ITMI941291A0 - Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi - Google Patents
Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasiInfo
- Publication number
- ITMI941291A0 ITMI941291A0 ITMI941291A ITMI941291A ITMI941291A0 IT MI941291 A0 ITMI941291 A0 IT MI941291A0 IT MI941291 A ITMI941291 A IT MI941291A IT MI941291 A ITMI941291 A IT MI941291A IT MI941291 A0 ITMI941291 A0 IT MI941291A0
- Authority
- IT
- Italy
- Prior art keywords
- metallopeptidase
- derivatives
- phosphonic acid
- inhibiting activity
- inhibiting
- Prior art date
Links
- 102000005741 Metalloproteases Human genes 0.000 title 1
- 108010006035 Metalloproteases Proteins 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 150000003009 phosphonic acids Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI941291A IT1270260B (it) | 1994-06-21 | 1994-06-21 | Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi |
PCT/EP1995/002343 WO1995035302A1 (en) | 1994-06-21 | 1995-06-16 | Phosphinic acid derivatives with metallopeptidase inhibitory activity |
SI9520067A SI9520067A (en) | 1994-06-21 | 1995-06-16 | Phosphinic acid derivates with metallopeptidase inhibitory activity. |
US08/750,035 US5739123A (en) | 1994-06-21 | 1995-06-16 | Phosphinic acid derivatives with metallopeptidase inhibitory activity |
AU28842/95A AU2884295A (en) | 1994-06-21 | 1995-06-16 | Phosphinic acid derivatives with metallopeptidase inhibitory activity |
DE69503904T DE69503904T2 (de) | 1994-06-21 | 1995-06-16 | Phosphinsaeurederivate mit metallopeptidase inhibtorischer wirkung |
JP8501655A JPH10501546A (ja) | 1994-06-21 | 1995-06-16 | メタロペプチダーゼ阻害作用を有するホスフィン酸誘導体 |
ES95924260T ES2122646T3 (es) | 1994-06-21 | 1995-06-16 | Derivados de acido fosfinico con actividad inhibidora de la metalopeptidasa. |
AT95924260T ATE169301T1 (de) | 1994-06-21 | 1995-06-16 | Phosphinsaeurederivate mit metallopeptidase inhibtorischer wirkung |
EP95924260A EP0766687B1 (en) | 1994-06-21 | 1995-06-16 | Phosphinic acid derivatives with metallopeptidase inhibitory activity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI941291A IT1270260B (it) | 1994-06-21 | 1994-06-21 | Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI941291A0 true ITMI941291A0 (it) | 1994-06-21 |
ITMI941291A1 ITMI941291A1 (it) | 1995-12-21 |
IT1270260B IT1270260B (it) | 1997-04-29 |
Family
ID=11369146
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI941291A IT1270260B (it) | 1994-06-21 | 1994-06-21 | Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi |
Country Status (10)
Country | Link |
---|---|
US (1) | US5739123A (it) |
EP (1) | EP0766687B1 (it) |
JP (1) | JPH10501546A (it) |
AT (1) | ATE169301T1 (it) |
AU (1) | AU2884295A (it) |
DE (1) | DE69503904T2 (it) |
ES (1) | ES2122646T3 (it) |
IT (1) | IT1270260B (it) |
SI (1) | SI9520067A (it) |
WO (1) | WO1995035302A1 (it) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1276710B1 (it) * | 1995-06-14 | 1997-11-03 | Zambon Spa | Derivati dell'acido fosfinico ad attivita' inibitrice delle metallopeptidasi |
FR2755135B1 (fr) | 1996-10-25 | 2002-12-27 | Inst Nat Sante Rech Med | Nouveaux derives d'(alpha-aminophosphino)peptides, leur procede de preparation et les compositions qui les contiennent |
FR2777780B1 (fr) | 1998-04-22 | 2001-05-04 | Inst Nat Sante Rech Med | Derives d'(alpha-aminophosphino) peptides, leur procede de preparation et les compositions qui les contiennent |
