IT1270260B - Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi - Google Patents
Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasiInfo
- Publication number
- IT1270260B IT1270260B ITMI941291A ITMI941291A IT1270260B IT 1270260 B IT1270260 B IT 1270260B IT MI941291 A ITMI941291 A IT MI941291A IT MI941291 A ITMI941291 A IT MI941291A IT 1270260 B IT1270260 B IT 1270260B
- Authority
- IT
- Italy
- Prior art keywords
- metallopeptidase
- acid derivatives
- phosphonic acid
- inhibitive
- activities
- Prior art date
Links
- 102000005741 Metalloproteases Human genes 0.000 title 1
- 108010006035 Metalloproteases Proteins 0.000 title 1
- 229940042400 direct acting antivirals phosphonic acid derivative Drugs 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 150000003007 phosphonic acid derivatives Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000005541 ACE inhibitor Substances 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids R2P(=O)(OH); Thiophosphinic acids, i.e. R2P(=X)(XH) (X = S, Se)
- C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Abstract
Vengono descritti composti di formula (FORMULA I) in cui R. R1, R2, m ed X hamo i significati riportati nella descrizione.I composti di formula I sono dotati di attività mista ACE - inibitrice e NEP - inibitrice e sono utili nel trattamento di disturbi cardiovascolari.
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI941291A IT1270260B (it) | 1994-06-21 | 1994-06-21 | Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi |
DE69503904T DE69503904T2 (de) | 1994-06-21 | 1995-06-16 | Phosphinsaeurederivate mit metallopeptidase inhibtorischer wirkung |
EP95924260A EP0766687B1 (en) | 1994-06-21 | 1995-06-16 | Phosphinic acid derivatives with metallopeptidase inhibitory activity |
ES95924260T ES2122646T3 (es) | 1994-06-21 | 1995-06-16 | Derivados de acido fosfinico con actividad inhibidora de la metalopeptidasa. |
PCT/EP1995/002343 WO1995035302A1 (en) | 1994-06-21 | 1995-06-16 | Phosphinic acid derivatives with metallopeptidase inhibitory activity |
US08/750,035 US5739123A (en) | 1994-06-21 | 1995-06-16 | Phosphinic acid derivatives with metallopeptidase inhibitory activity |
SI9520067A SI9520067A (en) | 1994-06-21 | 1995-06-16 | Phosphinic acid derivates with metallopeptidase inhibitory activity. |
JP8501655A JPH10501546A (ja) | 1994-06-21 | 1995-06-16 | メタロペプチダーゼ阻害作用を有するホスフィン酸誘導体 |
AU28842/95A AU2884295A (en) | 1994-06-21 | 1995-06-16 | Phosphinic acid derivatives with metallopeptidase inhibitory activity |
AT95924260T ATE169301T1 (de) | 1994-06-21 | 1995-06-16 | Phosphinsaeurederivate mit metallopeptidase inhibtorischer wirkung |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI941291A IT1270260B (it) | 1994-06-21 | 1994-06-21 | Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI941291A0 ITMI941291A0 (it) | 1994-06-21 |
ITMI941291A1 ITMI941291A1 (it) | 1995-12-21 |
IT1270260B true IT1270260B (it) | 1997-04-29 |
Family
ID=11369146
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI941291A IT1270260B (it) | 1994-06-21 | 1994-06-21 | Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi |
Country Status (10)
Country | Link |
---|---|
US (1) | US5739123A (it) |
EP (1) | EP0766687B1 (it) |
JP (1) | JPH10501546A (it) |
AT (1) | ATE169301T1 (it) |
AU (1) | AU2884295A (it) |
DE (1) | DE69503904T2 (it) |
ES (1) | ES2122646T3 (it) |
IT (1) | IT1270260B (it) |
SI (1) | SI9520067A (it) |
WO (1) | WO1995035302A1 (it) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1276710B1 (it) * | 1995-06-14 | 1997-11-03 | Zambon Spa | Derivati dell'acido fosfinico ad attivita' inibitrice delle metallopeptidasi |
