them
JPH0635457B2 (ja) * 1985-06-28 1994-05-11 杏林製薬株式会社 ピリドンカルボン酸誘導体およびその製造方法
DE3608745A1 (de) * 1985-07-24 1987-01-29 Bayer Ag Bakterizide zubereitungen zur anwendung auf dem gebiet der veterinaermedizin
US4782180A (en) * 1985-09-09 1988-11-01 Warner-Lambert Company Process for tetrafluorobenzoic acid
JPS6259263A (ja) * 1985-09-10 1987-03-14 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
AU594983B2 (en) * 1985-10-29 1990-03-22 Dainippon Pharmaceutical Co. Ltd. Novel quinoline derivatives and processes for preparation thereof
DE3617803A1 (de) * 1985-11-07 1987-11-19 Bayer Ag Verwendung von gyrasehemmern zur dekontamination von mycoplasma-infizierten zellkulturen
US4668680A (en) * 1985-12-12 1987-05-26 Warner-Lambert Company 5-amino-6,8-difluoroquinolones as antibacterial agents
US4772706A (en) * 1986-01-13 1988-09-20 Warner-Lambert Company Process for quinoline-3-carboxylic acid antibacterial agents
JPH089597B2 (ja) * 1986-01-21 1996-01-31 杏林製薬株式会社 選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法
US4692454A (en) * 1986-02-03 1987-09-08 Warner-Lambert Company Opthalmic use of quinolone antibiotics
US4840956A (en) * 1986-02-18 1989-06-20 Warner-Lambert Company Novel disubstituted-7-pyrrolidinoquinoline antibacterial agents
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
DE3606698A1 (de) * 1986-03-01 1987-09-03 Bayer Ag 7-(1-pyrrolidinyl)-chinoloncarbonsaeure -derivate
JPS62215572A (ja) * 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
JPS63198664A (ja) * 1986-03-31 1988-08-17 Sankyo Co Ltd キノロンカルボン酸誘導体
EP0242789A3 (en) * 1986-04-25 1990-09-05 Dainippon Pharmaceutical Co., Ltd. Novel quinoline derivates and processes for preparation thereof
GB8612137D0 (en) * 1986-05-19 1986-06-25 Fujisawa Pharmaceutical Co Quinolone compounds
US4762845A (en) * 1986-05-21 1988-08-09 Abbott Laboratories 7-(3-Substituted imino-1-pyrrolidinyl)-quinolone-3-carboxylic acids
DE3635218A1 (de) * 1986-10-16 1988-04-21 Bayer Ag 7-amino-1-cyclopropyl-8-chlor-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3641312A1 (de) * 1986-12-03 1988-06-09 Bayer Ag Verfahren zur herstellung von chinolincarbonsaeuren
US5290934A (en) * 1987-04-16 1994-03-01 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
US5591744A (en) * 1987-04-16 1997-01-07 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
DE3724466A1 (de) * 1987-07-24 1989-02-02 Bayer Ag Verfahren zur herstellung von chinoloncarbonsaeuren
US4851418A (en) * 1987-08-21 1989-07-25 Warner-Lambert Company Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent
JPH02138278A (ja) * 1987-10-12 1990-05-28 Yoshitomi Pharmaceut Ind Ltd キノロンカルボン酸化合物
US4889857A (en) * 1987-10-12 1989-12-26 Yoshitomi Pharmaceutical Industries, Ltd. Quinolonecarboxylic acid compounds and pharmaceutical use thereof
US5173484A (en) * 1988-02-05 1992-12-22 Bayer Aktiengesellschaft Quinolone- and naphthyridone carboxylic acid derivatives, process for their production, antibacterial compositions and feed additives containing them
JPH0674261B2 (ja) * 1988-06-21 1994-09-21 塩野義製薬株式会社 キノロンカルボン酸誘導体
US5039682A (en) * 1988-06-21 1991-08-13 Pfizer Inc. 6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acid derivatives and intermediates therefor
US5103040A (en) * 1988-06-21 1992-04-07 Pfizer Inc. 6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acid derivatives and intermediates therefor
US5104868A (en) * 1988-06-21 1992-04-14 Pfizer Inc. Tricyclic derivatives of 7-substituted-6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acids and esters
US5233091A (en) * 1988-06-21 1993-08-03 Pfizer Inc. 6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acid derivatives and intermediates therefor
US5262417A (en) * 1988-12-06 1993-11-16 The Upjohn Company Antibacterial quinolone compounds
DE3918544A1 (de) * 1989-06-07 1990-12-13 Bayer Ag Verfahren zur herstellung von 7-(3-amino- sowie 3-amino-methyl-1-pyrrolidinyl)-3-chinolon- carbonsaeuren sowie -naphthyridoncarbonsaeuren
FR2657895A1 (fr) * 1990-02-05 1991-08-09 Inst Textile De France Materiau antiseptique a greffons complexes par des ions metalliques et procede de preparation.
JP2644610B2 (ja) * 1990-06-12 1997-08-25 三共株式会社 キノロンカルボン酸誘導体
US5342846A (en) * 1990-12-05 1994-08-30 Synphar Laboratories, Inc. 7-substituted-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid compounds and 7-(substituted triazolyl pyrrolidin-1-yl) 4-oxoquinoline-3-carboxylic acid derivatives useful as antibacterial agents
DE4128681A1 (de) * 1991-08-29 1993-03-04 Bayer Ag Substituierte mandelsaeurederivate, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
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FR2692577B1 (fr) * 1992-05-26 1996-02-02 Bouchara Sa Nouvelles quinolones fluorees, leur procede de preparation et les compositions pharmaceutiques en renfermant.
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CN1114607C (zh) 1997-06-26 2003-07-16 同和药品工业株式会社 喹诺酮羧酸衍生物
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US20080139574A1 (en) * 2006-11-30 2008-06-12 Cadila Healthcare Limited Novel quinoline derivatives
CN102516167A (zh) * 2011-11-22 2012-06-27 太仓市运通化工厂 一种喹诺酮类化合物的合成方法
US9573902B2 (en) * 2013-02-15 2017-02-21 Laurus Labs Private Ltd. Process for the preparation of Ivacaftor and its intermediates