US6528499B1 (en) * | 2000-04-27 | 2003-03-04 | Georgetown University | Ligands for metabotropic glutamate receptors and inhibitors of NAALADase |
PT3699162T (pt) | 2006-11-08 | 2022-10-11 | Molecular Insight Pharm Inc | Heterodímeros de ácido glutâmico |
FR2934267B1 (fr) * | 2008-07-23 | 2010-08-13 | Pharmaleads | Derives aminophosphiniques utiles dans le traitement de la douleur |
DE102008055916A1 (de) * | 2008-11-05 | 2010-05-06 | Clariant International Limited | Verfahren zur Herstellung von mono-hydroxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Allylalkoholen und ihre Verwendung |
DE102008055914A1 (de) * | 2008-11-05 | 2010-05-06 | Clariant International Limited | Verfahren zur Herstellung von mono-hydroxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Acroleinen und ihre Verwendung |
WO2010051883A1 (de) * | 2008-11-05 | 2010-05-14 | Clariant International Ltd | Verfahren zur herstellung von dialkylphosphinsäuren, -estern und -salzen mittels allylalkoholen/acroleinen und ihre verwendung |
CN102186864A (zh) * | 2008-11-07 | 2011-09-14 | 科莱恩金融(Bvi)有限公司 | 利用丙烯酸衍生物制备二烷基次膦酸、二烷基次膦酸酯和二烷基次膦酸盐的方法,以及它们的用途 |
DE102008056341A1 (de) * | 2008-11-07 | 2010-05-12 | Clariant International Limited | Verfahren zur Herstellung von monoaminofunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Acrylnitrilen und ihre Verwendung |
DE102008056339A1 (de) * | 2008-11-07 | 2010-05-12 | Clariant International Limited | Verfahren zur Herstellung von mono-aminofunktionalisierten Dialkylphosphinsäuren, -estern und -salzen und ihre Verwendung |
DE102008056342A1 (de) * | 2008-11-07 | 2010-05-12 | Clariant International Limited | Verfahren zur Herstellung von Dialkylphosphinsäuren, -estern und -salzen mittels Acrylnitrilen und ihre Verwendung |
CN102171226B (zh) | 2008-11-11 | 2015-02-11 | 科莱恩金融(Bvi)有限公司 | 利用烯丙基化合物制备单烯丙基官能化的二烷基次膦酸、其盐或酯的方法以及它们的用途 |
DE102008060035A1 (de) * | 2008-12-02 | 2010-06-10 | Clariant International Limited | Verfahren zur Herstellung von mono-hydroxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Vinylester einer Carbonsäure und ihre Verwendung |
DE102008060036A1 (de) * | 2008-12-02 | 2010-06-10 | Clariant International Limited | Verfahren zur Herstellung von mono-carboxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Vinylester einer Carbonsäure und ihre Verwendung |
DE102008060535A1 (de) * | 2008-12-04 | 2010-06-10 | Clariant International Limited | Verfahren zur Herstellung von mono-carboxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Vinylether und ihre Verwendung |
EP2706057B1 (en) | 2008-12-05 | 2016-04-20 | Molecular Insight Pharmaceuticals, Inc. | Bis(imidazolyl)compounds and radionuclide complexes |
DE102008063642A1 (de) | 2008-12-18 | 2010-06-24 | Clariant International Limited | Verfahren zur Herstellung von monocarboxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Alkylenoxiden und ihre Verwendung |
DE102008063668A1 (de) | 2008-12-18 | 2010-07-01 | Clariant International Limited | Verfahren zur Herstellung von Alkylphosponsäuren, -estern und -salzen mittels Oxidation von Alkylphosphonigsäuren und ihre Verwendung |
WO2010069545A2 (de) | 2008-12-18 | 2010-06-24 | Clariant International Ltd | Verfahren zur herstellung von ethylendialkylphosphinsäuren, -estern und -salzen mittels acetylen und ihre verwendung |