FR2755135B1 (fr) * | 1996-10-25 | 2002-12-27 | Inst Nat Sante Rech Med | Nouveaux derives d'(alpha-aminophosphino)peptides, leur procede de preparation et les compositions qui les contiennent |
FR2777780B1 (fr) | 1998-04-22 | 2001-05-04 | Inst Nat Sante Rech Med | Derives d'(alpha-aminophosphino) peptides, leur procede de preparation et les compositions qui les contiennent |
US6528499B1 (en) * | 2000-04-27 | 2003-03-04 | Georgetown University | Ligands for metabotropic glutamate receptors and inhibitors of NAALADase |
EP2097111B1 (en) * | 2006-11-08 | 2015-07-15 | Molecular Insight Pharmaceuticals, Inc. | Heterodimers of glutamic acid |
FR2934267B1 (fr) * | 2008-07-23 | 2010-08-13 | Pharmaleads | Derives aminophosphiniques utiles dans le traitement de la douleur |
DE102008055914A1 (de) * | 2008-11-05 | 2010-05-06 | Clariant International Limited | Verfahren zur Herstellung von mono-hydroxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Acroleinen und ihre Verwendung |
DE102008055916A1 (de) * | 2008-11-05 | 2010-05-06 | Clariant International Limited | Verfahren zur Herstellung von mono-hydroxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Allylalkoholen und ihre Verwendung |
JP5619756B2 (ja) * | 2008-11-05 | 2014-11-05 | クラリアント・ファイナンス・(ビーブイアイ)・リミテッド | アルキルアルコール/アクロレインを使用したジアルキルホスフィン酸、−エステル及び−塩の製造方法及びそれらの使用 |
WO2010051893A1 (de) * | 2008-11-07 | 2010-05-14 | Clariant International Ltd | Verfahren zur herstellung von dialkylphosphinsäuren, -estern und -salzen mittels acrylsäurederivaten und ihre verwendung |
DE102008056342A1 (de) * | 2008-11-07 | 2010-05-12 | Clariant International Limited | Verfahren zur Herstellung von Dialkylphosphinsäuren, -estern und -salzen mittels Acrylnitrilen und ihre Verwendung |
DE102008056339A1 (de) * | 2008-11-07 | 2010-05-12 | Clariant International Limited | Verfahren zur Herstellung von mono-aminofunktionalisierten Dialkylphosphinsäuren, -estern und -salzen und ihre Verwendung |
DE102008056341A1 (de) * | 2008-11-07 | 2010-05-12 | Clariant International Limited | Verfahren zur Herstellung von monoaminofunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Acrylnitrilen und ihre Verwendung |
CN102171226B (zh) | 2008-11-11 | 2015-02-11 | 科莱恩金融(Bvi)有限公司 | 利用烯丙基化合物制备单烯丙基官能化的二烷基次膦酸、其盐或酯的方法以及它们的用途 |
DE102008060036A1 (de) * | 2008-12-02 | 2010-06-10 | Clariant International Limited | Verfahren zur Herstellung von mono-carboxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Vinylester einer Carbonsäure und ihre Verwendung |
DE102008060035A1 (de) * | 2008-12-02 | 2010-06-10 | Clariant International Limited | Verfahren zur Herstellung von mono-hydroxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Vinylester einer Carbonsäure und ihre Verwendung |
DE102008060535A1 (de) | 2008-12-04 | 2010-06-10 | Clariant International Limited | Verfahren zur Herstellung von mono-carboxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Vinylether und ihre Verwendung |
WO2010065899A2 (en) | 2008-12-05 | 2010-06-10 | Molecular Insight Pharmaceuticals, Inc. | Technetium-and rhenium-bis(heteroaryl)complexes and methods of use thereof |
DE102008063642A1 (de) | 2008-12-18 | 2010-06-24 | Clariant International Limited | Verfahren zur Herstellung von monocarboxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Alkylenoxiden und ihre Verwendung |
DE102008063668A1 (de) | 2008-12-18 | 2010-07-01 | Clariant International Limited | Verfahren zur Herstellung von Alkylphosponsäuren, -estern und -salzen mittels Oxidation von Alkylphosphonigsäuren und ihre Verwendung |