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DE3033157A1 (de) * 1980-09-03 1982-04-01 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3142854A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
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DE3306771A1 (de) * 1983-02-25 1984-08-30 Bayer Ag, 5090 Leverkusen Chinoloncarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3306772A1 (de) * 1983-02-25 1984-08-30 Bayer Ag, 5090 Leverkusen Chinolonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
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IL74244A (en) * 1984-02-17 1988-06-30 Warner Lambert Co Quinoline derivatives,their preparation and pharmaceutical compositions containing them
DE3420116A1 (de) * 1984-05-30 1985-12-05 Bayer Ag, 5090 Leverkusen Immunstimulierende mittel
JPS6191183A (ja) * 1984-10-11 1986-05-09 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
DE3441788A1 (de) * 1984-11-15 1986-05-15 Bayer Ag, 5090 Leverkusen Alkyl-1-cyclopropyl-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel

Also Published As

Publication number Publication date
HK27088A (en) 1988-04-22
ES540890A0 (es) 1985-12-01
DK163992C (da) 1992-09-21
JPH0826001B2 (ja) 1996-03-13
KR870000921B1 (ko) 1987-05-07
JPH0764731B2 (ja) 1995-07-12
JPH0643402B2 (ja) 1994-06-08
AU573765B2 (en) 1988-06-23
DK164902B (da) 1992-09-07
PT78588A (en) 1984-06-01
AU3530084A (en) 1986-05-15
EP0126355A1 (de) 1984-11-28
DK154591A (da) 1991-09-03
US4556658A (en) 1985-12-03
DK247084A (da) 1984-11-19
US4556658B1 (es) 1987-09-15
GR79952B (es) 1984-10-31
KR860004048A (ko) 1986-06-16
DE3318145A1 (de) 1984-11-22
ES540892A0 (es) 1985-12-01
ES8602755A1 (es) 1985-12-01
EP0126355B1 (de) 1987-09-09
DK154591D0 (da) 1991-09-03
ES8602754A1 (es) 1985-12-01
DK164902C (da) 1993-01-18
JPH0592922A (ja) 1993-04-16
DK8402470A (es) 1984-11-19
DK163992B (da) 1992-04-27
CY1487A (en) 1989-12-08
PT78588B (en) 1986-06-26
ES8507535A1 (es) 1985-09-01
DK247084D0 (da) 1984-05-17
ES8602753A1 (es) 1985-12-01
CA1304738C (en) 1992-07-07
JPH0559007A (ja) 1993-03-09
DE3465989D1 (en) 1987-10-15
JPS59212474A (ja) 1984-12-01
US4952695A (en) 1990-08-28
ES540891A0 (es) 1985-12-01

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