DE102008063627A1 (de) | 2008-12-18 | 2010-06-24 | Clariant International Limited | Verfahren zur Herstellung von monohydroxyfunktionalisierten Dialkylphosphinsäuren,-estern und -salzen mittels Ethylenoxid und ihre Verwendung |
DE102008064012A1 (de) | 2008-12-19 | 2010-06-24 | Clariant International Limited | Halogenfreie Addukte von Alkylphosphonigsäurederivaten und diesterbildenden Olefinen, halogenfreie Verfahren zu deren Herstellung und ihre Verwendung |
DE102008064003A1 (de) | 2008-12-19 | 2010-06-24 | Clariant International Limited | Verfahren zur Herstellung von mono-funktionalisierten Dialkylphosphinsäuren, -estern und -salzen und ihre Verwendung |
BR112012000209B8 (pt) | 2009-06-15 | 2021-07-27 | Molecular Insight Pharm Inc | heterodímeros de ácido glutâmico e seus processos de preparação |
EP2800471A4 (en) | 2012-01-06 | 2015-11-04 | Molecular Insight Pharm Inc | METAL COMPLEX OF POLY (CARBOXYL) AMINE CONTAINING LIGANDS HAVING AFFINITY FOR CARBON IX ANHYDRASE |
HUE035739T2 (en) | 2013-01-14 | 2018-05-28 | Molecular Insight Pharm Inc | Triazine-based radiopharmaceuticals and radiological imaging agents |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4379146A (en) * | 1981-02-17 | 1983-04-05 | Merck & Co., Inc. | Substituted phosphonamides as antihypertensives |
US4432972A (en) * | 1981-08-03 | 1984-02-21 | E. R. Squibb & Sons, Inc. | Phosphonamidate compounds |
US4396772A (en) * | 1981-11-23 | 1983-08-02 | F. R. Squibb & Sons, Inc. | Phosphinylalkanoyl amino acids |
DE3600365A1 (de) * | 1986-01-09 | 1987-07-16 | Hoechst Ag | Neue thyroninderivate |
IT1224405B (it) * | 1987-12-23 | 1990-10-04 | Simes | Composti attivi sul sistema cardiovascolare |
US5155100A (en) * | 1991-05-01 | 1992-10-13 | Ciba-Geigy Corporation | Phosphono/biaryl substituted dipeptide derivatives |
US5250522A (en) * | 1992-10-09 | 1993-10-05 | Ciba-Geigy Corporation | Phosphono/biaryl substituted amino acid derivatives |
EP0623143A1 (en) * | 1992-01-15 | 1994-11-09 | Merck & Co. Inc. | Substituted phosphinic acid-containing peptidyl derivatives as antidegenerative agents |
IT1254521B (it) * | 1992-03-17 | 1995-09-25 | Zambon Spa | Derivati della 2-ammino-tetralina attivi sul sistema cardiovascolare |
-
1994
- 1994-06-21 IT ITMI941291A patent/IT1270260B/it active IP Right Grant
-
1995
- 1995-06-16 DE DE69503904T patent/DE69503904T2/de not_active Expired - Fee Related
- 1995-06-16 JP JP8501655A patent/JPH10501546A/ja not_active Ceased
- 1995-06-16 AT AT95924260T patent/ATE169301T1/de not_active IP Right Cessation
- 1995-06-16 EP EP95924260A patent/EP0766687B1/en not_active Expired - Lifetime
- 1995-06-16 SI SI9520067A patent/SI9520067A/sl not_active IP Right Cessation
- 1995-06-16 WO PCT/EP1995/002343 patent/WO1995035302A1/en active IP Right Grant
- 1995-06-16 US US08/750,035 patent/US5739123A/en not_active Expired - Fee Related
- 1995-06-16 AU AU28842/95A patent/AU2884295A/en not_active Abandoned
- 1995-06-16 ES ES95924260T patent/ES2122646T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE169301T1 (de) | 1998-08-15 |
EP0766687A1 (en) | 1997-04-09 |
IT1270260B (it) | 1997-04-29 |
SI9520067A (en) | 1997-10-31 |
WO1995035302A1 (en) | 1995-12-28 |
JPH10501546A (ja) | 1998-02-10 |
ITMI941291A1 (it) | 1995-12-21 |
DE69503904D1 (de) | 1998-09-10 |
US5739123A (en) | 1998-04-14 |
ES2122646T3 (es) | 1998-12-16 |
EP0766687B1 (en) | 1998-08-05 |
DE69503904T2 (de) | 1999-04-22 |
AU2884295A (en) | 1996-01-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970825 |