DE102008063627A1 (de) | 2008-12-18 | 2010-06-24 | Clariant International Limited | Verfahren zur Herstellung von monohydroxyfunktionalisierten Dialkylphosphinsäuren,-estern und -salzen mittels Ethylenoxid und ihre Verwendung |
ES2446666T3 (es) | 2008-12-18 | 2014-03-10 | Clariant Finance (Bvi) Limited | Procedimiento para la preparación de ácidos etilen-dialquil-fosfínicos, o de sus ésteres y sales, mediante acetileno, y su utilización |
DE102008064003A1 (de) | 2008-12-19 | 2010-06-24 | Clariant International Limited | Verfahren zur Herstellung von mono-funktionalisierten Dialkylphosphinsäuren, -estern und -salzen und ihre Verwendung |
DE102008064012A1 (de) | 2008-12-19 | 2010-06-24 | Clariant International Limited | Halogenfreie Addukte von Alkylphosphonigsäurederivaten und diesterbildenden Olefinen, halogenfreie Verfahren zu deren Herstellung und ihre Verwendung |
BR112012000210A2 (pt) | 2009-06-15 | 2019-09-24 | Molecular Insight Pharm Inc | processo para a produção de heterodímeoros de ácido glutâmico. |
EP2800471A4 (en) | 2012-01-06 | 2015-11-04 | Molecular Insight Pharm Inc | METAL COMPLEX OF POLY (CARBOXYL) AMINE CONTAINING LIGANDS HAVING AFFINITY FOR CARBON IX ANHYDRASE |
EP3545978B1 (en) | 2013-01-14 | 2021-09-08 | Molecular Insight Pharmaceuticals, Inc. | Triazine based radiopharmaceuticals and radioimaging agents |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4379146A (en) * | 1981-02-17 | 1983-04-05 | Merck & Co., Inc. | Substituted phosphonamides as antihypertensives |
US4432972A (en) * | 1981-08-03 | 1984-02-21 | E. R. Squibb & Sons, Inc. | Phosphonamidate compounds |
US4396772A (en) * | 1981-11-23 | 1983-08-02 | F. R. Squibb & Sons, Inc. | Phosphinylalkanoyl amino acids |
DE3600365A1 (de) * | 1986-01-09 | 1987-07-16 | Hoechst Ag | Neue thyroninderivate |
IT1224405B (it) * | 1987-12-23 | 1990-10-04 | Simes | Composti attivi sul sistema cardiovascolare |
US5155100A (en) * | 1991-05-01 | 1992-10-13 | Ciba-Geigy Corporation | Phosphono/biaryl substituted dipeptide derivatives |
US5250522A (en) * | 1992-10-09 | 1993-10-05 | Ciba-Geigy Corporation | Phosphono/biaryl substituted amino acid derivatives |
WO1993014112A1 (en) * | 1992-01-15 | 1993-07-22 | Merck & Co., Inc. | Substituted phosphinic acid-containing peptidyl derivatives as antidegenerative agents |
IT1254521B (it) * | 1992-03-17 | 1995-09-25 | Zambon Spa | Derivati della 2-ammino-tetralina attivi sul sistema cardiovascolare |
-
1994
- 1994-06-21 IT ITMI941291A patent/IT1270260B/it active IP Right Grant
-
1995
- 1995-06-16 WO PCT/EP1995/002343 patent/WO1995035302A1/en active IP Right Grant
- 1995-06-16 EP EP95924260A patent/EP0766687B1/en not_active Expired - Lifetime
- 1995-06-16 DE DE69503904T patent/DE69503904T2/de not_active Expired - Fee Related
- 1995-06-16 AT AT95924260T patent/ATE169301T1/de not_active IP Right Cessation
- 1995-06-16 US US08/750,035 patent/US5739123A/en not_active Expired - Fee Related
- 1995-06-16 JP JP8501655A patent/JPH10501546A/ja not_active Ceased
- 1995-06-16 ES ES95924260T patent/ES2122646T3/es not_active Expired - Lifetime
- 1995-06-16 SI SI9520067A patent/SI9520067A/sl not_active IP Right Cessation
- 1995-06-16 AU AU28842/95A patent/AU2884295A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2884295A (en) | 1996-01-15 |
SI9520067A (en) | 1997-10-31 |
EP0766687A1 (en) | 1997-04-09 |
JPH10501546A (ja) | 1998-02-10 |
US5739123A (en) | 1998-04-14 |
DE69503904D1 (de) | 1998-09-10 |
ES2122646T3 (es) | 1998-12-16 |
ITMI941291A0 (it) | 1994-06-21 |
ATE169301T1 (de) | 1998-08-15 |
ITMI941291A1 (it) | 1995-12-21 |
WO1995035302A1 (en) | 1995-12-28 |
DE69503904T2 (de) | 1999-04-22 |
EP0766687B1 (en) | 1998-08-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970825 |